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MKTSYRTAVHDAIADALRDDPRVLLMGEDVARYGGTYAVSKGLLEEFGPDRVRDTPLSELGFVGIGIGAA LGGLRPIVEIMTVNFSLLALDQIVNTAAALRHMSGGQFSVPLVVRMATGAGRQLAAQHSHSLEGWYAHIP GIKVVAPATVEDAYGMLSTALQDPDPVIMFEHVQLYNTSADVAELGAQDISRAAIRRQGSDVSLITYGGS LPKVLDAADQLALAGIDCEVIDLRVLRPLDTETFVGSVRKTHRAVIVDEGWRTGSLAAEISTQITEQAFF DLDAPVARVCSAEVPIPYARHLEQAALPQRDTIVAAAQGLFGGQP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1409 | - | - | 100% (325) | transketolase, central region |
| M. vanbaalenii PYR-1 | Mvan_0912 | - | 6e-67 | 41.23% (325) | transketolase, central region |
| M. vanbaalenii PYR-1 | Mvan_4085 | - | 3e-60 | 41.74% (321) | transketolase, central region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2524c | pdhB | 2e-56 | 39.81% (309) | pyruvate dehydrogenase E1 component beta subunit PdhB |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv2496c | pdhB | 4e-56 | 39.81% (309) | pyruvate dehydrogenase E1 component beta subunit PdhB |
| M. leprae Br4923 | MLBr_01038 | dxs | 1e-05 | 23.33% (240) | 1-deoxy-D-xylulose-5-phosphate synthase |
| M. abscessus ATCC 19977 | MAB_0896c | - | 2e-68 | 45.14% (319) | putative pyruvate dehydrogenase E1 component, beta subunit |
| M. marinum M | MMAR_3490 | - | 1e-150 | 80.25% (324) | pyruvate dehydrogenase E1 component (beta subunit) |
| M. avium 104 | MAV_2948 | - | 6e-65 | 44.51% (319) | acetoin:2,6-dichlorophenolindophenol oxidoreductase beta |
| M. smegmatis MC2 155 | MSMEG_4711 | - | 2e-61 | 42.86% (308) | pyruvate dehydrogenase E1 component subunit beta |
| M. thermoresistible (build 8) | TH_4167 | - | 8e-60 | 40.39% (307) | PUTATIVE acetoin:2,6-dichlorophenolindophenol oxidoreductase |
| M. ulcerans Agy99 | MUL_3774 | pdhB | 3e-57 | 40.06% (317) | pyruvate dehydrogenase E1 component (beta subunit) PdhB |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1409|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3490|M.marinum_M --------------------------------------------------
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu MATQLDVEAPTSANDRAIALYRLMSKVHHADARVRKGLSSGEIAMSYWPV
MLBr_01038|M.leprae_Br4923 ------MLEQIRRPADLQHLSQQQLRDLAAEIRELLVHKVAATGGHLGPN
Mvan_1409|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3490|M.marinum_M --------------------------------------------------
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu TGQEAMSAGAALALSDGDQLVSTYRGLGDVVAKGIDLAGYFGEILGRRTG
MLBr_01038|M.leprae_Br4923 LGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLTGRCQDFDSLRKKAG
Mvan_1409|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3490|M.marinum_M --------------------------------------------------
