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TQIADRPARPDETLAVAVSDITQSLTMVQAINRALYDAMAADERVLVFGEDVAVEGGVFRVTEGLADTFG ADRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHLAKYRTRTRGEVDMPVTVRIPS FGGIGAAEHHSDSTESYWVHTAGLKVVVPSTPGDAYWLLRHAIACPDPVMYLEPKRRYHGRGMVDTSRPE PPIGHAMVRRSGTDVTVVTYGNLVSTALSSADTAEQQHDWSLEVIDLRSLAPLDFDTIAASIQRTGRCVV MHEGPRSLGYGAGLAARIQEEMFYQLEAPVLRACGFDTPYPPARLEKLWLPGPDRLLDCVERVLRQP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2496c | pdhB | - | 100% (348) | PROBABLE PYRUVATE DEHYDROGENASE E1 COMPONENT (BETA SUBUNIT) PDHB (PYRUVATE DECARBOXYLASE) (PYRUVATE DEHYDROGENASE) (PYRUVIC DEHYDROGENASE) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2524c | pdhB | 0.0 | 99.71% (348) | pyruvate dehydrogenase E1 component beta subunit PdhB |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0896c | - | 1e-101 | 57.23% (318) | putative pyruvate dehydrogenase E1 component, beta subunit |
| M. marinum M | MMAR_3843 | pdhB | 1e-175 | 85.92% (348) | pyruvate dehydrogenase E1 component (beta subunit) PdhB |
| M. avium 104 | MAV_1676 | - | 1e-174 | 84.05% (351) | pyruvate dehydrogenase E1 component subunit beta |
| M. smegmatis MC2 155 | MSMEG_4711 | - | 1e-152 | 74.37% (359) | pyruvate dehydrogenase E1 component subunit beta |
| M. thermoresistible (build 8) | TH_0717 | pdhB | 1e-153 | 74.71% (348) | PROBABLE PYRUVATE DEHYDROGENASE E1 COMPONENT (BETA SUBUNIT) |
| M. ulcerans Agy99 | MUL_3774 | pdhB | 1e-174 | 85.06% (348) | pyruvate dehydrogenase E1 component (beta subunit) PdhB |
| M. vanbaalenii PYR-1 | Mvan_4085 | - | 1e-143 | 70.79% (356) | transketolase, central region |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2496c|M.tuberculosis_H37Rv --MTQIADRPARPDE------------TLAVAVSDI---TQSLTMVQAIN
Mb2524c|M.bovis_AF2122/97 --MTQIADRPARPDE------------TLAVAVSDI---TQSLTMVQAIN
MMAR_3843|M.marinum_M --MTQIADPPARPGP------------APAAPVVGT---MQSLTMVQALN
MUL_3774|M.ulcerans_Agy99 --MTQIADPPARPGP------------APAAPVVGT---MQSLTMVQALN
MAV_1676|M.avium_104 --MTQLADRPTGHGE------------TLTAAVQDVALGAQALTMVQALN
MSMEG_4711|M.smegmatis_MC2_155 --MTQIIDRPAAQGDAPEPWGSILTPAAAQAPVPAV----TELTMVQAIN
TH_0717|M.thermoresistible__bu MTVTQLIERPLVT---------------ARPPVP-------ELTLAQAVN
Mvan_4085|M.vanbaalenii_PYR-1 --MTQLIERPFGFDDDAAE----PQRTPVAVPVAPI----APISMAQAIN
MAB_0896c|M.abscessus_ATCC_199 ---------------------------------------MTVTTMAQALN
::.**:*
Rv2496c|M.tuberculosis_H37Rv RALYDAMAADERVLVFGEDVAVEGGVFRVTEGLADTFGADRCFDTPLAES
