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STDPPAEAPSQQPAWRLEYAEPGMLVYSIPGVELPKLPLVRSGGWVPGGAPSAEGLPDKHSALHYARYIG RVGVLAAALGLGAVIAGTPGIARAEPEADSTTSSSTDSDASEASEAVTTDQEASETEEAPESEDVLESDT GETAATEDDAEAEAEAEADAEAEAAAEAEADAEAEAEAEGGTADEDETARASGDAVEQPTATTEYTGGST TEPAMLIPAPPDVQSPTDTEVTTGSPAVSAETDTTAPAEPTPQPAPTGAVRQALDTVLAPLAAPESPAVQ RAETPVLWTVFAWTRRTFFNATPVVRYDDTTTSQLQNTITGRVTATDSDTPTLTLTASAPANGGTVLLRP DGTFTYTVPTTMYAGGTDTFTVTASDADGPAHIHGLTGLLHLVSLGLVGHSGHSATATVTLDIAAVTAPI LGTPAYQLDTAEHGTGAVPGALHVTGPEGLTYTLTGGPAEGEVTLDARTGAFIYTPTSVARHQASAEDAT PDELADTFTITVTDNLGGTISVPVAVAIDPSNQSPTVTLVVSVPDSEGTVHVSVAVADPDNDATTYFVVH DPAYGTLTATPDGYDYNPTAEAVRIGVRADTLTVTASDLHHGSDTETVTVPIGSDDAAPAGLLAATAYSS TDIQLPAAATVITLRGRNYLGSLSPDRMDDHFGGMFAEDPYTMVKLTYPDSENSDAIDDAVAMLDAQLMS TPGDIIVMGHSFGAQVCSRWMRVYARDPVRRAMADRLTFVLTGNPLRSDNGKVVGMLEIDAWIGLPTPTT TPWQIIDVARRWDGWADWPDDSSNATAARNARAGQNYLHPNYDDVDLYDPQNTVWRNGNTTYVLTHEDDL PMFRYWWGVPSDFESVVRAEVESAYNRPSADIPVPVRPVQSWWWQMVLRWLEIENPA*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_1597 | - | - | 100% (898) | hypothetical protein Mvan_1597 |
M. vanbaalenii PYR-1 | Mvan_5913 | - | 5e-42 | 29.47% (621) | putative outer membrane adhesin like proteiin |
M. vanbaalenii PYR-1 | Mvan_5004 | - | 5e-40 | 27.65% (622) | hypothetical protein Mvan_5004 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1465 | PE16 | 1e-11 | 28.74% (247) | PE family protein |
M. gilvum PYR-GCK | Mflv_4855 | - | 3e-39 | 30.25% (605) | YVTN beta-propeller repeat-containing protein |
M. tuberculosis H37Rv | Rv1430 | PE16 | 1e-11 | 28.74% (247) | PE family protein |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_1963 | - | 6e-06 | 23.44% (256) | MmpS family protein |
M. marinum M | MMAR_2416 | lgt | 5e-11 | 30.37% (191) | prolipoprotein diacylglyceryl transferases Lgt |
M. avium 104 | MAV_3172 | - | 5e-09 | 36.21% (116) | prolipoprotein diacylglyceryl transferase |
M. smegmatis MC2 155 | MSMEG_4734 | - | 5e-14 | 32.28% (189) | hypothetical protein MSMEG_4734 |
M. thermoresistible (build 8) | TH_3724 | - | 4e-16 | 34.62% (208) | PUTATIVE putative PE-PPE, C-terminal domain protein |
M. ulcerans Agy99 | MUL_1034 | - | 2e-06 | 22.22% (252) | PE family protein |
CLUSTAL 2.0.9 multiple sequence alignment Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK MGYSKYVGRVGALALALGIGTAVATPAWAESPSTSESASSESKAPQKPSS Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK RRSTPATSGDSANGGDSAGKSGSDGSTASAGGNDNDSPVEDEADIEVAPE Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK PEAAEDAPPLVDEVVEESDAHDGNSASAAPEVDSPSTAVPSDATGVSEAE Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK APAHETLASLSPDQDPEPVDTEIADAPTPLGYALAVTAPPVEPAPAPLVR Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK