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MADQEMTMREALNLALDQALAADERVFLLGEDIADPGASGPTAGLSTKYGCDRVLDTPISEAAIVGAAIG AAIDGLLPVAEIMIMDFIGIAADQLINNAAKLRFMTAGRTSAPLTVRTQVYAGLSTGATHSQSLEAWFMH IPGLKVIVPATPRDGKGLLSSAIFDPDPCLFIETIRLQGKKGLVPVEPGFRIPLGQADIKRPGTDVSLIG YGRPVHDALAAAAMLGDQGVSAEVVDLRTLVPLDVDTVVASVRRTRRAVIVHDAVQFAGPGAEVAAILHS RLFSELAAPVERVAARFVPNPAAAALEAQVYPSPERIAAAALKTLGRTLTGATAHG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2948 | - | - | 100% (336) | acetoin:2,6-dichlorophenolindophenol oxidoreductase beta subunit |
| M. avium 104 | MAV_1676 | - | 7e-63 | 42.81% (327) | pyruvate dehydrogenase E1 component subunit beta |
| M. avium 104 | MAV_3577 | dxs | 5e-09 | 27.96% (279) | 1-deoxy-D-xylulose-5-phosphate synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2524c | pdhB | 3e-62 | 42.01% (319) | pyruvate dehydrogenase E1 component beta subunit PdhB |
| M. gilvum PYR-GCK | Mflv_3923 | - | 6e-07 | 27.71% (249) | 1-deoxy-D-xylulose-5-phosphate synthase |
| M. tuberculosis H37Rv | Rv2496c | pdhB | 5e-62 | 42.01% (319) | pyruvate dehydrogenase E1 component beta subunit PdhB |
| M. leprae Br4923 | MLBr_01038 | dxs | 2e-06 | 29.25% (253) | 1-deoxy-D-xylulose-5-phosphate synthase |
| M. abscessus ATCC 19977 | MAB_0896c | - | 4e-63 | 44.44% (315) | putative pyruvate dehydrogenase E1 component, beta subunit |
| M. marinum M | MMAR_3490 | - | 8e-65 | 42.24% (322) | pyruvate dehydrogenase E1 component (beta subunit) |
| M. smegmatis MC2 155 | MSMEG_4711 | - | 2e-62 | 43.63% (314) | pyruvate dehydrogenase E1 component subunit beta |
| M. thermoresistible (build 8) | TH_4167 | - | 4e-93 | 53.21% (327) | PUTATIVE acetoin:2,6-dichlorophenolindophenol oxidoreductase |
| M. ulcerans Agy99 | MUL_3774 | pdhB | 1e-60 | 41.59% (327) | pyruvate dehydrogenase E1 component (beta subunit) PdhB |
| M. vanbaalenii PYR-1 | Mvan_1409 | - | 7e-65 | 44.51% (319) | transketolase, central region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu MATQLDVEAPTSANDRAIALYRLMSKVHHADARVRKGLSSGEIAMSYWPV
MMAR_3490|M.marinum_M --------------------------------------------------
Mvan_1409|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK ------MLEQIRGPADLQHLSRAQMEDLAREIRDFLIHKVAATGGHLGPN
MLBr_01038|M.leprae_Br4923 ------MLEQIRRPADLQHLSQQQLRDLAAEIRELLVHKVAATGGHLGPN
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu TGQEAMSAGAALALSDGDQLVSTYRGLGDVVAKGIDLAGYFGEILGRRTG
MMAR_3490|M.marinum_M --------------------------------------------------
Mvan_1409|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK LGVVELTLALHRVFDSPHDPILFDTGHQAYVHKMLTGRSRDFDTLRKKDG
