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TVTTMAQALNAALRDALHDDDSVVVFGEDVGTLGGVFRVTDGLTETFGANRCFDTPLAESGIIGFAVGMA MGGFRPVVEMQFDAFAYPAFEQVVSHVAKLRNRTRGVLSVPMVIRVPYAGGIGGVEHHCDSSEAYYAHTP GLKVVTPATVADAYGLLREAIDDPDPVVFLEPKRLYFSRADVELGRGAKIGEAQVLRAGTDVTLIAYGPS VEPALQAAAAAADEGRDIEVVDLRSIAPFDDQSVTASVRKTGRCVIVQEAQGFGGVGAEIAARIQERCFH HLAAPVLRVSGYDIPYPAPRLERWYLPSTDRILDAVDRLQWDDHPDSRWVVSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0896c | - | - | 100% (334) | putative pyruvate dehydrogenase E1 component, beta subunit |
| M. abscessus ATCC 19977 | MAB_4917c | - | e-106 | 59.06% (320) | pyruvate dehydrogenase E1 component beta subunit |
| M. abscessus ATCC 19977 | MAB_2990c | - | 9e-12 | 28.70% (230) | 1-deoxy-D-xylulose-5-phosphate synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2524c | pdhB | 1e-101 | 57.55% (318) | pyruvate dehydrogenase E1 component beta subunit PdhB |
| M. gilvum PYR-GCK | Mflv_3923 | - | 4e-12 | 27.04% (233) | 1-deoxy-D-xylulose-5-phosphate synthase |
| M. tuberculosis H37Rv | Rv2496c | pdhB | 1e-101 | 57.23% (318) | pyruvate dehydrogenase E1 component beta subunit PdhB |
| M. leprae Br4923 | MLBr_01038 | dxs | 6e-12 | 27.66% (235) | 1-deoxy-D-xylulose-5-phosphate synthase |
| M. marinum M | MMAR_3843 | pdhB | 1e-103 | 58.70% (322) | pyruvate dehydrogenase E1 component (beta subunit) PdhB |
| M. avium 104 | MAV_1676 | - | 1e-103 | 58.68% (317) | pyruvate dehydrogenase E1 component subunit beta |
| M. smegmatis MC2 155 | MSMEG_4711 | - | 1e-104 | 59.06% (320) | pyruvate dehydrogenase E1 component subunit beta |
| M. thermoresistible (build 8) | TH_0717 | pdhB | 1e-100 | 57.73% (317) | PROBABLE PYRUVATE DEHYDROGENASE E1 COMPONENT (BETA SUBUNIT) |
| M. ulcerans Agy99 | MUL_3774 | pdhB | 1e-103 | 58.39% (322) | pyruvate dehydrogenase E1 component (beta subunit) PdhB |
| M. vanbaalenii PYR-1 | Mvan_4085 | - | 1e-102 | 59.49% (316) | transketolase, central region |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
TH_0717|M.thermoresistible__bu --------------------------------------------------
Mvan_4085|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3843|M.marinum_M --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MAV_1676|M.avium_104 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK MLEQIRGPADLQHLSRAQMEDLAREIRDFLIHKVAATGGHLGPNLGVVEL
MLBr_01038|M.leprae_Br4923 MLEQIRRPADLQHLSQQQLRDLAAEIRELLVHKVAATGGHLGPNLGVVEL
MSMEG_4711|M.smegmatis_MC2_155 ---MTQIIDRPAAQGDAPE------------------------PWGSILT
TH_0717|M.thermoresistible__bu -MTVTQLIERPLVT------------------------------------
Mvan_4085|M.vanbaalenii_PYR-1 ---MTQLIERPFGFDDDAA------------------------E----PQ
