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MKTTYRTAVHDGLHDALSNDPRVVLMGEDVGRYGGTYAASKGLLEEFGPERVRDTPLSELGFVGIGIGAA LNGLRPIVEVMTVNFSLLALDQIVNTAAALRHMSGGQFSVPIVVRMATGAGRQLAAQHSHSLEPWYAHVP GIKVLAPATVEDAYGMLAPALADPDPVIIFEHVQLYNTSADIDVLKPTDICKAAVRRSGTDVTLIAYGGC LAKALDAANELSLNGIECEVVDLRVLRPLDTDTILESVRKTHRAVVIDEAWRSGSLAGEISAQIMEGAFY DLDAPVSRVCSVEVPIPYAKHLEQAALPQPDKIIAAVQALFGDQS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3490 | - | - | 100% (325) | pyruvate dehydrogenase E1 component (beta subunit) |
| M. marinum M | MMAR_3843 | pdhB | 2e-63 | 41.01% (317) | pyruvate dehydrogenase E1 component (beta subunit) PdhB |
| M. marinum M | MMAR_3322 | - | 3e-52 | 36.07% (341) | pyruvate dehydrogenase E1 component (beta subunit) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2524c | pdhB | 7e-61 | 40.26% (313) | pyruvate dehydrogenase E1 component beta subunit PdhB |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv2496c | pdhB | 2e-60 | 40.26% (313) | pyruvate dehydrogenase E1 component beta subunit PdhB |
| M. leprae Br4923 | MLBr_01038 | dxs | 1e-05 | 24.38% (242) | 1-deoxy-D-xylulose-5-phosphate synthase |
| M. abscessus ATCC 19977 | MAB_0896c | - | 1e-70 | 44.55% (321) | putative pyruvate dehydrogenase E1 component, beta subunit |
| M. avium 104 | MAV_2948 | - | 6e-65 | 42.24% (322) | acetoin:2,6-dichlorophenolindophenol oxidoreductase beta |
| M. smegmatis MC2 155 | MSMEG_4711 | - | 3e-63 | 41.99% (312) | pyruvate dehydrogenase E1 component subunit beta |
| M. thermoresistible (build 8) | TH_0717 | pdhB | 7e-64 | 42.99% (321) | PROBABLE PYRUVATE DEHYDROGENASE E1 COMPONENT (BETA SUBUNIT) |
| M. ulcerans Agy99 | MUL_3774 | pdhB | 1e-62 | 40.38% (317) | pyruvate dehydrogenase E1 component (beta subunit) PdhB |
| M. vanbaalenii PYR-1 | Mvan_1409 | - | 1e-150 | 80.25% (324) | transketolase, central region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
TH_0717|M.thermoresistible__bu --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3490|M.marinum_M --------------------------------------------------
Mvan_1409|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
MLBr_01038|M.leprae_Br4923 MLEQIRRPADLQHLSQQQLRDLAAEIRELLVHKVAATGGHLGPNLGVVEL
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
TH_0717|M.thermoresistible__bu --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3490|M.marinum_M --------------------------------------------------
Mvan_1409|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
MLBr_01038|M.leprae_Br4923 TLALHRVFDSPHDPIIFDTGHQAYVHKMLTGRCQDFDSLRKKAGLSGYPS
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
TH_0717|M.thermoresistible__bu --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3490|M.marinum_M --------------------------------------------------
Mvan_1409|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
MLBr_01038|M.leprae_Br4923 RAESEHDWVESSHASTALSYADGLAKAFELAGNRNRHVVAVVGDGALTGG