QPRGPVGVILGGPAAMIDIAAKALQMLFNPGPTVPGDPPLLLGVLAFVRR Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK EIQRTFFNSSPTAVADTTSTSEGLPTRISVLDNDTDPNIDDVLTVTDFTQ Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK AANGVVELNADGSFTYTPTTGYSGTDTFTYTISDEASEWHGHVAGFVRGH Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK TSTATVSVTVLPPPVNESPSAAGDSATTAEDTPAVIDVKANDSDPNGDDI Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK SIASVGTAQHGAVAVLDGKITYTPESNFHGTDTFDYTITDGDLSDTATVT Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK VTVTPVNDAPVAVHDAITVAGSSVANVINVLGNDTDPDTEVTLTVAEVGA Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK PNHGGTVTIVDGNAIAYTPAAGFSGTETFSYTVSDGELTDTATVTVSVEQ Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK VVPSNIAPSAYDNVSYYTTNENTTLNVFANDGLIEWDAFDPDGDALTAGL Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK ATGPAHGTLDLNPDGSFTYTPDFGFIGDDSFRYTVTDGASSSNIATVGIS Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK VTPAGSSNTGNNRPPRAFDDFANIRENTTLTVPAGQGLLSTRSAHDADGD Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK SLTVDLVTATTNGHVSVDADGSYTYAPNDGYVGEDSFTYTISDGQATSSA Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK ATVTILVHAASEQTAPEAYGDDQIVVQDSSLTVSTENGLTSRFNAYDNEG Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK DALTAALATGPSNGQVTVNSDGSYTYTPNDGYIGEDSFTYTVSDGQLVSA Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK AATVYIDVQSNAYNMETGITIGPDGKVYVLHGTTRSNPDGTTGGSFHLAS Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK RNSDGSLTDLVQLSGASADSLPTGLAAGSDGRIYVADHLTGSITVYDRSG Mvan_1597|M.vanbaalenii_PYR-1 -----------------------------------------MSTDPPAEA MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M ------------------------------------------------MT MAV_3172|M.avium_104 -------------------------------------------------M Mflv_4855|M.gilvum_PYR-GCK GYSPTLIASIPAAAGIALDSKGRIYVTTVDYTDPDRAVGQLWILDSTGTQ Mvan_1597|M.vanbaalenii_PYR-1 PSQQPAWRLEYAEPGMLVYSIPGVELPKLPLVRSGGWVPGGAPSAEGLPD MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 --MSFVFAVPEMVAATASD----LASLGAALSEATAAAAIPTTQVLAAAA Rv1430|M.tuberculosis_H37Rv --MSFVFAVPEMVAATASD----LASLGAALSEATAAAAIPTTQVLAAAA MUL_1034|M.ulcerans_Agy99 --MSYVLTAPDLLASAATD----VDGIAATLQVANSAAAALTSGLLAAAQ MSMEG_4734|M.smegmatis_MC2_155 ------MRDVRVGLIALLS----VMALGLVSTVVSVAAAAARTSVLIMGG TH_3724|M.thermoresistible__bu --------------VVAVG----ALTWGGX-GVASPAGQPERAAALRLTA MMAR_2416|M.marinum_M ATVLAYFPSPPRGVWHLGP----LPIRAYAFFIIIGIVMGLMIGDRRFAA MAV_3172|M.avium_104 TKLLAYFPSPPQGVWHLGP----VPIRAYALFIIAGIVAALLIGDRRWEA Mflv_4855|M.gilvum_PYR-GCK IGRPIDLAGPAAGVAVASNGDVYVAGLSGGLSVYSHRVLQTNITAEDLPG Mvan_1597|M.vanbaalenii_PYR-1 KHSALHYARYIGRVGVLAAALGLGAVIAGTPGIARAEPEADSTTSSSTDS MAB_1963|M.abscessus_ATCC_1997 ------------------------------MSGTDNPGSGNPGEVPDLDG