Mb2524c|M.bovis_AF2122/97 ---MTQIADRPARPDE----------------------------------
Rv2496c|M.tuberculosis_H37Rv ---MTQIADRPARPDE----------------------------------
MMAR_3843|M.marinum_M ---MTQIADPPARPGP----------------------------------
MUL_3774|M.ulcerans_Agy99 ---MTQIADPPARPGP----------------------------------
MAV_1676|M.avium_104 ---MTQLADRPTGHGE----------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK TLALHRVFDSPHDPILFDTGHQAYVHKMLTGRSRDFDTLRKKDGLSGYPS
MLBr_01038|M.leprae_Br4923 TLALHRVFDSPHDPIIFDTGHQAYVHKMLTGRCQDFDSLRKKAGLSGYPS
MSMEG_4711|M.smegmatis_MC2_155 PAAAQAPVPAV----TELTMVQAINRALRDAMAADERVLVFGEDVATLG-
TH_0717|M.thermoresistible__bu ---ARPPVP-------ELTLAQAVNRALHDAMAADQRVLVFGQDVARLG-
Mvan_4085|M.vanbaalenii_PYR-1 RTPVAVPVAPI----APISMAQAINRALHDAMRVDDRVLVFGEDVATLG-
Mb2524c|M.bovis_AF2122/97 --TLAVAVSDI---TQSLTMVQAINRALYDAMAADERVLVFGEDVAVEG-
Rv2496c|M.tuberculosis_H37Rv --TLAVAVSDI---TQSLTMVQAINRALYDAMAADERVLVFGEDVAVEG-
MMAR_3843|M.marinum_M --APAAPVVGT---MQSLTMVQALNQALHDAMAADDRVLVFGEDVGIAG-
MUL_3774|M.ulcerans_Agy99 --APAAPVVGT---MQSLTMVQALNQALHDAMAADDRVLVFGEDVGIAG-
MAV_1676|M.avium_104 --TLTAAVQDVALGAQALTMVQALNRALHDAMAADERVLVFGEDVAVQG-
MAB_0896c|M.abscessus_ATCC_199 --------------MTVTTMAQALNAALRDALHDDDSVVVFGEDVGTLG-
Mflv_3923|M.gilvum_PYR-GCK RSESEHDWVESSHASSALSYADGLAKAFELNGHRNRHVVAVVGDGALTGG
MLBr_01038|M.leprae_Br4923 RAESEHDWVESSHASTALSYADGLAKAFELAGNRNRHVVAVVGDGALTGG
: .:.: *: : *:.. * . *
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
TH_0717|M.thermoresistible__bu --------------------------------------------------
Mvan_4085|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3843|M.marinum_M --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MAV_1676|M.avium_104 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK MCWEALNNIAASRRPVVIVVNDNGRSYAPTIGGFAEHLAGLRLQPGYERV
MLBr_01038|M.leprae_Br4923 MCWEALNNIAATPRPVVIVVNDNGRSYAPTIGGVADHLATLRLQPAYERL
MSMEG_4711|M.smegmatis_MC2_155 --------------------------------------------------
TH_0717|M.thermoresistible__bu --------------------------------------------------
Mvan_4085|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2524c|M.bovis_AF2122/97 --------------------------------------------------
Rv2496c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3843|M.marinum_M --------------------------------------------------
MUL_3774|M.ulcerans_Agy99 --------------------------------------------------
MAV_1676|M.avium_104 --------------------------------------------------
MAB_0896c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3923|M.gilvum_PYR-GCK LEEGRKAVRGVPMIGEFCYQCMHSIKAGIKDALSPQVMFTDLGLKYVGPI
MLBr_01038|M.leprae_Br4923 LEKGRDALHSLPLIGQIAYRFMHSVKAGIKDSLSPQLLFTDLGLKYVGPV