Mb2524c|M.bovis_AF2122/97 --------------------------------MTQIADRPARPD------
Rv2496c|M.tuberculosis_H37Rv --------------------------------MTQIADRPARPD------
MUL_3774|M.ulcerans_Agy99 --------------------------------MTQIADPPARPG------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------MTQIIDRPAAQGDAPEPW
TH_0717|M.thermoresistible__bu ------------------------------MTVTQLIERPLVT-------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3490|M.marinum_M --------------------------------------------------
Mvan_1409|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
MLBr_01038|M.leprae_Br4923 MCWEALNNIAATPRPVVIVVNDNGRSYAPTIGGVADHLATLRLQPAYERL
Mb2524c|M.bovis_AF2122/97 -----ETLAVAVSDITQSLTMVQAINRALYDAMA-----ADERVLVFGED
Rv2496c|M.tuberculosis_H37Rv -----ETLAVAVSDITQSLTMVQAINRALYDAMA-----ADERVLVFGED
MUL_3774|M.ulcerans_Agy99 -----PAPAAPVVGTMQSLTMVQALNQALHDAMA-----ADDRVLVFGED
MSMEG_4711|M.smegmatis_MC2_155 GSILTPAAAQAPVPAVTELTMVQAINRALRDAMA-----ADERVLVFGED
TH_0717|M.thermoresistible__bu --------ARPPVP---ELTLAQAVNRALHDAMA-----ADQRVLVFGQD
MAB_0896c|M.abscessus_ATCC_199 ---------------MTVTTMAQALNAALRDALH-----DDDSVVVFGED
MMAR_3490|M.marinum_M ----------------MKTTYRTAVHDGLHDALS-----NDPRVVLMGED
Mvan_1409|M.vanbaalenii_PYR-1 ----------------MKTSYRTAVHDAIADALR-----DDPRVLLMGED
MAV_2948|M.avium_104 -------------MADQEMTMREALNLALDQALA-----ADERVFLLGED
MLBr_01038|M.leprae_Br4923 LEKGRDALHSLPLIGQIAYRFMHSVKAGIKDSLSPQLLFTDLGLKYVGPV
::: .: ::: * : .*
Mb2524c|M.bovis_AF2122/97 VAVEGGVFRVTEGLADTFG-------------------------------
Rv2496c|M.tuberculosis_H37Rv VAVEGGVFRVTEGLADTFG-------------------------------
MUL_3774|M.ulcerans_Agy99 VGIAGGVFRVTEGLAETFG-------------------------------
MSMEG_4711|M.smegmatis_MC2_155 VATLGGVFRVTDGLTESFG-------------------------------
TH_0717|M.thermoresistible__bu VARLGGVFRVTDGLSAAFG-------------------------------
MAB_0896c|M.abscessus_ATCC_199 VGTLGGVFRVTDGLTETFG-------------------------------
MMAR_3490|M.marinum_M VGRYGGTYAASKGLLEEFG-------------------------------
Mvan_1409|M.vanbaalenii_PYR-1 VARYGGTYAVSKGLLEEFG-------------------------------
MAV_2948|M.avium_104 IADPG-ASGPTAGLSTKYG-------------------------------
MLBr_01038|M.leprae_Br4923 DGHDEHAVEVALRKARGFGGPVIVHVVTRKGMGYPPAEADQAEQMHTCGV
. . : :*
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
TH_0717|M.thermoresistible__bu --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_3490|M.marinum_M --------------------------------------------------
Mvan_1409|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
MLBr_01038|M.leprae_Br4923 MDPTTGQPTKIAAPDWTAIFSDALIGYAMKRRDIVAITAAMPGPTGLTAF
Mb2524c|M.bovis_AF2122/97 ----ADRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVV
Rv2496c|M.tuberculosis_H37Rv ----ADRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVV
MUL_3774|M.ulcerans_Agy99 ----EHRCFDTPLAESALIGIAVGLALRGFVPVPEIQFDDFSYPAFDQVV
MSMEG_4711|M.smegmatis_MC2_155 ----AERCFDTPLAESAIIGIAVGFAIRGFVPVPEIQFDGFSYPAFDQIA