MLBr_01038|M.leprae_Br4923 LGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLTGRCQDFDSLRKKAG
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu LSRGKAGAMGISDPDHGIAWTTGIVGAGPLFANGIALAASIRGTGQVVLV
MMAR_3490|M.marinum_M --------------------------------------------------
Mvan_1409|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK LSGYPS----RSESEHDWVESSHASSALSYADGLAKAFELNGHRNRHVVA
MLBr_01038|M.leprae_Br4923 LSGYPS----RAESEHDWVESSHASTALSYADGLAKAFELAGNRNRHVVA
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu SFGDGATSIGYVHEAMNMAALWNLPVVFFCQNNAWAECTAMERYTRTARL
MMAR_3490|M.marinum_M --------------------------------------------------
Mvan_1409|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK VVGDGALTGGMCWEALNNIAASRRPVVIVVNDNGRSYAPTIG--------
MLBr_01038|M.leprae_Br4923 VVGDGALTGGMCWEALNNIAATPRPVVIVVNDNGRSYAPTIG--------
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu SDRAQGYGMPGVTVDGTDPRAVHDAVAEAVTRARSGGGPTFVEALAYRLQ
MMAR_3490|M.marinum_M --------------------------------------------------
Mvan_1409|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK ------------------------------------GFAEHLAGLRLQPG
MLBr_01038|M.leprae_Br4923 ------------------------------------GVADHLATLRLQPA
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2948|M.avium_104 --------------------------------------------------
TH_4167|M.thermoresistible__bu GHYFGDTMAYADPDELAAKRADPPFDRYRRRLIDEGIATAATLDQIDAEL
MMAR_3490|M.marinum_M --------------------------------------------------
Mvan_1409|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK YERVLEEGRKAVRGVPMIGEFCYQCMHSIKAGIKDALSPQVMFTDLGLKY
MLBr_01038|M.leprae_Br4923 YERLLEKGRDALHSLPLIGQIAYRFMHSVKAGIKDSLSPQLLFTDLGLKY
Mb2524c|M.bovis_AF2122/97 ---------------MTQIADRPARP-----------DETLAVAVSDITQ
Rv2496c|M.tuberculosis_H37Rv ---------------MTQIADRPARP-----------DETLAVAVSDITQ
MUL_3774|M.ulcerans_Agy99 ---------------MTQIADPPARP-----------GPAPAAPVVGTMQ
MSMEG_4711|M.smegmatis_MC2_155 ---------------MTQIIDRPAAQGDAPEPWGSILTPAAAQAPVPAVT
MAB_0896c|M.abscessus_ATCC_199 ------------------------------------------------MT
MAV_2948|M.avium_104 ---------------------------------MAD-------------Q
TH_4167|M.thermoresistible__bu AAQVDAAFAAARDAEPLGPEELTGDVFTGNGTELADGTVPRVALPEGETE
MMAR_3490|M.marinum_M -------------------------------------------------M
Mvan_1409|M.vanbaalenii_PYR-1 -------------------------------------------------M
Mflv_3923|M.gilvum_PYR-GCK VGPIDGHDESAVEGALRHARAFNAPVVVHVVTRKGMGYAPAENDVDEQMH
MLBr_01038|M.leprae_Br4923 VGPVDGHDEHAVEVALRKARGFGGPVIVHVVTRKGMGYPPAEADQAEQMH
Mb2524c|M.bovis_AF2122/97 SLTMVQAINRALYDAMAADERVLVFGEDVAV---EGGVFRVTEGLADTFG
