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SDPVSYTRKDSIAVISMDDGKVNALGPAMQQALNAAIDNADRDDVGALVITGNGRVFSGGFDLKILTSGE VQPAIDMLRGGFELAYRLLSYPKPVVMACTGHAIAMGAFLLSCGDHRVAAHAYNIQANEVAIGMTIPYAA LEIMKLRLTRSAYQQATGLAKTFFGETALAAGFIDEIALPEVVVSRAEEAAREFAGLNQHAHAATKLRSR ADALTAIRAGIDGIAAEFGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0632c | echA3 | - | 100% (231) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv3039c | echA17 | 2e-14 | 32.04% (181) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv2486 | echA14 | 6e-11 | 28.04% (214) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0649c | echA3 | 1e-127 | 100.00% (231) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_5125 | - | 5e-66 | 55.60% (232) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_01724 | - | 1e-12 | 30.54% (203) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_4588c | - | 9e-13 | 32.86% (213) | enoyl-CoA hydratase/isomerase |
| M. marinum M | MMAR_0962 | echA3 | 1e-109 | 84.85% (231) | enoyl-CoA hydratase, EchA3 |
| M. avium 104 | MAV_4534 | - | 1e-108 | 85.71% (231) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_1331 | - | 3e-70 | 55.98% (234) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_1874 | echA3 | 6e-71 | 59.13% (230) | PROBABLE ENOYL-CoA HYDRATASE ECHA3 (ENOYL HYDRASE) |
| M. ulcerans Agy99 | MUL_0713 | echA3 | 1e-109 | 85.28% (231) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_1226 | - | 4e-66 | 55.60% (232) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5125|M.gilvum_PYR-GCK MTGTVSYDLADS-----VATVTLDD-GKVNVLGPAMQAAINNALDR----
Mvan_1226|M.vanbaalenii_PYR-1 MTSTVSYEFADS-----VATISLDD-GKVNVLGPAMQAAINEALDR----
MSMEG_1331|M.smegmatis_MC2_155 MSSLVSYALNGN-----VATVTLDD-GKANALSPDMQAAINDALDQASLA
TH_1874|M.thermoresistible__bu MSSTVEYQLTDS-----VATITMDD-GKVNVLSPAMQGNLNEALDR----
Rv0632c|M.tuberculosis_H37Rv MSDPVSYTRKDS-----IAVISMDD-GKVNALGPAMQQALNAAIDN----
Mb0649c|M.bovis_AF2122/97 MSDPVSYTRKDS-----IAVISMDD-GKVNALGPAMQQALNAAIDN----
MMAR_0962|M.marinum_M MSGPVTYTHDDA-----IGVIRMDD-GKVNVLGPTMQQALNEAIDA----
MUL_0713|M.ulcerans_Agy99 MSGPVTYTHDDA-----IGVIRMDD-GKVNVLGPTMQQALNEAIDA----
MAV_4534|M.avium_104 MSGPVHYSTKGP-----VAVIRMDD-GKVNALGPTMQQALGEAIDR----
MAB_4588c|M.abscessus_ATCC_199 MADEVLIEQRDR-----VLLITINRPDARNAVNRAVSQGLAAAADQ---L
MLBr_01724|M.leprae_Br4923 MSEFVNIVVSDGSQDAGLAILLLSR-PPTNAMTRQFYREIAMAADEL---
*: * . : : :. *.: . : * *
Mflv_5125|M.gilvum_PYR-GCK AEADKAKAVVLAGNSRVFSGGFDLGVFQSGDAAAALGMLSGGFELSVRTL
Mvan_1226|M.vanbaalenii_PYR-1 AEADKAKAVVLAGNSRVFSGGFDLSVFQSGDAAAALGMLAGGFELSLRTL
MSMEG_1331|M.smegmatis_MC2_155 AGSGEVKALVVAGNSKVFSGGFDLSVFASGDAAAALGMLTGGFELAVRCL
TH_1874|M.thermoresistible__bu AEQDGAKAVVLAGNSRVFSGGFDLSVFSSGDVDAALGMLRGGFELAVRAL
Rv0632c|M.tuberculosis_H37Rv ADRDDVGALVITGNGRVFSGGFDLKILTSGEVQPAIDMLRGGFELAYRLL
Mb0649c|M.bovis_AF2122/97 ADRDDVGALVITGNGRVFSGGFDLKILTSGEVQPAIDMLRGGFELAYRLL
MMAR_0962|M.marinum_M ADRDNVGALVIAGNHRVFSGGFDLKVLTSGEAKPAIDMLRGGFELSYRLL
MUL_0713|M.ulcerans_Agy99 ADRDNVGALVIAGNHRVFSGGFDLKVLTSGEAKPAIDMLRGGFELSYRLL
MAV_4534|M.avium_104 AEADNAGALVITGNERVFSGGFDLKILTSGEVQPAVNMLRGGFELAYRLL
MAB_4588c|M.abscessus_ATCC_199 DSSADLSVAIITGAGGNFCAGMDLKAFVSGEAVLSE---RG---LGFTNV
MLBr_01724|M.leprae_Br4923 GRRDDVAAVILFGGHDIFSAGDDMQELRTLTAVEAGVAAEVRRQAVDAVA