TH_0717|M.thermoresistible__bu ----EERCFDTPLAESAIIGIAIGLAIRGFVPVPEIQFDGFSYPAFDQIV
MAB_0896c|M.abscessus_ATCC_199 ----ANRCFDTPLAESGIIGFAVGMAMGGFRPVVEMQFDAFAYPAFEQVV
MMAR_3490|M.marinum_M ----PERVRDTPLSELGFVGIGIGAALNGLRPIVEVMTVNFSLLALDQIV
Mvan_1409|M.vanbaalenii_PYR-1 ----PDRVRDTPLSELGFVGIGIGAALGGLRPIVEIMTVNFSLLALDQIV
MAV_2948|M.avium_104 ----CDRVLDTPISEAAIVGAAIGAAIDGLLPVAEIMIMDFIGIAADQLI
MLBr_01038|M.leprae_Br4923 GQCFPDRLFDVGIAEQHAMTSAAGLAMGRMHPVVAIYST-FLNRAFDQIM
.* *. ::* : . * *: : *: : * * :*:
Mb2524c|M.bovis_AF2122/97 SHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTAGLKV
Rv2496c|M.tuberculosis_H37Rv SHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTAGLKV
MUL_3774|M.ulcerans_Agy99 SHLAKYRTRTRGEVNMAVTVRIPSFGGIGAAEHHLDATESYWAHTAGLKV
MSMEG_4711|M.smegmatis_MC2_155 SHLAKYRMRTHGDIDMPVTVRIPSFGGIGAVEHHSESTETYWLHTAGLKV
TH_0717|M.thermoresistible__bu SHLAKYRMRTRGDVEMRVTVRIPSFGGIGAVEHHSESTETYWLHTAGLKV
MAB_0896c|M.abscessus_ATCC_199 SHVAKLRNRTRGVLSVPMVIRVPYAGGIGGVEHHCDSSEAYYAHTPGLKV
MMAR_3490|M.marinum_M NTAAALRHMSGGQFSVPIVVRMATGAGRQLAAQHSHSLEPWYAHVPGIKV
Mvan_1409|M.vanbaalenii_PYR-1 NTAAALRHMSGGQFSVPLVVRMATGAGRQLAAQHSHSLEGWYAHIPGIKV
MAV_2948|M.avium_104 NNAAKLRFMTAGRTSAPLTVRTQVYAGLSTGATHSQSLEAWFMHIPGLKV
MLBr_01038|M.leprae_Br4923 MDVALHKLP------VTMVIDRAGITGSDGPSHNGMWDLSMLGIVPGMRV
* : :.: * : .*::*
Mb2524c|M.bovis_AF2122/97 VVPSTPGDAYWLLRHAIACPDPVMYLEPKRRYHSRGMVDTSRP-EPPIGH
Rv2496c|M.tuberculosis_H37Rv VVPSTPGDAYWLLRHAIACPDPVMYLEPKRRYHGRGMVDTSRP-EPPIGH
MUL_3774|M.ulcerans_Agy99 VVPSTPGDAYWLLRHAIACPDPVMYLEPKRRYQVRGPVDTSRP-EPAIGQ
MSMEG_4711|M.smegmatis_MC2_155 VVPSTPSDAYWLLRESISSPDPVIYLEPKRRYWAREAVDTTTP-ALPIGR
TH_0717|M.thermoresistible__bu VAPGTPADAYWLLRHAITCPDPVIYLEPKRRYWARGPVDTTTP-AGPLGR
MAB_0896c|M.abscessus_ATCC_199 VTPATVADAYGLLREAIDDPDPVVFLEPKRLYFSRADVELGR--GAKIGE
MMAR_3490|M.marinum_M LAPATVEDAYGMLAPALADPDPVIIFEHVQLYNTSADIDVLK--PTDICK
Mvan_1409|M.vanbaalenii_PYR-1 VAPATVEDAYGMLSTALQDPDPVIMFEHVQLYNTSADVAELG--AQDISR
MAV_2948|M.avium_104 IVPATPRDGKGLLSSAIFDPDPCLFIETIRLQGKKGLVPVEPGFRIPLGQ
MLBr_01038|M.leprae_Br4923 AAPRDAIRLREELGEALDVDDGPTAIRFPKGDVCEDIPALKRRSGVDVLA
.* * :: * :. : :
Mb2524c|M.bovis_AF2122/97 AMVRRSGTDVTVVTYGNLVSTALSSADTAEQQHDWSLEVIDLRSLAPLDF
Rv2496c|M.tuberculosis_H37Rv AMVRRSGTDVTVVTYGNLVSTALSSADTAEQQHDWSLEVIDLRSLAPLDF
MUL_3774|M.ulcerans_Agy99 AMIRRAGADVTVITYGNLVSTALSAAEDAAHQQGWSLEVIDLRSLIPLDF
MSMEG_4711|M.smegmatis_MC2_155 AAVRRNGSDVTVITYGGLVATALSAAELAED-RGWSMEVVDLRSLNPLDF
TH_0717|M.thermoresistible__bu AAVARSGTDVTVITYGSLVTTALSAAELAADTHGWSLEVVDLRSLNPLDF
MAB_0896c|M.abscessus_ATCC_199 AQVLRAGTDVTLIAYGPSVEPALQAAAAAAD-EGRDIEVVDLRSIAPFDD
MMAR_3490|M.marinum_M AAVRRSGTDVTLIAYGGCLAKALDAANELSL-NGIECEVVDLRVLRPLDT
Mvan_1409|M.vanbaalenii_PYR-1 AAIRRQGSDVSLITYGGSLPKVLDAADQLAL-AGIDCEVIDLRVLRPLDT
MAV_2948|M.avium_104 ADIKRPGTDVSLIGYGRPVHDALAAAAMLGD-QGVSAEVVDLRTLVPLDV
MLBr_01038|M.leprae_Br4923 VPATGLAQDVLLVGVGVFASMALAVAKRLHN-QGIGVTVIDPRWVLPVCD
. . ** :: * .* * . *:* * : *.
