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GVGFTTRQVSFSSGGSRIAAELYLPAGPGPYPAVVFAHGFSGTMDWILPDFASVFAAGGLAVLLFDYRHF GSSEGQPRQLVDTGCQLEDIRAALAYARAHEAIDARRIGLWGTSLGGSHVINVASADPRIAAVVATVPAL DMYVGLRGRHRPATFRPGPARTVIATLRLVGAAALDAIRGRCGLRPYYLPVYGPLGHAVFSDPALAERFR HVESNSPTWRNEVTPRFLFHAPRYRDGTVERIRCPVLVTLARDDAEVSSPYVRRKLGHAADVEIMEYPVA HFDVYHGPVRAEIARDQRDFLVRHLLRGPNRATNSSGCGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1417 | - | - | 100% (321) | peptidase S15 |
| M. vanbaalenii PYR-1 | Mvan_2419 | - | 2e-44 | 37.62% (303) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_1972 | - | 6e-34 | 33.57% (286) | alpha/beta hydrolase fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2330c | - | 1e-07 | 30.00% (120) | hypothetical protein Mb2330c |
| M. gilvum PYR-GCK | Mflv_3465 | - | 1e-120 | 67.20% (311) | peptidase S15 |
| M. tuberculosis H37Rv | Rv2307c | - | 1e-07 | 30.00% (120) | hypothetical protein Rv2307c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2608 | - | 2e-34 | 34.98% (303) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_0385 | - | 1e-42 | 36.81% (307) | hypothetical protein MMAR_0385 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_4450 | - | 9e-39 | 33.23% (319) | alpha/beta hydrolase |
| M. thermoresistible (build 8) | TH_4007 | - | 5e-50 | 41.37% (307) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_1035 | - | 2e-41 | 36.66% (311) | hypothetical protein MUL_1035 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1417|M.vanbaalenii_PYR-1 MGVG--FTTRQVSFSSGGSRIAAELY--LPAG-PGPYPAVVFAHGFSGTM
Mflv_3465|M.gilvum_PYR-GCK MTAG--WTTSAVSFPCDGEQIAGVLY--RPEGGAPPFPCVVFAHGFSGTM
TH_4007|M.thermoresistible__bu -------VSTPVTFPAGGETCVGRLYGDAPGPADARKPCVVLCHGFGGTQ
MMAR_0385|M.marinum_M MTQ-----RQDVRFPCGEAMISAWLYRPAGADPARPVPMLVMAHGLGAVR
MUL_1035|M.ulcerans_Agy99 MTQ-----RQDVRFPCGEALISAWLYRPAGADPARPVPMLVMAHGLGAVR
MSMEG_4450|M.smegmatis_MC2_155 MAQPLSYTRDDVTFMSDGTSCAAWLYRPDGVNNP---PIVVLAHGFAAFR
MAB_2608|M.abscessus_ATCC_1997 MNR------QSIRFNSHGIDCEAWLYRAQTVEDT--APIVVMAHGVGGTK
Mb2330c|M.bovis_AF2122/97 ----------------------------MSLKRCRALPVVAIVALVASGV
Rv2307c|M.tuberculosis_H37Rv ----------------------------MSLKRCRALPVVAIVALVASGV
* :.: ...
Mvan_1417|M.vanbaalenii_PYR-1 DW-ILPDFASVFAAGGLAVLLFDYRHFGSSEGQPRQLVDTGCQLEDIRAA
Mflv_3465|M.gilvum_PYR-GCK DW-ILPDFAAVFCAAGLAVLTFDYRGFGSSEGTPRQIVNSARQLEDIRAA
TH_4007|M.thermoresistible__bu DTPAFTATARDFVRAGYLALTLDYRRFGESSGLPRQLVNIADQLDDIAAA
MMAR_0385|M.marinum_M TM-RLDAYAQRFSAAGYACLVFDYRNFGDSEGQPRQLLDIRMQLQDWAAA
MUL_1035|M.ulcerans_Agy99 TM-RLDAYAQRFSAAGYACLVFDYRNFGDSEGQPRQLLDIRMQLQDWAAA
MSMEG_4450|M.smegmatis_MC2_155 EL-RLDAYAARFAQAGYAALVFDYRHWGASDGQPRRILDIPKQQTDWRAA
MAB_2608|M.abscessus_ATCC_1997 DS-GLEPFAVRLAEAGMHALAFDYRGFGASDGFPRQHVSFTHQIGDYHAA
Mb2330c|M.bovis_AF2122/97 ITFIWSQQRRLIYFPSAGPVPSASSVLPAG-----RDVVVETQDGMRLGG
Rv2307c|M.tuberculosis_H37Rv IMFIWSQQRRLIYFPSAGPVPSASSVLPAG-----RDVVVETQDGMRLGG
: . : . : : * ..
