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GYAQFVGRVGALAVALGVGAATVALPGAAWAEPSDAASSSSADNTKAEDTAEDSTAADDARPDDAVDDEV NSGEDHDEEAPQSEDGGDGSDEDGGQPEKKTRGSYGSNRSEGELTGEDADEARADREDTDTEADVDVVAP EAEPTADEADDEADGGDPAEVAEPGVADDVAVEQPAEVSDDAPEPVESPISAPSSIVTALFAPKSWGDTA PADPVESPLLWTLLAFARRQFGQPRTEIGDSGTPTGTTELVDPGAAAVPEPGEVTKGDPGIFTGTVRGQV KATDPDGGWLTYSGSTSTEKGTVTVTPWGTFRYTPSATARHAAAADGASTEAKTDTFTVTVKDAAGNAVE VPVTVDILARNADPFGARARADNPSLTTGTAIIRVSAYDFDRDPLDITGPLSTGKGELVDNGDGTFTYTP TAAAREAASDPDAPDDARIDTLTFTISDGHGGIRTATVDVIVAAYAESSASTPGRAAGPVLVSSNGTIYQ VTYDLDSTNNPIRTRVSILDEDGQVLKTTDVIPGYPVEQALPVVRPDGSLLVTTYKASSNTSTVSIVDGQ GEVKTLGTVIGQPSAPMTVAPNGAVFFKTRQFASGSGDRLVRVSATGGLRVYQLGVAADSPSVAPDGSVY IVSRSFGVTSVLAVGPGGNSRRVSLPLGADTVNDVVIGQDGRGYLTVERNVFGTKTTRVYTFTGTSNTVR EIPGTPDGAKVITADGVYQYTYDESTGKSYISRITADTIETSDPIDGRVINPISVTPDGTVYVAVRNSAT GTDSVAIISTSGEVTTVDIPGTIFPVLPSVSPAVTGDDANPNIGDNGYVAYQSGGVSYLAVVNPDGTIAR TVTLPAGAVVATPVDFGPDGAAYQVIETRDEQGRVTSRAVLALSTDTVTPMLPGAPLQPNYPSIQFGPDG SGVLITVETGQSPFEYHFLRFDQDGATIATADLSGFLQSAQQDYVFWQEGVVFGPDGTPYATLTGADQGV WALTSTGPVKVLELDLGQGELVEPVKFGPDGTPYVTVSERVDGSYVTTVHTFTPVTML*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_5004 | - | - | 100% (1039) | hypothetical protein Mvan_5004 |
M. vanbaalenii PYR-1 | Mvan_1720 | - | 5e-63 | 27.82% (1071) | YVTN beta-propeller repeat-containing protein |
M. vanbaalenii PYR-1 | Mvan_1009 | - | 8e-50 | 33.86% (505) | putative outer membrane adhesin like proteiin |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0912 | - | 9e-05 | 45.00% (60) | hypothetical protein Mb0912 |
M. gilvum PYR-GCK | Mflv_1994 | - | 4e-85 | 34.41% (741) | hypothetical protein Mflv_1994 |
M. tuberculosis H37Rv | Rv0888 | - | 9e-05 | 45.00% (60) | hypothetical protein Rv0888 |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_0628 | - | 3e-06 | 23.85% (239) | hypothetical protein MAB_0628 |
M. marinum M | MMAR_3768 | rne | 1e-07 | 29.75% (158) | ribonuclease E Rne |
M. avium 104 | MAV_3172 | - | 6e-06 | 26.43% (140) | prolipoprotein diacylglyceryl transferase |
M. smegmatis MC2 155 | MSMEG_4365 | - | 3e-17 | 25.71% (350) | hypothetical protein MSMEG_4365 |
M. thermoresistible (build 8) | TH_2316 | - | 7e-10 | 35.09% (171) | conserved hypothetical protein |
M. ulcerans Agy99 | MUL_3715 | rne | 2e-06 | 24.24% (165) | ribonuclease E Rne |
CLUSTAL 2.0.9 multiple sequence alignment Mvan_5004|M.vanbaalenii_PYR-1 ----------------------------MGYAQFVGRVGALAVALGVGAA Mflv_1994|M.gilvum_PYR-GCK ----------------------------MALDRYIGRVGALAVALGIGSA Mb0912|M.bovis_AF2122/97 ----------------------------MDYAKRIGQVGALAVVLGVGAA Rv0888|M.tuberculosis_H37Rv ----------------------------MDYAKRIGQVGALAVVLGVGAA MSMEG_4365|M.smegmatis_MC2_155 ----------------------------------MGRIGALAVALGIGAA