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MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVSAAIAELFGAHGQEFQALSAQAS AFHDRFVRALSAAAGWYVDAEAANAALVDTAATGASELGSGGRTALILGSTGTPRPPFDYMQQVYDRYIA PHYLGYAFSGLYTPAQFQPWTGIPSLTYDQSVAEGAGYLHTAIMQQVAAGNDVVVLGFSQGASVATLEMR HLASLPAGVAPSPDQLSFVLLGNPNNPNGGILARFPGLYLQSLGLTFNGATPDTDYATTIYTTQYDGFAD FPKYPLNILADVNALLGIYYSHSLYYGLTPEQVASGIVLPVSSPDTNTTYILLPNEDLPLLQPLRGIVPE PLLDLIEPDLRAIIELGYDRTGYADVPTPAALFPVHIDPIAVPPQIGAAIGGPLTALDGLLDTVINDQLN PVVTSGIYQAGAELSVAAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLVDAIQDLAAGDLSG FNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv1430 | PE16 | - | 100% (528) | PE FAMILY PROTEIN |
M. tuberculosis H37Rv | Rv0151c | PE1 | e-101 | 41.73% (556) | PE family protein |
M. tuberculosis H37Rv | Rv0159c | PE3 | 1e-94 | 47.85% (418) | PE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1465 | PE16 | 0.0 | 100.00% (528) | PE family protein |
M. gilvum PYR-GCK | Mflv_1918 | - | 5e-38 | 37.79% (307) | hypothetical protein Mflv_1918 |
M. leprae Br4923 | MLBr_01232 | - | 7e-18 | 30.92% (249) | hypothetical protein MLBr_01232 |
M. abscessus ATCC 19977 | MAB_4141 | - | 8e-30 | 37.19% (242) | PE/PPE family protein |
M. marinum M | MMAR_2235 | - | 0.0 | 58.01% (612) | PE-PGRS family protein, PE16 |
M. avium 104 | MAV_1760 | - | 2e-19 | 27.95% (322) | hypothetical protein MAV_1760 |
M. smegmatis MC2 155 | MSMEG_5455 | - | 9e-42 | 32.65% (392) | PE family protein |
M. thermoresistible (build 8) | TH_3724 | - | 1e-49 | 36.96% (349) | PUTATIVE putative PE-PPE, C-terminal domain protein |
M. ulcerans Agy99 | MUL_1034 | - | 2e-89 | 45.27% (433) | PE family protein |
M. vanbaalenii PYR-1 | Mvan_4726 | - | 4e-38 | 34.51% (339) | hypothetical protein Mvan_4726 |
CLUSTAL 2.0.9 multiple sequence alignment Rv1430|M.tuberculosis_H37Rv MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVSAA Mb1465|M.bovis_AF2122/97 MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVSAA MMAR_2235|M.marinum_M MSFVVTAPETVVAAASQLTGIGSAIEAANAAAAALTTRLLPAAADEVSAG MUL_1034|M.ulcerans_Agy99 MSYVLTAPDLLASAATDVDGIAATLQVANSAAAALTSGLLAAAQDEVSAA Mflv_1918|M.gilvum_PYR-GCK --------------------MGKGDFGLKASEFTGRSSTRFADSVRRRPG MSMEG_5455|M.smegmatis_MC2_155 --------------------MGRLLHSLSTAFLVFVAVVVLCVSTS---- MLBr_01232|M.leprae_Br4923 --------------------MKRLLATTLAALTVGTVSGFGSTVASSEPG MAV_1760|M.avium_104 --------------------MKQLLAGVTALLSVSTAGYFGIGTAAADGG