MSMEG_4711|M.smegmatis_MC2_155 ------------------------------------------------GV
TH_0717|M.thermoresistible__bu ------------------------------------------------GV
Mvan_4085|M.vanbaalenii_PYR-1 ------------------------------------------------GV
Mb2524c|M.bovis_AF2122/97 ------------------------------------------------GV
Rv2496c|M.tuberculosis_H37Rv ------------------------------------------------GV
MMAR_3843|M.marinum_M ------------------------------------------------GV
MUL_3774|M.ulcerans_Agy99 ------------------------------------------------GV
MAV_1676|M.avium_104 ------------------------------------------------GV
MAB_0896c|M.abscessus_ATCC_199 ------------------------------------------------GV
Mflv_3923|M.gilvum_PYR-GCK DGHDESAVEGALRHARAFNAPVVVHVVTRKGMGYAPAENDVDEQMHACGV
MLBr_01038|M.leprae_Br4923 DGHDEHAVEVALRKARGFGGPVIVHVVTRKGMGYPPAEADQAEQMHTCGV
**
MSMEG_4711|M.smegmatis_MC2_155 FRVTDGLTESFGA-------------------------------------
TH_0717|M.thermoresistible__bu FRVTDGLSAAFGE-------------------------------------
Mvan_4085|M.vanbaalenii_PYR-1 FRVTEGLAETYGE-------------------------------------
Mb2524c|M.bovis_AF2122/97 FRVTEGLADTFGA-------------------------------------
Rv2496c|M.tuberculosis_H37Rv FRVTEGLADTFGA-------------------------------------
MMAR_3843|M.marinum_M FRVTEGLAETFGE-------------------------------------
MUL_3774|M.ulcerans_Agy99 FRVTEGLAETFGE-------------------------------------
MAV_1676|M.avium_104 FRVTEGLAEAFGE-------------------------------------
MAB_0896c|M.abscessus_ATCC_199 FRVTDGLTETFGA-------------------------------------
Mflv_3923|M.gilvum_PYR-GCK IDPETGLATSVPGPGWTAAFSETLIELAAKRRDIVAITAAMPGPTGLSAF
MLBr_01038|M.leprae_Br4923 MDPTTGQPTKIAAPDWTAIFSDALIGYAMKRRDIVAITAAMPGPTGLTAF
: * .
MSMEG_4711|M.smegmatis_MC2_155 -----ERCFDTPLAESAIIGIAVGFAIRGFVPVPEIQFDGFSYPAFDQIA
TH_0717|M.thermoresistible__bu -----ERCFDTPLAESAIIGIAIGLAIRGFVPVPEIQFDGFSYPAFDQIV
Mvan_4085|M.vanbaalenii_PYR-1 -----QRCFDTPLAESAIIGIAVGMAIRGLVPVPEIQFDGFAAPAFDQMV
Mb2524c|M.bovis_AF2122/97 -----DRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVV
Rv2496c|M.tuberculosis_H37Rv -----DRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVV
MMAR_3843|M.marinum_M -----HRCFDTPLAESALIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVV
MUL_3774|M.ulcerans_Agy99 -----HRCFDTPLAESALIGIAVGLALRGFVPVPEIQFDDFSYPAFDQVV
MAV_1676|M.avium_104 -----SRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVV
MAB_0896c|M.abscessus_ATCC_199 -----NRCFDTPLAESGIIGFAVGMAMGGFRPVVEMQFDAFAYPAFEQVV
Mflv_3923|M.gilvum_PYR-GCK RKRFPDRFFDVGIAEQHAMTSAAGLAMGGMHPVVALYST-FLNRAFDQML
MLBr_01038|M.leprae_Br4923 GQCFPDRLFDVGIAEQHAMTSAAGLAMGRMHPVVAIYST-FLNRAFDQIM
* **. :**. : * *:*: : ** : * **:*:
