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TSTVSYEFADSVATISLDDGKVNVLGPAMQAAINEALDRAEADKAKAVVLAGNSRVFSGGFDLSVFQSGD AAAALGMLAGGFELSLRTLTFPAPVIVAATGPAIAMGSFLLLSTDHRVGQPKSRCQAIEVAIGMTIPISA LEIMRMRLTPAAFERGAALAATFAGDDAVAGGWLDEIVPADQVLARAQQVAGEAAATLHPGAHLATKLKA RKPALDAIRAGIDGLATEFSLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1226 | - | - | 100% (233) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_4992 | - | 4e-11 | 33.15% (178) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_4083 | - | 5e-10 | 27.14% (199) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0649c | echA3 | 3e-66 | 55.60% (232) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_5125 | - | 1e-112 | 88.41% (233) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv0632c | echA3 | 3e-66 | 55.60% (232) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02498 | - | 7e-08 | 25.26% (190) | putative enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_3124 | - | 2e-09 | 29.29% (198) | enoyl-CoA hydratase |
| M. marinum M | MMAR_0962 | echA3 | 7e-68 | 56.47% (232) | enoyl-CoA hydratase, EchA3 |
| M. avium 104 | MAV_4534 | - | 2e-66 | 56.03% (232) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_1331 | - | 7e-87 | 70.94% (234) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_1874 | echA3 | 2e-91 | 71.67% (233) | PROBABLE ENOYL-CoA HYDRATASE ECHA3 (ENOYL HYDRASE) |
| M. ulcerans Agy99 | MUL_0713 | echA3 | 5e-68 | 56.47% (232) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1226|M.vanbaalenii_PYR-1 MTSTVSYEF-ADSVATISLDDG-KVNVLGPAMQAAINEALDR----AEAD
Mflv_5125|M.gilvum_PYR-GCK MTGTVSYDL-ADSVATVTLDDG-KVNVLGPAMQAAINNALDR----AEAD
MSMEG_1331|M.smegmatis_MC2_155 MSSLVSYAL-NGNVATVTLDDG-KANALSPDMQAAINDALDQASLAAGSG
TH_1874|M.thermoresistible__bu MSSTVEYQL-TDSVATITMDDG-KVNVLSPAMQGNLNEALDR----AEQD
Mb0649c|M.bovis_AF2122/97 MSDPVSYTR-KDSIAVISMDDG-KVNALGPAMQQALNAAIDN----ADRD
Rv0632c|M.tuberculosis_H37Rv MSDPVSYTR-KDSIAVISMDDG-KVNALGPAMQQALNAAIDN----ADRD
MMAR_0962|M.marinum_M MSGPVTYTH-DDAIGVIRMDDG-KVNVLGPTMQQALNEAIDA----ADRD
MUL_0713|M.ulcerans_Agy99 MSGPVTYTH-DDAIGVIRMDDG-KVNVLGPTMQQALNEAIDA----ADRD
MAV_4534|M.avium_104 MSGPVHYST-KGPVAVIRMDDG-KVNALGPTMQQALGEAIDR----AEAD
MLBr_02498|M.leprae_Br4923 MTIAVHYD---EKIAILELGD--DENRFTSVFLEEINSHLDE----IIAS
MAB_3124|M.abscessus_ATCC_1997 MTEPILLTHTEDRICTITLNRPQARNALSTALGEEIVKAVTAA---DADE
*: : : : :. * : . : : :
Mvan_1226|M.vanbaalenii_PYR-1 KAKAVVLAGNSRVFSGGFDLSVFQSG--DAAAALGMLAGGFELSLRTLTF
Mflv_5125|M.gilvum_PYR-GCK KAKAVVLAGNSRVFSGGFDLGVFQSG--DAAAALGMLSGGFELSVRTLTF
MSMEG_1331|M.smegmatis_MC2_155 EVKALVVAGNSKVFSGGFDLSVFASG--DAAAALGMLTGGFELAVRCLTF
TH_1874|M.thermoresistible__bu GAKAVVLAGNSRVFSGGFDLSVFSSG--DVDAALGMLRGGFELAVRALTF
Mb0649c|M.bovis_AF2122/97 DVGALVITGNGRVFSGGFDLKILTSG--EVQPAIDMLRGGFELAYRLLSY
Rv0632c|M.tuberculosis_H37Rv DVGALVITGNGRVFSGGFDLKILTSG--EVQPAIDMLRGGFELAYRLLSY
MMAR_0962|M.marinum_M NVGALVIAGNHRVFSGGFDLKVLTSG--EAKPAIDMLRGGFELSYRLLSY
MUL_0713|M.ulcerans_Agy99 NVGALVIAGNHRVFSGGFDLKVLTSG--EAKPAIDMLRGGFELSYRLLSY
MAV_4534|M.avium_104 NAGALVITGNERVFSGGFDLKILTSG--EVQPAVNMLRGGFELAYRLLSY
MLBr_02498|M.leprae_Br4923 GANGLVTTALGKFYSNGLDLDWLSAHRDQTQWYVGKVQG---LLARLLTL
MAB_3124|M.abscessus_ATCC_1997 NVDVMILTAADPVFCAGVDLKELGSG-----------DRAESLDPWWPEL
. :: :. .:. *.** : : *
Mvan_1226|M.vanbaalenii_PYR-1 PAPVIVAATGPAIAMGSFLLLSTDHRVG-QPKSRCQAIEVAIGMTIPISA
Mflv_5125|M.gilvum_PYR-GCK PVPVIIAATGPAIAMGSFLLLSGDHRVG-QPKTRCQAIEVAIGMTIPIAA
MSMEG_1331|M.smegmatis_MC2_155 PVPVIMAATGPAIAMGSFLLLSGDHRVG-SPRSRCQANEVAIGMTLPIAA
TH_1874|M.thermoresistible__bu PVPVIMAATGPAIAMGSFLLLCGDHRVG-SERTRCQANEVAIGMILPVAA
Mb0649c|M.bovis_AF2122/97 PKPVVMACTGHAIAMGAFLLSCGDHRVA-AHAYNIQANEVAIGMTIPYAA
Rv0632c|M.tuberculosis_H37Rv PKPVVMACTGHAIAMGAFLLSCGDHRVA-AHAYNIQANEVAIGMTIPYAA
MMAR_0962|M.marinum_M PKPVVIACTGHAIAMGAFLLCSGDHRVA-AHAYNVQANEVAIGMTIPYAA
MUL_0713|M.ulcerans_Agy99 PKPVVIACTGHAIAMGAFLLCSGDHRVA-AHAYNIQANEVAIGMTIPYAA
MAV_4534|M.avium_104 PKPVVMACTGHAIAMGAFLLSSGDHRVA-AHAYNIQANEVAIGMVIPYAA
MLBr_02498|M.leprae_Br4923 PIPTAAAVVGHAFGAGAMLAMAHDFRVMRADRGYFCFPEVDIRIPFTPGM
MAB_3124|M.abscessus_ATCC_1997 SKPVIGAINGAAVTGGLELALACDILIA-SEKARFADTHARVGILPTWGL
. *. * * *. * * . * : .. : : . .
