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MTTTERSTRKLTVAKAIVEAVTTEMERDPTVFALGEDIGKYGGVFGQTAGLLDRFGPDRIIDTPISETGF IGAAVGAAVEGMRPIVELMFVDFFGVCMDQIYNHMAKIHFFSGGNVRVPMVLTTAVGGGYSDGGQHSQCL WGTFAHLPGMKVVVPSSPADAKGMMIAAIRDDNPVVYMFHKGIMGLSWMSKTSRALGPVPREPYETPLGK ANVVRPGRDISIVTLSLSVHHALDVADELAKDGIDCEVVDLRSLVPLDTDTILESVGKTGRLLVVDEDYE SFGLSGEIIARVAERDPSVFKVAPSRVCVPDGSIPYARPLEMAVLPTPERIRAAIIEMLRK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0912 | - | - | 100% (341) | transketolase, central region |
| M. vanbaalenii PYR-1 | Mvan_1409 | - | 6e-67 | 41.23% (325) | transketolase, central region |
| M. vanbaalenii PYR-1 | Mvan_4085 | - | 1e-43 | 35.20% (321) | transketolase, central region |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2524c | pdhB | 2e-49 | 37.31% (335) | pyruvate dehydrogenase E1 component beta subunit PdhB |
| M. gilvum PYR-GCK | Mflv_3923 | - | 9e-09 | 26.45% (242) | 1-deoxy-D-xylulose-5-phosphate synthase |
| M. tuberculosis H37Rv | Rv2496c | pdhB | 3e-49 | 37.31% (335) | pyruvate dehydrogenase E1 component beta subunit PdhB |
| M. leprae Br4923 | MLBr_01038 | dxs | 5e-09 | 28.33% (240) | 1-deoxy-D-xylulose-5-phosphate synthase |
| M. abscessus ATCC 19977 | MAB_0896c | - | 1e-52 | 37.85% (325) | putative pyruvate dehydrogenase E1 component, beta subunit |
| M. marinum M | MMAR_3490 | - | 5e-69 | 43.56% (326) | pyruvate dehydrogenase E1 component (beta subunit) |
| M. avium 104 | MAV_2948 | - | 5e-64 | 39.76% (332) | acetoin:2,6-dichlorophenolindophenol oxidoreductase beta |
| M. smegmatis MC2 155 | MSMEG_4711 | - | 8e-46 | 36.53% (323) | pyruvate dehydrogenase E1 component subunit beta |
| M. thermoresistible (build 8) | TH_4167 | - | 3e-64 | 42.34% (333) | PUTATIVE acetoin:2,6-dichlorophenolindophenol oxidoreductase |
| M. ulcerans Agy99 | MUL_3774 | pdhB | 1e-48 | 35.24% (332) | pyruvate dehydrogenase E1 component (beta subunit) PdhB |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_0912|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3490|M.marinum_M --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu MATQLDVEAPTSANDRAIALYRLMSKVHHADARVRKGLSSGEIAMSYWPV
Mflv_3923|M.gilvum_PYR-GCK ------MLEQIRGPADLQHLSRAQMEDLAREIRDFLIHKVAATGGHLGPN
MLBr_01038|M.leprae_Br4923 ------MLEQIRRPADLQHLSQQQLRDLAAEIRELLVHKVAATGGHLGPN
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_0912|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3490|M.marinum_M --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu TGQEAMSAGAALALSDGDQLVSTYRGLGDVVAKGIDLAGYFGEILGRRTG
Mflv_3923|M.gilvum_PYR-GCK LGVVELTLALHRVFDSPHDPILFDTGHQAYVHKMLTGRSRDFDTLRKKDG