. :: * *..* *: : : . :
Mflv_5125|M.gilvum_PYR-GCK TFPVPVIIAATGPAIAMGSFLLLSGDHRVGQPKTRCQAIEVAIGMTIPIA
Mvan_1226|M.vanbaalenii_PYR-1 TFPAPVIVAATGPAIAMGSFLLLSTDHRVGQPKSRCQAIEVAIGMTIPIS
MSMEG_1331|M.smegmatis_MC2_155 TFPVPVIMAATGPAIAMGSFLLLSGDHRVGSPRSRCQANEVAIGMTLPIA
TH_1874|M.thermoresistible__bu TFPVPVIMAATGPAIAMGSFLLLCGDHRVGSERTRCQANEVAIGMILPVA
Rv0632c|M.tuberculosis_H37Rv SYPKPVVMACTGHAIAMGAFLLSCGDHRVAAHAYNIQANEVAIGMTIPYA
Mb0649c|M.bovis_AF2122/97 SYPKPVVMACTGHAIAMGAFLLSCGDHRVAAHAYNIQANEVAIGMTIPYA
MMAR_0962|M.marinum_M SYPKPVVIACTGHAIAMGAFLLCSGDHRVAAHAYNVQANEVAIGMTIPYA
MUL_0713|M.ulcerans_Agy99 SYPKPVVIACTGHAIAMGAFLLCSGDHRVAAHAYNIQANEVAIGMTIPYA
MAV_4534|M.avium_104 SYPKPVVMACTGHAIAMGAFLLSSGDHRVAAHAYNIQANEVAIGMVIPYA
MAB_4588c|M.abscessus_ATCC_199 PPRKPIIAAVEGFALAGGTELVLSCDLVVAGRSAKFGIPEVKRGLVAGAG
MLBr_01724|M.leprae_Br4923 TIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILADLVPDGD
. * : * * *:. * * . * *. . *: .:
Mflv_5125|M.gilvum_PYR-GCK ALEIMRARLTPAAFERSAALASTYVGDDAVAAGWLDEIVEADQVLTRAQQ
Mvan_1226|M.vanbaalenii_PYR-1 ALEIMRMRLTPAAFERGAALAATFAGDDAVAGGWLDEIVPADQVLARAQQ
MSMEG_1331|M.smegmatis_MC2_155 AIEIMRMRLTRAAFQRAISMAAVFSGDAAISAGWLDEIVEPDEVLDRAQQ
TH_1874|M.thermoresistible__bu ALEIMRMRLTPAAYQHAVSLATTFTGDAAIRAGWLDEVVDTDRVLPRARE
Rv0632c|M.tuberculosis_H37Rv ALEIMKLRLTRSAYQQATGLAKTFFGETALAAGFIDEIALPEVVVSRAEE
Mb0649c|M.bovis_AF2122/97 ALEIMKLRLTRSAYQQATGLAKTFFGETALAAGFIDEIALPEVVVSRAEE
MMAR_0962|M.marinum_M AMEVLKLRLTPSAYQQAAGLAKTFFGETALAAGFIDEISLPEVVLSRAEE
MUL_0713|M.ulcerans_Agy99 AMEVLKLRLTPSAYQQAAGLAKTFFGETALAAGFIDEISLPEVVLSRAEE
MAV_4534|M.avium_104 AMEIMKLRLTPSAYQQASGLAKTFFGETALAAGFVDEIVLPEVVVDRAEE
MAB_4588c|M.abscessus_ATCC_199 GLLRLPNRIPYQVAMELALTGESFTAEDAAKYGFINRLVDDGQALDTALE
MLBr_01724|M.leprae_Br4923 GLARLTRVAGVSRAKDLVFSGRFFDAAEALALGLIDDMVAPDDVYDIAAA
.: : . : . * * :: : . *
Mflv_5125|M.gilvum_PYR-GCK VAAEAATT-----------------------LHAGAHLATKLKARKYALD
Mvan_1226|M.vanbaalenii_PYR-1 VAGEAAAT-----------------------LHPGAHLATKLKARKPALD
MSMEG_1331|M.smegmatis_MC2_155 VATEAAA------------------------LHTNAHVASKLKARADAVT
TH_1874|M.thermoresistible__bu FAAEVATT-----------------------VHAHAHLASKLKARDAALK
Rv0632c|M.tuberculosis_H37Rv AAREFAG------------------------LNQHAHAATKLRSRADALT
Mb0649c|M.bovis_AF2122/97 AAREFAG------------------------LNQHAHAATKLRSRADALT
MMAR_0962|M.marinum_M AAREFAG------------------------LNQQAHNATKLRARAEALK
MUL_0713|M.ulcerans_Agy99 AAREFAG------------------------LNQQAHNATKLRARAEALK
MAV_4534|M.avium_104 AAAEFAE------------------------LNQRAHAATKLRARADALA
MAB_4588c|M.abscessus_ATCC_199 LAAKITANGPLAVAATKRIIIESASWAPEEAFAKQGEILMPIFVSEDAKE
MLBr_01724|M.leprae_Br4923 WARRFLDGLPHALAAAKAG------------INEVFDLEPAERIAAERRR
* . . .
Mflv_5125|M.gilvum_PYR-GCK AIRAGIDGLATEFTLG--
Mvan_1226|M.vanbaalenii_PYR-1 AIRAGIDGLATEFSLG--
MSMEG_1331|M.smegmatis_MC2_155 AIRAGIDGLAAEFGS---
TH_1874|M.thermoresistible__bu AIRAGIDGIATEFTGG--
Rv0632c|M.tuberculosis_H37Rv AIRAGIDGIAAEFGL---
Mb0649c|M.bovis_AF2122/97 AIRAGIDGIAAEFGL---
MMAR_0962|M.marinum_M AIRAGIDGIEAEFGL---
MUL_0713|M.ulcerans_Agy99 AIRAGIDGIEAEFGL---
MAV_4534|M.avium_104 AIRAGIDGIEAEFGL---
MAB_4588c|M.abscessus_ATCC_199 GAKAFAEKRAPVWQGK--
MLBr_01724|M.leprae_Br4923 YVEVFAAAQPSLLLGGCD
.. .