Rv2496c|M.tuberculosis_H37Rv SLTMVQAINRALYDAMAADERVLVFGEDVAV---EGGVFRVTEGLADTFG
MUL_3774|M.ulcerans_Agy99 SLTMVQALNQALHDAMAADDRVLVFGEDVGI---AGGVFRVTEGLAETFG
MSMEG_4711|M.smegmatis_MC2_155 ELTMVQAINRALRDAMAADERVLVFGEDVAT---LGGVFRVTDGLTESFG
MAB_0896c|M.abscessus_ATCC_199 VTTMAQALNAALRDALHDDDSVVVFGEDVGT---LGGVFRVTDGLTETFG
MAV_2948|M.avium_104 EMTMREALNLALDQALAADERVFLLGEDIADPG-ASG---PTAGLSTKYG
TH_4167|M.thermoresistible__bu ELGLVQAIHRTLDRAMAADDSIILLGEDIGDRS-GGGMFKITAGLSAKYG
MMAR_3490|M.marinum_M KTTYRTAVHDGLHDALSNDPRVVLMGEDVGR---YGGTYAASKGLLEEFG
Mvan_1409|M.vanbaalenii_PYR-1 KTSYRTAVHDAIADALRDDPRVLLMGEDVAR---YGGTYAVSKGLLEEFG
Mflv_3923|M.gilvum_PYR-GCK ACGVIDPETGLATSVPGPGWTAAFSETLIELAAKRRDIVAITAAMPGPTG
MLBr_01038|M.leprae_Br4923 TCGVMDPTTGQPTKIAAPDWTAIFSDALIGYAMKRRDIVAITAAMPGPTG
. . . : . : .: *
Mb2524c|M.bovis_AF2122/97 A--------DRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAF
Rv2496c|M.tuberculosis_H37Rv A--------DRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAF
MUL_3774|M.ulcerans_Agy99 E--------HRCFDTPLAESALIGIAVGLALRGFVPVPEIQFDDFSYPAF
MSMEG_4711|M.smegmatis_MC2_155 A--------ERCFDTPLAESAIIGIAVGFAIRGFVPVPEIQFDGFSYPAF
MAB_0896c|M.abscessus_ATCC_199 A--------NRCFDTPLAESGIIGFAVGMAMGGFRPVVEMQFDAFAYPAF
MAV_2948|M.avium_104 C--------DRVLDTPISEAAIVGAAIGAAIDGLLPVAEIMIMDFIGIAA
TH_4167|M.thermoresistible__bu E--------ERVRDTPIAESSIIGAALGASLAGLRPVAELMFMDFLGVAM
MMAR_3490|M.marinum_M P--------ERVRDTPLSELGFVGIGIGAALNGLRPIVEVMTVNFSLLAL
Mvan_1409|M.vanbaalenii_PYR-1 P--------DRVRDTPLSELGFVGIGIGAALGGLRPIVEIMTVNFSLLAL
Mflv_3923|M.gilvum_PYR-GCK LSAFRKRFPDRFFDVGIAEQHAMTSAAGLAMGGMHPVVALYST-FLNRAF
MLBr_01038|M.leprae_Br4923 LTAFGQCFPDRLFDVGIAEQHAMTSAAGLAMGRMHPVVAIYST-FLNRAF
.* *. ::* : . * :: : *: : * *
Mb2524c|M.bovis_AF2122/97 DQVVSHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTA
Rv2496c|M.tuberculosis_H37Rv DQVVSHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTA
MUL_3774|M.ulcerans_Agy99 DQVVSHLAKYRTRTRGEVNMAVTVRIPSFGGIGAAEHHLDATESYWAHTA
MSMEG_4711|M.smegmatis_MC2_155 DQIASHLAKYRMRTHGDIDMPVTVRIPSFGGIGAVEHHSESTETYWLHTA
MAB_0896c|M.abscessus_ATCC_199 EQVVSHVAKLRNRTRGVLSVPMVIRVPYAGGIGGVEHHCDSSEAYYAHTP
MAV_2948|M.avium_104 DQLINNAAKLRFMTAGRTSAPLTVRTQVYAGLSTGATHSQSLEAWFMHIP
TH_4167|M.thermoresistible__bu DQIANHVAKVRYMSGGRRGAPLVIRTMV--GTAAGAQHSQALEAWAMHTP
MMAR_3490|M.marinum_M DQIVNTAAALRHMSGGQFSVPIVVRMATGAGRQLAAQHSHSLEPWYAHVP
Mvan_1409|M.vanbaalenii_PYR-1 DQIVNTAAALRHMSGGQFSVPLVVRMATGAGRQLAAQHSHSLEGWYAHIP
Mflv_3923|M.gilvum_PYR-GCK DQMLMDVALHKLP------VTMVLDRSGITGPDGASHNGMWDLSILGIVP
MLBr_01038|M.leprae_Br4923 DQIMMDVALHKLP------VTMVIDRAGITGSDGPSHNGMWDLSMLGIVP
:*: * : .:.: * : .
