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EGQPGIPADLVRTLLGVLRQRLGLDTAWLSSFHDDTQTIEVLDGDAASFGLSPGLRTPLSESYCVRVIDG RLPSVVPDTSQNQTTHALPVTDEMGLGAYIGVPVPGHAGTTSGMVCLVSQEPKPYLGDDDLRLVRQAAEL IGTLIESPVRQADSVDRRSAIRRVVSELDFEVVFQAIHDVASGRAVGVEALARFPCEPFRPDAFFAEAAQ LGIGIQLELAIVRRVLSLLPQLPDDVFVSINISPAAALVAPWSELLADVEPSRIVLEITEHDAVPNYGAL DDVLEGCRAQGVRVAVDDVGAGFASFSHVLELAPEFVKIDHSIIRHIDVDDARRRLAQAIAEFAGQFGAM VIAEGVESQRELDAVRAAGIGCAQGFYLSRPKAHGHGFPAATATADPSEPLPTAVDLLGERRFELALAHS PIGMAVVGLDGSFLRTNRALRAMLGYSRRAMSELTFQDITHPDDLDLDLALVNECLEGRRRSYRIDKRYI AADGSIVWCALTAVIVHAPRDQPRCFVSQIVDVTADRLREAELVRRASTDPLTSIANRSAAWTRLEQLDQ SGEGYGVLFCDIERFKSVNDRHGHHAGDQLLVEVAQRLHDTLDPFDLAARWGGDEFLVITRCVEEPALAC LADRIIDRMDGTPITLPGGAEESVAMTIGFAAHRPGDGRSVDDVLDLADHQMCEQRRRRPRVRRRLGVSR PR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5174 | - | - | 100% (703) | diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) |
| M. gilvum PYR-GCK | Mflv_4571 | - | 1e-42 | 31.50% (381) | diguanylate phosphodiesterase |
| M. gilvum PYR-GCK | Mflv_2883 | - | 3e-24 | 31.77% (299) | diguanylate cyclase with PAS/PAC sensor |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1389c | - | 3e-16 | 26.69% (236) | hypothetical protein Mb1389c |
| M. tuberculosis H37Rv | Rv1354c | - | 4e-16 | 26.69% (236) | hypothetical protein Rv1354c |
| M. leprae Br4923 | MLBr_01750 | - | 8e-20 | 28.90% (218) | hypothetical protein MLBr_01750 |
| M. abscessus ATCC 19977 | MAB_3940c | - | 1e-12 | 36.30% (135) | hypothetical protein MAB_3940c |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_3132 | - | 3e-20 | 28.57% (217) | GGDEF domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2196 | - | 5e-17 | 27.98% (218) | sensory box/response regulator |
| M. thermoresistible (build 8) | TH_0811 | - | 8e-18 | 29.36% (218) | sensory box/response regulator |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_1152 | - | 0.0 | 75.51% (690) | diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2196|M.smegmatis_MC2_155 ------------MSESLDVLVTSVATQLMAVEAATSVSVSQQVLAELVSF
TH_0811|M.thermoresistible__bu ------------VSTELDLLVTGVATKLMAADAATARDVSRRVLADLVRA
MLBr_01750|M.leprae_Br4923 ------------MTRSLDELVTRVASKLMAATAATAVTISEGVLAILVEH
MAV_3132|M.avium_104 ------------MSGTLDHLVTAAAAELMAATAADAAQISERVLADLVSH
Mb1389c|M.bovis_AF2122/97 -------MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQ
Rv1354c|M.tuberculosis_H37Rv -------MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQ
Mflv_5174|M.gilvum_PYR-GCK MEG-QPGIPADLVRTLLGVLRQRLGLDTAWLSSFHDDTQTIEVLDGDAAS
Mvan_1152|M.vanbaalenii_PYR-1 MTGDQPELPVDLVRTLLGVLRQRLGLDAAWLSSFDDGMQVIEVLDGNADG
MAB_3940c|M.abscessus_ATCC_199 ----------------MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHA
: *
MSMEG_2196|M.smegmatis_MC2_155 FDVDVS----FLRHNDHRAHATRLVAEWPPRPVDAATDPIAVVHFADADP
TH_0811|M.thermoresistible__bu FELDFS----FLRHNDHEIRASKLIAEWPVRENVPDPDPIGVVHFEGADP
MLBr_01750|M.leprae_Br4923 FGVDVS----FLRHNNHDIHETKLIVEWPPRDYVPDPDPIGVVYFADADP
MAV_3132|M.avium_104 FGVNFG----FLRHNDHSIRATVLVAEWPPRN--VDPDPLGVIYFADADS
Mb1389c|M.bovis_AF2122/97 LGVDVS----FLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADP
Rv1354c|M.tuberculosis_H37Rv LGVDVS----FLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADP
Mflv_5174|M.gilvum_PYR-GCK FGLSPGLRTPLSESYCVRVIDGRLPSVVPDTSQNQTTHALPVTDEMGLGA
Mvan_1152|M.vanbaalenii_PYR-1 LGVSPGQRIGLPESYCVRVIDGRLPAVIPDTSADQTTAALPITRESGVGA
MAB_3940c|M.abscessus_ATCC_199 RKLDRT--------------------------------------------
:.