TH_2316|M.thermoresistible__bu ----------------------------------VGRVGALAVALGVGVA MMAR_3768|M.marinum_M --------------MVDGAPSSDPENEPTQREDLPDRLRVHSLARTLGTS MUL_3715|M.ulcerans_Agy99 --------------MVDGAPSSDPENEPTQREDLPDRLRVHSLARTLGTS MAB_0628|M.abscessus_ATCC_1997 MPKQDRGAPPRPPWLPEEDEQRGFLRSLRRKKRNPDEGEPNDESLTHETE MAV_3172|M.avium_104 ------------------------------MTKLLAYFPSPPQGVWHLGP Mvan_5004|M.vanbaalenii_PYR-1 TVALPGAAWAEPSDAASSSSADNTKAEDTAEDSTAADDARPDDAVDDEVN Mflv_1994|M.gilvum_PYR-GCK VAAMPGQASAKPDADGGSG----------MSETSVSGPARAGSGTDATSR Mb0912|M.bovis_AF2122/97 VTTHAIGSAAPTDPSSSST-----------DSPVDACSPLGGSASSLAAI Rv0888|M.tuberculosis_H37Rv VTTHAIGSAAPTDPSSSST-----------DSPVDACSPLGGSASSLAAI MSMEG_4365|M.smegmatis_MC2_155 LTTG-TGVAWADDSGASGGSTS------SSSSASDS------SSSSAGGS TH_2316|M.thermoresistible__bu VATGGTAVAWAD-SGSTASSSS------SQDSSSKSNPAQTRSSAKSGIG MMAR_3768|M.marinum_M SRRVLDALSALDGRIRSAHSSVDRVDAVRVRDLLAEQPAEEGQAEEGQQA MUL_3715|M.ulcerans_Agy99 SRRVLDALSALDGRIRSAHSSVDRVDAVRVRDLLAEQPAEEGQAEEDQQA MAB_0628|M.abscessus_ATCC_1997 WPSAPKTAAQKPSAESVKLSGQGRPTLTSGDESADGDQPVSDLSKYYTPP MAV_3172|M.avium_104 VPIRAYALFIIAGIVAALLIGD------RRWEARGGERGVIYDIALWTVP . Mvan_5004|M.vanbaalenii_PYR-1 SGEDHD-------------------------------------------- Mflv_1994|M.gilvum_PYR-GCK SGKPAQ-------------------------------------------- Mb0912|M.bovis_AF2122/97 PGASVP-------------------------------------------- Rv0888|M.tuberculosis_H37Rv PGASVP-------------------------------------------- MSMEG_4365|M.smegmatis_MC2_155 SGSASG-------------------------------------------- TH_2316|M.thermoresistible__bu SGAGSGPGSRLDRPASRA-------------------------------P MMAR_3768|M.marinum_M PDAVAAEVPDAPGEPAEPDEPESRLMLETQETVQVVETWVERPHYMPLFV MUL_3715|M.ulcerans_Agy99 PDAVAAEVPDAPGEPAEP---ESRLMLETQETVQVVETWVERPHYMPLFV MAB_0628|M.abscessus_ATCC_1997 RRAEPADDSSSASEPIAVPG---------------------------PVA MAV_3172|M.avium_104 FGLVGG-------------------------------------------- Mvan_5004|M.vanbaalenii_PYR-1 -----EEAPQSEDGGDGSDEDGGQPEKKTRGSYGSNRSEGELTGEDADEA Mflv_1994|M.gilvum_PYR-GCK -----SERSAATKPSGGSDPPDRSPR------------------------ Mb0912|M.bovis_AF2122/97 -----QVGVRQVDPGSIPDD------------------------------ Rv0888|M.tuberculosis_H37Rv -----QVGVRQVDPGSIPDD------------------------------ MSMEG_4365|M.smegmatis_MC2_155 ----GADAAKPRKPGVTKP------------RIQPTG------------- TH_2316|M.thermoresistible__bu LGGSGADSSATEQTGAVSSGTSAWRSAGMPAGTSLTG------------- MMAR_3768|M.marinum_M APQPISEPVAGDDADDESGDEGDDDEEQADRPANRRRRRGRRGRGRGRGE MUL_3715|M.ulcerans_Agy99 APQPISEPVAGDDADDESGDEGDDDEEQADRPGNRRRRRGRRGRGRGRGE MAB_0628|M.abscessus_ATCC_1997 ESDAQAPRIVRGPSADVAPEPQPTPQVEQLSSSVPVESSAMPEQEPEVPA MAV_3172|M.avium_104 -------------------------------------------------- Mvan_5004|M.vanbaalenii_PYR-1 