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MPRQRSLTRPQIAAAALEVVDTDGLGSLSMRTVARRLGMGTMSLYRYVADRDELEAMVVELVLESVDLRP PAGSARHRILVLAERVRDATARHPAVVPLLLAHRHRLPASLRWGEAVLGVLAEAGYAGKRRVYAFRALLA CTFGALEIQHHSALSGPGTRALAELPADEFPRLSETAAAARGIGAGDEFRHGLEILLRGLQI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2583 | - | - | 100% (202) | putative transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_3332 | - | 1e-19 | 29.52% (210) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_0442 | - | 4e-11 | 28.57% (203) | tetracycline repressor domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1388c | - | 6e-09 | 27.83% (212) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_1322 | - | 5e-10 | 27.03% (185) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1353c | - | 6e-09 | 27.83% (212) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3216c | - | 7e-14 | 28.24% (216) | TetR family transcriptional regulator |
| M. marinum M | MMAR_3679 | - | 2e-23 | 31.19% (202) | putative regulatory protein |
| M. avium 104 | MAV_5055 | - | 1e-12 | 27.72% (202) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_0654 | - | 4e-09 | 27.27% (198) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_3622 | - | 1e-23 | 31.19% (202) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_1315 | - | 3e-19 | 34.13% (208) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2583|M.smegmatis_MC2_155 -------------------------MP--------------RQRSLTRPQ
Mvan_1315|M.vanbaalenii_PYR-1 MSYAHGCTAVRLDRMTNEEERGTPPLPRALEVLWHDRAGGGRARRLSRQR
MMAR_3679|M.marinum_M --------MFTLRTMYLSTVWEG-----------------DVRARFTVSD
MUL_3622|M.ulcerans_Agy99 MISIRTSYVFTLRTMYLSTVWEG-----------------DVRARFTVSD
Mb1388c|M.bovis_AF2122/97 -----------MQTTPGKRQRRQ-------------------RGSINPED
Rv1353c|M.tuberculosis_H37Rv -----------MQTTPGKRQRRQ-------------------RGSINPED
TH_0654|M.thermoresistible__bu -------------------------------------------VQLRKSD
Mflv_1322|M.gilvum_PYR-GCK --------------------------------------------------
MAB_3216c|M.abscessus_ATCC_199 MARAQKCTVGVTDAVDETESGTVAGGAE-----------GRRPRSLTRAE
MAV_5055|M.avium_104 ----------------------------------------MRRAGLKREA
MSMEG_2583|M.smegmatis_MC2_155 IAAAALEVVDTDGLGSLSMRTVARRLGMGTMSLYRYVADRDELEAMVVEL
Mvan_1315|M.vanbaalenii_PYR-1 IVEAAIELADRDGLGALSMARLAERLGCGTMSLYRHVANKDELVTFMVSA
MMAR_3679|M.marinum_M IASAALAIVDQDGLSGLSMRSLAAALGTGPMTLYNYVRDRRELEALVADA
MUL_3622|M.ulcerans_Agy99 IASAALAIVDQDGLSGLSMRSLAAALGTGPMTLYNYVRDRRELEALVADA
Mb1388c|M.bovis_AF2122/97 IISGAFELAQQVSIDNLSMPLLGKHLGVGVTSIYWYFRKKDDLLNAMTDR
Rv1353c|M.tuberculosis_H37Rv IISGAFELAQQVSIDNLSMPLLGKHLGVGVTSIYWYFRKKDDLLNAMTDR
TH_0654|M.thermoresistible__bu VVDAATAILDNYGIADLTTRRLARELGVTAGALYWHFANKQELLGAVADR
Mflv_1322|M.gilvum_PYR-GCK -MKHLLELARRVGVDHVTMRGLAAEAGTSASSVYYHVKDKAALMDLLAES
MAB_3216c|M.abscessus_ATCC_199 ILDTAIALVDSEGLDQLTMRRLGSACGVEAMALYRHVHGRQDLLGGIVDH
MAV_5055|M.avium_104 VVRAAVKIADAEGIEAISMRRVSQALGVTPMALYRYLPDKDALIDVVVDE
: .: :: :. * ::* :. : * :..
MSMEG_2583|M.smegmatis_MC2_155 VLESVDLRPP-----AGSARHRILVLAERVRDATARHPAVVPLLLAHRHR
Mvan_1315|M.vanbaalenii_PYR-1 APGHPPGTTD-----RADWRDALTDWAVGLWDVYHRHPWILHATVIGPPA
MMAR_3679|M.marinum_M VVADVKVPAP-----TDDWRADVHAIATAMWETMRQHPNAIPLVLTRRTV
MUL_3622|M.ulcerans_Agy99 VVADVKVPAP-----IDDWRADVHAIATAMWETMRQHPNAIPLVLTRRTV
Mb1388c|M.bovis_AF2122/97 ALSKYVFATPYI--EAGDWRETLRNHARSMRKTFADNPVLCDLILIRAAL
Rv1353c|M.tuberculosis_H37Rv ALSKYVFATPYI--EAGDWRETLRNHARSMRKTFADNPVLCDLILIRAAL
TH_0654|M.thermoresistible__bu ILTPVPAGEP-----EPGWAERISSTAGRLRDALLSHTDGAELVSATFAA
Mflv_1322|M.gilvum_PYR-GCK VIESIEVPAD------GDWRRRISALYTNAWTVMYDIPGVAAMLQQRPLA
MAB_3216c|M.abscessus_ATCC_199 LVDKLYDDQLAARRQEDGWQDYLVRLAHGVREIAIGHPHLFPTLATRPPE
MAV_5055|M.avium_104 SLAVVPVPDP-----SGSVTAELLRCFGGLYDLLLDHPGLARAAGERPLE
. : .
