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MTGDQPELPVDLVRTLLGVLRQRLGLDAAWLSSFDDGMQVIEVLDGNADGLGVSPGQRIGLPESYCVRVI DGRLPAVIPDTSADQTTAALPITRESGVGAYVGVPVPVPGHGDATAGMVCVVSREPKPDLTDEDLQIVKQ VADLIGTLIDSPAPGADPTADQRKAIRRVLAERDFEVVFQAVHDAATGKVVGVEALARFPCEPFRPDAFF QQAAQLGLDIELETAIVRRVLSMIPQLPDDVFVAMNISPAAALAAPWHELLVDVDPSRIVLEITEHVAVG NYGALDDALESCRARGMRIAVDDVGAGFASFSHVLELTPEFVKIDQSITRHIDVDDARRRLAQAIAEFAG QIGATVIAEGVESQGELDAVVAAGITWAQGFCLSRPKPHAHGFPPSFATAASTERVLAPVDLLGDRPFEL ALTHSPIGMAVVGLDGGFLRTNRALRAMLGYSRGTLADMTFQQITHPDDLDADLAMVAECLEGRRRSYRI DKRYIAADGHIVWCALTVVLVHAPRDQPRCFVSQIVDVTADRAREAELARQAATDPLTAIANRSAAFRRL EQLDAGHDGYGVLFCDIERFKSVNDWCGHHAGDQLLVEVAARLLAAVDEGALVARWGGDEFLVVTDTVEE HELARLATRITEEVDRTPVTLADGTQMPVAMTIGFAAHRPGDGRSIDAVLDCADQAMYEQRRQRRNTVLH KGNEAIGLVE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1152 | - | - | 100% (710) | diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) |
| M. vanbaalenii PYR-1 | Mvan_3629 | - | 4e-28 | 31.35% (303) | diguanylate cyclase with PAS/PAC sensor |
| M. vanbaalenii PYR-1 | Mvan_2109 | - | 7e-21 | 30.99% (284) | diguanylate cyclase with PAS/PAC sensor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 3e-18 | 27.73% (238) | hypothetical protein Mb1389c |
| M. gilvum PYR-GCK | Mflv_5174 | - | 0.0 | 75.51% (690) | diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF |
| M. tuberculosis H37Rv | Rv1354c | - | 3e-18 | 27.73% (238) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_00397 | - | 4e-21 | 28.38% (296) | putative transporter protein |
| M. abscessus ATCC 19977 | MAB_3940c | - | 7e-16 | 32.62% (187) | hypothetical protein MAB_3940c |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_1410 | - | 4e-22 | 42.33% (163) | cyclic diguanylate phosphodiesterase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 2e-16 | 36.61% (183) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_0811 | - | 6e-18 | 29.09% (220) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
Mvan_1152|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5174|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 MKRWAVNPWRRSGVPARVGWLLAGGYGTAALLVLLSSVRGWRGPYGTRPV
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
Mvan_1152|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5174|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 DDLVMFVCLAVAAMCAARAARAASGRRRYGWLALTTALLGWAVGEVIWAV
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
Mvan_1152|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5174|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 YDVRPEFEHAAHPAAAEMVLLLFPVGAMTSLVLLSQLSRHSPRRLLLDGL
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
Mvan_1152|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5174|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 IVATSLFVISWVFVVEAQLREHTGTQVATLAEVFNDIVLMTTAILTLSRA
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