RADREDTDTEADVDVVAPEAEPTADEADDEADGGDPAEVAEPGVADDVAV Mflv_1994|M.gilvum_PYR-GCK ---------EVAVTEETTSGETADDEAEPVEETRDTVEIVPP-------- Mb0912|M.bovis_AF2122/97 -------LLNALIDFLAAVRNGLVPIIENRTPVANPQQVSVP-------- Rv0888|M.tuberculosis_H37Rv -------LLNALIDFLAAVRNGLVPIIENRTPVANPQQVSVP-------- MSMEG_4365|M.smegmatis_MC2_155 -------KIAESLKKTAKAVEGAVADAHKRAQQSAAQQAEKRAER----- TH_2316|M.thermoresistible__bu -------RLADSVRDAVKPWRPATTRSTDPTPVETPAEANPEAQP----- MMAR_3768|M.marinum_M QGANDGQDQPGDDGDEAPQKTGGNSTSSDDTEAQDGADSEESDNGDDDNG MUL_3715|M.ulcerans_Agy99 QGANDGQDQPGDDGDEAPQKAGGNSTSSDDSEAQDGADSEESDNGDDDNG MAB_0628|M.abscessus_ATCC_1997 SNPVVESALAVTGEPEPPLQAAATPEVTRPVVPRPEQPVTGPERVVVDSG MAV_3172|M.avium_104 -------RLYHLATDWRTYWGPGGAGFGAAVRIWDGG------------- Mvan_5004|M.vanbaalenii_PYR-1 EQPAEVSDDAPEPVESPISAPSSIVTALFAPKSWGDTAPADPVESPLLWT Mflv_1994|M.gilvum_PYR-GCK --------------TEPVTPASAVET---------EDEPDSPASSSLLWF Mb0912|M.bovis_AF2122/97 -----------------------------------EGGTVGPVR------ Rv0888|M.tuberculosis_H37Rv -----------------------------------EGGTVGPVR------ MSMEG_4365|M.smegmatis_MC2_155 -----------------------------------RAKLRAQIRPGKDTD TH_2316|M.thermoresistible__bu -----------------------------------DAHAGSPGESTAPET MMAR_3768|M.marinum_M SADG----------ANRRRRRRRRRKSGAGDDGDEGPAPDDPPNTVVHER MUL_3715|M.ulcerans_Agy99 SADG----------ASRRRRRRRRRKSGAGDDGDEGPAPDDPPNTVVHER MAB_0628|M.abscessus_ATCC_1997 SADPFSRFSLLEAQLRQMSLDESITDDELERHRRHSAPEAEPAAAPAAAL MAV_3172|M.avium_104 -------------------------------------------------- Mvan_5004|M.vanbaalenii_PYR-1 LLAFARRQFGQPRTEIGDSGTPTGTTELVDPGAAAVPEPGEVTKGDPGIF Mflv_1994|M.gilvum_PYR-GCK LGAAGRRQTDQQAGPDRDAASQTAAQAEAPIAATPVP------------- Mb0912|M.bovis_AF2122/97 ----------------FDACDPDGNRMTFAVRERGAPG------------ Rv0888|M.tuberculosis_H37Rv ----------------FDACDPDGNRMTFAVRERGAPG------------ MSMEG_4365|M.smegmatis_MC2_155 KQAPEKQ---------AGNEAKNAAQPATKTQRQLP-------------- TH_2316|M.thermoresistible__bu QPAPSSRGIRSMTAVLPDTESTNTESTNTESTVQHDDS------------ MMAR_3768|M.marinum_M APRSGGKSGNSDSGDDSGGNEIKGIDGSTRLEAKRQRRR----------- MUL_3715|M.ulcerans_Agy99 APRSGDKSGNSDSGDDSGGNEIKGIDGSTRLEAKRQRRR----------- MAB_0628|M.abscessus_ATCC_1997 SFTPPEVAASTPDGPTEALGEAQAAVESPSEEPAPTPTLG---------- MAV_3172|M.avium_104 ----------------------LGIWGAVALG------------------ Mvan_5004|M.vanbaalenii_PYR-1 TGTVRGQVKATDPDGGWLTYSGSTSTEKGTVTVTPWGTFRYTPSATARHA Mflv_1994|M.gilvum_PYR-GCK -------------------------------------------------- Mb0912|M.bovis_AF2122/97 -------------------------------------------------- Rv0888|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_4365|M.smegmatis_MC2_155 -------------------------------------------------- TH_2316|M.thermoresistible__bu -------------------------------------------------- MMAR_3768|M.marinum_M -------------------------------------------------- MUL_3715|M.ulcerans_Agy99 -------------------------------------------------- MAB_0628|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mvan_5004|M.vanbaalenii_PYR-1 AAADGASTEAKTDTFTVTVKDAAGNAVEVPVTVDILARNADPFGARARAD Mflv_1994|M.gilvum_PYR-GCK -------------------------------------------------- Mb0912|M.bovis_AF2122/97 -------------------------------------------------- Rv0888|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_4365|M.smegmatis_MC2_155 -------------------------------------------------- TH_2316|M.thermoresistible__bu -------------------------------------------------- MMAR_3768|M.marinum_M -------------------------------------------------- MUL_3715|M.ulcerans_Agy99 -------------------------------------------------- MAB_0628|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_3172|M.avium_104 -------------------------------------------------- Mvan_5004|M.vanbaalenii_PYR-1 NPSLTTGTAIIRVSAYDFDRDPLDITGPLSTGKGELVDNGDGTFTYTPTA Mflv_1994|M.gilvum_PYR-GCK -------------------------------------------------- Mb0912|M.bovis_AF2122/97 -------------------------------------------------- Rv0888|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_4365|M.smegmatis_MC2_155 -------------------------------------------------- TH_2316|M.thermoresistible__bu -------------------------------------------------- MMAR_3768|M.marinum_M -------------------------------------------------- MUL_3715|M.ulcerans_Agy99 -------------------------------------------------- MAB_0628|M.abscessus_ATCC_1997 ---------------------------------------------FTAPE MAV_3172|M.avium_104 -------------------------------------------------- Mvan_5004|M.vanbaalenii_PYR-1 AAREAASDPDAPDDARIDTLTFTISDGHGGIRTATVDVIVAAYAESSAST Mflv_1994|M.gilvum_PYR-GCK -------------------------------------------------- Mb0912|M.bovis_AF2122/97 -------------------------------------------------- Rv0888|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_4365|M.smegmatis_MC2_155 -------------------------------------------------- TH_2316|M.thermoresistible__bu ---------------------------------------------ERRSS MMAR_3768|M.marinum_M ---------DGRDAGRRRPPVLSEAEFLARREAVERVMVVRDRVRTEPPH MUL_3715|M.ulcerans_Agy99 ---------DGRDAGRRRPPVLSEAEFLARREAVERVMVVRDRVRTEPPH MAB_0628|M.abscessus_ATCC_1997 PEDDVPAVDQEAVGARGEQEAAVTAVPPIADRPEPNSAGNEPATDQTSDF MAV_3172|M.avium_104 -------------------------------------------------- Mvan_5004|M.vanbaalenii_PYR-1 PGRAAGPVLVSSNGTIYQVTYDLDSTNNPIRTRVSILDE---DGQVLKTT Mflv_1994|M.gilvum_PYR-GCK -GDASASPIIGVDGTVYQVTRTSSAGG--QFSTVTILDN---TGQIVSSG Mb0912|M.bovis_AF2122/97 -GPQHGIVTVDQRTASFIYTADPGFVG---TDTFSVNVS---DDTSLHVH