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TQIIDRPAAQGDAPEPWGSILTPAAAQAPVPAVTELTMVQAINRALRDAMAADERVLVFGEDVATLGGVF RVTDGLTESFGAERCFDTPLAESAIIGIAVGFAIRGFVPVPEIQFDGFSYPAFDQIASHLAKYRMRTHGD IDMPVTVRIPSFGGIGAVEHHSESTETYWLHTAGLKVVVPSTPSDAYWLLRESISSPDPVIYLEPKRRYW AREAVDTTTPALPIGRAAVRRNGSDVTVITYGGLVATALSAAELAEDRGWSMEVVDLRSLNPLDFDTVAD SVRRTGRAVVMHEGPRTLGFGAELAARISEELFYDLEAPVLRATGFDTPYPPARLEKLWLPGVDRLLDCV ERAMEQP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4711 | - | - | 100% (358) | pyruvate dehydrogenase E1 component subunit beta |
| M. smegmatis MC2 155 | MSMEG_2467 | - | 3e-39 | 34.67% (300) | transketolase, central region |
| M. smegmatis MC2 155 | MSMEG_4436 | - | 4e-10 | 27.91% (258) | transketolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2524c | pdhB | 1e-153 | 74.37% (359) | pyruvate dehydrogenase E1 component beta subunit PdhB |
| M. gilvum PYR-GCK | Mflv_3923 | - | 5e-05 | 25.13% (199) | 1-deoxy-D-xylulose-5-phosphate synthase |
| M. tuberculosis H37Rv | Rv2496c | pdhB | 1e-153 | 74.37% (359) | pyruvate dehydrogenase E1 component beta subunit PdhB |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4917c | - | 1e-104 | 57.45% (322) | pyruvate dehydrogenase E1 component beta subunit |
| M. marinum M | MMAR_3843 | pdhB | 1e-149 | 72.70% (359) | pyruvate dehydrogenase E1 component (beta subunit) PdhB |
| M. avium 104 | MAV_1676 | - | 1e-153 | 74.93% (359) | pyruvate dehydrogenase E1 component subunit beta |
| M. thermoresistible (build 8) | TH_0717 | pdhB | 1e-164 | 79.67% (359) | PROBABLE PYRUVATE DEHYDROGENASE E1 COMPONENT (BETA SUBUNIT) |
| M. ulcerans Agy99 | MUL_3774 | pdhB | 1e-148 | 71.87% (359) | pyruvate dehydrogenase E1 component (beta subunit) PdhB |
| M. vanbaalenii PYR-1 | Mvan_4085 | - | 1e-158 | 78.55% (359) | transketolase, central region |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2524c|M.bovis_AF2122/97 --MTQIADRPARPDE------------TLAVAVSDI------TQSLTMVQ
Rv2496c|M.tuberculosis_H37Rv --MTQIADRPARPDE------------TLAVAVSDI------TQSLTMVQ
MMAR_3843|M.marinum_M --MTQIADPPARPGP------------APAAPVVGT------MQSLTMVQ
MUL_3774|M.ulcerans_Agy99 --MTQIADPPARPGP------------APAAPVVGT------MQSLTMVQ
MAV_1676|M.avium_104 --MTQLADRPTGHGE------------TLTAAVQDVALG---AQALTMVQ
MSMEG_4711|M.smegmatis_MC2_155 --MTQIIDRPAAQGDAPEPWGSILTPAAAQAPVPAV-------TELTMVQ
TH_0717|M.thermoresistible__bu MTVTQLIERPLVT---------------ARPPVP----------ELTLAQ
Mvan_4085|M.vanbaalenii_PYR-1 --MTQLIERPFGFDDDAAE----PQRTPVAVPVAPI-------APISMAQ
MAB_4917c|M.abscessus_ATCC_199 --MTR----------------------------------------MTMSG
Mflv_3923|M.gilvum_PYR-GCK --MLEQIRGPADLQHLSRAQMEDLAREIRDFLIHKVAATGGHLGPNLGVV
: .