Mb2524c|M.bovis_AF2122/97 RALYDAMAADERVLVFGEDVAVEGGVFRVTEGLADTFGADRCFDTPLAES
MMAR_3843|M.marinum_M QALHDAMAADDRVLVFGEDVGIAGGVFRVTEGLAETFGEHRCFDTPLAES
MUL_3774|M.ulcerans_Agy99 QALHDAMAADDRVLVFGEDVGIAGGVFRVTEGLAETFGEHRCFDTPLAES
MAV_1676|M.avium_104 RALHDAMAADERVLVFGEDVAVQGGVFRVTEGLAEAFGESRCFDTPLAES
MSMEG_4711|M.smegmatis_MC2_155 RALRDAMAADERVLVFGEDVATLGGVFRVTDGLTESFGAERCFDTPLAES
TH_0717|M.thermoresistible__bu RALHDAMAADQRVLVFGQDVARLGGVFRVTDGLSAAFGEERCFDTPLAES
Mvan_4085|M.vanbaalenii_PYR-1 RALHDAMRVDDRVLVFGEDVATLGGVFRVTEGLAETYGEQRCFDTPLAES
MAB_0896c|M.abscessus_ATCC_199 AALRDALHDDDSVVVFGEDVGTLGGVFRVTDGLTETFGANRCFDTPLAES
** **: *: *:***:**. *******:**: ::* **********
Rv2496c|M.tuberculosis_H37Rv AIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHLAKYRTRTRGEVDM
Mb2524c|M.bovis_AF2122/97 AIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHLAKYRTRTRGEVDM
MMAR_3843|M.marinum_M ALIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHLAKYRTRTRGEVNM
MUL_3774|M.ulcerans_Agy99 ALIGIAVGLALRGFVPVPEIQFDDFSYPAFDQVVSHLAKYRTRTRGEVNM
MAV_1676|M.avium_104 AIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHLAKYRTRTRGAIDM
MSMEG_4711|M.smegmatis_MC2_155 AIIGIAVGFAIRGFVPVPEIQFDGFSYPAFDQIASHLAKYRMRTHGDIDM
TH_0717|M.thermoresistible__bu AIIGIAIGLAIRGFVPVPEIQFDGFSYPAFDQIVSHLAKYRMRTRGDVEM
Mvan_4085|M.vanbaalenii_PYR-1 AIIGIAVGMAIRGLVPVPEIQFDGFAAPAFDQMVSHLAKYRMRTRGDVDM
MAB_0896c|M.abscessus_ATCC_199 GIIGFAVGMAMGGFRPVVEMQFDAFAYPAFEQVVSHVAKLRNRTRGVLSV
.:**:*:*:*: *: ** *:*** *: ***:*:.**:** * **:* :.:
Rv2496c|M.tuberculosis_H37Rv PVTVRIPSFGGIGAAEHHSDSTESYWVHTAGLKVVVPSTPGDAYWLLRHA
Mb2524c|M.bovis_AF2122/97 PVTVRIPSFGGIGAAEHHSDSTESYWVHTAGLKVVVPSTPGDAYWLLRHA
MMAR_3843|M.marinum_M AVTVRIPSFGGIGAAEHHSDSTESYWAHTAGLKVVVPSTPGDAYWLLRHA
MUL_3774|M.ulcerans_Agy99 AVTVRIPSFGGIGAAEHHLDATESYWAHTAGLKVVVPSTPGDAYWLLRHA
MAV_1676|M.avium_104 PVTVRVPSFGGIGAAEHHSESTESYWAHTAGLKVVVPSNPADAYWLLRHA
MSMEG_4711|M.smegmatis_MC2_155 PVTVRIPSFGGIGAVEHHSESTETYWLHTAGLKVVVPSTPSDAYWLLRES
TH_0717|M.thermoresistible__bu RVTVRIPSFGGIGAVEHHSESTETYWLHTAGLKVVAPGTPADAYWLLRHA
Mvan_4085|M.vanbaalenii_PYR-1 PVTVRIPSFGGIGAVEHHSESTETYWLHTAGLKVVTPSTPTDAYWLLRYA
MAB_0896c|M.abscessus_ATCC_199 PMVIRVPYAGGIGGVEHHCDSSEAYYAHTPGLKVVTPATVADAYGLLREA
:.:*:* ****..*** :::*:*: **.*****.*.. *** *** :
Rv2496c|M.tuberculosis_H37Rv IACPDPVMYLEPKRRYHGRGMVDTSRPEPPIGHAMVRRSGTDVTVVTYGN
Mb2524c|M.bovis_AF2122/97 IACPDPVMYLEPKRRYHSRGMVDTSRPEPPIGHAMVRRSGTDVTVVTYGN
MMAR_3843|M.marinum_M IACPDPVMYLEPKRRYQVRGPVDTSRPEPAIGQAMIRRAGADVTVITYGN