TH_3724|M.thermoresistible__bu ------------------------VVAVGALTWGGXGVASPAGQPER--- Mvan_4726|M.vanbaalenii_PYR-1 --------------------MRRRLRSAAWGLLSLVIAVLFAWGSVVT-- MAB_4141|M.abscessus_ATCC_1997 -------------------MAGQYSVPGKRHSLRRYVATITAVAATCT-- Rv1430|M.tuberculosis_H37Rv IAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALVD- Mb1465|M.bovis_AF2122/97 IAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALVD- MMAR_2235|M.marinum_M IAALMSTHAQEYQLLGGQLATYHDQLVQALDRTAGWYADAETGNAALLRN MUL_1034|M.ulcerans_Agy99 IAKVFSAYGQEYQAAIAQASAFHTEFTRALAAAGAAYAQAEAANASLITA Mflv_1918|M.gilvum_PYR-GCK GATYGLYRHDGLGVGTWAWVFARSSRSFPRSRRCWRYPRGVPTPVAVLVA MSMEG_5455|M.smegmatis_MC2_155 ----------------------------------------MPTAAHLLLN MLBr_01232|M.leprae_Br4923 E------------------------------------PWLPPSPVPVREN MAV_1760|M.avium_104 P------------------------------------IGGPPTPGAPGD- TH_3724|M.thermoresistible__bu -----------------------------------------AAALRLTAT Mvan_4726|M.vanbaalenii_PYR-1 -----------------------------------------STSA--GAG MAB_4141|M.abscessus_ATCC_1997 ----------------------------------------VLAPLAMESR Rv1430|M.tuberculosis_H37Rv -----------------------TAATGAS--------ELGSGGRTALIL Mb1465|M.bovis_AF2122/97 -----------------------TAATGAS--------ELGSGGRTALIL MMAR_2235|M.marinum_M VQQELLTGLTAPGRAWS---GAGAASAGASGVDALMSSALLSGGRSVLVV MUL_1034|M.ulcerans_Agy99 GVSDALTAITTPIQSLLGPAAIGTGGAGSAGALTAVSSTLMADPVVALIM Mflv_1918|M.gilvum_PYR-GCK -------------------------------------------NTTALVM MSMEG_5455|M.smegmatis_MC2_155 -------------------------------------------HPHALVI MLBr_01232|M.leprae_Br4923 -----------------------------------------SPAKIVYAL MAV_1760|M.avium_104 --------------------------------------------QTAYAL TH_3724|M.thermoresistible__bu --------------------------------------------ADAIIM Mvan_4726|M.vanbaalenii_PYR-1 ---------------------------------------------TALVM MAB_4141|M.abscessus_ATCC_1997 --------------------------------------------TIASTL . : Rv1430|M.tuberculosis_H37Rv GSTGTPRP----PFDYMQQVYDRYIAPHYLGYAFSGLY-------TPAQF Mb1465|M.bovis_AF2122/97 GSTGTPRP----PFDYMQQVYDRYIAPHYLGYAFSGLY-------TPAQF MMAR_2235|M.marinum_M GSTGTPRP----SYRFMREVYDLFVAPHYFGDSLFGVQ-------TPAQF MUL_1034|M.ulcerans_Agy99 GGTSVPLP----GPGYVSDINNNYIQPLFSGAIPQALF-------TPEQF Mflv_1918|M.gilvum_PYR-GCK GGTFHPLTGPRDSPEFVTAYLDNAVDNQISAAYGYAVTNAVAV-YTPEEF MSMEG_5455|M.smegmatis_MC2_155 