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SGPVTYTHDDAIGVIRMDDGKVNVLGPTMQQALNEAIDAADRDNVGALVIAGNHRVFSGGFDLKVLTSGE AKPAIDMLRGGFELSYRLLSYPKPVVIACTGHAIAMGAFLLCSGDHRVAAHAYNIQANEVAIGMTIPYAA MEVLKLRLTPSAYQQAAGLAKTFFGETALAAGFIDEISLPEVVLSRAEEAAREFAGLNQQAHNATKLRAR AEALKAIRAGIDGIEAEFGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0713 | echA3 | - | 100% (231) | enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_4319 | echA3_1 | 2e-20 | 30.52% (213) | enoyl-CoA hydratase, EchA3_1 |
| M. ulcerans Agy99 | MUL_1899 | echA17 | 2e-15 | 30.94% (181) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0649c | echA3 | 1e-109 | 85.28% (231) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_5125 | - | 2e-68 | 57.33% (232) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv0632c | echA3 | 1e-109 | 85.28% (231) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_01724 | - | 3e-12 | 29.21% (202) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_3124 | - | 6e-11 | 27.32% (205) | enoyl-CoA hydratase |
| M. marinum M | MMAR_0962 | echA3 | 1e-128 | 99.57% (231) | enoyl-CoA hydratase, EchA3 |
| M. avium 104 | MAV_4534 | - | 1e-107 | 83.55% (231) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_1331 | - | 8e-67 | 54.27% (234) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_1874 | echA3 | 3e-68 | 57.39% (230) | PROBABLE ENOYL-CoA HYDRATASE ECHA3 (ENOYL HYDRASE) |
| M. vanbaalenii PYR-1 | Mvan_1226 | - | 7e-68 | 56.47% (232) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5125|M.gilvum_PYR-GCK MTGTVSYDLADS-----VATVTLDDGKVN-VLGPAMQAAINNALDR----
Mvan_1226|M.vanbaalenii_PYR-1 MTSTVSYEFADS-----VATISLDDGKVN-VLGPAMQAAINEALDR----
MSMEG_1331|M.smegmatis_MC2_155 MSSLVSYALNGN-----VATVTLDDGKAN-ALSPDMQAAINDALDQASLA
TH_1874|M.thermoresistible__bu MSSTVEYQLTDS-----VATITMDDGKVN-VLSPAMQGNLNEALDR----
MUL_0713|M.ulcerans_Agy99 MSGPVTYTHDDA-----IGVIRMDDGKVN-VLGPTMQQALNEAIDA----
MMAR_0962|M.marinum_M MSGPVTYTHDDA-----IGVIRMDDGKVN-VLGPTMQQALNEAIDA----
Mb0649c|M.bovis_AF2122/97 MSDPVSYTRKDS-----IAVISMDDGKVN-ALGPAMQQALNAAIDN----
Rv0632c|M.tuberculosis_H37Rv MSDPVSYTRKDS-----IAVISMDDGKVN-ALGPAMQQALNAAIDN----
MAV_4534|M.avium_104 MSGPVHYSTKGP-----VAVIRMDDGKVN-ALGPTMQQALGEAIDR----
