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AKQATAEKRQRRERGSINPDDIIKGAFELAEQVGIDNLSMPLLGKHLGVGVTSIYWYFRKKDDLLNAMTD RALRQYAFATPYVEAKDWRETLANHARSMRQTFNGNPILCDLILIRSALSPRAAKLGVQEVERAIGSLVE AGLSPEDAFDTYSAMSVHVRGSVVLQRLREKNLAGEDGHGDIDDTMTIDPESAPLLAAVTQKGHHLSASD DRNFEYGLECILDHAARLIEQNAKPARKATPAKSTARKR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1989 | - | - | 100% (250) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1315 | - | 9e-11 | 27.75% (209) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_2792 | - | 2e-08 | 27.17% (173) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1388c | - | 4e-96 | 70.08% (244) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_4355 | - | 1e-126 | 91.39% (244) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1353c | - | 4e-96 | 70.08% (244) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1508c | - | 7e-54 | 45.30% (234) | putative HTH-type transcriptional regulator |
| M. marinum M | MMAR_4019 | - | 1e-104 | 73.90% (249) | transcriptional regulatory protein |
| M. avium 104 | MAV_1586 | - | 1e-107 | 75.49% (253) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_2225 | - | 1e-106 | 78.14% (247) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_1116 | - | 2e-93 | 71.37% (234) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN |
| M. ulcerans Agy99 | MUL_3884 | - | 1e-102 | 72.29% (249) | transcriptional regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1989|M.vanbaalenii_PYR-1 --------MAKQATAE------KRQRRERGSINPDDIIKGAFELAEQVGI
Mflv_4355|M.gilvum_PYR-GCK --------MARQATAE------KRQRRERGSINPDDIIKGAFELAEQVGI
MSMEG_2225|M.smegmatis_MC2_155 --------MAKQPAAE------KRQRRERGSINPEDIIKGAFELAEKVSI
MMAR_4019|M.marinum_M ---MEVPVVAKRAAAD------KRQRRERGSINPDDIISGAFELAEQVSI
MUL_3884|M.ulcerans_Agy99 ---MEVPVVAKRAAAD------KRQRRERGSINPDDIISGAFELAEQVSI
MAV_1586|M.avium_104 --------MAKQATAD------KRQRRERGSINPDDIITGAFELAEQVSI
Mb1388c|M.bovis_AF2122/97 ----------MQTTPG------KRQRRQRGSINPEDIISGAFELAQQVSI
Rv1353c|M.tuberculosis_H37Rv ----------MQTTPG------KRQRRQRGSINPEDIISGAFELAQQVSI
TH_1116|M.thermoresistible__bu --------VAKQATAD------KRRRRERGSINPDDIVAGAFELAEEVGI
MAB_1508c|M.abscessus_ATCC_199 MRHAGVGHEARTTSTQGPSHSPKRERRRRGSITAEDIIAGAFELAEEIGI
.:. **.**.****..:**: ******:::.*
Mvan_1989|M.vanbaalenii_PYR-1 DNLSMPLLGKHLGVGVTSIYWYFRKKDDLLNAMTDRALRQYAFATPYVEA
Mflv_4355|M.gilvum_PYR-GCK DNLSMPLLGKHLGVGVTSIYWYFRKKDDLLNAMTDRALRQYAFATPYVEA
MSMEG_2225|M.smegmatis_MC2_155 DNLSMPLLGKHLGVGVTSIYWYFRKKDDLLNAMTDRALREFVVATPYVEA
MMAR_4019|M.marinum_M DNLSMPMLGKHLGVGVTSIYWYFRKKDDLLNAMTDRALSKYVFATPYVEA
MUL_3884|M.ulcerans_Agy99 DNLSMPMLGKHLGVGVTSIYWYFRKKDDLLNAMTDRALSKYVFATPYVEG
MAV_1586|M.avium_104 DNLSMPLLGKHLGVGVTSIYWYFRKKDDLLNAMTDRALSKYVFATPYVEA
Mb1388c|M.bovis_AF2122/97 DNLSMPLLGKHLGVGVTSIYWYFRKKDDLLNAMTDRALSKYVFATPYIEA
Rv1353c|M.tuberculosis_H37Rv DNLSMPLLGKHLGVGVTSIYWYFRKKDDLLNAMTDRALSKYVFATPYIEA
TH_1116|M.thermoresistible__bu DNLSMPLLGKHLGVGVTSIYWYFRKKDDLLNEMTNRALRQYVFETPYVEA
MAB_1508c|M.abscessus_ATCC_199 SGLSMPLLAKHLDVGVTSIYWYFRKKGELLDAMTDRATKQYHFAAPFVGD