GGTGTPVP----PPEYVNGQTDNYIGAEFPGEYRYAVH-------TPQNF MLBr_01232|M.leprae_Br4923 GGARPPTFD---WDYYTIRAGDEFFPDVNRKLIDYPARAPFR--YVPTFL MAV_1760|M.avium_104 GGAHVLGIP---YDQYIRMEGADWFPGQQRQIVRYPAGQVQG--HVLERL TH_3724|M.thermoresistible__bu PGTKIGYIP---SQDEFTAYATAVIGATAGAPGAVDYLG------VPGEF Mvan_4726|M.vanbaalenii_PYR-1 GGNGHPLSVPQDTPDYINKYVTAADDAFIAPSGLCGPQCSLVATYTPAQI MAB_4141|M.abscessus_ATCC_1997 ASYVIGIGG---NNDGASANIPRKLGGAYSVDYHPVSY--------PGAI . : Rv1430|M.tuberculosis_H37Rv QPWT----------GIPSLTYDQSVAEGAGYLHTAIMQQVAA-------- Mb1465|M.bovis_AF2122/97 QPWT----------GIPSLTYDQSVAEGAGYLHTAIMQQVAA-------- MMAR_2235|M.marinum_M QPFT----------GIPNLTFDESAATGASYLHAAITQQLAD-------- MUL_1034|M.ulcerans_Agy99 WPVTP---------GLGNLTFNQSVAQGVTLLNDAINTQLAL-------- Mflv_1918|M.gilvum_PYR-GCK FPLG------------G-LTFDDSVAEGLANLGRCLRAEPGCVFNADPAV MSMEG_5455|M.smegmatis_MC2_155 WPVY------------GSMSFDESTVAGLAALQAEMAKEG---------- MLBr_01232|M.leprae_Br4923 VPGP-----------RDEVTIGEAIAVATKNLNQAIHRGTEP-------- MAV_1760|M.avium_104 FPGIGKLDESFPGLGMDGPSVGESVAEGIDNLDAAIRTTGRP-------- TH_3724|M.thermoresistible__bu WPATG----------LDSLTFDASVAXGQAMLTPMVDGAIES-------- Mvan_4726|M.vanbaalenii_PYR-1 RFVNG----------IFDMTYDESVAVGQANLNDCIQGSDCTATLAPYSE MAB_4141|M.abscessus_ATCC_1997 WPVSG----------LTAPTFKTSVAQGRTNLNDEIVTAGNQ-------- : : . . * : Rv1430|M.tuberculosis_H37Rv -----------GNDVVVLGFSQGASVATLEMRHLASLPAGVAPSPDQLSF Mb1465|M.bovis_AF2122/97 -----------GNDVVVLGFSQGASVATLEMRHLASLPAGVAPSPDQLSF MMAR_2235|M.marinum_M -----------GNRVVVAGFSQGASVATLEMRHLQSLPIDSRPSPEDLSF MUL_1034|M.ulcerans_Agy99 -----------GNKVVAFGYSQSATIVNNEILALMAMGTG-APDPGDLSF Mflv_1918|M.gilvum_PYR-GCK AARVGTVAPRHDDTFVVFGYSQSAAVASLLK---RQLIDAPGPEPAATTF MSMEG_5455|M.smegmatis_MC2_155 ---------HFGSPLVILGYSSSTRILTADK---NRRIAD-GDYAVDINY MLBr_01232|M.leprae_Br4923 --------------AAVVGLSQGSLALDTEQE--QLATDPTAPPPDQLTF MAV_1760|M.avium_104 --------------GTAIGLSEGAFVVDGEQA--RLANDPTAPPPNTLNF TH_3724|M.thermoresistible__bu -----------DTPIVVFGHSQSAVIATKEKQRLLAEYPDPDTAP-DVTF Mvan_4726|M.vanbaalenii_PYR-1 TG----PHTVADSTYVIYAYSQSATVAANQK-----LQLIAHPVASTVSF MAB_4141|M.abscessus_ATCC_1997 -------------PITIVGYSLGAVVVSKSHS---DLLQRYPGGNPNIQF . . * .: : Rv1430|M.tuberculosis_H37Rv VLLGNPNNPNGGILARFPGLYLQSLGLTFNGATPDT-----DYATTIYTT Mb1465|M.bovis_AF2122/97 VLLGNPNNPNGGILARFPGLYLQSLGLTFNGATPDT-----DYATTIYTT MMAR_2235|M.marinum_M VLLGNPNNPNGGILARFPGLYIQSVGLTFNGATPVT-----EYPTTVYTT