MLBr_01038|M.leprae_Br4923 LGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLTGRCQDFDSLRKKAG
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_0912|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3490|M.marinum_M --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu LSRGKAGAMGISDPDHGIAWTTGIVGAGPLFANGIALAASIRGTGQVVLV
Mflv_3923|M.gilvum_PYR-GCK LSGYPS----RSESEHDWVESSHASSALSYADGLAKAFELNGHRNRHVVA
MLBr_01038|M.leprae_Br4923 LSGYPS----RAESEHDWVESSHASTALSYADGLAKAFELAGNRNRHVVA
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_0912|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3490|M.marinum_M --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu SFGDGATSIGYVHEAMNMAALWNLPVVFFCQNNAWAECTAMERYTRTARL
Mflv_3923|M.gilvum_PYR-GCK VVGDGALTGGMCWEALNNIAASRRPVVIVVNDNGRSYAPTIG--------
MLBr_01038|M.leprae_Br4923 VVGDGALTGGMCWEALNNIAATPRPVVIVVNDNGRSYAPTIG--------
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_0912|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3490|M.marinum_M --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu SDRAQGYGMPGVTVDGTDPRAVHDAVAEAVTRARSGGGPTFVEALAYRLQ
Mflv_3923|M.gilvum_PYR-GCK ------------------------------------GFAEHLAGLRLQPG
MLBr_01038|M.leprae_Br4923 ------------------------------------GVADHLATLRLQPA
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_0912|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_3490|M.marinum_M --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu GHYFGDTMAYADPDELAAKRADPPFDRYRRRLIDEGIATAATLDQIDAEL
Mflv_3923|M.gilvum_PYR-GCK YERVLEEGRKAVRGVPMIGEFCYQCMHSIKAGIKDALSPQVMFTDLGLKY
MLBr_01038|M.leprae_Br4923 YERLLEKGRDALHSLPLIGQIAYRFMHSVKAGIKDSLSPQLLFTDLGLKY
Mb2524c|M.bovis_AF2122/97 --------MTQIADRPARPD-----------ETLAVA-------VSDITQ
Rv2496c|M.tuberculosis_H37Rv --------MTQIADRPARPD-----------ETLAVA-------VSDITQ
MUL_3774|M.ulcerans_Agy99 --------MTQIADPPARPG-----------PAPAAP-------VVGTMQ
MSMEG_4711|M.smegmatis_MC2_155 --------MTQIIDRPAAQGDAPEPWGSILTPAAAQA-------PVPAVT
MAB_0896c|M.abscessus_ATCC_199 ------------------------------------------------MT
Mvan_0912|M.vanbaalenii_PYR-1 ---------------------------------MTT--------TERSTR
MMAR_3490|M.marinum_M ---------------------------------MKT--------TYR---
MAV_2948|M.avium_104 ---------------------------------MAD-------------Q
TH_4167|M.thermoresistible__bu AAQVDAAFAAARDAEPLGPEELTGDVFTGNGTELADGTVPRVALPEGETE
Mflv_3923|M.gilvum_PYR-GCK VGPIDGHDESAVEGALRHARAFNAPVVVHVVTRKGMGYAPAENDVDEQMH
MLBr_01038|M.leprae_Br4923 VGPVDGHDEHAVEVALRKARGFGGPVIVHVVTRKGMGYPPAEADQAEQMH
Mb2524c|M.bovis_AF2122/97 SLTMVQAINRALYDAMAADERVLVFGEDVA---VEGGVFRVTEGLADTFG