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu LSRGKAGAMGISDPDHGIAWTTGIVGAGPLFANGIALAASIRGTGQVVLV
MLBr_01038|M.leprae_Br4923 ----LSGYPSRAESEHDWVESSHASTALSYADGLAKAFELAGNRNRHVVA
Mvan_1409|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3490|M.marinum_M --------------------------------------------------
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu SFGDGATSIGYVHEAMNMAALWNLPVVFFCQNNAWAECTAMERYTRTARL
MLBr_01038|M.leprae_Br4923 VVGDGALTGGMCWEALNNIAATPRPVVIVVNDNGRSYAPTIG--------
Mvan_1409|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3490|M.marinum_M --------------------------------------------------
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu SDRAQGYGMPGVTVDGTDPRAVHDAVAEAVTRARSGGGPTFVEALAYRLQ
MLBr_01038|M.leprae_Br4923 ------------------------------------GVADHLATLRLQPA
Mvan_1409|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3490|M.marinum_M --------------------------------------------------
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu GHYFGDTMAYADPDELAAKRADPPFDRYRRRLIDEGIATAATLDQIDAEL
MLBr_01038|M.leprae_Br4923 YERLLEKGRDALHSLPLIGQIAYRFMHSVKAGIKDSLSPQLLFTDLGLKY
Mvan_1409|M.vanbaalenii_PYR-1 -------------------------------------------------M
MMAR_3490|M.marinum_M -------------------------------------------------M
Mb2524c|M.bovis_AF2122/97 --------MTQIADRPARP-----------DETLAVAVSD-------ITQ
Rv2496c|M.tuberculosis_H37Rv --------MTQIADRPARP-----------DETLAVAVSD-------ITQ
MUL_3774|M.ulcerans_Agy99 --------MTQIADPPARP-----------GPAPAAPVVG-------TMQ
MSMEG_4711|M.smegmatis_MC2_155 --------MTQIIDRPAAQGDAPEPWGSILTPAAAQAPVP-------AVT
MAB_0896c|M.abscessus_ATCC_199 ------------------------------------------------MT
MAV_2948|M.avium_104 ---------------------------------MAD-------------Q
TH_4167|M.thermoresistible__bu AAQVDAAFAAARDAEPLGPEELTGDVFTGNGTELADGTVPRVALPEGETE
MLBr_01038|M.leprae_Br4923 VGPVDGHDEHAVEVALRKARGFGGPVIVHVVTRKGMGYPPAEADQAEQMH
Mvan_1409|M.vanbaalenii_PYR-1 KTSYRTAVHDAIADALRDDPRVLLMGEDVA---RYGGTYAVSKGLLEEFG
MMAR_3490|M.marinum_M KTTYRTAVHDGLHDALSNDPRVVLMGEDVG---RYGGTYAASKGLLEEFG
Mb2524c|M.bovis_AF2122/97 SLTMVQAINRALYDAMAADERVLVFGEDVA---VEGGVFRVTEGLADTFG
Rv2496c|M.tuberculosis_H37Rv SLTMVQAINRALYDAMAADERVLVFGEDVA---VEGGVFRVTEGLADTFG
MUL_3774|M.ulcerans_Agy99 SLTMVQALNQALHDAMAADDRVLVFGEDVG---IAGGVFRVTEGLAETFG
MSMEG_4711|M.smegmatis_MC2_155 ELTMVQAINRALRDAMAADERVLVFGEDVA---TLGGVFRVTDGLTESFG
MAB_0896c|M.abscessus_ATCC_199 VTTMAQALNAALRDALHDDDSVVVFGEDVG---TLGGVFRVTDGLTETFG
MAV_2948|M.avium_104 EMTMREALNLALDQALAADERVFLLGEDIAD-PGASG---PTAGLSTKYG
TH_4167|M.thermoresistible__bu ELGLVQAIHRTLDRAMAADDSIILLGEDIGD-RSGGGMFKITAGLSAKYG
MLBr_01038|M.leprae_Br4923 TCGVMDPTTGQPTKIAAPDWTAIFSDALIGYAMKRRDIVAITAAMPGPTG