Mb2524c|M.bovis_AF2122/97 GLKVVVPSTPGDAYWLLRHAIACPDPVMYLEPKRRY---HSRGMVDTSRP
Rv2496c|M.tuberculosis_H37Rv GLKVVVPSTPGDAYWLLRHAIACPDPVMYLEPKRRY---HGRGMVDTSRP
MUL_3774|M.ulcerans_Agy99 GLKVVVPSTPGDAYWLLRHAIACPDPVMYLEPKRRY---QVRGPVDTSRP
MSMEG_4711|M.smegmatis_MC2_155 GLKVVVPSTPSDAYWLLRESISSPDPVIYLEPKRRY---WAREAVDTTTP
MAB_0896c|M.abscessus_ATCC_199 GLKVVTPATVADAYGLLREAIDDPDPVVFLEPKRLY---FSRADVELGR-
MAV_2948|M.avium_104 GLKVIVPATPRDGKGLLSSAIFDPDPCLFIETIRLQ--GKKGLVPVEPGF
TH_4167|M.thermoresistible__bu GLKVVWPSTAADAAGLLNACLREDDPCLFIESMKLYYGGGKGPVPVAD-Y
MMAR_3490|M.marinum_M GIKVLAPATVEDAYGMLAPALADPDPVIIFEHVQLY----NTSADIDVLK
Mvan_1409|M.vanbaalenii_PYR-1 GIKVVAPATVEDAYGMLSTALQDPDPVIMFEHVQLY----NTSADVAELG
Mflv_3923|M.gilvum_PYR-GCK GMRVAAPRDGARLREELAEAVEVKDGPTAVRFPKGD--VGEDIPAIERRD
MLBr_01038|M.leprae_Br4923 GMRVAAPRDAIRLREELGEALDVDDGPTAIRFPKGD--VCEDIPALKRRS
*::* * * .: * .. :
Mb2524c|M.bovis_AF2122/97 EPPIGHAMVRRSGTDVTVVTYGNLVSTALSSADTAEQQHDWSLEVIDLRS
Rv2496c|M.tuberculosis_H37Rv EPPIGHAMVRRSGTDVTVVTYGNLVSTALSSADTAEQQHDWSLEVIDLRS
MUL_3774|M.ulcerans_Agy99 EPAIGQAMIRRAGADVTVITYGNLVSTALSAAEDAAHQQGWSLEVIDLRS
MSMEG_4711|M.smegmatis_MC2_155 ALPIGRAAVRRNGSDVTVITYGGLVATALSAAELAEDR-GWSMEVVDLRS
MAB_0896c|M.abscessus_ATCC_199 GAKIGEAQVLRAGTDVTLIAYGPSVEPALQAAAAAADE-GRDIEVVDLRS
MAV_2948|M.avium_104 RIPLGQADIKRPGTDVSLIGYGRPVHDALAAAAMLGDQ-GVSAEVVDLRT
TH_4167|M.thermoresistible__bu VIPLGQADVKRVGSDVTICTYGVLVHAALEAAKTLAGE-GVSVEVVDLRT
MMAR_3490|M.marinum_M PTDICKAAVRRSGTDVTLIAYGGCLAKALDAANELSLN-GIECEVVDLRV
Mvan_1409|M.vanbaalenii_PYR-1 AQDISRAAIRRQGSDVSLITYGGSLPKVLDAADQLALA-GIDCEVIDLRV
Mflv_3923|M.gilvum_PYR-GCK GVDVLAVPADGLSDDVLIIAVGAFAAMSVAVAERLRDQ-GIGVTVVDPRW
MLBr_01038|M.leprae_Br4923 GVDVLAVPATGLAQDVLLVGVGVFASMALAVAKRLHNQ-GIGVTVIDPRW
: . . ** : * : * . *:* *
Mb2524c|M.bovis_AF2122/97 LAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQEEMFYQLEAP
Rv2496c|M.tuberculosis_H37Rv LAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQEEMFYQLEAP
MUL_3774|M.ulcerans_Agy99 LIPLDFETIAASIRRTGRCVVLHEGPRSLGYGAGLAARIQEELFYELEAP
MSMEG_4711|M.smegmatis_MC2_155 LNPLDFDTVADSVRRTGRAVVMHEGPRTLGFGAELAARISEELFYDLEAP
MAB_0896c|M.abscessus_ATCC_199 IAPFDDQSVTASVRKTGRCVIVQEAQGFGGVGAEIAARIQERCFHHLAAP
MAV_2948|M.avium_104 LVPLDVDTVVASVRRTRRAVIVHDAVQFAGPGAEVAAILHSRLFSELAAP
TH_4167|M.thermoresistible__bu LVPLDLQTVLDSVRKTKRLVVAHESVGFCGPGAEIAAAVGTELFAELAAP
MMAR_3490|M.marinum_M LRPLDTDTILESVRKTHRAVVIDEAWRSGSLAGEISAQIMEGAFYDLDAP
Mvan_1409|M.vanbaalenii_PYR-1 LRPLDTETFVGSVRKTHRAVIVDEGWRTGSLAAEISTQITEQAFFDLDAP
Mflv_3923|M.gilvum_PYR-GCK VLPVP-AAINTLAAAHKLVVTVEDNGGHGGVGSAVSAALRRAEIDVPCRD
MLBr_01038|M.leprae_Br4923 VLPVC-DGVLELAHTHKLIVTLEDNGVNGGVGAAVSTALRQVEIDTPCRD
: *. . * .: . .. ::: : :
Mb2524c|M.bovis_AF2122/97 VLRACGFDTPYPPAR-LEKLWLPGPDRLLDCVERVLRQP-----------
Rv2496c|M.tuberculosis_H37Rv VLRACGFDTPYPPAR-LEKLWLPGPDRLLDCVERVLRQP-----------
MUL_3774|M.ulcerans_Agy99 VLRACGFDTPYPPAR-LERLWLPGPDRLLDCVERVLGQP-----------
MSMEG_4711|M.smegmatis_MC2_155 VLRATGFDTPYPPAR-LEKLWLPGVDRLLDCVERAMEQP-----------
MAB_0896c|M.abscessus_ATCC_199 VLRVSGYDIPYPAPR-LERWYLPSTDRILDAVDRLQWDDHPDSRWVVSA-
MAV_2948|M.avium_104 VERVAARFVPNPAAAALEAQVYPSPERIAAAALKTLGRTLTGATAHG---
TH_4167|M.thermoresistible__bu IQRVAGTYTPVPRAATLEAACRPDATKLSDAVRRIM--------------
MMAR_3490|M.marinum_M VSRVCSVEVPIPYAKHLEQAALPQPDKIIAAVQALFGDQS----------
Mvan_1409|M.vanbaalenii_PYR-1 VARVCSAEVPIPYARHLEQAALPQRDTIVAAAQGLFGGQP----------
Mflv_3923|M.gilvum_PYR-GCK AALPQAFFDHASRGEVLAEVGLTERTIARQITGWVAALG-----ATAGDR
MLBr_01038|M.leprae_Br4923 VGLPQEFYDHASRSEVLADLGLTDQDVARRITGWVVAFGHCGSGDDAGQY
. * . .
Mb2524c|M.bovis_AF2122/97 --------
Rv2496c|M.tuberculosis_H37Rv --------
MUL_3774|M.ulcerans_Agy99 --------
MSMEG_4711|M.smegmatis_MC2_155 --------
MAB_0896c|M.abscessus_ATCC_199 --------
MAV_2948|M.avium_104 --------
TH_4167|M.thermoresistible__bu --------
MMAR_3490|M.marinum_M --------
Mvan_1409|M.vanbaalenii_PYR-1 --------
Mflv_3923|M.gilvum_PYR-GCK QVSESVD-
MLBr_01038|M.leprae_Br4923 GPRSSQTM