Rv2496c|M.tuberculosis_H37Rv SLTMVQAINRALYDAMAADERVLVFGEDVA---VEGGVFRVTEGLADTFG
MUL_3774|M.ulcerans_Agy99 SLTMVQALNQALHDAMAADDRVLVFGEDVG---IAGGVFRVTEGLAETFG
MSMEG_4711|M.smegmatis_MC2_155 ELTMVQAINRALRDAMAADERVLVFGEDVA---TLGGVFRVTDGLTESFG
MAB_0896c|M.abscessus_ATCC_199 VTTMAQALNAALRDALHDDDSVVVFGEDVG---TLGGVFRVTDGLTETFG
Mvan_0912|M.vanbaalenii_PYR-1 KLTVAKAIVEAVTTEMERDPTVFALGEDIG---KYGGVFGQTAGLLDRFG
MMAR_3490|M.marinum_M -----TAVHDGLHDALSNDPRVVLMGEDVG---RYGGTYAASKGLLEEFG
MAV_2948|M.avium_104 EMTMREALNLALDQALAADERVFLLGEDIAD-PGASG---PTAGLSTKYG
TH_4167|M.thermoresistible__bu ELGLVQAIHRTLDRAMAADDSIILLGEDIGD-RSGGGMFKITAGLSAKYG
Mflv_3923|M.gilvum_PYR-GCK ACGVIDPETGLATSVPGPGWTAAFSETLIELAAKRRDIVAITAAMPGPTG
MLBr_01038|M.leprae_Br4923 TCGVMDPTTGQPTKIAAPDWTAIFSDALIGYAMKRRDIVAITAAMPGPTG
. . : . : .: *
Mb2524c|M.bovis_AF2122/97 A--------DRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAF
Rv2496c|M.tuberculosis_H37Rv A--------DRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAF
MUL_3774|M.ulcerans_Agy99 E--------HRCFDTPLAESALIGIAVGLALRGFVPVPEIQFDDFSYPAF
MSMEG_4711|M.smegmatis_MC2_155 A--------ERCFDTPLAESAIIGIAVGFAIRGFVPVPEIQFDGFSYPAF
MAB_0896c|M.abscessus_ATCC_199 A--------NRCFDTPLAESGIIGFAVGMAMGGFRPVVEMQFDAFAYPAF
Mvan_0912|M.vanbaalenii_PYR-1 P--------DRIIDTPISETGFIGAAVGAAVEGMRPIVELMFVDFFGVCM
MMAR_3490|M.marinum_M P--------ERVRDTPLSELGFVGIGIGAALNGLRPIVEVMTVNFSLLAL
MAV_2948|M.avium_104 C--------DRVLDTPISEAAIVGAAIGAAIDGLLPVAEIMIMDFIGIAA
TH_4167|M.thermoresistible__bu E--------ERVRDTPIAESSIIGAALGASLAGLRPVAELMFMDFLGVAM
Mflv_3923|M.gilvum_PYR-GCK LSAFRKRFPDRFFDVGIAEQHAMTSAAGLAMGGMHPVVALYST-FLNRAF
MLBr_01038|M.leprae_Br4923 LTAFGQCFPDRLFDVGIAEQHAMTSAAGLAMGRMHPVVAIYST-FLNRAF
.* *. ::* : . * :: : *: : * .
Mb2524c|M.bovis_AF2122/97 DQVVSHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTA
Rv2496c|M.tuberculosis_H37Rv DQVVSHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTA
MUL_3774|M.ulcerans_Agy99 DQVVSHLAKYRTRTRGEVNMAVTVRIPSFGGIGAAEHHLDATESYWAHTA
MSMEG_4711|M.smegmatis_MC2_155 DQIASHLAKYRMRTHGDIDMPVTVRIPSFGGIGAVEHHSESTETYWLHTA
MAB_0896c|M.abscessus_ATCC_199 EQVVSHVAKLRNRTRGVLSVPMVIRVPYAGGIGGVEHHCDSSEAYYAHTP
Mvan_0912|M.vanbaalenii_PYR-1 DQIYNHMAKIHFFSGGNVRVPMVLTTAVGGGYSDGGQHSQCLWGTFAHLP
MMAR_3490|M.marinum_M DQIVNTAAALRHMSGGQFSVPIVVRMATGAGRQLAAQHSHSLEPWYAHVP
MAV_2948|M.avium_104 DQLINNAAKLRFMTAGRTSAPLTVRTQVYAGLSTGATHSQSLEAWFMHIP
TH_4167|M.thermoresistible__bu DQIANHVAKVRYMSGGRRGAPLVIRTMV--GTAAGAQHSQALEAWAMHTP
Mflv_3923|M.gilvum_PYR-GCK DQMLMDVALHKLP------VTMVLDRSGITGPDGASHNGMWDLSILGIVP
MLBr_01038|M.leprae_Br4923 DQIMMDVALHKLP------VTMVIDRAGITGSDGPSHNGMWDLSMLGIVP
:*: * : .:.: * : .