Mb2524c|M.bovis_AF2122/97 AINRALYDAMAADERVLVFG------------------------------
Rv2496c|M.tuberculosis_H37Rv AINRALYDAMAADERVLVFG------------------------------
MMAR_3843|M.marinum_M ALNQALHDAMAADDRVLVFG------------------------------
MUL_3774|M.ulcerans_Agy99 ALNQALHDAMAADDRVLVFG------------------------------
MAV_1676|M.avium_104 ALNRALHDAMAADERVLVFG------------------------------
MSMEG_4711|M.smegmatis_MC2_155 AINRALRDAMAADERVLVFG------------------------------
TH_0717|M.thermoresistible__bu AVNRALHDAMAADQRVLVFG------------------------------
Mvan_4085|M.vanbaalenii_PYR-1 AINRALHDAMRVDDRVLVFG------------------------------
MAB_4917c|M.abscessus_ATCC_199 ALDAGLRSALEDDDKVIVMG------------------------------
Mflv_3923|M.gilvum_PYR-GCK ELTLALHRVFDSPHDPILFDTGHQAYVHKMLTGRSRDFDTLRKKDGLSGY
: .* .: . :::.
Mb2524c|M.bovis_AF2122/97 ----------EDVAVEGGVFRVTEGLADTFGAD----RCFDTPLAESAII
Rv2496c|M.tuberculosis_H37Rv ----------EDVAVEGGVFRVTEGLADTFGAD----RCFDTPLAESAII
MMAR_3843|M.marinum_M ----------EDVGIAGGVFRVTEGLAETFGEH----RCFDTPLAESALI
MUL_3774|M.ulcerans_Agy99 ----------EDVGIAGGVFRVTEGLAETFGEH----RCFDTPLAESALI
MAV_1676|M.avium_104 ----------EDVAVQGGVFRVTEGLAEAFGES----RCFDTPLAESAII
MSMEG_4711|M.smegmatis_MC2_155 ----------EDVATLGGVFRVTDGLTESFGAE----RCFDTPLAESAII
TH_0717|M.thermoresistible__bu ----------QDVARLGGVFRVTDGLSAAFGEE----RCFDTPLAESAII
Mvan_4085|M.vanbaalenii_PYR-1 ----------EDVATLGGVFRVTEGLAETYGEQ----RCFDTPLAESAII
MAB_4917c|M.abscessus_ATCC_199 ----------EDVGKLGGVFRVTDGLQKDFGDH----RVIDTPLAESGII
Mflv_3923|M.gilvum_PYR-GCK PSRSESEHDWVESSHASSALSYADGLAKAFELNGHRNRHVVAVVGDGALT
: . ...: ::** : * . : :.:..:
Mb2524c|M.bovis_AF2122/97 G------------------IAVGLALRGFVPVP-----------------
Rv2496c|M.tuberculosis_H37Rv G------------------IAVGLALRGFVPVP-----------------
MMAR_3843|M.marinum_M G------------------IAVGLALRGFVPVP-----------------
MUL_3774|M.ulcerans_Agy99 G------------------IAVGLALRGFVPVP-----------------
MAV_1676|M.avium_104 G------------------IAVGLALRGFVPVP-----------------
MSMEG_4711|M.smegmatis_MC2_155 G------------------IAVGFAIRGFVPVP-----------------
TH_0717|M.thermoresistible__bu G------------------IAIGLAIRGFVPVP-----------------
Mvan_4085|M.vanbaalenii_PYR-1 G------------------IAVGMAIRGLVPVP-----------------
MAB_4917c|M.abscessus_ATCC_199 G------------------TAVGLAMRGYRPVC-----------------
Mflv_3923|M.gilvum_PYR-GCK GGMCWEALNNIAASRRPVVIVVNDNGRSYAPTIGGFAEHLAGLRLQPGYE
* .:. *. *.