Mvan_1417|M.vanbaalenii_PYR-1 LAYARAHEAIDARRIGLWGTSLGGSHVINVASADPRIAAVVATVPALDMY
Mflv_3465|M.gilvum_PYR-GCK LDVVRNRADVDPGRIGLWGTSLGGSHVLQIAAEDPRVAAVVANVPALDMY
TH_4007|M.thermoresistible__bu VGHARTHPGVDPDRIVLWGTSLGGGHVVTAAARDPRIAAVIAQIP----Y
MMAR_0385|M.marinum_M VAYARTCDGVDQARIGLWGTSFGGGHVIATAARLPGIAAVVAQCP---FT
MUL_1035|M.ulcerans_Agy99 VAYARTCDGVDQARIGLWGTSFGGGHVIATAARLPGIAAVVAQCP---FT
MSMEG_4450|M.smegmatis_MC2_155 IAYARSLDNVDTTRLVGWGSSFGGGHVLTLAARDHEFAAAIVQVP---HV
MAB_2608|M.abscessus_ATCC_1997 VNMARRLPGVDPTRIVLWGVSLAGGHVMAVAGARNDVAAVIALTP---LV
Mb2330c|M.bovis_AF2122/97 WYFPHTSGGSGPAVLVCNGNAGDRSMRAELAVALHGLGLSVLLFD----Y
Rv2307c|M.tuberculosis_H37Rv WYFPHTSGGSGPAVLVCNGNAGDRSMRAELAVALHGLGLSVLLFD----Y
: . : * : . * .. :
Mvan_1417|M.vanbaalenii_PYR-1 VGLRGRHRPATFRPGPARTVIATLRLVGAAALDAIRGRCGLRPYYLPVYG
Mflv_3465|M.gilvum_PYR-GCK TGLRGRHRSPDYRPGPAQIVVAVARLLSAAVVDEVRGRLGRSPRYLPVYG
TH_4007|M.thermoresistible__bu NGFP--------RKVEGRSTAATLRLLAVMVRDATRGALGLSPVYIKQVG
MMAR_0385|M.marinum_M DGIAS---------VLAIAPTTAIRVTARSMRDLIGSRLGRPPVMIPTAG
MUL_1035|M.ulcerans_Agy99 DGIAS---------VLAIAPTTAIRVTARSMRDLIGSRLGRPPVMIPTAG
MSMEG_4450|M.smegmatis_MC2_155 SGPAS---------AFSQSPKLVARLIAAGLRDQIGAWFGGAPHRVTSIG
MAB_2608|M.abscessus_ATCC_1997 DGIAA---------ARSAMTEHSAGTLLRSAVTGLRSRLGRQQRTIPIVG
Mb2330c|M.bovis_AF2122/97 RGYGG---------NPGRPSEQGLAADARAAQEWLSGQSDVDPARIAYFG
Rv2307c|M.tuberculosis_H37Rv RGYGG---------NPGRPSEQGLAADARAAQEWLSGQSDVDPARIAYFG
* . . . : *
Mvan_1417|M.vanbaalenii_PYR-1 PLGHAVFSDPALAERFRHVESN---------SPTWRNEVTPRFLFHAPRY
Mflv_3465|M.gilvum_PYR-GCK RLGRAFFADPALAQRFRAVEAQ---------APSWRNAVAPRFLLHAPRY
TH_4007|M.thermoresistible__bu PAGETAVIAGARAQQTVDAMT----------SATWRNEVAPRSLWDMWRY
MMAR_0385|M.marinum_M KPGEVALMTAPDAYP---GYLG-----LMPQGTQVPNEVAARIGIKVLGY