Mb2524c|M.bovis_AF2122/97 GLKVVVPSTPGDAYWLLRHAIACPD-PVMYLEPKRRYH---------SRG
Rv2496c|M.tuberculosis_H37Rv GLKVVVPSTPGDAYWLLRHAIACPD-PVMYLEPKRRYH---------GRG
MUL_3774|M.ulcerans_Agy99 GLKVVVPSTPGDAYWLLRHAIACPD-PVMYLEPKRRYQ---------VRG
MSMEG_4711|M.smegmatis_MC2_155 GLKVVVPSTPSDAYWLLRESISSPD-PVIYLEPKRRYW---------ARE
MAB_0896c|M.abscessus_ATCC_199 GLKVVTPATVADAYGLLREAIDDPD-PVVFLEPKRLYF---------SRA
Mvan_0912|M.vanbaalenii_PYR-1 GMKVVVPSSPADAKGMMIAAIRDDN-PVVYMFHKGIMGLSWMSKTSRALG
MMAR_3490|M.marinum_M GIKVLAPATVEDAYGMLAPALADPD-PVIIFEHVQLY------NTSADID
MAV_2948|M.avium_104 GLKVIVPATPRDGKGLLSSAIFDPD-PCLFIETIRLQ-------GKKGLV
TH_4167|M.thermoresistible__bu GLKVVWPSTAADAAGLLNACLREDD-PCLFIESMKLYY-----GGGKGPV
Mflv_3923|M.gilvum_PYR-GCK GMRVAAPRDGARLREELAEAVEVKDGPTAVRFPKGDVG---------EDI
MLBr_01038|M.leprae_Br4923 GMRVAAPRDAIRLREELGEALDVDDGPTAIRFPKGDVC---------EDI
*::* * : .: : *
Mb2524c|M.bovis_AF2122/97 MVDTSRPEPPIGHAMVRRSGTDVTVVTYGNLVSTALSSADTAEQQHDWSL
Rv2496c|M.tuberculosis_H37Rv MVDTSRPEPPIGHAMVRRSGTDVTVVTYGNLVSTALSSADTAEQQHDWSL
MUL_3774|M.ulcerans_Agy99 PVDTSRPEPAIGQAMIRRAGADVTVITYGNLVSTALSAAEDAAHQQGWSL
MSMEG_4711|M.smegmatis_MC2_155 AVDTTTPALPIGRAAVRRNGSDVTVITYGGLVATALSAAELAEDR-GWSM
MAB_0896c|M.abscessus_ATCC_199 DVELGR-GAKIGEAQVLRAGTDVTLIAYGPSVEPALQAAAAAADE-GRDI
Mvan_0912|M.vanbaalenii_PYR-1 PVPREPYETPLGKANVVRPGRDISIVTLSLSVHHALDVADELAKD-GIDC
MMAR_3490|M.marinum_M VLKP----TDICKAAVRRSGTDVTLIAYGGCLAKALDAANELSLN-GIEC
MAV_2948|M.avium_104 PVEPG-FRIPLGQADIKRPGTDVSLIGYGRPVHDALAAAAMLGDQ-GVSA
TH_4167|M.thermoresistible__bu PVAD--YVIPLGQADVKRVGSDVTICTYGVLVHAALEAAKTLAGE-GVSV
Mflv_3923|M.gilvum_PYR-GCK PAIERRDGVDVLAVPADGLSDDVLIIAVGAFAAMSVAVAERLRDQ-GIGV
MLBr_01038|M.leprae_Br4923 PALKRRSGVDVLAVPATGLAQDVLLVGVGVFASMALAVAKRLHNQ-GIGV
: . . *: : . :: * .