MUL_1034|M.ulcerans_Agy99 IMVGAPNNPDGGLLARFPGFYIPFLDVSFNGATPAAN----PYPTSIFTA Mflv_1918|M.gilvum_PYR-GCK MLAANPMRPNGGVLGRFPALTIPILGITFHGATPTAGVDG-AYRTVDVVR MSMEG_5455|M.smegmatis_MC2_155 VLVSDVAKGNGGVMARFPGWHIPILGVTFDGATRTDSDGY-AFDTKSISF MLBr_01232|M.leprae_Br4923 NTFGDPSGYHGFGKSVLASIFRPGDYIPLIDYTMPQRMDS-QYDSNRVVA MAV_1760|M.avium_104 ATFGDPIGRHAFGQSFLTAMFGVGSVVPALDYTMPPPYES-QYDTNRFVA TH_3724|M.thermoresistible__bu VMVANPNRPNGGLLARFPGLYIPILGVTFNGATPAPADG--PFDSYDVAR Mvan_4726|M.vanbaalenii_PYR-1 LLVANPNRPDGGILERFVGAYIPLLGITFNGSTPTFSPQPRPLTTVDVAR MAB_4141|M.abscessus_ATCC_1997 VLMGSANTPNGGIFARFPWLKIPLADIESNGAWEPD-----QFKTKVINT . .. : : . : Rv1430|M.tuberculosis_H37Rv QYDGFA-DFPKYPLNILADVNALLGIYYSHS-LYYGLTPEQ-VASGIVLP Mb1465|M.bovis_AF2122/97 QYDGFA-DFPKYPLNILADVNALLGIYYSHS-LYYGLTPEQ-VASGIVLP MMAR_2235|M.marinum_M QYDGFA-DFPQYPLNVVADVNALLGISYSHS-LYYGLTPDQ-VAAGVVLP MUL_1034|M.ulcerans_Agy99 QYDGIA-HAPQYRLNILSDINAIMGYFYVHG-NYPDLMSGQ-AIQ---LP Mflv_1918|M.gilvum_PYR-GCK QYDGLGGDFPVRPLNLLATVNALLGYGIMHG-ETVDVPFAQ-ARFQ---- MSMEG_5455|M.smegmatis_MC2_155 VHDGWS-DFPVYPLNVLALANAVAGIAVLHP-TYPELDRPD-LVPV---- MLBr_01232|M.leprae_Br4923 AYDGLS-EFPDRADNLLAQLNCFAGGAISHT-PSGFFNPED-VPPQNIRT MAV_1760|M.avium_104 AYDSIA-DFPDRPDNMFALANTLMGLATGHT-AVAFTNPSM-VPPQNIRT TH_3724|M.thermoresistible__bu EFDGWA-DFPRYPLNLVATANAILGIYYLHG-GYYELLTENPDILDDPER Mvan_4726|M.vanbaalenii_PYR-1 QYDGWA-DFPTNPLNLLADLNAIMGTILLHP-NYSDAGTPQ--------- MAB_4141|M.abscessus_ATCC_1997 EYDTYG-DFPAY-FNPLALANSIAAIQYAHPDAYYDRIDPAALDDPDNPN .* . . * * .: * . . * Rv1430|M.tuberculosis_H37Rv VSSPDT-NTTYILLPNEDLPLLQPLRGI----VPEPLLDLIEPDLRAIIE Mb1465|M.bovis_AF2122/97 VSSPDT-NTTYILLPNEDLPLLQPLRGI----VPEPLLDLIEPDLRAIIE MMAR_2235|M.marinum_M VSSPDV-NTTYILIPNEHLPLLQPLRGI----VPDSVLDGIEPGLRDVVE MUL_1034|M.ulcerans_Agy99 TSPGYTGNTDYYMYLTQDLPLVQPIRDIPY--AGPPLADLIQPQLRVLVD Mflv_1918|M.gilvum_PYR-GCK ---GREGDTDYYLIGTDLLPLLQPLLLF----VPRPILSALDAPLRVLVE MSMEG_5455|M.smegmatis_MC2_155 ---GSTGDTEYFVIGTDIMPLLMPLETIG---VPRPILLAVDEPLRVLVE MLBr_01232|M.leprae_Br4923 TVNSRGAKTTTYLIPVNHLPLTLPLRYLG---WSDALVDQIDAVLQPKID MAV_1760|M.avium_104 TINSRGAKDTTIMIPEKHLPLVMPLKYIG---IDENTLNKLDAILTPRVN TH_3724|M.thermoresistible__bu TIVQQYGDTTYYLIRTEQLPLLRPLRDLG---VPEEFVDALEPYVRRIVD Mvan_4726|M.vanbaalenii_PYR-1 -LQGQYQDSTYYLIPAPITPVLVPLTWVPI--VGKPLAIALDPAVRVLVE MAB_4141|M.abscessus_ATCC_1997 VVKTVQGNTTYYLVRAEHLPLLQPLRDLTNPIGASFVLDAIEPTLRVFID . : *: *: . :: : :: Rv1430|M.tuberculosis_H37Rv LGYDRTG----YADVPTPAALFPVHIDP---------------------- Mb1465|M.bovis_AF2122/97 LGYDRTG----YADVPTPAALFPVHIDP---------------------- MMAR_2235|M.marinum_M LGYDRTG----YADVPTPASLFPANVNPNVVAGAFVEGAVRGIDNGLAGM MUL_1034|M.ulcerans_Agy99 LGYSDYGPGLSYADVPTPAGLL---------------------------- Mflv_1918|M.gilvum_PYR-GCK DAYDRDAG----PGDPTTARWWPVKDFAGTAAKLIASVPVAVDNLTEGFG MSMEG_5455|M.smegmatis_MC2_155 AGYRRDIA----PGAPTPARLIPIVNPITLTRNFIAAIPVGVDDAMEELG MLBr_01232|M.leprae_Br4923 AAYAYNDN------------------------------------------ MAV_1760|M.avium_104 AGYSRNDD------------------------------------------ TH_3724|M.thermoresistible__bu LGYDRNTP----YGEPAPVRVLPP-------------------------- Mvan_4726|M.vanbaalenii_PYR-1 MGYDRTVN----PGQPTPARYLYVPNLIKAALNFAMAIPTGWDDAISYLT MAB_4141|M.abscessus_ATCC_1997 MAYDRDTG----PGTTTQFSFFTPSKNIVDAFNKLPTAIAEGAHNVENGL .* Rv1430|M.tuberculosis_H37Rv ----------------------------------IAVPPQIGAAIGGP-- Mb1465|M.bovis_AF2122/97 ----------------------------------IAVPPQIGAAIGGP-- MMAR_2235|M.marinum_M GLPPLPDLPAAPLLPEIWSNAPPIPGWPASVPSAIAVPPQLGGAIAGP-- MUL_1034|M.ulcerans_Agy99 -------------------------------------------SVPNP-- Mflv_1918|M.gilvum_PYR-GCK ------------------------------LGRVLGTPVPGVFGVGG--- MSMEG_5455|M.smegmatis_MC2_155 ------------------------------HGRPLGTQPSGVFGVGGEDT MLBr_01232|M.leprae_Br4923 -------------------------------------------PLNKP-- MAV_1760|M.avium_104 -------------------------------------------PATAP-- TH_3724|M.thermoresistible__bu -----------------------------------------LTPAPGP-- Mvan_4726|M.vanbaalenii_PYR-1 GDP--------------------------DCRPFHTTVPASPFGVGGPPV MAB_4141|M.abscessus_ATCC_1997 AG--------------------------ATPKQSASPEKPASPPVPQPGP Rv1430|M.tuberculosis_H37Rv --------------LTALDGLLDTVINDQLNPVVTSGIYQAGAELSVAAA Mb1465|M.bovis_AF2122/97 --------------LTALDGLLDTVINDQLNPVVTSGIYQAGAELSVAAA MMAR_2235|M.marinum_M --------------LDHLYRTLDSVINGQINPAITSGIYQYGADLSAEAA MUL_1034|M.ulcerans_Agy99 --------------FAVSYYLLKGSLQAP---------YGAAVEIGVEAG Mflv_1918|M.gilvum_PYR-GCK ---------------PDLPDVDEGGAVTSDIDEDAVAQRDSASSTERSAP MSMEG_5455|M.smegmatis_MC2_155 EL-KGLPAGVISLAKPTLPVSSHTTVVEKTERKDLAKPAAEPEPVVEDEP MLBr_01232|M.leprae_Br4923 ---------------------------------------ISVDPVNGMDP MAV_1760|M.avium_104 ---------------------------------------VQVDPVHGFDP TH_3724|M.thermoresistible__bu ---------------ATQHNAGQGITVASATSTPDKRTPVVEAPVEEPPV