MLBr_01724|M.leprae_Br4923 MSEFVNIVVSDGSQDAGLAILLLSRPPTN-AMTRQFYREIAMAADEL---
MAB_3124|M.abscessus_ATCC_1997 MTEPILLTHTEDR----ICTITLNRPQARNALSTALGEEIVKAVTAA---
*: : : : :. .. .: : : *
Mflv_5125|M.gilvum_PYR-GCK AEADKAKAVVLAGNSRVFSGGFDLGVFQSGDAAAALGMLSGGFELSVRTL
Mvan_1226|M.vanbaalenii_PYR-1 AEADKAKAVVLAGNSRVFSGGFDLSVFQSGDAAAALGMLAGGFELSLRTL
MSMEG_1331|M.smegmatis_MC2_155 AGSGEVKALVVAGNSKVFSGGFDLSVFASGDAAAALGMLTGGFELAVRCL
TH_1874|M.thermoresistible__bu AEQDGAKAVVLAGNSRVFSGGFDLSVFSSGDVDAALGMLRGGFELAVRAL
MUL_0713|M.ulcerans_Agy99 ADRDNVGALVIAGNHRVFSGGFDLKVLTSGEAKPAIDMLRGGFELSYRLL
MMAR_0962|M.marinum_M ADRDNVGALVIAGNHRVFSGGFDLKVLTSGEAKPAIDMLRGGFELSYRLL
Mb0649c|M.bovis_AF2122/97 ADRDDVGALVITGNGRVFSGGFDLKILTSGEVQPAIDMLRGGFELAYRLL
Rv0632c|M.tuberculosis_H37Rv ADRDDVGALVITGNGRVFSGGFDLKILTSGEVQPAIDMLRGGFELAYRLL
MAV_4534|M.avium_104 AEADNAGALVITGNERVFSGGFDLKILTSGEVQPAVNMLRGGFELAYRLL
MLBr_01724|M.leprae_Br4923 GRRDDVAAVILFGGHDIFSAGDDMQELRTLTAVEAGVAAEVRRQAVDAVA
MAB_3124|M.abscessus_ATCC_1997 DADENVDVMILTAADPVFCAGVDLKELGSGDRAESLDPWWP---------
. .::: . :*..* *: : : :
Mflv_5125|M.gilvum_PYR-GCK TFPVPVIIAATGPAIAMGSFLLLSGDHRVGQPKTRCQAIEVAIGMTIPIA
Mvan_1226|M.vanbaalenii_PYR-1 TFPAPVIVAATGPAIAMGSFLLLSTDHRVGQPKSRCQAIEVAIGMTIPIS
MSMEG_1331|M.smegmatis_MC2_155 TFPVPVIMAATGPAIAMGSFLLLSGDHRVGSPRSRCQANEVAIGMTLPIA
TH_1874|M.thermoresistible__bu TFPVPVIMAATGPAIAMGSFLLLCGDHRVGSERTRCQANEVAIGMILPVA
MUL_0713|M.ulcerans_Agy99 SYPKPVVIACTGHAIAMGAFLLCSGDHRVAAHAYNIQANEVAIGMTIPYA
MMAR_0962|M.marinum_M SYPKPVVIACTGHAIAMGAFLLCSGDHRVAAHAYNVQANEVAIGMTIPYA
Mb0649c|M.bovis_AF2122/97 SYPKPVVMACTGHAIAMGAFLLSCGDHRVAAHAYNIQANEVAIGMTIPYA
Rv0632c|M.tuberculosis_H37Rv SYPKPVVMACTGHAIAMGAFLLSCGDHRVAAHAYNIQANEVAIGMTIPYA
MAV_4534|M.avium_104 SYPKPVVMACTGHAIAMGAFLLSSGDHRVAAHAYNIQANEVAIGMVIPYA
MLBr_01724|M.leprae_Br4923 TIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILADLVPDGD
MAB_3124|M.abscessus_ATCC_1997 ELSKPVIGAINGAAVTGGLELALACDILIASEKARFADTHARVGILPTWG
. *.: * .* *: * * . * :. . . .:
Mflv_5125|M.gilvum_PYR-GCK ALEIMRARLTPAAFERSAALASTYVGDDAVAAGWLDEIVEADQVLTRAQQ
Mvan_1226|M.vanbaalenii_PYR-1 ALEIMRMRLTPAAFERGAALAATFAGDDAVAGGWLDEIVPADQVLARAQQ
