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VTRSEISFRSGQDACSGWHFTSGGALRRVVVMAHGFGGTKDSGLEPFAQRFAAAGIDVLAFDYRGFGASG GVPRQSLSVRRQIDDYNAAVEAAKTLDGVDPSRVGLWGASFSGGHVLRVAAERDDIGAVISLTPLTSGLA VSRAAAASRDMVTSLRWTLTGVRSRFAVRRGGRPTMMPLVAPVGEPGALALDGAYESYTALAGPTWRNEI DSSVGLEVVGVRTNAAAKKMRCPLLVQIADFDQYVPAAAVATTAAHGRAQVHHYPCDHFDVWPGHDWFDK TVSDQVAFLTRTFSVVRGTLID
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1972 | - | - | 100% (302) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_2419 | - | 5e-44 | 38.38% (297) | alpha/beta hydrolase fold |
| M. vanbaalenii PYR-1 | Mvan_1417 | - | 6e-34 | 33.57% (286) | peptidase S15 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2330c | - | 5e-08 | 33.87% (124) | hypothetical protein Mb2330c |
| M. gilvum PYR-GCK | Mflv_4372 | - | 1e-140 | 79.93% (294) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv2307c | - | 5e-08 | 33.87% (124) | hypothetical protein Rv2307c |
| M. leprae Br4923 | MLBr_02603 | - | 1e-06 | 26.10% (272) | hypothetical protein MLBr_02603 |
| M. abscessus ATCC 19977 | MAB_2608 | - | 3e-78 | 49.16% (297) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_0385 | - | 8e-52 | 39.19% (296) | hypothetical protein MMAR_0385 |
| M. avium 104 | MAV_4997 | - | 2e-06 | 27.14% (269) | lysophospholipase |
| M. smegmatis MC2 155 | MSMEG_2203 | - | 1e-119 | 67.34% (297) | alpha/beta hydrolase |
| M. thermoresistible (build 8) | TH_2707 | - | 2e-60 | 46.04% (265) | PUTATIVE putative alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_1035 | - | 2e-50 | 38.33% (300) | hypothetical protein MUL_1035 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1972|M.vanbaalenii_PYR-1 --MT-RSEISFRSGQDACSGWHFTSG------GALRRV--VVMAHGFGGT
Mflv_4372|M.gilvum_PYR-GCK --MS-RTEVAFPSGGDTCSAWHFAAD------GVRRPV--VVMAHGFGGT
MSMEG_2203|M.smegmatis_MC2_155 --MT-YTEFTFHSGGQRCSAWHFPAGS----GGSGNPV--VVMAHGFGGT
MAB_2608|M.abscessus_ATCC_1997 --MN-RQSIRFNSHGIDCEAWLYRAQT----VEDTAPI--VVMAHGVGGT
TH_2707|M.thermoresistible__bu --MS-NPLRIPAEGGAMLAASHFPATSDALRGPNGRPG--VVMAHGLGAT
MMAR_0385|M.marinum_M --MTQRQDVRFPCGEAMISAWLYRPAG----ADPARPVPMLVMAHGLGAV
MUL_1035|M.ulcerans_Agy99 --MTQRQDVRFPCGEALISAWLYRPAG----ADPARPVPMLVMAHGLGAV
MLBr_02603|M.leprae_Br4923 MTITRTERNFYGVGGVRIVYDVWMPDT--------RPRAVIILAHGFG-E
MAV_4997|M.avium_104 --MNRTERSFDGVGGVRIVYDVWTPEV--------APRAVLVLAHGFG-E
Mb2330c|M.bovis_AF2122/97 --MSLKRCRALPVVAIVALVASGVITFIWS-----QQRRLIYFPSAGPVP
Rv2307c|M.tuberculosis_H37Rv --MSLKRCRALPVVAIVALVASGVIMFIWS-----QQRRLIYFPSAGPVP
:. : :. .