MSMEG_2583|M.smegmatis_MC2_155 LPAS--LRW----GEAVLGVLAEAGYAGKRRVYAFRALLACTFGALEIQH
Mvan_1315|M.vanbaalenii_PYR-1 DPGQ--LAW----LDAGLAALSGTGLSERDKLAAVMALLHFVRGASALDI
MMAR_3679|M.marinum_M SASS--YMV----ADRLIAALGRSGVGDADLLASFRGVLGLVMGSAQAEL
MUL_3622|M.ulcerans_Agy99 WASS--YMV----ADRLIAALGRSGVGDADLLASFRGVLGLVMGSAQAEL
Mb1388c|M.bovis_AF2122/97 SPKT--ARLGAQEMEKAIANLVTAGLSLEDAFDIYSAVSVHVRGSVVLDR
Rv1353c|M.tuberculosis_H37Rv SPKT--ARLGAQEMEKAIANLVTAGLSLEDAFDIYSAVSVHVRGSVVLDR
TH_0654|M.thermoresistible__bu GQSR--VLD--EILARFAAAAAAAGLEGSRAVLAARTIVHYVLGFTGDEQ
Mflv_1322|M.gilvum_PYR-GCK GAAH--AMD-----RTARAIMAEAGWDGEQISRAHAVLYIHLLGSIQLAH
MAB_3216c|M.abscessus_ATCC_199 APWVRPPLRSMKWMETFLDTLISYGFDDRAAVSAYRAYTTFLLGQLLLEV
MAV_5055|M.avium_104 GPFATRLGN------NVLTLLQHNKIDEADAANLLVSAFSLTLGCALYRT
*
MSMEG_2583|M.smegmatis_MC2_155 HSALSGPGTRALAELP-----ADEFPRLSETAAAARGIGAGD---EFRHG
Mvan_1315|M.vanbaalenii_PYR-1 EAADHHDTAPDYPALLRRLVTGERFPALAAALQAEAFDADGDRLADFRSG
MMAR_3679|M.marinum_M AGPLAGTGREKEQVAVAARIGGLAGAEHPHIAALAQASQRSTPAADFERA
MUL_3622|M.ulcerans_Agy99 AGPLAGTGREKEQVAVAARIGGLAGAEHPHIAALAQASQRSTPAADFERA
Mb1388c|M.bovis_AF2122/97 LSRKSQSAGSGPSAIEHPVAIDPATTPLLAHATGRGHRIGAPDETNFEYG
Rv1353c|M.tuberculosis_H37Rv LSRKSQSAGSGPSAIEHPVAIDPATTPLLAHATGRGHRIGAPDETNFEYG
TH_0654|M.thermoresistible__bu SRLQWDAAG----------------------AEVAEPPADDNPSARFAFG
Mflv_1322|M.gilvum_PYR-GCK HLRDS----------------------------GIDGGSDDGAHSVFQHG
MAB_3216c|M.abscessus_ATCC_199 SARGASLSSVEDELPEKTLR---SLSSYPNLQRMQKQLSEDHSATEFEEA
MAV_5055|M.avium_104 SRSGRTASSRLSQVG---------DEAPAVRRLRGRLTVASADDTVFRDA
* .
MSMEG_2583|M.smegmatis_MC2_155 LEILLRGLQI-----------------------------------
Mvan_1315|M.vanbaalenii_PYR-1 LDQFLDGIDSRVRRSR-----------------------------
MMAR_3679|M.marinum_M LDILLAGIESFERRRDRR---------------------------
MUL_3622|M.ulcerans_Agy99 LDILLAGIESFERRRDRR---------------------------
Mb1388c|M.bovis_AF2122/97 LECILDHAGRLIEQSSKAAGEVAVRRPTATADAPTPGARAKAVAR
Rv1353c|M.tuberculosis_H37Rv LECILDHAGRLIEQSSKAAGEVAVRRPTATADAPTPGARAKAVAR
TH_0654|M.thermoresistible__bu LNLLINGIAAEIDAAARKSE-------------------------
Mflv_1322|M.gilvum_PYR-GCK LRVILTGLQHTSPLP------------------------------
MAB_3216c|M.abscessus_ATCC_199 LESLLDRLENGAPR-------------------------------
MAV_5055|M.avium_104 LTRLIAGYVTTAAKTGGRRR-------------------------
* ::