Mvan_1226|M.vanbaalenii_PYR-1 LEIMRMRLTPAAFERGAALAATFAGDDAVAGGWLDEIVPADQVLARAQQV
Mflv_5125|M.gilvum_PYR-GCK LEIMRARLTPAAFERSAALASTYVGDDAVAAGWLDEIVEADQVLTRAQQV
MSMEG_1331|M.smegmatis_MC2_155 IEIMRMRLTRAAFQRAISMAAVFSGDAAISAGWLDEIVEPDEVLDRAQQV
TH_1874|M.thermoresistible__bu LEIMRMRLTPAAYQHAVSLATTFTGDAAIRAGWLDEVVDTDRVLPRAREF
Mb0649c|M.bovis_AF2122/97 LEIMKLRLTRSAYQQATGLAKTFFGETALAAGFIDEIALPEVVVSRAEEA
Rv0632c|M.tuberculosis_H37Rv LEIMKLRLTRSAYQQATGLAKTFFGETALAAGFIDEIALPEVVVSRAEEA
MMAR_0962|M.marinum_M MEVLKLRLTPSAYQQAAGLAKTFFGETALAAGFIDEISLPEVVLSRAEEA
MUL_0713|M.ulcerans_Agy99 MEVLKLRLTPSAYQQAAGLAKTFFGETALAAGFIDEISLPEVVLSRAEEA
MAV_4534|M.avium_104 MEIMKLRLTPSAYQQASGLAKTFFGETALAAGFVDEIVLPEVVVDRAEEA
MLBr_02498|M.leprae_Br4923 AALIQAKLAPQAATASMTTGRRFGGGEAARLGIVDNTAAEDAVTAVAVDL
MAB_3124|M.abscessus_ATCC_1997 TTLLPLSVGRGLARRMSLTGDYLSAEDALRAGLVTEVVAHNELLPAAKRL
:: : . . * * : : : : *
Mvan_1226|M.vanbaalenii_PYR-1 AGEAAAT-------------------LHPGAHLATKLKARKPALDAIRAG
Mflv_5125|M.gilvum_PYR-GCK AAEAATT-------------------LHAGAHLATKLKARKYALDAIRAG
MSMEG_1331|M.smegmatis_MC2_155 ATEAAA--------------------LHTNAHVASKLKARADAVTAIRAG
TH_1874|M.thermoresistible__bu AAEVATT-------------------VHAHAHLASKLKARDAALKAIRAG
Mb0649c|M.bovis_AF2122/97 AREFAG--------------------LNQHAHAATKLRSRADALTAIRAG
Rv0632c|M.tuberculosis_H37Rv AREFAG--------------------LNQHAHAATKLRSRADALTAIRAG
MMAR_0962|M.marinum_M AREFAG--------------------LNQQAHNATKLRARAEALKAIRAG
MUL_0713|M.ulcerans_Agy99 AREFAG--------------------LNQQAHNATKLRARAEALKAIRAG
MAV_4534|M.avium_104 AAEFAE--------------------LNQRAHAATKLRARADALAAIRAG
MLBr_02498|M.leprae_Br4923 LHPLGG--------------------KDPGTLGVIKQTMFGHAAAALSAN
MAB_3124|M.abscessus_ATCC_1997 AATIAGNNQPAVRELLASYRRIESELVGNGLQVALDDAHRWIDQNSIAEG
. . . :: .
Mvan_1226|M.vanbaalenii_PYR-1 IDGLATEFSLG------
Mflv_5125|M.gilvum_PYR-GCK IDGLATEFTLG------
MSMEG_1331|M.smegmatis_MC2_155 IDGLAAEFGS-------
TH_1874|M.thermoresistible__bu IDGIATEFTGG------
Mb0649c|M.bovis_AF2122/97 IDGIAAEFGL-------
Rv0632c|M.tuberculosis_H37Rv IDGIAAEFGL-------
MMAR_0962|M.marinum_M IDGIEAEFGL-------
MUL_0713|M.ulcerans_Agy99 IDGIEAEFGL-------
MAV_4534|M.avium_104 IDGIEAEFGL-------
MLBr_02498|M.leprae_Br4923 A----------------
MAB_3124|M.abscessus_ATCC_1997 VEARRTAIMERGRSQNA