Mvan_1972|M.vanbaalenii_PYR-1 KDSGLEPFAQRFAAAGIDVLAFDYRGFGAS-GGVPRQSLSVRRQIDDYNA
Mflv_4372|M.gilvum_PYR-GCK KDSGLEPFALRFAEAGFDVFAFDYRGFGAS-EGTPRQSLSVRRQIDDYHA
MSMEG_2203|M.smegmatis_MC2_155 KDSGLQPFAERFSAAGLDAVAFDYRGFGAS-EGEPRQSISVERQLADYDA
MAB_2608|M.abscessus_ATCC_1997 KDSGLEPFAVRLAEAGMHALAFDYRGFGAS-DGFPRQHVSFTHQIGDYHA
TH_2707|M.thermoresistible__bu RDSGLAGFAAALADAGADVITFDYRNFAES-DGTPRQLVSLRGQIRDYHA
MMAR_0385|M.marinum_M RTMRLDAYAQRFSAAGYACLVFDYRNFGDS-EGQPRQLLDIRMQLQDWAA
MUL_1035|M.ulcerans_Agy99 RTMRLDAYAQRFSAAGYACLVFDYRNFGDS-EGQPRQLLDIRMQLQDWAA
MLBr_02603|M.leprae_Br4923 HARRYDHVAHYFAAAGLATYALDLRGHGRS-AGKRVLVRDLSEYNADFDI
MAV_4997|M.avium_104 HARRYDHVARRFGAAGLVTYALDHRGHGRS-GGKRVLVRDIHEYTTDFDT
Mb2330c|M.bovis_AF2122/97 SASSVLPAGRDVVVETQDGMRLGGWYFPHTSGGSGPAVLVCNGNAGDRSM
Rv2307c|M.tuberculosis_H37Rv SASSVLPAGRDVVVETQDGMRLGGWYFPHTSGGSGPAVLVCNGNAGDRSM
. . :. . : * *
Mvan_1972|M.vanbaalenii_PYR-1 AVEAAKTLDGVDPSRVGLWGASFSGGHVLRVAAERDDIGAVISLTPLTSG
Mflv_4372|M.gilvum_PYR-GCK AIHAARQLDGVDPDRVALWGASFSGGHVVRVAAERADVAAVIALTPLTSG
MSMEG_2203|M.smegmatis_MC2_155 AIRAAQAMPGVDPRKVVLWGSSFSGSHVLRAAARNTDVAAVIAMTPLTSG
MAB_2608|M.abscessus_ATCC_1997 AVNMARRLPGVDPTRIVLWGVSLAGGHVMAVAGARNDVAAVIALTPLVDG
TH_2707|M.thermoresistible__bu ALRYLRSMPDVDARRVAVWGVSLSGGHVLKVAAEDPAVAAVISVTPAVDG
MMAR_0385|M.marinum_M AVAYARTCDGVDQARIGLWGTSFGGGHVIATAARLPGIAAVVAQCPFTDG
MUL_1035|M.ulcerans_Agy99 AVAYARTCDGVDQARIGLWGTSFGGGHVIATAARLPGIAAVVAQCPFTDG
MLBr_02603|M.leprae_Br4923 LVGIATRDHPG--LKRIVAGHSMGGAIVFAYGVERPDNYDLMVLS-----
MAV_4997|M.avium_104 LVGIATREHHG--LKCIVVGHSMGGGIVFAYGVERPDNYDLMVLS-----
Mb2330c|M.bovis_AF2122/97 RAELAVALHGLGLSVLLFDYRGYGG------NPGRPSEQGLAADARAAQE
Rv2307c|M.tuberculosis_H37Rv RAELAVALHGLGLSVLLFDYRGYGG------NPGRPSEQGLAADARAAQE
. . .* :
Mvan_1972|M.vanbaalenii_PYR-1 LAVSRAAAASRDMVTSLRWTLTGVRSRFAVRRGGRPTMMPLVAPVGEPGA
Mflv_4372|M.gilvum_PYR-GCK VAVSRSAMASRDTVTSLKWTLTGLKSRIAVGRGGSPTLMPLVSPVGQPGA
MSMEG_2203|M.smegmatis_MC2_155 LAASRAAVTQRDVATALRWTLKGVKSRVAAAVGGAPTMMPLTAKPGEPGA
MAB_2608|M.abscessus_ATCC_1997 IAAARSAMTEHSAGTLLRSAVTGLRSRLGRQQ----RTIPIVGRAGELAA
TH_2707|M.thermoresistible__bu LAAVATLARANGPVHLAKLVGRGLSDVLAAALGRPPVPAPIVGHPGELAA
MMAR_0385|M.marinum_M IASVLAIAPT----TAIRVTARSMRDLIGSRLGRPPVMIPTAGKPGEVAL
MUL_1035|M.ulcerans_Agy99 IASVLAIAPT----TAIRVTARSMRDLIGSRLGRPPVMIPTAGKPGEVAL
MLBr_02603|M.leprae_Br4923 ----GPAVAAQDMVSPLRAVVGKGLGLVAPGLPVHQLEVDAISRNRAVVA
MAV_4997|M.avium_104 ----GPAVAAQDQVSPLLALAAKVLGVIVPGLPAQELDADAVSRDPEVVA
Mb2330c|M.bovis_AF2122/97 WLSGQSDVDP----ARIAYFGESLGAAVAVGLAVQRPPAALVLRSPFTSL
Rv2307c|M.tuberculosis_H37Rv WLSGQSDVDP----ARIAYFGESLGAAVAVGLAVQRPPAALVLRSPFTSL
. .