Mb2524c|M.bovis_AF2122/97 EIQFDG------------FSYPAFDQVVS---------------------
Rv2496c|M.tuberculosis_H37Rv EIQFDG------------FSYPAFDQVVS---------------------
MMAR_3843|M.marinum_M EIQFDG------------FSYPAFDQVVS---------------------
MUL_3774|M.ulcerans_Agy99 EIQFDD------------FSYPAFDQVVS---------------------
MAV_1676|M.avium_104 EIQFDG------------FSYPAFDQVVS---------------------
MSMEG_4711|M.smegmatis_MC2_155 EIQFDG------------FSYPAFDQIAS---------------------
TH_0717|M.thermoresistible__bu EIQFDG------------FSYPAFDQIVS---------------------
Mvan_4085|M.vanbaalenii_PYR-1 EIQFDG------------FAAPAFDQMVS---------------------
MAB_4917c|M.abscessus_ATCC_199 EIQFDG------------FVYPAFDQIVS---------------------
Mflv_3923|M.gilvum_PYR-GCK RVLEEGRKAVRGVPMIGEFCYQCMHSIKAGIKDALSPQVMFTDLGLKYVG
.: :. * .:..: :
Mb2524c|M.bovis_AF2122/97 -------HLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVH
Rv2496c|M.tuberculosis_H37Rv -------HLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVH
MMAR_3843|M.marinum_M -------HLAKYRTRTRGEVNMAVTVRIPSFGGIGAAEHHSDSTESYWAH
MUL_3774|M.ulcerans_Agy99 -------HLAKYRTRTRGEVNMAVTVRIPSFGGIGAAEHHLDATESYWAH
MAV_1676|M.avium_104 -------HLAKYRTRTRGAIDMPVTVRVPSFGGIGAAEHHSESTESYWAH
MSMEG_4711|M.smegmatis_MC2_155 -------HLAKYRMRTHGDIDMPVTVRIPSFGGIGAVEHHSESTETYWLH
TH_0717|M.thermoresistible__bu -------HLAKYRMRTRGDVEMRVTVRIPSFGGIGAVEHHSESTETYWLH
Mvan_4085|M.vanbaalenii_PYR-1 -------HLAKYRMRTRGDVDMPVTVRIPSFGGIGAVEHHSESTETYWLH
MAB_4917c|M.abscessus_ATCC_199 -------QVAKLHYRTKGAVGMPLTIRIPFGGGIGAVEHHSESPEAYFAH
Mflv_3923|M.gilvum_PYR-GCK PIDGHDESAVEGALRHARAFNAPVVVHVVTRKGMGYAPAENDVDEQMHAC
.: * . :.::: *:* . . : *
Mb2524c|M.bovis_AF2122/97 -----TAGLKVVVPST-------------PGDAYWLLRHAIACPDPVMYL
Rv2496c|M.tuberculosis_H37Rv -----TAGLKVVVPST-------------PGDAYWLLRHAIACPDPVMYL
MMAR_3843|M.marinum_M -----TAGLKVVVPST-------------PGDAYWLLRHAIACPDPVMYL
MUL_3774|M.ulcerans_Agy99 -----TAGLKVVVPST-------------PGDAYWLLRHAIACPDPVMYL
MAV_1676|M.avium_104 -----TAGLKVVVPSN-------------PADAYWLLRHAIACPDPVMYL
MSMEG_4711|M.smegmatis_MC2_155 -----TAGLKVVVPST-------------PSDAYWLLRESISSPDPVIYL
TH_0717|M.thermoresistible__bu -----TAGLKVVAPGT-------------PADAYWLLRHAITCPDPVIYL
Mvan_4085|M.vanbaalenii_PYR-1 -----TAGLKVVTPST-------------PTDAYWLLRYAIASRDPVIFL
MAB_4917c|M.abscessus_ATCC_199 -----TAGLRVVSCSS-------------PQDAYDMIRQAVACDDPVVFF
Mflv_3923|M.gilvum_PYR-GCK GVIDPETGLATSVPGPGWTAAFSETLIELAAKRRDIVAITAAMPGPTGLS
:** . . . . :: : : .*.