Mvan_1152|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5174|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 RPGDRPSRSLLACGIATISVTDIAMVFYTGIGSYHTDDIGDLARVAGVGT
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
Mvan_1152|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5174|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 LALAGLASVYEQPAPGSPDEIEFRTRLWLPYLPLILAAAVGWGHAAGKAI
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
Mvan_1152|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5174|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 HEPMLAALGILVAAVLARQFVVLVDNQNLLSEVAREAFRDNLTGLANRAL
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
Mvan_1152|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5174|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 FVHRLEQAVARRHPDGTPIAVLCLDLDNFKAVNDALGHPAGDELLVRVAE
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 ---------------------MCNDTATPQLEELVTTVANQLMTVDAATS
Rv1354c|M.tuberculosis_H37Rv ---------------------MCNDTATPQLEELVTTVANQLMTVDAATS
MSMEG_2196|M.smegmatis_MC2_155 --------------------------MSESLDVLVTSVATQLMAVEAATS
TH_0811|M.thermoresistible__bu --------------------------VSTELDLLVTGVATKLMAADAATA
Mvan_1152|M.vanbaalenii_PYR-1 --------------MTGDQPELPVDLVRTLLGVLRQRLGLDAAWLSSFDD
Mflv_5174|M.gilvum_PYR-GCK --------------MEG-QPGIPADLVRTLLGVLRQRLGLDTAWLSSFHD
MAV_1410|M.avium_104 RLTAALGDSGTIARLGGDEFAAVIEASVDESQAAAHRILEAFTGAILIDG
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 -----------------------------MDHTTKCDAEQYFQAIVTSMA
Mb1389c|M.bovis_AF2122/97 AEVSQRVLAYLVEQLGVD----VSFLRHNDRDRRATR-------------
Rv1354c|M.tuberculosis_H37Rv AEVSQRVLAYLVEQLGVD----VSFLRHNDRDRRATR-------------
MSMEG_2196|M.smegmatis_MC2_155 VSVSQQVLAELVSFFDVD----VSFLRHNDHRAHATR-------------
TH_0811|M.thermoresistible__bu RDVSRRVLADLVRAFELD----FSFLRHNDHEIRASK-------------
Mvan_1152|M.vanbaalenii_PYR-1 GMQVIEVLDGNADGLGVSPGQRIGLPESYCVRVIDGR-------------
Mflv_5174|M.gilvum_PYR-GCK DTQTIEVLDGDAASFGLSPGLRTPLSESYCVRVIDGR-------------
MAV_1410|M.avium_104 IPITVRPSIGFTVCTGASTCTVDQLLRHADLAMYAAKREGGQCIRSFMPD
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 DGVIVVDIDGRIESINPAATRILGLRAHDVVDMKHGH-------------
Mb1389c|M.bovis_AF2122/97 --LVAEWPPRLNIPDPDPLRLIYFADADPVFA------------------
Rv1354c|M.tuberculosis_H37Rv --LVAEWPPRLNIPDPDPLRLIYFADADPVFA------------------
MSMEG_2196|M.smegmatis_MC2_155 --LVAEWPPRPVDAATDPIAVVHFADADPVFA------------------
TH_0811|M.thermoresistible__bu --LIAEWPVRENVPDPDPIGVVHFEGADPVFA------------------
Mvan_1152|M.vanbaalenii_PYR-1 --LPAVIPDTSADQTTAALPITRESGVGAYVGVP----------------
Mflv_5174|M.gilvum_PYR-GCK --LPSVVPDTSQNQTTHALPVTDEMGLGAYIG------------------
MAV_1410|M.avium_104 LPLPYAFPPPPGSAAPTAVAAVAAGGNGAAPASPPQVATAATSSPSPHDA
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 -------PFCFYDTDNQRVDLER---------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