Mvan_4726|M.vanbaalenii_PYR-1 YTGAIDPYGEPTPYLAPPVETHGEAAPGSGSPAAHPAGTEPPETVTFSPT MAB_4141|M.abscessus_ATCC_1997 TNPGSATTQIPAPEAPTPSVVSLSTAEPPAPPASAKAADPTAISVSTAGA Rv1430|M.tuberculosis_H37Rv GYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLV-----------D Mb1465|M.bovis_AF2122/97 GYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLV-----------D MMAR_2235|M.marinum_M RHGASSELLNAIYVGRQVLPILIEGPGVILTADTYYSI-----------N MUL_1034|M.ulcerans_Agy99 ------------LLGPESFPDTYPWVPSLNPGLNFYLG-----------Q Mflv_1918|M.gilvum_PYR-GCK AEESRSAVGGADSDGRDDVVDPEPAAPEAETSEAETVT-----------E MSMEG_5455|M.smegmatis_MC2_155 AVEDETPVADTKKASPKPLRPKVRGPISFDAPKLPTIR-----------K MLBr_01232|M.leprae_Br4923 ----IAGIDAELR---DSILNVFAQLRSILPPPPG--------------- MAV_1760|M.avium_104 AEVTAPANQATFGGGADPLSQIMAGAMSVLSHGAGEAD-----------H TH_3724|M.thermoresistible__bu QTGRSTLKREKPVSARHLVRNSLRAVPGLRRGEPAATP-----------T Mvan_4726|M.vanbaalenii_PYR-1 TESTPSTLLPETPAESEDMPPDFVENDTPDSDEVSPTE-----------D MAB_4141|M.abscessus_ATCC_1997 STARDQDFQPDTKPDPKSTPPPTKDSVGEADKSKNTLKPTLRLPKLPVAQ . Rv1430|M.tuberculosis_H37Rv AIQDLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV Mb1465|M.bovis_AF2122/97 AIQDLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV MMAR_2235|M.marinum_M AIKDLAAGNLSGFNQNLQLIPATNAMLLTFGATIPIAAGVSAYIGRDFP- MUL_1034|M.ulcerans_Agy99 PSVTLLSLLSGGLGDIFHLIPPP-----VFP------------------- Mflv_1918|M.gilvum_PYR-GCK TEADD---------ADDADDGADADDEDIDADGADADGEDTAGNTAEAA- MSMEG_5455|M.smegmatis_MC2_155 ATGDRPLKRLLSALTPKRPKPASSHDAGPAAGNKDTDNADKPAARADDAA MLBr_01232|M.leprae_Br4923 -------------------------------------------------- MAV_1760|M.avium_104 -------------------------------------------------- TH_3724|M.thermoresistible__bu PDVTPDVTPDAPAGQPEPAEPNESAAPPAAAEADDASE------------ Mvan_4726|M.vanbaalenii_PYR-1 DALKDTETINESQDGPTESASGVSGEDAADADSRSADADSLSADAGDSAP MAB_4141|M.abscessus_ATCC_1997 PGTAPKSPKFPSLKNHLKSVPGLSEKKNPAADASSKHSQPANAPAHTSDK Rv1430|M.tuberculosis_H37Rv ------------- Mb1465|M.bovis_AF2122/97 ------------- MMAR_2235|M.marinum_M ------------- MUL_1034|M.ulcerans_Agy99 ------------- Mflv_1918|M.gilvum_PYR-GCK ------------- MSMEG_5455|M.smegmatis_MC2_155 ------------- MLBr_01232|M.leprae_Br4923 ------------- MAV_1760|M.avium_104 ------------- TH_3724|M.thermoresistible__bu ------------- Mvan_4726|M.vanbaalenii_PYR-1 ADAAAADTAA--- MAB_4141|M.abscessus_ATCC_1997 TSDHASETGRGAA