Mb1465|M.bovis_AF2122/97 DEVSAAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAAN Rv1430|M.tuberculosis_H37Rv DEVSAAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAAN MUL_1034|M.ulcerans_Agy99 DEVSAAIAKVFSAYGQEYQAAIAQASAFHTEFTRALAAAGAAYAQAEAAN MSMEG_4734|M.smegmatis_MC2_155 SGDPLTTDQDGLPFIRDYTSKVVGNYVIPSASRPGSGIPGGPYNAVAVIT TH_3724|M.thermoresistible__bu TADAIIMPGTKIGYIPSQD-------EFTAYATAVIGATAGAPGAVDYLG MMAR_2416|M.marinum_M RGGERGVIYDIALWMVPFGLIGGRLYHLSTDWQTYFGEGGAGLGAALRIW MAV_3172|M.avium_104 RGGERGVIYDIALWTVPFGLVGGRLYHLATDWRTYWGPGGAGFGAAVRIW Mflv_4855|M.gilvum_PYR-GCK FLHGLAIGPDGTAYIANWEAVSSSGELLDGAINIVNPADPTNIKQLPGVS Mvan_1597|M.vanbaalenii_PYR-1 DASEASEAVTTDQEASETEEAPESEDVLESDTGETAATEDDAEAEAEAEA MAB_1963|M.abscessus_ATCC_1997 PNEEAAAPDSSGADSAAFHSQAYSAPESEQFTSPYVPYDEYETQLVD--- Mb1465|M.bovis_AF2122/97 AALVDTAAT--------------GASELGSGGR----------------- Rv1430|M.tuberculosis_H37Rv AALVDTAAT--------------GASELGSGGR----------------- MUL_1034|M.ulcerans_Agy99 ASLITAGVSDALTAITTPIQSLLGPAAIGTGGAGSAGALTAVSSTLMADP MSMEG_4734|M.smegmatis_MC2_155 PAQFNSGEP----------------------------------------- TH_3724|M.thermoresistible__bu VPGEFWPAT----------------------------------------- MMAR_2416|M.marinum_M DGG----------------------------------------------- MAV_3172|M.avium_104 DGG----------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK DPWGVVYANG-----LLYVTSTATQSVITLDPANATPFVNPNENAGGGAL Mvan_1597|M.vanbaalenii_PYR-1 DAEAEAAAEA---------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -TALILGSTGTPRPPFDYMQQVYDRYIAPHYLGYAFSGLYTPAQFQPWT- Rv1430|M.tuberculosis_H37Rv -TALILGSTGTPRPPFDYMQQVYDRYIAPHYLGYAFSGLYTPAQFQPWT- MUL_1034|M.ulcerans_Agy99 VVALIMGGTSVPLPGPGYVSDINNNYIQPLFSGAIPQALFTPEQFWPVTP MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------L MAV_3172|M.avium_104 -------------------------------------------------L Mflv_4855|M.gilvum_PYR-GCK DPYTYDVKTGIALGPTGDTFVIRGSVTYSPADGSSESTFYLARQNEDGSF Mvan_1597|M.vanbaalenii_PYR-1 ---------------------------------EADAEAEAEAEGGTADE MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 GIPSLTYDQSVAEGAGYLHTAIMQQVAAGN-------------DVVVLGF Rv1430|M.tuberculosis_H37Rv GIPSLTYDQSVAEGAGYLHTAIMQQVAAGN-------------DVVVLGF MUL_1034|M.ulcerans_Agy99 GLGNLTFNQSVAQGVTLLNDAINTQLALGN-------------KVVAFGY MSMEG_4734|M.smegmatis_MC2_155 GDTSLTFDDSVAAGAGKLATCIESGDECDINEDLGSDRPAPGDNLVVFGY TH_3724|M.thermoresistible__bu GLDSLTFDASVAXGQAMLTPMVDGAIESDT-------------PIVVFGH MMAR_2416|M.marinum_M GIWGAVTLGTVGAWIGCRRRGIPLPAFLDA---------------VAPGV MAV_3172|M.avium_104 GIWGAVALGAVGAWIGCRRHGIPLPAFADA---------------LAPGI Mflv_4855|M.gilvum_PYR-GCK SDLAEIDGSPTSLAVGPDGRLFVTDNETGIVTMYDPSDGYSARAVAAIPN Mvan_1597|M.vanbaalenii_PYR-1 