Rv0888|M.tuberculosis_H37Rv -GPQHGIVTVDQRTASFIYTADPGFVG---TDTFSVNVS---DDTSLHVH MSMEG_4365|M.smegmatis_MC2_155 -AAPAVKVPDVITSVRARSDEVAREITTGVTGIRTAIEN---AAPRIALP TH_2316|M.thermoresistible__bu LRSTAASVPELSTPVRLADATAVRALAERLTERRSVTLE---SVR--AFT MMAR_3768|M.marinum_M PGSRYTQIAVLEDGIVVEHFVTSAASASLVGNIYLGIVQNVLPSMEAAFV MUL_3715|M.ulcerans_Agy99 PGSRYTQIAVLEDGIVVEHFVTSAASASLVGNIYLGIVQNVLPSMEAAFV MAB_0628|M.abscessus_ATCC_1997 SSPKPEESADSGDSLAPQPPAVEQPTAAEVVEPPESAPAAGGGDADARAA MAV_3172|M.avium_104 --AVGAWIGCRRHGIPLPAFADALAPGIILAQAIGRLGN-------YFNQ Mvan_5004|M.vanbaalenii_PYR-1 DVIPGYPVEQALPVVRPDGSLLVTTYKASSNTSTVSIVDGQGEVKTLGTV Mflv_1994|M.gilvum_PYR-GCK EVRG----TVMDAVARPDGTLVVFSRRFIS--TTVSTVSSDGTVTPIANL Mb0912|M.bovis_AF2122/97 GLAG-----------------------------YLGPFHGHDDVATVTVF Rv0888|M.tuberculosis_H37Rv GLAG-----------------------------YLGPFHGHDDVATVTVF MSMEG_4365|M.smegmatis_MC2_155 DLRP----------------TTNL-------ARPVTPVALKAAQPVQ--- TH_2316|M.thermoresistible__bu DVAA----------------TTALTSAASVAAATVEPVALITAAPEATPA MMAR_3768|M.marinum_M DIGRGRNGVLYAGEVNWDAAGLGGADRKIEQALKPGDYIVVQVSKDPVGH MUL_3715|M.ulcerans_Agy99 DIGRGRNGVLYAGEVNWDAAGLGGADRKIEQALKPGDYIVVQVSKDPVGH MAB_0628|M.abscessus_ATCC_1997 ALLQRIEARRAELDEELAAHDAADAQARAFEPEPAPFVPMVAPWASVPEP MAV_3172|M.avium_104 ELYG--------------------------RETTLPWGLEIFYRRDPSGY : Mvan_5004|M.vanbaalenii_PYR-1 IGQPSAPMTVAPNGAVFFKTRQFASGSGDRLVRVSATGGLRVYQLG---- Mflv_1994|M.gilvum_PYR-GCK LGTPLNPPRVGPDGALYFG-----AGLPDLLSPVGANVGYRTYRISPRNT Mb0912|M.bovis_AF2122/97 VGNTPTDTISGDFSMLTYN----IAGLPFPLSSAILPRFFYTKEIG---- Rv0888|M.tuberculosis_H37Rv VGNTPTDTISGDFSMLTYN----IAGLPFPLSSAILPRFFYTKEIG---- MSMEG_4365|M.smegmatis_MC2_155 VSPPRPTITGLVRGLLTAAAGFSPRAATAPVAPAPSPAAWALLAFARREF TH_2316|M.thermoresistible__bu VDAEQPAAPRLVTGLL-AAVGLAPFTANSPLAPTQSTPLLALLGWARRET MMAR_3768|M.marinum_M KGARLTTQVSLAGRYLVYVPGASSTGISRKLPDTERQRLKEILREVVPSD MUL_3715|M.ulcerans_Agy99 KGARLTTQVSLAGRYLVYVAGASSTGISRKLPDTERQRLKEILREVVPSD MAB_0628|M.abscessus_ATCC_1997 VRSPAPEAAAPANDADETADTATSSSGAAELEGFAPLVDEDIVISAPAVY MAV_3172|M.avium_104 IDPHSLDGVSTGQVALVVQPTFLYELLWNLLIFVALLYADRRLTLG---- : Mvan_5004|M.vanbaalenii_PYR-1 ----VAADSPSVAPDGSVYIVSRSFGVTSVLAVGPGGNSRRVSLPLGADT Mflv_1994|M.gilvum_PYR-GCK VRAFAFDTDVAIADDGTAYLVSRRYGISVLRVIPTAGLGRTTLLPLGTDP Mb0912|M.bovis_AF2122/97 ----KRLNAYYVANVQEDFAYHQFLIKKSKMPSQTPPEPPTLLWPIGVPF Rv0888|M.tuberculosis_H37Rv ----KRLNAYYVANVQEDFAYHQFLIKKSKMPSQTPPEPPTLLWPIGVPF MSMEG_4365|M.smegmatis_MC2_155 ERAFTPGAATALAAPAITTSAVTSAAVVNPLPGRLD--SVPVGWVTGVSN TH_2316|M.thermoresistible__bu DRAYTQQARSLVTA---RPAVVSTAAVVDPLPADLIGETERIGRITGPG- MMAR_3768|M.marinum_M AGVIIRTASEGVKEDDIRADVTRLQERWNQIEAKAVEIKQKAAGAAVALY MUL_3715|M.ulcerans_Agy99 AGVIIRTASEGVKEDDIRADVTRLQERWNQIEAKAVEIKQKAAGAAVALY