MSMEG_4711|M.smegmatis_MC2_155 SHLAKYRMRTHGDIDMPVTVRIPSFGGIGAVEHHSESTETYWLHTAGLKV
TH_0717|M.thermoresistible__bu SHLAKYRMRTRGDVEMRVTVRIPSFGGIGAVEHHSESTETYWLHTAGLKV
Mvan_4085|M.vanbaalenii_PYR-1 SHLAKYRMRTRGDVDMPVTVRIPSFGGIGAVEHHSESTETYWLHTAGLKV
Mb2524c|M.bovis_AF2122/97 SHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTAGLKV
Rv2496c|M.tuberculosis_H37Rv SHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTAGLKV
MMAR_3843|M.marinum_M SHLAKYRTRTRGEVNMAVTVRIPSFGGIGAAEHHSDSTESYWAHTAGLKV
MUL_3774|M.ulcerans_Agy99 SHLAKYRTRTRGEVNMAVTVRIPSFGGIGAAEHHLDATESYWAHTAGLKV
MAV_1676|M.avium_104 SHLAKYRTRTRGAIDMPVTVRVPSFGGIGAAEHHSESTESYWAHTAGLKV
MAB_0896c|M.abscessus_ATCC_199 SHVAKLRNRTRGVLSVPMVIRVPYAGGIGGVEHHCDSSEAYYAHTPGLKV
Mflv_3923|M.gilvum_PYR-GCK MDVALHKLP------VTMVLDRSGITGPDGASHNGMWDLSILGIVPGMRV
MLBr_01038|M.leprae_Br4923 MDVALHKLP------VTMVIDRAGITGSDGPSHNGMWDLSMLGIVPGMRV
.:* : : :.: . * .. .*: : ..*::*
MSMEG_4711|M.smegmatis_MC2_155 VVPSTPSDAYWLLRESISSPD-PVIYLEPKRRYWAREAVDTTTPALPIGR
TH_0717|M.thermoresistible__bu VAPGTPADAYWLLRHAITCPD-PVIYLEPKRRYWARGPVDTTTPAGPLGR
Mvan_4085|M.vanbaalenii_PYR-1 VTPSTPTDAYWLLRYAIASRD-PVIFLEPKRRYWAKEVVDTGNPADPIGR
Mb2524c|M.bovis_AF2122/97 VVPSTPGDAYWLLRHAIACPD-PVMYLEPKRRYHSRGMVDTSRPEPPIGH
Rv2496c|M.tuberculosis_H37Rv VVPSTPGDAYWLLRHAIACPD-PVMYLEPKRRYHGRGMVDTSRPEPPIGH
MMAR_3843|M.marinum_M VVPSTPGDAYWLLRHAIACPD-PVMYLEPKRRYQVRGPVDTSRPEPAIGQ
MUL_3774|M.ulcerans_Agy99 VVPSTPGDAYWLLRHAIACPD-PVMYLEPKRRYQVRGPVDTSRPEPAIGQ
MAV_1676|M.avium_104 VVPSNPADAYWLLRHAIACPD-PVMYLEPKRRYQGRGLVDAGRPEPPIGR
MAB_0896c|M.abscessus_ATCC_199 VTPATVADAYGLLREAIDDPD-PVVFLEPKRLYFSRADVELGR-GAKIGE
Mflv_3923|M.gilvum_PYR-GCK AAPRDGARLREELAEAVEVKDGPTAVRFPKGDVGEDIPAIERRDGVDVLA
MLBr_01038|M.leprae_Br4923 AAPRDAIRLREELGEALDVDDGPTAIRFPKGDVCEDIPALKRRSGVDVLA
..* * :: * *. ** . :
MSMEG_4711|M.smegmatis_MC2_155 AAVRRNGSDVTVITYGGLVATALSAAELAED-RGWSMEVVDLRSLNPLDF
TH_0717|M.thermoresistible__bu AAVARSGTDVTVITYGSLVTTALSAAELAADTHGWSLEVVDLRSLNPLDF
Mvan_4085|M.vanbaalenii_PYR-1 AAIRRAGDDVTVLTYGPLVATALNAAELSPH----GLEVVDLRSLNPLDF
Mb2524c|M.bovis_AF2122/97 AMVRRSGTDVTVVTYGNLVSTALSSADTAEQQHDWSLEVIDLRSLAPLDF
Rv2496c|M.tuberculosis_H37Rv AMVRRSGTDVTVVTYGNLVSTALSSADTAEQQHDWSLEVIDLRSLAPLDF
MMAR_3843|M.marinum_M AMIRRAGADVTVITYGNLVSTALSAAEDAAHQQGWSLEVIDLRSLIPLDF
MUL_3774|M.ulcerans_Agy99 AMIRRAGADVTVITYGNLVSTALSAAEDAAHQQGWSLEVIDLRSLIPLDF
MAV_1676|M.avium_104 AMVRRAGTDVTVVTYGSLVATAVGAAEEAQHQRGWSLEVIDLRSLVPLDF
MAB_0896c|M.abscessus_ATCC_199 AQVLRAGTDVTLIAYGPSVEPALQAAAAAAD-EGRDIEVVDLRSIAPFDD
Mflv_3923|M.gilvum_PYR-GCK VPADGLSDDVLIIAVGAFAAMSVAVAERLRD-QGIGVTVVDPRWVLPVP-
MLBr_01038|M.leprae_Br4923 VPATGLAQDVLLVGVGVFASMALAVAKRLHN-QGIGVTVIDPRWVLPVC-
. . ** :: * . :: * . .: *:* * : *.