DETARASGDAVEQPTATTEYTGGSTTEPAMLIPAPPDVQSPTDTEVTTGS MAB_1963|M.abscessus_ATCC_1997 GEEPPPPRWPWVVGVAAIIAAITLVASVAL-------------------L . . Mb1465|M.bovis_AF2122/97 SQGASVATLEMRHLASLPAGVAPSPDQLSFVLLGNPNNPNGGILARFPG- Rv1430|M.tuberculosis_H37Rv SQGASVATLEMRHLASLPAGVAPSPDQLSFVLLGNPNNPNGGILARFPG- MUL_1034|M.ulcerans_Agy99 SQSATIVNNEILALMAMGTG-APDPGDLSFIMVGAPNNPDGGLLARFPG- MSMEG_4734|M.smegmatis_MC2_155 SQSAAIATLEKARLAALYP-YGEGP-DVSFILTANGNRPNGGFLARGPKG TH_3724|M.thermoresistible__bu SQSAVIATKEKQRLLAEYPDPDTAP-DVTFVMVANPNRPNGGLLARFPG- MMAR_2416|M.marinum_M VMGQAIGRLGNYFNQELYGRETTVPWGLEIFYR---RDPSGFVDVHSLDG MAV_3172|M.avium_104 ILAQAIGRLGNYFNQELYGRETTLPWGLEIFYR---RDPSGYIDPHSLDG Mflv_4855|M.gilvum_PYR-GCK AAGIAVDASGRIFVTTVTSDESGEPTGQLWILDATGSQIGQPVDLRLPSA Mvan_1597|M.vanbaalenii_PYR-1 PAVSAETDTTAPAEPTPQPAPTGAVRQALDTVLAPLAAPESPAVQRAETP MAB_1963|M.abscessus_ATCC_1997 VAGRSDETNGAAKSSTVIPTPSTTPWNEIITTTTPPPPPPPPPPTTEPPP Mb1465|M.bovis_AF2122/97 ----LYLQSLGLTFNG--ATPDTD-YATTIYTTQYDGFADFP--KYPLNI Rv1430|M.tuberculosis_H37Rv ----LYLQSLGLTFNG--ATPDTD-YATTIYTTQYDGFADFP--KYPLNI MUL_1034|M.ulcerans_Agy99 ----FYIPFLDVSFNG--ATPAANPYPTSIFTAQYDGIAHAP--QYRLNI MSMEG_4734|M.smegmatis_MC2_155 VTIPLGTPGGGVTFNGSTPT--DTQYSTIDVAIQYDGWADQP--INPANL TH_3724|M.thermoresistible__bu ----LYIPILGVTFNGATPAPADGPFDSYDVAREFDGWADFP--RYPLNL MMAR_2416|M.marinum_M ----VSTGQVAVVVQPTFLYELIWNLLVFAALIYLDRRFTIG--HGRLFA MAV_3172|M.avium_104 ----VSTGQVALVVQPTFLYELLWNLLIFVALLYADRRLTLG--HGRLFA Mflv_4855|M.gilvum_PYR-GCK G---VAVASNGNVYAAG-LFGGLAIFDPATELLETISSTDLPGFLHGIAV Mvan_1597|M.vanbaalenii_PYR-1 VLWTVFAWTRRTFFNATPVVRYDDTTTSQLQNTITGRVTATDSDTPTLTL MAB_1963|M.abscessus_ATCC_1997 P---PPPPVVTETVTVEPPPPPPPPVTTHEAPPPVTTTTTPPP-PPPPTT Mb1465|M.bovis_AF2122/97 LADVNALLGIYYSHSLYYGLTP-EQVASGIVLPVSSPDT----------- Rv1430|M.tuberculosis_H37Rv LADVNALLGIYYSHSLYYGLTP-EQVASGIVLPVSSPDT----------- MUL_1034|M.ulcerans_Agy99 LSDINAIMGYFYVHGNYPDLMS-GQAIQ---LPTSPGYTG---------- MSMEG_4734|M.smegmatis_MC2_155 LAVANANAGQRLLHPHYADYSLGSPGIIDQ------GQYG---------- TH_3724|M.thermoresistible__bu VATANAILGIYYLHGGYYELLTENPDILDDPERTIVQQYG---------- MMAR_2416|M.marinum_M SYVALYCVGRFCVELLRDDTATHIAGIRINSFTSTFVFIG---------- MAV_3172|M.avium_104 LYVAGYCVGRFCVELLRDDTATHIAGIRINSFTSTFVFIG---------- Mflv_4855|M.gilvum_PYR-GCK GPDGTAYIGTWEGSNAYGDLLNGAIIIVKPGEPTTIKQVTGVSQPWGIAF Mvan_1597|M.vanbaalenii_PYR-1 TASAPANGGTVLLRPDGTFTYTVPTTMYAGGTDTFTVTAS---------- MAB_1963|M.abscessus_ATCC_1997 TTPAGPRQITYSVTGSKAPLDRISITWTDGSGRTRVNPN----------- Mb1465|M.bovis_AF2122/97 ------------NTTYILLPNEDLPLLQPLRGI--VPEPLLDLIEPDLRA Rv1430|M.tuberculosis_H37Rv ------------NTTYILLPNEDLPLLQPLRGI--VPEPLLDLIEPDLRA MUL_1034|M.ulcerans_Agy99 ------------NTDYYMYLTQDLPLVQPIRDIPYAGPPLADLIQPQLRV MSMEG_4734|M.smegmatis_MC2_155 ------------DTRYLMIPTDTLPLLYELSQTPIVGSFLADVLDAPLRV TH_3724|M.thermoresistible__bu ------------DTTYYLIRTEQLPLLRPLRDLGVP-EEFVDALEPYVRR MMAR_2416|M.marinum_M ------------AVVYIILAPKGREDPASVRGTAAAAEEVPEPEPAGEVA MAV_3172|M.avium_104 ------------AVVYLMAAPKGREDPESLRGNQYVEEEPAEPEPATVAA Mflv_4855|M.gilvum_PYR-GCK ANGMILAVSADTQTVVTLNPADATTFIKPSSDNGSDGAGSAEFASASTAV Mvan_1597|M.vanbaalenii_PYR-1 ----------DADGPAHIHGLTGLLHLVSLGLVGHSGHSATATVTLDIAA MAB_1963|M.abscessus_ATCC_1997 ---------------VYIPWSITVTPISNSEIGSVSASSFLRLSQLNCTI : Mb1465|M.bovis_AF2122/97 IIELGYDRTG----YADVPTPAALFPVHIDPIAVP--------------- Rv1430|M.tuberculosis_H37Rv IIELGYDRTG----YADVPTPAALFPVHIDPIAVP--------------- MUL_1034|M.ulcerans_Agy99 LVDLGYSDYGPGLSYADVPTPAGLLSVP-NPFAVS--------------- MSMEG_4734|M.smegmatis_MC2_155 LVESGYDRTS----SPGEPKPWTLVPAKDPLKTAADFLVA---------- TH_3724|M.thermoresistible__bu IVDLGYDRNT----PYGEPAPVRVLPPLTPAP------------------ MMAR_2416|M.marinum_M TAAAPAGDTE-GDEPTGLAETAKAAEVAEPETVGS--------------- MAV_3172|M.avium_104 TTEAAT---------EGVAAPADG-------------------------- Mflv_4855|M.gilvum_PYR-GCK TMSATAAHTAAVSTSISVSTKTATTAPAMASTANTANSSYGTHVTIDLDG Mvan_1597|M.vanbaalenii_PYR-1 VTAPILGTPAYQLDTAEHGTGAVPGALHVTGPEGLT-------------- MAB_1963|M.abscessus_ATCC_1997 TTSDGQVLSS----NNNNSAQATC-------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------IPTGWDN TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M --------------------------------------------AVAGDE MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK TPTNVTLSANGTRGYVVVGNQVKIIELGASAPVIVDSVNVGVNPNMVAVN Mvan_1597|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 --------PQIGAAIGGPLTALDGLLDTVINDQLNPVVTSGIYQAGAELS Rv1430|M.tuberculosis_H37Rv --------PQIGAAIGGPLTALDGLLDTVINDQLNPVVTSGIYQAGAELS MUL_1034|M.ulcerans_Agy99 --------YYL---LKGSLQAP--------------------YGAAVEIG MSMEG_4734|M.smegmatis_MC2_155 AIEDVNGTRPFGTVRPGPFGVGGPDVDYLDPDEDLTKEASKEASKGTELA TH_3724|M.thermoresistible__bu -----------------------------------GPATQHNAGQGITVA MMAR_2416|M.marinum_M STADTEASDAVESEVGEAAEAEAPEAEAEEAEVGEVEVAEAVEGEVEEAE MAV_3172|M.avium_104 ---------------AEAAGADATAQRPEESAEPDVEKPESEETEAEAAE Mflv_4855|M.gilvum_PYR-GCK SFGTVAYVTNSGDGTVSIIDKARPTPLTVTVGSNPTGIALSANGTRAYVS Mvan_1597|M.vanbaalenii_PYR-1 --------YTLTGGPAEGEVTLDARTGAFIYTPTSVARHQASAEDATPDE MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 VAAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLVD------- Rv1430|M.tuberculosis_H37Rv VAAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLVD------- MUL_1034|M.ulcerans_Agy99 VEAG------------LLGPESFPDTYPWVPSLNPGLNFYLGQ------- MSMEG_4734|M.smegmatis_MC2_155 DDSSVKATLVSRLTDATEAEADAVTAKIGAVTEKTQAKVTTLT------- TH_3724|M.thermoresistible__bu