MAB_0628|M.abscessus_ATCC_1997 EEAPADAGLDDVILESELPDEAEAPAARAVDPEPAGETADVAPESAAPES MAV_3172|M.avium_104 -----HGRLFALYVAGYCVGRFCVELLRDDTATHIAGIRINSFTSTFVFI : Mvan_5004|M.vanbaalenii_PYR-1 VNDVVIGQDGRGYLTVERNVFGTKTTR--------VYTFTGTSNTVREIP Mflv_1994|M.gilvum_PYR-GCK S-APVLGPDGTAHVTAGVTWFGSPQTR--------VYTATGDSIAAHTVA Mb0912|M.bovis_AF2122/97 SDGLNTLSEFKVQRLDRQTWYECTSDN--------CLTLKGFTYSQMRLP Rv0888|M.tuberculosis_H37Rv SDGLNTLSEFKVQRLDRQTWYECTSDN--------CLTLKGFTYSQMRLP MSMEG_4365|M.smegmatis_MC2_155 PSGNWPQTNNTAGFDIWGTDLGIMWDGGEWNGQRFVHTAFGDTFSGPNMS TH_2316|M.thermoresistible__bu ------ITDGPNRLNIYGTDLGIMWDMGEWRGQRAVHVVFGDTFSGPNMS MMAR_3768|M.marinum_M EEPDVLVKVIRDLFNEDFAGLVVSGDDAWDTINEYVSSVAPDLVSKLSKY MUL_3715|M.ulcerans_Agy99 EEPDVLVKVIRDLFNEDFAGLVVSGDDAWDTINEYVSSVAPDLVSKLSKY MAB_0628|M.abscessus_ATCC_1997 PAQTPTADRQEESISVVAPEPGSAEPSPWQNRSAVEVAATGEPQATPAYY MAV_3172|M.avium_104 GAVVYLMAAPKGREDPES-------------------------------- Mvan_5004|M.vanbaalenii_PYR-1 GTPDGAKVITADGVYQYTYDE--S----TGKSYISRITADTIETSDPIDG Mflv_1994|M.gilvum_PYR-GCK GLPAGAVVG-ADGVYLATFVE--PGSEGPGTSYVSRLTAGGVGTSGLIEG Mb0912|M.bovis_AF2122/97 GG------------------------------------------------ Rv0888|M.tuberculosis_H37Rv GG------------------------------------------------ MSMEG_4365|M.smegmatis_MC2_155 GWWRSNVLLISTDNVLSDGLG--LVQTGTAYQFIPASGRNLFGLFGGSEV TH_2316|M.thermoresistible__bu GDWISNAIMISTSRTLYENPAGFLEQTGPAFQFIP--GGQLLSWFFPAEV MMAR_3768|M.marinum_M EPAVGSEGQVGPDVFAVHRIDEQLAKAMDRKVWLPSGGTLVIDRTEAMTV MUL_3715|M.ulcerans_Agy99 EPAVGSEGQVGPDVFAVHRIDEHLAKAMDRKVWLPSGGTLVIDRTEAMTV MAB_0628|M.abscessus_ATCC_1997 VPPAASPQPDTQAPPAQEPAAQVPPGWSPPQPYPGQWPQPAPAAPQPYGG MAV_3172|M.avium_104 -------------------------------------------------- Mvan_5004|M.vanbaalenii_PYR-1 RVINPISVTPDGTVYVAVRNSATGTDSVAIISTS---------------- Mflv_1994|M.gilvum_PYR-GCK -RIAEFQVTAEGTVFAPIDG-AGAETPVAVIDRD---------------- Mb0912|M.bovis_AF2122/97 ---------DTVDVYNLHTNTGGGPTTNANLAQV---------------- Rv0888|M.tuberculosis_H37Rv ---------DTVDVYNLHTNTGGGPTTNANLAQV---------------- MSMEG_4365|M.smegmatis_MC2_155 TVIPTAGVQIDGTQYVNYMSVRSWDTPGRWTTNF---------------- TH_2316|M.thermoresistible__bu TVIPTAGVHANGTQYVNYMSVRQWGVPGSWTTNF---------------- MMAR_3768|M.marinum_M VDVNTGKFTGSGGNLEQTVTKNNLEAAEEIVRQLRLRD------------ MUL_3715|M.ulcerans_Agy99 VDVNTGKFTGSGGNLEQTVTKNNLEAAEEIVRQLRLRD------------ MAB_0628|M.abscessus_ATCC_1997 QQFPSQPPPQPTSVQGQWQWVPQQPQGPQSAAQQEPPAGYPPPPQGGTPP MAV_3172|M.avium_104 ---------LRGNQYVEEEPAEPEPATVAATTEA---------------- Mvan_5004|M.vanbaalenii_PYR-1 ------------GEVTTVDIPGTIFPVLPSVSPAV--TGDDANPNIGDNG Mflv_1994|M.gilvum_PYR-GCK ------------GTVHTVLLPGTLVVGRRAIR-------DGGTYNVEDVG Mb0912|M.bovis_AF2122/97 ------------ANYIQQNSAGRAVIVTGDFN----------------AR