MSMEG_4711|M.smegmatis_MC2_155 DTVADSVRRTGRAVVMHEGPRTLGFGAELAARIS-EELFYDLEAPVLRAT
TH_0717|M.thermoresistible__bu DTIAESVRRTGRAVVLHEGPRTLGFGAELAARIT-EELFYDLEAPVLRAT
Mvan_4085|M.vanbaalenii_PYR-1 DTVAASVRKTGRAVVMHEGARTVGFGAELAARIS-EECFYDLEAPVLRAT
Mb2524c|M.bovis_AF2122/97 DTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQ-EEMFYQLEAPVLRAC
Rv2496c|M.tuberculosis_H37Rv DTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQ-EEMFYQLEAPVLRAC
MMAR_3843|M.marinum_M ETIAASIRRTGRCVVLHEGPRSLGYGAGLAARIQ-EELFYELEAPVLRAC
MUL_3774|M.ulcerans_Agy99 ETIAASIRRTGRCVVLHEGPRSLGYGAGLAARIQ-EELFYELEAPVLRAC
MAV_1676|M.avium_104 DTIATSIHRTGRCVVMHEGPRTLGYGAELAARIQ-EELFYELEAPVLRAC
MAB_0896c|M.abscessus_ATCC_199 QSVTASVRKTGRCVIVQEAQGFGGVGAEIAARIQ-ERCFHHLAAPVLRVS
Mflv_3923|M.gilvum_PYR-GCK AAINTLAAAHKLVVTVEDNGGHGGVGSAVSAALRRAEIDVPCRDAALPQA
MLBr_01038|M.leprae_Br4923 DGVLELAHTHKLIVTLEDNGVNGGVGAAVSTALRQVEIDTPCRDVGLPQE
: * :.: * *: ::: : . *
MSMEG_4711|M.smegmatis_MC2_155 GFDTPYPPARLEKLWLPGVDRLLDCVERAMEQP-----------------
TH_0717|M.thermoresistible__bu GFDTPYPPARLEKLWLPGPDRLLDCVERSLGYP-----------------
Mvan_4085|M.vanbaalenii_PYR-1 GFDTPYPPARLEKLWLPGVDRLLDCVDKAMGQP-----------------
Mb2524c|M.bovis_AF2122/97 GFDTPYPPARLEKLWLPGPDRLLDCVERVLRQP-----------------
Rv2496c|M.tuberculosis_H37Rv GFDTPYPPARLEKLWLPGPDRLLDCVERVLRQP-----------------
MMAR_3843|M.marinum_M GFDTPYPPARLERLWLPGPDRLLDCVERVLGQP-----------------
MUL_3774|M.ulcerans_Agy99 GFDTPYPPARLERLWLPGPDRLLDCVERVLGQP-----------------
MAV_1676|M.avium_104 GFDTPYPPARLEKWWLPGPDRLLDCVERTLELP-----------------
MAB_0896c|M.abscessus_ATCC_199 GYDIPYPAPRLERWYLPSTDRILDAVDRLQWDDHPDSRWVVSA-------
Mflv_3923|M.gilvum_PYR-GCK FFDHASRGEVLAEVGLTERTIARQITGWVAALG-----ATAGDRQVSESV
MLBr_01038|M.leprae_Br4923 FYDHASRSEVLADLGLTDQDVARRITGWVVAFGHCGSGDDAGQYGPRSSQ
:* . * *. .
MSMEG_4711|M.smegmatis_MC2_155 --
TH_0717|M.thermoresistible__bu --
Mvan_4085|M.vanbaalenii_PYR-1 --
Mb2524c|M.bovis_AF2122/97 --
Rv2496c|M.tuberculosis_H37Rv --
MMAR_3843|M.marinum_M --
MUL_3774|M.ulcerans_Agy99 --
MAV_1676|M.avium_104 --
MAB_0896c|M.abscessus_ATCC_199 --
Mflv_3923|M.gilvum_PYR-GCK D-
MLBr_01038|M.leprae_Br4923 TM