Mb2524c|M.bovis_AF2122/97 EPKRRYHSRGM-VDTSRPEPPIGHAMVRRSGTDVTVVTYGNLVSTALSSA
Rv2496c|M.tuberculosis_H37Rv EPKRRYHGRGM-VDTSRPEPPIGHAMVRRSGTDVTVVTYGNLVSTALSSA
MMAR_3843|M.marinum_M EPKRRYQVRGP-VDTSRPEPAIGQAMIRRAGADVTVITYGNLVSTALSAA
MUL_3774|M.ulcerans_Agy99 EPKRRYQVRGP-VDTSRPEPAIGQAMIRRAGADVTVITYGNLVSTALSAA
MAV_1676|M.avium_104 EPKRRYQGRGL-VDAGRPEPPIGRAMVRRAGTDVTVVTYGSLVATAVGAA
MSMEG_4711|M.smegmatis_MC2_155 EPKRRYWAREA-VDTTTPALPIGRAAVRRNGSDVTVITYGGLVATALSAA
TH_0717|M.thermoresistible__bu EPKRRYWARGP-VDTTTPAGPLGRAAVARSGTDVTVITYGSLVTTALSAA
Mvan_4085|M.vanbaalenii_PYR-1 EPKRRYWAKEV-VDTGNPADPIGRAAIRRAGDDVTVLTYGPLVATALNAA
MAB_4917c|M.abscessus_ATCC_199 EPKRRYWEKGE-VDTALVPVPLGAARVVRSGTAATIAAYGPMVAVANAAA
Mflv_3923|M.gilvum_PYR-GCK AFRKRFPDRFFDVGIAEQHAMTSAAGLAMGGMHPVVALYSTFLNRAFDQM
::*: : *. . * : * .: *. :: *
Mb2524c|M.bovis_AF2122/97 DTAEQQHDWSLEVIDLRS------------LAPLDFDTIAASIQRTG---
Rv2496c|M.tuberculosis_H37Rv DTAEQQHDWSLEVIDLRS------------LAPLDFDTIAASIQRTG---
MMAR_3843|M.marinum_M EDAAHQQGWSLEVIDLRS------------LIPLDFETIAASIRRTG---
MUL_3774|M.ulcerans_Agy99 EDAAHQQGWSLEVIDLRS------------LIPLDFETIAASIRRTG---
MAV_1676|M.avium_104 EEAQHQRGWSLEVIDLRS------------LVPLDFDTIATSIHRTG---
MSMEG_4711|M.smegmatis_MC2_155 ELAED-RGWSMEVVDLRS------------LNPLDFDTVADSVRRTG---
TH_0717|M.thermoresistible__bu ELAADTHGWSLEVVDLRS------------LNPLDFDTIAESVRRTG---
Mvan_4085|M.vanbaalenii_PYR-1 ELSPH----GLEVVDLRS------------LNPLDFDTVAASVRKTG---
MAB_4917c|M.abscessus_ATCC_199 ELAAT-EGISVEVVDLRS------------LSPVDFDTLEASVRKTG---
Mflv_3923|M.gilvum_PYR-GCK LMDVALHKLPVTMVLDRSGITGPDGASHNGMWDLSILGIVPGMRVAAPRD
: :: ** : :.: : .:: :.