Rv0888|M.tuberculosis_H37Rv ------------ANYIQQNSAGRAVIVTGDFN----------------AR MSMEG_4365|M.smegmatis_MC2_155 ------------SAISVYDPSTDTWVLAPSTIRSAGWFRSSTLYVPGSQN TH_2316|M.thermoresistible__bu ------------SAISRYDQATDTWVTVPSSVRSAGWLRSSTPYRAGDQN MMAR_3768|M.marinum_M -----------IGGIVVIDFIDMVLESNRDLVLRRLTEALARDRTRHQVS MUL_3715|M.ulcerans_Agy99 -----------IGGIVVIDFIDMVLESNRDLVLRRLTEALARDRTRHQVS MAB_0628|M.abscessus_ATCC_1997 ANYRAPQAYRMPPSLDEAEVINRGRYAPRSGWRKAVHRSTGGRVNPGDSR MAV_3172|M.avium_104 -------------ATEGVAAPADGAEAAG-----------------ADAT Mvan_5004|M.vanbaalenii_PYR-1 YVAYQSGGVSYLAVVNPDGTIARTVTLPAGA------------------V Mflv_1994|M.gilvum_PYR-GCK YVNYATGGREYVAVLSADGTVARTIELPEGA------------------T Mb0912|M.bovis_AF2122/97 YSDDQSALLQFAQVNGLTDAWVQVEHGPTTP------------------P Rv0888|M.tuberculosis_H37Rv YSDDQSALLQFAQVNGLTDAWVQVEHGPTTP------------------P MSMEG_4365|M.smegmatis_MC2_155 FQQAAYVLQPEDQVGEDGIRYLYAFGTPSGR------------------A TH_2316|M.thermoresistible__bu FQQMAYVLQPVDQVGEDGVRYVYAFGTPSGR------------------Q MMAR_3768|M.marinum_M EVTSLGLVQLTRKRLGTGLVEAFSTSCPHCS------------------G MUL_3715|M.ulcerans_Agy99 EVTSLGLVQLTRKRLGTGLIEAFSTSCPHCS------------------G MAB_0628|M.abscessus_ATCC_1997 KDRERDLLLASIRQPILGDYRIAVLSIKGGVGKTTTTLGLGSAFATIRTD MAV_3172|M.avium_104 AQRPEESAEPDVEKPESEETEAEAAEEPESE------------------- Mvan_5004|M.vanbaalenii_PYR-1 VATPVDFGPDGAAYQVIETRDEQGRVTSRAVLALSTDTVTPMLPGAPLQP Mflv_1994|M.gilvum_PYR-GCK GGS-VFYSPDGAAFEMLEYRDAQGQTTFRQILALASTTYTDKVPGGRFTY Mb0912|M.bovis_AF2122/97 FAPTCMVGNECELLDKIFYRSGQG-------VTLQAVSYGNEAPKFFNSK Rv0888|M.tuberculosis_H37Rv FAPTCMVGNECELLDKIFYRSGQG-------VTLQAVSYGNEAPKFFNSK MSMEG_4365|M.smegmatis_MC2_155 GSAYLSRVPEDAVTDLSKYEYWDGNRWVTGNAAVAAPVIGDSTRSTGLFG TH_2316|M.thermoresistible__bu GSVHLSRVPEEHITDVSKYEYWDGNAWVS-SAAHAAPIIGESTRSAGLFG MMAR_3768|M.marinum_M RGILLHADPVDSAPTTGRKADSGGRRNRRSKKNRAEEPSEKEAVAKVPTH MUL_3715|M.ulcerans_Agy99 RGILLHADPVDSAPTTGRKADSGGRRNRRSKKNRAEEPSEKEAVAKVPTY MAB_0628|M.abscessus_ATCC_1997 RIIAVDANPDRGTLAERVRDHSTQSTVRDLLNDQNIRSYADVRNHTRMAT MAV_3172|M.avium_104 ---ETEAAEEPGEPEAEEPEEPEAEEPEEPETEEPEADSDEEPE------ Mvan_5004|M.vanbaalenii_PYR-1 N---YPSIQFGPDGSGVLITVETGQSP---FEYHFLRFDQDGATIATADL Mflv_1994|M.gilvum_PYR-GCK V---RDTVVFGPDGVGYLLTGSVSTQIGASQDLDVLGFNAAGETVSRAGG Mb0912|M.bovis_AF2122/97 G---EPLSDHSP---------------------AVVGFHYVADNVAVR-- Rv0888|M.tuberculosis_H37Rv G---EPLSDHSP---------------------AVVGFHYVADNVAVR-- MSMEG_4365|M.smegmatis_MC2_155 F---IVDWANDP---------------------NVLGGYLGGLVGAKTGG TH_2316|M.thermoresistible__bu F---IIDWANDP---------------------NVFGGYLGGLFGAKTGG MMAR_3768|M.marinum_M APGEHPMFKAMAASSSSEAEHGDGEVEESGEELTAAVDDQTAVQVALDLG MUL_3715|M.ulcerans_Agy99 APGEHPMFKAMAASSSSEAEHGDGEVEESGEELTAAVDDQTAVQVALDLG