Mb2524c|M.bovis_AF2122/97 DTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQEEMFYQLEAPVLRACG
Rv2496c|M.tuberculosis_H37Rv DTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQEEMFYQLEAPVLRACG
MUL_3774|M.ulcerans_Agy99 ETIAASIRRTGRCVVLHEGPRSLGYGAGLAARIQEELFYELEAPVLRACG
MSMEG_4711|M.smegmatis_MC2_155 DTVADSVRRTGRAVVMHEGPRTLGFGAELAARISEELFYDLEAPVLRATG
TH_0717|M.thermoresistible__bu DTIAESVRRTGRAVVLHEGPRTLGFGAELAARITEELFYDLEAPVLRATG
MAB_0896c|M.abscessus_ATCC_199 QSVTASVRKTGRCVIVQEAQGFGGVGAEIAARIQERCFHHLAAPVLRVSG
MMAR_3490|M.marinum_M DTILESVRKTHRAVVIDEAWRSGSLAGEISAQIMEGAFYDLDAPVSRVCS
Mvan_1409|M.vanbaalenii_PYR-1 ETFVGSVRKTHRAVIVDEGWRTGSLAAEISTQITEQAFFDLDAPVARVCS
MAV_2948|M.avium_104 DTVVASVRRTRRAVIVHDAVQFAGPGAEVAAILHSRLFSELAAPVERVAA
MLBr_01038|M.leprae_Br4923 G-VLELAHTHKLIVTLEDNGVNGGVGAAVSTALRQVEIDTPCRDVGLPQE
. : * :.: . .. ::: : . : *
Mb2524c|M.bovis_AF2122/97 FDTPYPPAR-LEKLWLPGPDRLLDCVERVLRQP-----------------
Rv2496c|M.tuberculosis_H37Rv FDTPYPPAR-LEKLWLPGPDRLLDCVERVLRQP-----------------
MUL_3774|M.ulcerans_Agy99 FDTPYPPAR-LERLWLPGPDRLLDCVERVLGQP-----------------
MSMEG_4711|M.smegmatis_MC2_155 FDTPYPPAR-LEKLWLPGVDRLLDCVERAMEQP-----------------
TH_0717|M.thermoresistible__bu FDTPYPPAR-LEKLWLPGPDRLLDCVERSLGYP-----------------
MAB_0896c|M.abscessus_ATCC_199 YDIPYPAPR-LERWYLPSTDRILDAVDRLQWDDHPDSRWVVSA-------
MMAR_3490|M.marinum_M VEVPIPYAKHLEQAALPQPDKIIAAVQALFGDQS----------------
Mvan_1409|M.vanbaalenii_PYR-1 AEVPIPYARHLEQAALPQRDTIVAAAQGLFGGQP----------------
MAV_2948|M.avium_104 RFVPNPAAAALEAQVYPSPERIAAAALKTLGRTLTGATAHG---------
MLBr_01038|M.leprae_Br4923 FYDHASRSEVLADLGLTDQDVARRITGWVVAFGHCGSGDDAGQYGPRSSQ
. . * . : .
Mb2524c|M.bovis_AF2122/97 --
Rv2496c|M.tuberculosis_H37Rv --
MUL_3774|M.ulcerans_Agy99 --
MSMEG_4711|M.smegmatis_MC2_155 --
TH_0717|M.thermoresistible__bu --
MAB_0896c|M.abscessus_ATCC_199 --
MMAR_3490|M.marinum_M --
Mvan_1409|M.vanbaalenii_PYR-1 --
MAV_2948|M.avium_104 --
MLBr_01038|M.leprae_Br4923 TM