Mvan_1152|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5174|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 ARRPPRGIRAALGMLAIGVVAFSVSSVAHPDAGHGIFSATALYSALNAVA
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
Mvan_1152|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5174|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 AGLIALRACRIPADRWAWALIAAGMACSAVGDVVYAVWVPDGRSPSVADP
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
Mvan_1152|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5174|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1410|M.avium_104 EYLAYYPFVYAGLLLLMRARLKRLPIAVQLDSVVCALTLAAVAAALTAGP
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --------------------------------------------------
Rv1354c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_2196|M.smegmatis_MC2_155 --------------------------------------------------
TH_0811|M.thermoresistible__bu --------------------------------------------------
Mvan_1152|M.vanbaalenii_PYR-1 ----------------------------------------------VPVP
Mflv_5174|M.gilvum_PYR-GCK ----------------------------------------------VPVP
MAV_1410|M.avium_104 LHQAAVHAPKTVWVGLAYPWCDLMLLALAAGMLPILGWRNEIRWALLVAG
MAB_3940c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00397|M.leprae_Br4923 --------------------------------------------------
Mb1389c|M.bovis_AF2122/97 --LCEHAKEPLVFRPEP---ATEDYQRLIEEARGVPVTSAAAVPLVSGEI
Rv1354c|M.tuberculosis_H37Rv --LCEHAKEPLVFRPEP---ATEDYQRLIEEARGVPVTSAAAVPLVSGEI
MSMEG_2196|M.smegmatis_MC2_155 --MAEHLKEPAVFRPEP---LYDDYQRTIEAGRHIPATSMACVPLLSGDV
TH_0811|M.thermoresistible__bu --LAEHAKEIHIFRPEP---ATDEFQRLIEESSGVPASTVAAVPLVSGEI
Mvan_1152|M.vanbaalenii_PYR-1 GHGDATAGMVCVVSREPKPDLTDEDLQIVKQVADLIGTLIDSPAPGADPT
Mflv_5174|M.gilvum_PYR-GCK GHAGTTSGMVCLVSQEPKPYLGDDDLRLVRQAAELIGTLIESPVRQAD-S
MAV_1410|M.avium_104 LVLFAVADGAYLFQTAAGSYRVGSLLDVCWPASSVLIAMASWAPPPATAT
MAB_3940c|M.abscessus_ATCC_199 ---------------------------MIVSYIRSTAWMGFLRQWWTEPV
MLBr_00397|M.leprae_Br4923 -----------------------EVMRVVRREVTTVSKVVGIDQHSGQRL
Mb1389c|M.bovis_AF2122/97 TTGL---------------LGFIKFGDRKWHEAELNALMTIAT-------
Rv1354c|M.tuberculosis_H37Rv TTGL---------------LGFIKFGDRKWHEAELNALMTIAT-------
MSMEG_2196|M.smegmatis_MC2_155 TTGV---------------LGFVKFGDREWLPAELNALKAIAS-------
TH_0811|M.thermoresistible__bu TTGV---------------LGFVKYGDRQWHPDELNALKAIAS-------
Mvan_1152|M.vanbaalenii_PYR-1 ADQR---------------KAIRRVLAERDFEVVFQAVHDAATGKVVGVE
Mflv_5174|M.gilvum_PYR-GCK VDRR---------------SAIRRVVSELDFEVVFQAIHDVASGRAVGVE
MAV_1410|M.avium_104 QARRRFSPYVTPVASTIVALGVIVLAHHSRSAATLAALSLVVG-------
MAB_3940c|M.abscessus_ATCC_199 PTGW-----------------LRGFLHARKLDRTVRNLIG----------
MLBr_00397|M.leprae_Br4923 WLSVN--------------VSLLAYKAPPHSALVVS--------------
. .
Mb1389c|M.bovis_AF2122/97 -------------LFAQVQARVAAEARLRYLADHDDLTGLHNR-RALLQH