MAB_0628|M.abscessus_ATCC_1997 SRLEVLASEQDPAVSEAFGEIDYRNTIDILQRYYNIILTDCGTGIMHSAM MAV_3172|M.avium_104 --------------------------------------EESGEAPEQPVA . Mvan_5004|M.vanbaalenii_PYR-1 SGFLQSAQQDYVFWQEGVVFGPDGTPYATLTG--ADQGVW----ALTSTG Mflv_1994|M.gilvum_PYR-GCK LTNPVTTYENNPYRTV-LAFGRDGTAYVTLYFTPDDPGVY----AVTATG Mb0912|M.bovis_AF2122/97 -------------------------------------------------- Rv0888|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_4365|M.smegmatis_MC2_155 NVSELSVQYNEYLGKYVVLYGDG-NNNIQMRIADRPEGPWSDPIELASSA TH_2316|M.thermoresistible__bu NVGEMSVQYNEYLGKYVILYGNGRTNNIEMRIADSPEGPWSDPIILATPQ MMAR_3768|M.marinum_M QTDETEETDETDETDETDDFDDDSDDSDDSDEDDDSDETNDTDVDAGEDE MUL_3715|M.ulcerans_Agy99 ---ETEESEETDGTDETDDFDDDSDDSDDSDEDDDTDETNDTDVDADEDE MAB_0628|M.abscessus_ATCC_1997 AGVLDLAHTIVLVSSPAMDSARSASATLDWLMQHGYSSLVREAHVVLSAS MAV_3172|M.avium_104 EEPEPAPQQPETKRRWGARLRDRLSGR----------------------- Mvan_5004|M.vanbaalenii_PYR-1 PVKVLE-----------------------------------LDLGQGELV Mflv_1994|M.gilvum_PYR-GCK ARKVVD-----------------------------------LEYVQYRQG Mb0912|M.bovis_AF2122/97 -------------------------------------------------- Rv0888|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_4365|M.smegmatis_MC2_155 DYPGLY-----------------------------------APMIHPWSG TH_2316|M.thermoresistible__bu QYPGLY-----------------------------------APMIHPWSG MMAR_3768|M.marinum_M DTDDDSDEDSDDDSDEDEDTEDDELDDDLDEDDLDDDLDEDDDDLDDELD MUL_3715|M.ulcerans_Agy99 DTDDDS--------DEDEDTEDD---------------DELDDDLDDELD MAB_0628|M.abscessus_ATCC_1997 RPGSAG-----------------------IKLDKVYEHFQARCRSIHMIP MAV_3172|M.avium_104 -------------------------------------------------- Mvan_5004|M.vanbaalenii_PYR-1 EPVKFGPDGTPYVTVSERVDG--SYVTTVHTFTPVTML------------ Mflv_1994|M.gilvum_PYR-GCK FPPTFGLDGTGYVTSAELLSGDADGIALVTVFSPVTDL------------ Mb0912|M.bovis_AF2122/97 -------------------------------------------------- Rv0888|M.tuberculosis_H37Rv -------------------------------------------------- MSMEG_4365|M.smegmatis_MC2_155 TGMLEDDNGDPDVNNLYWNMSLWGDYNVVLMQTDLSGLKTVAV------- TH_2316|M.thermoresistible__bu TGYLLDENGDPDPESLYWNMSMWGPYNVYLMQTDLSSLVEV--------- MMAR_3768|M.marinum_M DDDSDSDDEDGESELTEPAAGRPAALEVTTIAERPRRRRAAGRPAGPPIH MUL_3715|M.ulcerans_Agy99 DDDSDSDDEDSESELTEPAAGRPAALEVTTIAERPRRRRAAGRPAGPPIH MAB_0628|M.abscessus_ATCC_1997 FDPHLAEGADVDFNLLNADTNAAYLKLAGAISESFPRLRVRGDEQR---- MAV_3172|M.avium_104 -------------------------------------------------- Mvan_5004|M.vanbaalenii_PYR-1 -- Mflv_1994|M.gilvum_PYR-GCK -- Mb0912|M.bovis_AF2122/97 -- Rv0888|M.tuberculosis_H37Rv -- MSMEG_4365|M.smegmatis_MC2_155 -- TH_2316|M.thermoresistible__bu -- MMAR_3768|M.marinum_M LG MUL_3715|M.ulcerans_Agy99 LG MAB_0628|M.abscessus_ATCC_1997 -- MAV_3172|M.avium_104 --