..****:*.***.*************.:**: **:** :: . :*::
Mvan_1989|M.vanbaalenii_PYR-1 KDWRETLANHARSMRQTFNGNPILCDLILIR-SALSPRAAKLGVQEVERA
Mflv_4355|M.gilvum_PYR-GCK RDWRETLANHARTMRKTFNGNPILCDLILIR-SALSPRAAKVGVQQVEKA
MSMEG_2225|M.smegmatis_MC2_155 KDWRESLANHARTMRKAFMGNPILCDLILIR-SALSPRAARVGVQEVESA
MMAR_4019|M.marinum_M SDWRETLRNHARLMRKTFMGNPILCDLILIR-SALSPKAARLGAQEMERA
MUL_3884|M.ulcerans_Agy99 SDWRETLRNHARLMRKTFMSNPILCDLILIR-SALSPKTARLGAQKMERA
MAV_1586|M.avium_104 SDWRETLRNHARLMRKTFMGNPILCDLILIR-AALSPKAARLGAQEMEKA
Mb1388c|M.bovis_AF2122/97 GDWRETLRNHARSMRKTFADNPVLCDLILIR-AALSPKTARLGAQEMEKA
Rv1353c|M.tuberculosis_H37Rv GDWRETLRNHARSMRKTFADNPVLCDLILIR-AALSPKTARLGAQEMEKA
TH_1116|M.thermoresistible__bu GNWRESLRNHARNMRKTFLSSPILTDLVLIR-GALNTKIRKLGLQQMEAA
MAB_1508c|M.abscessus_ATCC_199 ETWQDALRSHTHRMREAFRERPVLVELILMRTSELSSEALQASIQNLESL
*:::* .*:: **::* *:* :*:*:* . *... : . *::*
Mvan_1989|M.vanbaalenii_PYR-1 IGSLVEAGLSPEDAFDTYSAMSVHVRGSVVLQRLREKNLAGEDGHGDIDD
Mflv_4355|M.gilvum_PYR-GCK IGSLVEAGLSPEDAFDTYSAMSVHVRGSVVLQRLREKNLAGDDGHGDIDD
MSMEG_2225|M.smegmatis_MC2_155 IAGLVEAGLSVEDAFDTYSAVSVHVRGSVVLHRLYEKNRANDNAPGDFEE
MMAR_4019|M.marinum_M IANLVEAGLSPEDAFDTYAAVSIHVRGSVVLHRLYEKTQSADSGPRAIED
MUL_3884|M.ulcerans_Agy99 IANLVEAGLSPEDAFDTYAAVSIHVRGSVVLHRLYEKTQSADSGPRAIED
MAV_1586|M.avium_104 VANLVQAGLSPEDAFDTYSAISVHVRGSVVLQRLYEKNQSSDVGPRAIED
Mb1388c|M.bovis_AF2122/97 IANLVTAGLSLEDAFDIYSAVSVHVRGSVVLDRLSRKSQSAGSGPSAIEH
Rv1353c|M.tuberculosis_H37Rv IANLVTAGLSLEDAFDIYSAVSVHVRGSVVLDRLSRKSQSAGSGPSAIEH
TH_1116|M.thermoresistible__bu IDSLVQAGLSPEDAFDTYSAVSVHVRGSVVLERLHEKTQDLFNGG---DE
MAB_1508c|M.abscessus_ATCC_199 VRTLIGVGFSPDNALDVYFALSLHIRGVVVLEHMDTVMPASGEAR-----
: *: .*:* ::*:* * *:*:*:** ***.:: .
Mvan_1989|M.vanbaalenii_PYR-1 TMTIDPESAPLLAAVTQKGHHLSASDDRNFEYGLECILDHAARLIEQNAK
Mflv_4355|M.gilvum_PYR-GCK TMAIDPETAPLLAAVTQKGHHLSASDDRNFEFGLDCILENAARLIEK-AK
MSMEG_2225|M.smegmatis_MC2_155 AMVIDPETTPLLAQVTSEGHRIGAADEQNFEYGLKCILDHAARLIEE--K
MMAR_4019|M.marinum_M AMNIDPLTTPLLAQVSGKGHRIATPDEANFEYGLDCILDHAGRLIDERAK
MUL_3884|M.ulcerans_Agy99 AMNIDPLTTPLLAQVSGKGHRIATPDEANFEYGLDCILDHAGRLIDERAK
MAV_1586|M.avium_104 AVAIDPEKTPLLAQVTRIGHRIGAPDETNFEYGLTCILDHASRLIEE-GK
Mb1388c|M.bovis_AF2122/97 PVAIDPATTPLLAHATGRGHRIGAPDETNFEYGLECILDHAGRLIEQSSK
Rv1353c|M.tuberculosis_H37Rv PVAIDPATTPLLAHATGRGHRIGAPDETNFEYGLECILDHAGRLIEQSSK
TH_1116|M.thermoresistible__bu PSAVDPASTPIIAELLAKGHRLAEADERNFEYTLECILDHAERLIEERAA
MAB_1508c|M.abscessus_ATCC_199 SLVPSATLAPTLHELASRGHSIATISDANFDFTVEAIIERAENLLAQDIA
. .. :* : ** :. .: **:: : .*::.* .*: :
Mvan_1989|M.vanbaalenii_PYR-1 PARKATPA---------KSTARKR-----
Mflv_4355|M.gilvum_PYR-GCK TTRKAP--------------ARKR-----
MSMEG_2225|M.smegmatis_MC2_155 PAKKTR---------------RKVTAG--
MMAR_4019|M.marinum_M AAKSAPSR-PRKAAKPPAPRTRAKATTR-
MUL_3884|M.ulcerans_Agy99 AAKSAPSR-PRKAAKPPAPRTRAKATTR-
MAV_1586|M.avium_104 GAKAGPSR-QRKPAKSSAARGRTKAPANR
Mb1388c|M.bovis_AF2122/97 AAGEVAVRRPTATADAPTPGARAKAVAR-
Rv1353c|M.tuberculosis_H37Rv AAGEVAVRRPTATADAPTPGARAKAVAR-
TH_1116|M.thermoresistible__bu GGTRK------------------------
MAB_1508c|M.abscessus_ATCC_199 AREAS------------------------