. * .. . :. . : .: *
Mvan_1409|M.vanbaalenii_PYR-1 P--------DRVRDTPLSELGFVGIGIGAALGGLRPIVEIMTVNFSLLAL
MMAR_3490|M.marinum_M P--------ERVRDTPLSELGFVGIGIGAALNGLRPIVEVMTVNFSLLAL
Mb2524c|M.bovis_AF2122/97 A--------DRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAF
Rv2496c|M.tuberculosis_H37Rv A--------DRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAF
MUL_3774|M.ulcerans_Agy99 E--------HRCFDTPLAESALIGIAVGLALRGFVPVPEIQFDDFSYPAF
MSMEG_4711|M.smegmatis_MC2_155 A--------ERCFDTPLAESAIIGIAVGFAIRGFVPVPEIQFDGFSYPAF
MAB_0896c|M.abscessus_ATCC_199 A--------NRCFDTPLAESGIIGFAVGMAMGGFRPVVEMQFDAFAYPAF
MAV_2948|M.avium_104 C--------DRVLDTPISEAAIVGAAIGAAIDGLLPVAEIMIMDFIGIAA
TH_4167|M.thermoresistible__bu E--------ERVRDTPIAESSIIGAALGASLAGLRPVAELMFMDFLGVAM
MLBr_01038|M.leprae_Br4923 LTAFGQCFPDRLFDVGIAEQHAMTSAAGLAMGRMHPVVAIYST-FLNRAF
.* *. ::* : . * :: : *: : * *
Mvan_1409|M.vanbaalenii_PYR-1 DQIVNTAAALRHMSGGQFSVPLVVRMATGAGRQLAAQHSHSLEGWYAHIP
MMAR_3490|M.marinum_M DQIVNTAAALRHMSGGQFSVPIVVRMATGAGRQLAAQHSHSLEPWYAHVP
Mb2524c|M.bovis_AF2122/97 DQVVSHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTA
Rv2496c|M.tuberculosis_H37Rv DQVVSHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTA
MUL_3774|M.ulcerans_Agy99 DQVVSHLAKYRTRTRGEVNMAVTVRIPSFGGIGAAEHHLDATESYWAHTA
MSMEG_4711|M.smegmatis_MC2_155 DQIASHLAKYRMRTHGDIDMPVTVRIPSFGGIGAVEHHSESTETYWLHTA
MAB_0896c|M.abscessus_ATCC_199 EQVVSHVAKLRNRTRGVLSVPMVIRVPYAGGIGGVEHHCDSSEAYYAHTP
MAV_2948|M.avium_104 DQLINNAAKLRFMTAGRTSAPLTVRTQVYAGLSTGATHSQSLEAWFMHIP
TH_4167|M.thermoresistible__bu DQIANHVAKVRYMSGGRRGAPLVIRTMV--GTAAGAQHSQALEAWAMHTP
MLBr_01038|M.leprae_Br4923 DQIMMDVALHKLP------VTMVIDRAGITGSDGPSHNGMWDLSMLGIVP
:*: * : .:.: * : .
Mvan_1409|M.vanbaalenii_PYR-1 GIKVVAPATVEDAYGMLSTALQDPDPVIMFEHVQLY---NTSADVAELG-
MMAR_3490|M.marinum_M GIKVLAPATVEDAYGMLAPALADPDPVIIFEHVQLY---NTSADIDVLK-
Mb2524c|M.bovis_AF2122/97 GLKVVVPSTPGDAYWLLRHAIACPDPVMYLEPKRRY---HSRGMVDTSRP
Rv2496c|M.tuberculosis_H37Rv GLKVVVPSTPGDAYWLLRHAIACPDPVMYLEPKRRY---HGRGMVDTSRP
MUL_3774|M.ulcerans_Agy99 GLKVVVPSTPGDAYWLLRHAIACPDPVMYLEPKRRY---QVRGPVDTSRP
MSMEG_4711|M.smegmatis_MC2_155 GLKVVVPSTPSDAYWLLRESISSPDPVIYLEPKRRY---WAREAVDTTTP
MAB_0896c|M.abscessus_ATCC_199 GLKVVTPATVADAYGLLREAIDDPDPVVFLEPKRLY---FSRADVELGR-
MAV_2948|M.avium_104 GLKVIVPATPRDGKGLLSSAIFDPDPCLFIETIRLQ--GKKGLVPVEPGF
TH_4167|M.thermoresistible__bu GLKVVWPSTAADAAGLLNACLREDDPCLFIESMKLYYGGGKGPVPVAD-Y
MLBr_01038|M.leprae_Br4923 GMRVAAPRDAIRLREELGEALDVDDGPTAIRFPKGD--VCEDIPALKRRS
*::* * * .: * :. :
Mvan_1409|M.vanbaalenii_PYR-1 AQDISRAAIRRQGSDVSLITYGGSLPKVLDAADQLALA-GIDCEVIDLRV
MMAR_3490|M.marinum_M PTDICKAAVRRSGTDVTLIAYGGCLAKALDAANELSLN-GIECEVVDLRV