Rv1354c|M.tuberculosis_H37Rv -------------LFAQVQARVAAEARLRYLADHDDLTGLHNR-RALLQH
MSMEG_2196|M.smegmatis_MC2_155 -------------LFAQVQARIEAEERLRYLADHDHLTGLYNR-RALMAH
TH_0811|M.thermoresistible__bu -------------LFAQVQARVEAEERLRYLAEHDDLTGLHNR-RALLAH
Mvan_1152|M.vanbaalenii_PYR-1 ALARFPCEPFRPDAFFQQAAQLGLDIELETAIVRRVLSMIPQLPDDVFVA
Mflv_5174|M.gilvum_PYR-GCK ALARFPCEPFRPDAFFAEAAQLGIGIQLELAIVRRVLSLLPQLPDDVFVS
MAV_1410|M.avium_104 -----------AGRFSLTFRDVSLLHSHDRHAMTDELTALPNR-RQLVTA
MAB_3940c|M.abscessus_ATCC_199 -------------GYALIFAAICIAVQFSDTGPRSMIG-------RVIVG
MLBr_00397|M.leprae_Br4923 --------------FSDISAHHLSIERLTYEATHDCLTGLANR-RFAEDQ
: :
Mb1389c|M.bovis_AF2122/97 LDQRLAPGQPGP----------VAALFLDLDRLKAINDYLGHAAGDQFIH
Rv1354c|M.tuberculosis_H37Rv LDQRLAPGQPGP----------VAALFLDLDRLKAINDYLGHAAGDQFIH
MSMEG_2196|M.smegmatis_MC2_155 LEARLAPGQPGP----------VAVMFFDLDRLKAINDYLGHTAGDAFIS
TH_0811|M.thermoresistible__bu LDARLAAGQPGP----------VSALYFDLDRLKAVNDYLGHTVGDWFIR
Mvan_1152|M.vanbaalenii_PYR-1 MNISPAAALAAP----------WHELLVDVDPSRIVLEITEHVAVGNYGA
Mflv_5174|M.gilvum_PYR-GCK INISPAAALVAP----------WSELLADVEPSRIVLEITEHDAVPNYGA
MAV_1410|M.avium_104 LQGLPASASPGAGSMPSRANPRRALLLLSLSDFHEITESIGRQFGDELLC
MAB_3940c|M.abscessus_ATCC_199 LCAVGSLG---------------WALRWAVGPWPSLREAVAFVAFADIGI
MLBr_00397|M.leprae_Br4923 ITKSLQHDERSR---------LAAVLLLDLDDFKVINDSLGHDVGDAVLQ
: : : : :
Mb1389c|M.bovis_AF2122/97 VFAQRIGDALVGESLIARLGGD------EFVLIPASPMSADAAQPLAERL
Rv1354c|M.tuberculosis_H37Rv VFAQRIGDALVGESLIARLGGD------EFVLIPASPMSADAAQPLAERL
MSMEG_2196|M.smegmatis_MC2_155 ILAQRLQRGDDAPKLIARLGGD------EFVVVPDDPMSLDEATALAYRL
TH_0811|M.thermoresistible__bu VLAERLREGAGPDDLIARLGGD------EFVVVPSGPVDADAALELANRL
Mvan_1152|M.vanbaalenii_PYR-1 LDDALESCRARGMRIAVDDVGAGFASFSHVLELTPEFVKIDQSITRHIDV
Mflv_5174|M.gilvum_PYR-GCK LDDVLEGCRAQGVRVAVDDVGAGFASFSHVLELAPEFVKIDHSIIRHIDV
MAV_1410|M.avium_104 HIANRLAGSVRRDDLLARVGDD------QFAVLLADGANLTAASAQAGRL
MAB_3940c|M.abscessus_ATCC_199 AVACWQDSDPLAG------------------LVGTVLFTPVGAYVSFFLA
MLBr_00397|M.leprae_Br4923 TVAQRLRSAVRPDDVVARLGGD------EFIVLLRGPLSDMNANDVAKRL
: :
Mb1389c|M.bovis_AF2122/97 RDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRR----ADQAALA
Rv1354c|M.tuberculosis_H37Rv RDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRR----ADQAALA
MSMEG_2196|M.smegmatis_MC2_155 QSVLRERVTVDGEMLTRTVSIGIAQGIPGKDSTSDVLNR----ADHAVLT
TH_0811|M.thermoresistible__bu RSRLQQQVCVDGEMLTRTASIGVAQGTPGRDTTSDLLRR----ADQAVLT
Mvan_1152|M.vanbaalenii_PYR-1 DDARRRLAQAIAEFAGQIGATVIAEGVESQGELDAVVAAGITWAQGFCLS
Mflv_5174|M.gilvum_PYR-GCK DDARRRLAQAIAEFAGQFGAMVIAEGVESQRELDAVRAAGIGCAQGFYLS
MAV_1410|M.avium_104 LEALSEPIALDPITVQVDGRIAIALCPDHCDHPRELLSR-----AETALA
MAB_3940c|M.abscessus_ATCC_199 NRLLVAHVAWCAPMIIALSSRLFAEGTVG---------------------
MLBr_00397|M.leprae_Br4923 HTTLSESLVVDQLTVPIGASVGILEVRPDDRRRAADILR---DADSAMYA
.