SATSTPD----KRTPVVEAPVEEPPVQTGRSTLKREKPVSARH------- MMAR_2416|M.marinum_M EAEPGEVEVAEAVEGEVEAAAEAEEAEEAEEAEEAEEAEEAEPGEIEVAE MAV_3172|M.avium_104 EPE----------------------SEETEAAEEPGEPEAEEP------- Mflv_4855|M.gilvum_PYR-GCK NTNSNTVSIIDYGGGVLQLPKVVANVPVGSRPTSIAVNSTGTVAYVTNEG Mvan_1597|M.vanbaalenii_PYR-1 LADTFTITVTDNLGGTISVPVAVAIDPSNQSPTVTLVVSVPDSE------ MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 ------------------------AIQDLAAGDLSG-------------F Rv1430|M.tuberculosis_H37Rv ------------------------AIQDLAAGDLSG-------------F MUL_1034|M.ulcerans_Agy99 ------------------------PSVTLLSLLSGG-------------L MSMEG_4734|M.smegmatis_MC2_155 ------------------------KPRPQAADEAGDEADAEPSE-----P TH_3724|M.thermoresistible__bu ------------------------LVRNSLRAVPG--------------- MMAR_2416|M.marinum_M AVEGEVEAAAEAEEAEVGEVEAVDEAAEAEAPEVGEIEAAEAVEGEVEVA MAV_3172|M.avium_104 ------------------------EEPEAEEPEE---------------- Mflv_4855|M.gilvum_PYR-GCK GDTVSIIRYNGSGSPSVSTVNVSAQPQSVKTDDTGTKAIVYSRGGIVTII Mvan_1597|M.vanbaalenii_PYR-1 -----------------GTVHVSVAVADPDNDATTYFVVHDPAYGTLTAT MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 NQNLQLIPATNIA------------------------------------- Rv1430|M.tuberculosis_H37Rv NQNLQLIPATNIA------------------------------------- MUL_1034|M.ulcerans_Agy99 GDIFHLIPPP---------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 SESSESEPSGSET------------------------------------- TH_3724|M.thermoresistible__bu --LRRGEPAATPT------------------------------------- MMAR_2416|M.marinum_M AEAEEAEAGEDEPKEAEEVAEAE-----------------------GSEA MAV_3172|M.avium_104 PETEEPEADSDE-------------------------------------- Mflv_4855|M.gilvum_PYR-GCK NGSGSVPTATTVPGRHFSYADYPGFVAISSDGRTAFVTEHDSPRRVTIID Mvan_1597|M.vanbaalenii_PYR-1 PDGYDYNPTAEAVRIG---------------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 --------------------LLVFAAGIPAVAAVAILTGQDFPV------ Rv1430|M.tuberculosis_H37Rv --------------------LLVFAAGIPAVAAVAILTGQDFPV------ MUL_1034|M.ulcerans_Agy99 ----------------------VFP------------------------- MSMEG_4734|M.smegmatis_MC2_155 --------------------PETSDTKKPMTVAKDSGSEDKAVTKPADAK TH_3724|M.thermoresistible__bu --------------------PDVTPDVTPDAPAG---------------Q MMAR_2416|M.marinum_M EDKTVQAIDGGQTGVDDAGEADAEPDDDSTAAEPEVVVEQADIEEIEPQE MAV_3172|M.avium_104 -----------------------EPE------------------------ Mflv_4855|M.gilvum_PYR-GCK TANPGVTPRFVDLPDYSHSIVSLPDGTRAFTVAHDALWVIESKTGQATPV Mvan_1597|M.vanbaalenii_PYR-1 ----------VRADTLTVTASDLHHGSDTETVTVPIGSDDAAPAGLLAAT MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 PEPKEKSEDTSAGKRGRHSSGLTAKPSDKESAPKHRAPDSDTASAKPSRE TH_3724|M.thermoresistible__bu PEPAEPNE------------------------------------------ MMAR_2416|M.marinum_M