Mb2524c|M.bovis_AF2122/97 EPPIGHAMVRRSGTDVTVVTYGNLVSTALSSADTAEQQHDWSLEVIDLRS
Rv2496c|M.tuberculosis_H37Rv EPPIGHAMVRRSGTDVTVVTYGNLVSTALSSADTAEQQHDWSLEVIDLRS
MUL_3774|M.ulcerans_Agy99 EPAIGQAMIRRAGADVTVITYGNLVSTALSAAEDAAHQQGWSLEVIDLRS
MSMEG_4711|M.smegmatis_MC2_155 ALPIGRAAVRRNGSDVTVITYGGLVATALSAAELAEDR-GWSMEVVDLRS
MAB_0896c|M.abscessus_ATCC_199 GAKIGEAQVLRAGTDVTLIAYGPSVEPALQAAAAAADE-GRDIEVVDLRS
MAV_2948|M.avium_104 RIPLGQADIKRPGTDVSLIGYGRPVHDALAAAAMLGDQ-GVSAEVVDLRT
TH_4167|M.thermoresistible__bu VIPLGQADVKRVGSDVTICTYGVLVHAALEAAKTLAGE-GVSVEVVDLRT
MLBr_01038|M.leprae_Br4923 GVDVLAVPATGLAQDVLLVGVGVFASMALAVAKRLHNQ-GIGVTVIDPRW
: . . ** : * .* * . *:* *
Mvan_1409|M.vanbaalenii_PYR-1 LRPLDTETFVGSVRKTHRAVIVDEGWRTGSLAAEISTQITEQAFFDLDAP
MMAR_3490|M.marinum_M LRPLDTDTILESVRKTHRAVVIDEAWRSGSLAGEISAQIMEGAFYDLDAP
Mb2524c|M.bovis_AF2122/97 LAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQEEMFYQLEAP
Rv2496c|M.tuberculosis_H37Rv LAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQEEMFYQLEAP
MUL_3774|M.ulcerans_Agy99 LIPLDFETIAASIRRTGRCVVLHEGPRSLGYGAGLAARIQEELFYELEAP
MSMEG_4711|M.smegmatis_MC2_155 LNPLDFDTVADSVRRTGRAVVMHEGPRTLGFGAELAARISEELFYDLEAP
MAB_0896c|M.abscessus_ATCC_199 IAPFDDQSVTASVRKTGRCVIVQEAQGFGGVGAEIAARIQERCFHHLAAP
MAV_2948|M.avium_104 LVPLDVDTVVASVRRTRRAVIVHDAVQFAGPGAEVAAILHSRLFSELAAP
TH_4167|M.thermoresistible__bu LVPLDLQTVLDSVRKTKRLVVAHESVGFCGPGAEIAAAVGTELFAELAAP
MLBr_01038|M.leprae_Br4923 VLPVCDG-VLELAHTHKLIVTLEDNGVNGGVGAAVSTALRQVEIDTPCRD
: *. . : * .: . .. ::: : :
Mvan_1409|M.vanbaalenii_PYR-1 VARVCSAEVPIPYARHLEQAALPQRDTIVAAAQGLFGGQP----------
MMAR_3490|M.marinum_M VSRVCSVEVPIPYAKHLEQAALPQPDKIIAAVQALFGDQS----------
Mb2524c|M.bovis_AF2122/97 VLRACGFDTPYPPAR-LEKLWLPGPDRLLDCVERVLRQP-----------
Rv2496c|M.tuberculosis_H37Rv VLRACGFDTPYPPAR-LEKLWLPGPDRLLDCVERVLRQP-----------
MUL_3774|M.ulcerans_Agy99 VLRACGFDTPYPPAR-LERLWLPGPDRLLDCVERVLGQP-----------
MSMEG_4711|M.smegmatis_MC2_155 VLRATGFDTPYPPAR-LEKLWLPGVDRLLDCVERAMEQP-----------
MAB_0896c|M.abscessus_ATCC_199 VLRVSGYDIPYPAPR-LERWYLPSTDRILDAVDRLQWDDHPDSRWVVSA-
MAV_2948|M.avium_104 VERVAARFVPNPAAAALEAQVYPSPERIAAAALKTLGRTLTGATAHG---
TH_4167|M.thermoresistible__bu IQRVAGTYTPVPRAATLEAACRPDATKLSDAVRRIM--------------
MLBr_01038|M.leprae_Br4923 VGLPQEFYDHASRSEVLADLGLTDQDVARRITGWVVAFGHCGSGDDAGQY
: . . * . .
Mvan_1409|M.vanbaalenii_PYR-1 --------
MMAR_3490|M.marinum_M --------
Mb2524c|M.bovis_AF2122/97 --------
Rv2496c|M.tuberculosis_H37Rv --------
MUL_3774|M.ulcerans_Agy99 --------
MSMEG_4711|M.smegmatis_MC2_155 --------
MAB_0896c|M.abscessus_ATCC_199 --------
MAV_2948|M.avium_104 --------
TH_4167|M.thermoresistible__bu --------
MLBr_01038|M.leprae_Br4923 GPRSSQTM