Mb1389c|M.bovis_AF2122/97 AKHAGGDSVAIFTAD-------------MSVSGELRNDIELHLRRGIESD
Rv1354c|M.tuberculosis_H37Rv AKHAGGDSVAIFTAD-------------MSVSGELRNDIELHLRRGIESD
MSMEG_2196|M.smegmatis_MC2_155 AKGSGGNRVAVFSDA-------------MAMEIDFRNDIELHLQSVIEGG
TH_0811|M.thermoresistible__bu AKSAGGNQITVFTDD-------------MSLEAEFRNDIELHLQSVIQDE
Mvan_1152|M.vanbaalenii_PYR-1 RPKPHAHGFPPSFAT-------------AASTERVLAPVDLLGDRPFELA
Mflv_5174|M.gilvum_PYR-GCK RPKAHGHGFPAATAT-------------ADPSEPLPTAVDLLGERRFELA
MAV_1410|M.avium_104 HAKSARSKIAVYDSA-------------FEAHRDNDTNLIEELRTALFDT
MAB_3940c|M.abscessus_ATCC_199 ---------AAMTAL-------------VKVTSMLLVVVLIPAVIQFGIA
MLBr_00397|M.leprae_Br4923 AKNKKQCAVTPQQLVPFVALIALFVFFTAAAGAKFYAPSNLLVILQQTVV
.
Mb1389c|M.bovis_AF2122/97 ALRLVY-LPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLA
Rv1354c|M.tuberculosis_H37Rv ALRLVY-LPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLA
MSMEG_2196|M.smegmatis_MC2_155 ALVLHY-LPEIDMRTGEVLAAEALVRWEHPTRGLLSPDSFIGVAESINLA
TH_0811|M.thermoresistible__bu ALLLHF-LPEVDMRTGEILATEALVRWHHPTRGLLAPDTFIGVAESVNLA
Mvan_1152|M.vanbaalenii_PYR-1 LTHSPIGMAVVGLDGGFLRTNRALRAMLGYSRGTLADMTFQQITHPDDLD
Mflv_5174|M.gilvum_PYR-GCK LAHSPIGMAVVGLDGSFLRTNRALRAMLGYSRRAMSELTFQDITHPDDLD
MAV_1410|M.avium_104 DELKLHYQPKIDGRDGSIHSVEAVLRWQHPTRGTLLPEEFLPVAERAGLM
MAB_3940c|M.abscessus_ATCC_199 VVRWDALAAQRDPLTGLLNRRGIYAEWQRLYGELRREQPLDGDQVTAAAI
MLBr_00397|M.leprae_Br4923 LAIVGYGMTFVIMAGSVDLSVGSIVALTGVTAALVAAQNQFAAIVTALLV
. .
Mb1389c|M.bovis_AF2122/97 GELDR----WVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTGG---F
Rv1354c|M.tuberculosis_H37Rv GELDR----WVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTGG---F
MSMEG_2196|M.smegmatis_MC2_155 GELGR----WVLRTACAEFSRWRANGVGRNIVLRINVSPVQLVTDG---F
TH_0811|M.thermoresistible__bu GELGR----WVMRTACGEFAKWRAEGIGLDAVLRINVSPVQLVTDG---F
Mvan_1152|M.vanbaalenii_PYR-1 ADLAMVAECLEGRRRSYRIDKRYIAADGHIVWCALTVVLVHAPRDQPRCF
Mflv_5174|M.gilvum_PYR-GCK LDLALVNECLEGRRRSYRIDKRYIAADGSIVWCALTAVIVHAPRDQPRCF
MAV_1410|M.avium_104 RKISN----RTLSMALQQVRSWREE--GLRLTVAVNLSTTNLLDIE---L
MAB_3940c|M.abscessus_ATCC_199 VDIDR----------FKSINDRYGHGTGDRVLIDVAHALTCGTTGT----
MLBr_00397|M.leprae_Br4923 GLAAG--MVNGIVFAYGKIPSFVSTLGMLQVCRGITLMISDSSAKP----
. :
Mb1389c|M.bovis_AF2122/97 VDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVG---VH
Rv1354c|M.tuberculosis_H37Rv VDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVG---VH
MSMEG_2196|M.smegmatis_MC2_155 VESVAGIMKEFGLPRGSVCLEITESVVVQDIETTRTTLTGLHNVG---VQ
TH_0811|M.thermoresistible__bu VASVADIIDEFGLDGSSVCLEITESVVVQDIKTTRITLEGLNEVG---VQ
Mvan_1152|M.vanbaalenii_PYR-1 VSQIVDVTADRAREAELARQAATDPLTAIANRSAAFRRLEQLDAGHDGYG
Mflv_5174|M.gilvum_PYR-GCK VSQIVDVTADRLREAELVRRASTDPLTSIANRSAAWTRLEQLDQSGEGYG
MAV_1410|M.avium_104 VGTVERLLANYDLPADALILEITESALVDSVR-SRNTVTALQRLG---IR
MAB_3940c|M.abscessus_ATCC_199 -----SVVGRSGGEEFLVVTVCPASAVAEFATRLRQAVTASMPAG-----
MLBr_00397|M.leprae_Br4923 -MPFHGILGAMGAMPWILIVCLFVTILAGILFQFTMFGRWVKAIG-----
.