MUL_3774|M.ulcerans_Agy99 IACPDPVMYLEPKRRYQVRGPVDTSRPEPAIGQAMIRRAGADVTVITYGN
MAV_1676|M.avium_104 IACPDPVMYLEPKRRYQGRGLVDAGRPEPPIGRAMVRRAGTDVTVVTYGS
MSMEG_4711|M.smegmatis_MC2_155 ISSPDPVIYLEPKRRYWAREAVDTTTPALPIGRAAVRRNGSDVTVITYGG
TH_0717|M.thermoresistible__bu ITCPDPVIYLEPKRRYWARGPVDTTTPAGPLGRAAVARSGTDVTVITYGS
Mvan_4085|M.vanbaalenii_PYR-1 IASRDPVIFLEPKRRYWAKEVVDTGNPADPIGRAAIRRAGDDVTVLTYGP
MAB_0896c|M.abscessus_ATCC_199 IDDPDPVVFLEPKRLYFSRADVELGR-GAKIGEAQVLRAGTDVTLIAYGP
* ***::***** * : *: :*.* : * * ***:::**
Rv2496c|M.tuberculosis_H37Rv LVSTALSSADTAEQQHDWSLEVIDLRSLAPLDFDTIAASIQRTGRCVVMH
Mb2524c|M.bovis_AF2122/97 LVSTALSSADTAEQQHDWSLEVIDLRSLAPLDFDTIAASIQRTGRCVVMH
MMAR_3843|M.marinum_M LVSTALSAAEDAAHQQGWSLEVIDLRSLIPLDFETIAASIRRTGRCVVLH
MUL_3774|M.ulcerans_Agy99 LVSTALSAAEDAAHQQGWSLEVIDLRSLIPLDFETIAASIRRTGRCVVLH
MAV_1676|M.avium_104 LVATAVGAAEEAQHQRGWSLEVIDLRSLVPLDFDTIATSIHRTGRCVVMH
MSMEG_4711|M.smegmatis_MC2_155 LVATALSAAELAED-RGWSMEVVDLRSLNPLDFDTVADSVRRTGRAVVMH
TH_0717|M.thermoresistible__bu LVTTALSAAELAADTHGWSLEVVDLRSLNPLDFDTIAESVRRTGRAVVLH
Mvan_4085|M.vanbaalenii_PYR-1 LVATALNAAELSPH----GLEVVDLRSLNPLDFDTVAASVRKTGRAVVMH
MAB_0896c|M.abscessus_ATCC_199 SVEPALQAAAAAAD-EGRDIEVVDLRSIAPFDDQSVTASVRKTGRCVIVQ
* .*: :* : . .:**:****: *:* :::: *:::***.*:::
Rv2496c|M.tuberculosis_H37Rv EGPRSLGYGAGLAARIQEEMFYQLEAPVLRACGFDTPYPPARLEKLWLPG
Mb2524c|M.bovis_AF2122/97 EGPRSLGYGAGLAARIQEEMFYQLEAPVLRACGFDTPYPPARLEKLWLPG
MMAR_3843|M.marinum_M EGPRSLGYGAGLAARIQEELFYELEAPVLRACGFDTPYPPARLERLWLPG
MUL_3774|M.ulcerans_Agy99 EGPRSLGYGAGLAARIQEELFYELEAPVLRACGFDTPYPPARLERLWLPG
MAV_1676|M.avium_104 EGPRTLGYGAELAARIQEELFYELEAPVLRACGFDTPYPPARLEKWWLPG
MSMEG_4711|M.smegmatis_MC2_155 EGPRTLGFGAELAARISEELFYDLEAPVLRATGFDTPYPPARLEKLWLPG
TH_0717|M.thermoresistible__bu EGPRTLGFGAELAARITEELFYDLEAPVLRATGFDTPYPPARLEKLWLPG
Mvan_4085|M.vanbaalenii_PYR-1 EGARTVGFGAELAARISEECFYDLEAPVLRATGFDTPYPPARLEKLWLPG
MAB_0896c|M.abscessus_ATCC_199 EAQGFGGVGAEIAARIQERCFHHLAAPVLRVSGYDIPYPAPRLERWYLPS
*. * ** :**** *. *:.* *****. *:* ***..***: :**.
Rv2496c|M.tuberculosis_H37Rv PDRLLDCVERVLRQP----------
Mb2524c|M.bovis_AF2122/97 PDRLLDCVERVLRQP----------
MMAR_3843|M.marinum_M PDRLLDCVERVLGQP----------
MUL_3774|M.ulcerans_Agy99 PDRLLDCVERVLGQP----------
MAV_1676|M.avium_104 PDRLLDCVERTLELP----------
MSMEG_4711|M.smegmatis_MC2_155 VDRLLDCVERAMEQP----------
TH_0717|M.thermoresistible__bu PDRLLDCVERSLGYP----------
Mvan_4085|M.vanbaalenii_PYR-1 VDRLLDCVDKAMGQP----------
MAB_0896c|M.abscessus_ATCC_199 TDRILDAVDRLQWDDHPDSRWVVSA
**:**.*::