MSMEG_1331|M.smegmatis_MC2_155 AIEIMRMRLTRAAFQRAISMAAVFSGDAAISAGWLDEIVEPDEVLDRAQQ
TH_1874|M.thermoresistible__bu ALEIMRMRLTPAAYQHAVSLATTFTGDAAIRAGWLDEVVDTDRVLPRARE
MUL_0713|M.ulcerans_Agy99 AMEVLKLRLTPSAYQQAAGLAKTFFGETALAAGFIDEISLPEVVLSRAEE
MMAR_0962|M.marinum_M AMEVLKLRLTPSAYQQAAGLAKTFFGETALAAGFIDEISLPEVVLSRAEE
Mb0649c|M.bovis_AF2122/97 ALEIMKLRLTRSAYQQATGLAKTFFGETALAAGFIDEIALPEVVVSRAEE
Rv0632c|M.tuberculosis_H37Rv ALEIMKLRLTRSAYQQATGLAKTFFGETALAAGFIDEIALPEVVVSRAEE
MAV_4534|M.avium_104 AMEIMKLRLTPSAYQQASGLAKTFFGETALAAGFVDEIVLPEVVVDRAEE
MLBr_01724|M.leprae_Br4923 GLARLTRVAGVSRAKDLVFSGRFFDAAEALALGLIDDMVAPDDVYDIAAA
MAB_3124|M.abscessus_ATCC_1997 LTTLLPLSVGRGLARRMSLTGDYLSAEDALRAGLVTEVVAHNELLPAAKR
: . . . . *: * : :: : : *
Mflv_5125|M.gilvum_PYR-GCK VAAEAATT-------------------LHAGAHLATK-------LKARKY
Mvan_1226|M.vanbaalenii_PYR-1 VAGEAAAT-------------------LHPGAHLATK-------LKARKP
MSMEG_1331|M.smegmatis_MC2_155 VATEAAA--------------------LHTNAHVASK-------LKARAD
TH_1874|M.thermoresistible__bu FAAEVATT-------------------VHAHAHLASK-------LKARDA
MUL_0713|M.ulcerans_Agy99 AAREFAG--------------------LNQQAHNATK-------LRARAE
MMAR_0962|M.marinum_M AAREFAG--------------------LNQQAHNATK-------LRARAE
Mb0649c|M.bovis_AF2122/97 AAREFAG--------------------LNQHAHAATK-------LRSRAD
Rv0632c|M.tuberculosis_H37Rv AAREFAG--------------------LNQHAHAATK-------LRSRAD
MAV_4534|M.avium_104 AAAEFAE--------------------LNQRAHAATK-------LRARAD
MLBr_01724|M.leprae_Br4923 WARRFLDG-------------------LPHALAAAKAGINEVFDLEPAER
MAB_3124|M.abscessus_ATCC_1997 LAATIAGNNQPAVRELLASYRRIESELVGNGLQVALDDAHRWIDQNSIAE
* : * ..
Mflv_5125|M.gilvum_PYR-GCK ALDAIRAGIDGLATEFTLG------
Mvan_1226|M.vanbaalenii_PYR-1 ALDAIRAGIDGLATEFSLG------
MSMEG_1331|M.smegmatis_MC2_155 AVTAIRAGIDGLAAEFGS-------
TH_1874|M.thermoresistible__bu ALKAIRAGIDGIATEFTGG------
MUL_0713|M.ulcerans_Agy99 ALKAIRAGIDGIEAEFGL-------
MMAR_0962|M.marinum_M ALKAIRAGIDGIEAEFGL-------
Mb0649c|M.bovis_AF2122/97 ALTAIRAGIDGIAAEFGL-------
Rv0632c|M.tuberculosis_H37Rv ALTAIRAGIDGIAAEFGL-------
MAV_4534|M.avium_104 ALAAIRAGIDGIEAEFGL-------
MLBr_01724|M.leprae_Br4923 IAAERRRYVEVFAAAQPSLLLGGCD
MAB_3124|M.abscessus_ATCC_1997 GVEARRTAIMERGRSQNA-------
* :