Mvan_1972|M.vanbaalenii_PYR-1 LALDGAYESYTALA--GPTWRNEIDSSVGLEVVGVRTNAAAKKMRCPLLV
Mflv_4372|M.gilvum_PYR-GCK LALEGAYESYTALA--GPTWRNEIDSSIGLQVVGVRTTAAAKKLRCPLLV
MSMEG_2203|M.smegmatis_MC2_155 LALDGAYESYLSIA--GPTWRNEVDAGVGMELARVRTAAAAKALKCPVLV
MAB_2608|M.abscessus_ATCC_1997 LTSDGYYEAHLAIA--GPAWRNEIDATVGTQLVSYRPTRCASRIGCPILV
TH_2707|M.thermoresistible__bu LTAPGAVEGMLTTA--GPSWRNAIAARLFLQMGTYRPIADVSRVQCPVLM
MMAR_0385|M.marinum_M MTAPDAYPGYLGLMPQGTQVPNEVAARIGIKVLGYRPGRSARKIACPILF
MUL_1035|M.ulcerans_Agy99 MTAPDAYPGYLGLMPQGTQVPNEVAARIGIKVLGYRPGRSARKIACPILF
MLBr_02603|M.leprae_Br4923 AYKDDPLVYHGKVP---------AGVGRVMLQVGETMTRRAPVLTTPLLV
MAV_4997|M.avium_104 AYRNDPLVYHGKVP---------AGVGRALLQVGETMPQRAPALTAPLLV
Mb2330c|M.bovis_AF2122/97 AEVGAVHYPWLPLR--------------RLLLDHYPSIERIASVHAPVLV
Rv2307c|M.tuberculosis_H37Rv AEVGAVHYPWLPLR--------------RLLLDHYPSIERIASVHAPVLV
: *:*.
Mvan_1972|M.vanbaalenii_PYR-1 QIADFDQYVPAAAVATTAAHGRAQ-----VHHYPCDHFDVWPGHDWFDKT
Mflv_4372|M.gilvum_PYR-GCK QIADFDQYVPADAVAKTAAHGRAQ-----VHHYACDHFDVWPGNDWFDKT
MSMEG_2203|M.smegmatis_MC2_155 QIADFDRFVPADSVAKTAVQARAQ-----VHHYACDHFDVWPGHDWFDTA
MAB_2608|M.abscessus_ATCC_1997 QIADFDRAAPPHAAAKAAFKARAE-----VRHYPCDHFGVYHGQECHELV
TH_2707|M.thermoresistible__bu QIADHDQSAPPAAATRAATRLGAT-----VHRYPCDHFDVYPGTSCHDRA
MMAR_0385|M.marinum_M CVCETDSVAPAGPTLRYAARAPRG----EVIRYPEGHFAIYLG-DAFERV
MUL_1035|M.ulcerans_Agy99 CVCETDSVAPAGPTLRYAARAPRGEVSGEVIRYPEGHFAIYLG-DAFEHV
MLBr_02603|M.leprae_Br4923 VHGSEDRLVLVDGSHRLVECVGSTD--VELKVYPGLYHEVFNE-PERDQV
MAV_4997|M.avium_104 VHGSDDRLIPVAGSRRLVECVGSAD--VELKVYPGLYHEVFNE-PEREQV
Mb2330c|M.bovis_AF2122/97 IAGGSDDIVPATLSEWLVAAAAEPKRYVVVPGVGHNDPELLDG----RVM
Rv2307c|M.tuberculosis_H37Rv IAGGSDDIVPATLSERLVAAAAEPKRYVVVPGVGHNDPELLDG----RVM
* . : :
Mvan_1972|M.vanbaalenii_PYR-1 VSDQVAFLTRTFSVVRGTLID----
Mflv_4372|M.gilvum_PYR-GCK VTDQIAFLRRTLTRQ----------
MSMEG_2203|M.smegmatis_MC2_155 VTDQIAFLRRTLSLR----------
MAB_2608|M.abscessus_ATCC_1997 IGHQISFLSRHLSIEAVSHTEALHG
TH_2707|M.thermoresistible__bu VAHQVAFLRRVLAPAEVAS------
MMAR_0385|M.marinum_M VADQLGFLDKHLKPAGQP-------
MUL_1035|M.ulcerans_Agy99 VADQLGFLDKHLKPAGQP-------
MLBr_02603|M.leprae_Br4923 LEDVVCWILKRL-------------
MAV_4997|M.avium_104 LDDVVGWITARL-------------
Mb2330c|M.bovis_AF2122/97 LDAIRRFLTETAVLGQ---------
Rv2307c|M.tuberculosis_H37Rv LDAIRRFLTETAVLGQ---------
: ::