MUL_1035|M.ulcerans_Agy99 KPGEVALMTAPDAYP---GYLG-----LMPQGTQVPNEVAARIGIKVLGY
MSMEG_4450|M.smegmatis_MC2_155 RPGEFAMMTSPGAYELVEEMAGGEAAEHMRAQLEAENDVAARIALRVPLY
MAB_2608|M.abscessus_ATCC_1997 RAGELAALTSDGYYEAHLAIAG----------PAWRNEIDATVGTQLVSY
Mb2330c|M.bovis_AF2122/97 ESLGAAVAVGLAVQRPPAALVLRSPFTSLAEVGAVHYPWLPLRRLLLDHY
Rv2307c|M.tuberculosis_H37Rv ESLGAAVAVGLAVQRPPAALVLRSPFTSLAEVGAVHYPWLPLRRLLLDHY
. *
Mvan_1417|M.vanbaalenii_PYR-1 RDGTVER-IRCPVLVTLARDDAEVSSPYVRRKLGHAADV----EIMEYPV
Mflv_3465|M.gilvum_PYR-GCK RDGTIER-VRCPVLVTLARDDAEVSTPFVERKVRRGRDV----EIRKYPA
TH_4007|M.thermoresistible__bu RPGAHASFVRAPLLVCLGANDAETPAEKAAELARRAPRG----ELRTYDH
MMAR_0385|M.marinum_M RPGRSARKIACPILFCVCETDSVAPAGPTLRYAARAPRG----EVIRYPE
MUL_1035|M.ulcerans_Agy99 RPGRSARKIACPILFCVCETDSVAPAGPTLRYAARAPRGEVSGEVIRYPE
MSMEG_4450|M.smegmatis_MC2_155 SPGRHAAKITAPTLVQLATKDDVTPYAKARKIVARIPNG----EVRSYDI
MAB_2608|M.abscessus_ATCC_1997 RPTRCASRIGCPILVQIADFDRAAPPHAAAKAAFKARAE-----VRHYPC
Mb2330c|M.bovis_AF2122/97 PSIERIASVHAPVLVIAGGSDDIVPATLSEWLVAAAAEPKRYVVVPGVGH
Rv2307c|M.tuberculosis_H37Rv PSIERIASVHAPVLVIAGGSDDIVPATLSERLVAAAAEPKRYVVVPGVGH
: .* *. * .. :
Mvan_1417|M.vanbaalenii_PYR-1 AHFDVYHG-PVRAEIARDQRDFLVRHLLRGPNRATNSSGCGR
Mflv_3465|M.gilvum_PYR-GCK GHFDMYHG-AVRDEVARDQREFLIRHLQ--PDRAARKDR---
TH_4007|M.thermoresistible__bu AHFEFDRD-DVRRRVTADQLAFLARVLPR-------------
MMAR_0385|M.marinum_M GHFAIYLG-DAFERVVADQLGFLDKHLKPAGQP---------
MUL_1035|M.ulcerans_Agy99 GHFAIYLG-DAFEHVVADQLGFLDKHLKPAGQP---------
MSMEG_4450|M.smegmatis_MC2_155 THFEPYVD-PHFEQIVTDQIDFLNRHVG-AGTR---------
MAB_2608|M.abscessus_ATCC_1997 DHFGVYHGQECHELVIGHQISFLSRHLSIEAVSHTEALHG--
Mb2330c|M.bovis_AF2122/97 NDPELLDG----RVMLDAIRRFLTETAVLGQ-----------
Rv2307c|M.tuberculosis_H37Rv NDPELLDG----RVMLDAIRRFLTETAVLGQ-----------
. . : ** .