Mb2524c|M.bovis_AF2122/97 EVIDLRSLAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQEEM
Rv2496c|M.tuberculosis_H37Rv EVIDLRSLAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQEEM
MUL_3774|M.ulcerans_Agy99 EVIDLRSLIPLDFETIAASIRRTGRCVVLHEGPRSLGYGAGLAARIQEEL
MSMEG_4711|M.smegmatis_MC2_155 EVVDLRSLNPLDFDTVADSVRRTGRAVVMHEGPRTLGFGAELAARISEEL
MAB_0896c|M.abscessus_ATCC_199 EVVDLRSIAPFDDQSVTASVRKTGRCVIVQEAQGFGGVGAEIAARIQERC
Mvan_0912|M.vanbaalenii_PYR-1 EVVDLRSLVPLDTDTILESVGKTGRLLVVDEDYESFGLSGEIIARVAERD
MMAR_3490|M.marinum_M EVVDLRVLRPLDTDTILESVRKTHRAVVIDEAWRSGSLAGEISAQIMEGA
MAV_2948|M.avium_104 EVVDLRTLVPLDVDTVVASVRRTRRAVIVHDAVQFAGPGAEVAAILHSRL
TH_4167|M.thermoresistible__bu EVVDLRTLVPLDLQTVLDSVRKTKRLVVAHESVGFCGPGAEIAAAVGTEL
Mflv_3923|M.gilvum_PYR-GCK TVVDPRWVLPVP-AAINTLAAAHKLVVTVEDNGGHGGVGSAVSAALRRAE
MLBr_01038|M.leprae_Br4923 TVIDPRWVLPVC-DGVLELAHTHKLIVTLEDNGVNGGVGAAVSTALRQVE
*:* * : *. : : .: . .. : : :
Mb2524c|M.bovis_AF2122/97 FYQLEAPVLRACGFDTPYPPAR-LEKLWLPGPDRLLDCVERVLRQP----
Rv2496c|M.tuberculosis_H37Rv FYQLEAPVLRACGFDTPYPPAR-LEKLWLPGPDRLLDCVERVLRQP----
MUL_3774|M.ulcerans_Agy99 FYELEAPVLRACGFDTPYPPAR-LERLWLPGPDRLLDCVERVLGQP----
MSMEG_4711|M.smegmatis_MC2_155 FYDLEAPVLRATGFDTPYPPAR-LEKLWLPGVDRLLDCVERAMEQP----
MAB_0896c|M.abscessus_ATCC_199 FHHLAAPVLRVSGYDIPYPAPR-LERWYLPSTDRILDAVDRLQWDDHPDS
Mvan_0912|M.vanbaalenii_PYR-1 PSVFKVAPSRVCVPDGSIPYARPLEMAVLPTPERIRAAIIEMLRK-----
MMAR_3490|M.marinum_M FYDLDAPVSRVCSVEVPIPYAKHLEQAALPQPDKIIAAVQALFGDQS---
MAV_2948|M.avium_104 FSELAAPVERVAARFVPNPAAAALEAQVYPSPERIAAAALKTLGRTLTGA
TH_4167|M.thermoresistible__bu FAELAAPIQRVAGTYTPVPRAATLEAACRPDATKLSDAVRRIM-------
Mflv_3923|M.gilvum_PYR-GCK IDVPCRDAALPQAFFDHASRGEVLAEVGLTERTIARQITGWVAALG----
MLBr_01038|M.leprae_Br4923 IDTPCRDVGLPQEFYDHASRSEVLADLGLTDQDVARRITGWVVAFGHCGS
. * .
Mb2524c|M.bovis_AF2122/97 ---------------
Rv2496c|M.tuberculosis_H37Rv ---------------
MUL_3774|M.ulcerans_Agy99 ---------------
MSMEG_4711|M.smegmatis_MC2_155 ---------------
MAB_0896c|M.abscessus_ATCC_199 RWVVSA---------
Mvan_0912|M.vanbaalenii_PYR-1 ---------------
MMAR_3490|M.marinum_M ---------------
MAV_2948|M.avium_104 TAHG-----------
TH_4167|M.thermoresistible__bu ---------------
Mflv_3923|M.gilvum_PYR-GCK -ATAGDRQVSESVD-
MLBr_01038|M.leprae_Br4923 GDDAGQYGPRSSQTM