Mb1389c|M.bovis_AF2122/97 IAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRG----
Rv1354c|M.tuberculosis_H37Rv IAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRG----
MSMEG_2196|M.smegmatis_MC2_155 VAIDDFGTGYSVLSLLKSLPVDTLKIDRSFVAELGSNPGDLPIVRA----
TH_0811|M.thermoresistible__bu VAIDDFGTGYSVLSHLKTLPVDTLKIDKGFVQDLGNSPGDLAIVRA----
Mvan_1152|M.vanbaalenii_PYR-1 VLFCDIERFKSVNDWCGHHAGDQLLVEVAARLLAAVDEGALVARWGGDEF
Mflv_5174|M.gilvum_PYR-GCK VLFCDIERFKSVNDRHGHHAGDQLLVEVAQRLHDTLDPFDLAARWGGDEF
MAV_1410|M.avium_104 ISIDDYGTGWSSLARLQEVSVDELKLDRIFVARLAHDARSVAIVRS----
MAB_3940c|M.abscessus_ATCC_199 ------------IAVTASVGVAAQAVSRVVSATSQEAIEVLTACAD----
MLBr_00397|M.leprae_Br4923 --------GNERVATLAGVPTRGIKVAIFAICGLTAGLGGIVLASRLG--
: :
Mb1389c|M.bovis_AF2122/97 --IMTLAEGFQLDVVAEGVETEAAARI-------LLDQR-----CYRAQG
Rv1354c|M.tuberculosis_H37Rv --IMTLAEGFQLDVVAEGVETEAAARI-------LLDQR-----CYRAQG
MSMEG_2196|M.smegmatis_MC2_155 --VIALAGAFGLQLVAEGVETERAALT-------LLRHG-----CYRAQG
TH_0811|M.thermoresistible__bu --IIALAEAFGLQLVAEGVETEAAALT-------LLRHG-----CHRAQG
Mvan_1152|M.vanbaalenii_PYR-1 LVVTDTVEEHELARLATRITEEVDRTP-------VTLADGTQMPVAMTIG
Mflv_5174|M.gilvum_PYR-GCK LVITRCVEEPALACLADRIIDRMDGTP-------ITLPGGAEESVAMTIG
MAV_1410|M.avium_104 --TVALADNLGADLVAEGVENEDTLDA-------LRRYG-----CNITQG
MAB_3940c|M.abscessus_ATCC_199 ------------RAMYEAKHDGGDQSR-------ILHAD------DDSEG
MLBr_00397|M.leprae_Br4923 AGTPTAATGFEIDVIAAVVIGGTPLTGGLGRLSGTLIGAIIISMLSNGMV
:
Mb1389c|M.bovis_AF2122/97 FLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS------------
Rv1354c|M.tuberculosis_H37Rv FLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS------------
MSMEG_2196|M.smegmatis_MC2_155 FLLSKPILGSEMQTLLAKGRVPVHFSAAPRM---------------
TH_0811|M.thermoresistible__bu FLLSRPIPSNEMRELLARGRIPMRFSATP-----------------
Mvan_1152|M.vanbaalenii_PYR-1 FAAHRPGDGRSIDAVLDCADQAMYEQRRQRRNTVLHKGNEAIGLVE
Mflv_5174|M.gilvum_PYR-GCK FAAHRPGDGRSVDDVLDLADHQMCEQRRRRPRVRRRLGVSRPR---
MAV_1410|M.avium_104 FVHTPPLPPDELRAWIASHAPDPSQSRG------------------
MAB_3940c|M.abscessus_ATCC_199 RYLWRSGA--------------------------------------
MLBr_00397|M.leprae_Br4923 FMGVGNAASQIIKGIMLAAAVFVFLQRRKIGIIK------------