PEAEAVAAAEATDADEGDGEPAEPASDDLDAVAAEDADVDVDATATEAEE MAV_3172|M.avium_104 ------------------------------------------------EE Mflv_4855|M.gilvum_PYR-GCK YVPADNNFSQHQRIAISSDGRRVIAADNFGSLTAFYLSGGGSVKPPNLDW Mvan_1597|M.vanbaalenii_PYR-1 AYSSTDIQLPAAATVITLRGRNYLGSLSPDRMDDHFGGMFAEDPYTMVKL MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 KNSAPKHAAAAKDDRQTKPRAAHG-------------------------- TH_3724|M.thermoresistible__bu -SAAPPAAAEADDASE---------------------------------- MMAR_2416|M.marinum_M SGDESPEPAADSEEPEADESAPEDSAEDTSSGESDTQSELEQSQTIEQGS MAV_3172|M.avium_104 SGEAPEQPVAE--EPEPAPQQPE--------------------------- Mflv_4855|M.gilvum_PYR-GCK LRNSPTASSTAVTTDSLLTKIPTSTPDTIRIQKSTDGGTTRVVVYISGVK Mvan_1597|M.vanbaalenii_PYR-1 TYPDSENSDAIDDAVAMLDAQLMSTPGDIIVMGHSFGAQVCSRWMRVYAR MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 ---------------AAAKDAGARDKQHKQDKQDKQAASAAKK------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M DQTSAGDGEGPPPSAAVDGDTGPTRQGWRGRLRNRMRRSGR--------- MAV_3172|M.avium_104 -----------------------TKRRWGARLRDRL--SGR--------- Mflv_4855|M.gilvum_PYR-GCK EPSLQAAGSYWAVLRAKQGITDENMRDTINKAISDIEKDGTTVSEIMLVG Mvan_1597|M.vanbaalenii_PYR-1 DPVRRAMADRLTFVLTGNPLRSDNGKVVGMLEIDAWIGLPTPTTTPWQII MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK FSKGGMTAQNYASKRSFLGIDIYNETYGDKVKAVITFASPLVRKADEYGY Mvan_1597|M.vanbaalenii_PYR-1 DVARRWDGWADWPDDSSNATAARNARAGQNYLHPNYDDVDLYDPQNTVWR MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK GVDVVHLAAQNDYLPRDEFFGGVLGWVDGQQVTQASNRGVRETFINERSD Mvan_1597|M.vanbaalenii_PYR-1 NGNTTYVLTHEDDLPMFRYWWGVPSDFESVVRAEVESAYNRPSADIPVPV MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 -------------------------------------------------- Rv1430|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1034|M.ulcerans_Agy99 -------------------------------------------------- MSMEG_4734|M.smegmatis_MC2_155 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_2416|M.marinum_M -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mflv_4855|M.gilvum_PYR-GCK WKTIYTYDTKSFSKDPITRHSVDNYHLVAKNYDANASRWIQSKLVTSAIT Mvan_1597|M.vanbaalenii_PYR-1 RPVQSWWWQMVLRWLEIENPA----------------------------- MAB_1963|M.abscessus_ATCC_1997 -------------------------------------------------- Mb1465|M.bovis_AF2122/97 ----------------------- Rv1430|M.tuberculosis_H37Rv ----------------------- MUL_1034|M.ulcerans_Agy99 ----------------------- MSMEG_4734|M.smegmatis_MC2_155 ----------------------- TH_3724|M.thermoresistible__bu ----------------------- MMAR_2416|M.marinum_M ----------------------- MAV_3172|M.avium_104 ----------------------- Mflv_4855|M.gilvum_PYR-GCK RFFKGTINEIDLDPNSPKTTKTF Mvan_1597|M.vanbaalenii_PYR-1 ----------------------- MAB_1963|M.abscessus_ATCC_1997 -----------------------