Mb2524c|M.bovis_AF2122/97 ---------RCVVMHEGPRSLGYG--------------------------
Rv2496c|M.tuberculosis_H37Rv ---------RCVVMHEGPRSLGYG--------------------------
MMAR_3843|M.marinum_M ---------RCVVLHEGPRSLGYG--------------------------
MUL_3774|M.ulcerans_Agy99 ---------RCVVLHEGPRSLGYG--------------------------
MAV_1676|M.avium_104 ---------RCVVMHEGPRTLGYG--------------------------
MSMEG_4711|M.smegmatis_MC2_155 ---------RAVVMHEGPRTLGFG--------------------------
TH_0717|M.thermoresistible__bu ---------RAVVLHEGPRTLGFG--------------------------
Mvan_4085|M.vanbaalenii_PYR-1 ---------RAVVMHEGARTVGFG--------------------------
MAB_4917c|M.abscessus_ATCC_199 ---------RLIVVHEAPVFMGLG--------------------------
Mflv_3923|M.gilvum_PYR-GCK GARLREELAEAVEVKDGPTAVRFPKGDVGEDIPAIERRDGVDVLAVPADG
. : :::.. :
Mb2524c|M.bovis_AF2122/97 -------------AGLAARIQEEMFYQ-----------------------
Rv2496c|M.tuberculosis_H37Rv -------------AGLAARIQEEMFYQ-----------------------
MMAR_3843|M.marinum_M -------------AGLAARIQEELFYE-----------------------
MUL_3774|M.ulcerans_Agy99 -------------AGLAARIQEELFYE-----------------------
MAV_1676|M.avium_104 -------------AELAARIQEELFYE-----------------------
MSMEG_4711|M.smegmatis_MC2_155 -------------AELAARISEELFYD-----------------------
TH_0717|M.thermoresistible__bu -------------AELAARITEELFYD-----------------------
Mvan_4085|M.vanbaalenii_PYR-1 -------------AELAARISEECFYD-----------------------
MAB_4917c|M.abscessus_ATCC_199 -------------AEIAARITERCFYH-----------------------
Mflv_3923|M.gilvum_PYR-GCK LSDDVLIIAVGAFAAMSVAVAERLRDQGIGVTVVDPRWVLPVPAAINTLA
* ::. : *. .
Mb2524c|M.bovis_AF2122/97 --------------------LEAPVLRACGFDTPYPPARLEKLWLPGPDR
Rv2496c|M.tuberculosis_H37Rv --------------------LEAPVLRACGFDTPYPPARLEKLWLPGPDR
MMAR_3843|M.marinum_M --------------------LEAPVLRACGFDTPYPPARLERLWLPGPDR
MUL_3774|M.ulcerans_Agy99 --------------------LEAPVLRACGFDTPYPPARLERLWLPGPDR
MAV_1676|M.avium_104 --------------------LEAPVLRACGFDTPYPPARLEKWWLPGPDR
MSMEG_4711|M.smegmatis_MC2_155 --------------------LEAPVLRATGFDTPYPPARLEKLWLPGVDR
TH_0717|M.thermoresistible__bu --------------------LEAPVLRATGFDTPYPPARLEKLWLPGPDR
Mvan_4085|M.vanbaalenii_PYR-1 --------------------LEAPVLRATGFDTPYPPARLEKLWLPGVDR
MAB_4917c|M.abscessus_ATCC_199 --------------------LEAPVLRVGGFALPYPANKVEHHYLPDAER
Mflv_3923|M.gilvum_PYR-GCK AAHKLVVTVEDNGGHGGVGSAVSAALRRAEIDVPCRDAALPQAFFDHASR
:..** : * : : :: .*
Mb2524c|M.bovis_AF2122/97 -----LLDCVERVLRQP----------------------
Rv2496c|M.tuberculosis_H37Rv -----LLDCVERVLRQP----------------------
MMAR_3843|M.marinum_M -----LLDCVERVLGQP----------------------
MUL_3774|M.ulcerans_Agy99 -----LLDCVERVLGQP----------------------
MAV_1676|M.avium_104 -----LLDCVERTLELP----------------------
MSMEG_4711|M.smegmatis_MC2_155 -----LLDCVERAMEQP----------------------
TH_0717|M.thermoresistible__bu -----LLDCVERSLGYP----------------------
Mvan_4085|M.vanbaalenii_PYR-1 -----LLDCVDKAMGQP----------------------
MAB_4917c|M.abscessus_ATCC_199 -----VMDAVDRAIAA-----------------------
Mflv_3923|M.gilvum_PYR-GCK GEVLAEVGLTERTIARQITGWVAALGATAGDRQVSESVD
:. .:: :