MSMEG_2196|M.smegmatis_MC2_155 VFAMAEHLK--------EPAVFRPEP---LYDDYQRTIEAGRHIPATSMA
TH_0811|M.thermoresistible__bu VFALAEHAK--------EIHIFRPEP---ATDEFQRLIEESSGVPASTVA
MLBr_01750|M.leprae_Br4923 VFAMAEYLK--------EPAVLRPEP---ANADYQRRIEEGASVPAVSLA
MAV_3132|M.avium_104 VFARVETMK--------EPDVLRPEP---ANADYQRNIEDGTGIPEVSLA
Mb1389c|M.bovis_AF2122/97 VFALCEHAK--------EPLVFRPEP---ATEDYQRLIEEARGVPVTSAA
Rv1354c|M.tuberculosis_H37Rv VFALCEHAK--------EPLVFRPEP---ATEDYQRLIEEARGVPVTSAA
Mflv_5174|M.gilvum_PYR-GCK YIG--VPVPGHAGTTSGMVCLVSQEPKPYLGDDDLRLVRQAAELIGTLIE
Mvan_1152|M.vanbaalenii_PYR-1 YVGVPVPVPGHGDATAGMVCVVSREPKPDLTDEDLQIVKQVADLIGTLID
MAB_3940c|M.abscessus_ATCC_199 ----------------------------------VRNLIGGYALIFAAIC
: : :
MSMEG_2196|M.smegmatis_MC2_155 CVPLLSGDVTTGVLGFVKFGDREWLPAELNALKAIAS-------------
TH_0811|M.thermoresistible__bu AVPLVSGEITTGVLGFVKYGDRQWHPDELNALKAIAS-------------
MLBr_01750|M.leprae_Br4923 CVPLLSGEITTGVLGFVKYGDREWHDDELRALQAIAT-------------
MAV_3132|M.avium_104 AVPLLSGDVTTGTLGFVKFGDREWLSEELNALQAIAA-------------
Mb1389c|M.bovis_AF2122/97 AVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIAT-------------
Rv1354c|M.tuberculosis_H37Rv AVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIAT-------------
Mflv_5174|M.gilvum_PYR-GCK SPVRQAD-SVDRRSAIRRVVSELDFEVVFQAIHDVASGRAVGVEALARFP
Mvan_1152|M.vanbaalenii_PYR-1 SPAPGADPTADQRKAIRRVLAERDFEVVFQAVHDAATGKVVGVEALARFP
MAB_3940c|M.abscessus_ATCC_199 IAVQFSDTGPRSMIGRVIVG-----------LCAVGS-------------
:. . : .:
MSMEG_2196|M.smegmatis_MC2_155 -------LFAQVQARIEAEERLRYLADHDHLTGLYNR-RALMAHLEARLA
TH_0811|M.thermoresistible__bu -------LFAQVQARVEAEERLRYLAEHDDLTGLHNR-RALLAHLDARLA
MLBr_01750|M.leprae_Br4923 -------LFAQLQARIVAEEQLRYLAEHDDLTGLLNR-RALIAHLDERLA
MAV_3132|M.avium_104 -------LFAQLQARVVAEEQIHYLAEHDELTGLLNR-RALIAHLDKRLA
Mb1389c|M.bovis_AF2122/97 -------LFAQVQARVAAEARLRYLADHDDLTGLHNR-RALLQHLDQRLA
Rv1354c|M.tuberculosis_H37Rv -------LFAQVQARVAAEARLRYLADHDDLTGLHNR-RALLQHLDQRLA
Mflv_5174|M.gilvum_PYR-GCK CEPFRPDAFFAEAAQLGIGIQLELAIVRRVLSLLPQLPDDVFVSINISPA
Mvan_1152|M.vanbaalenii_PYR-1 CEPFRPDAFFQQAAQLGLDIELETAIVRRVLSMIPQLPDDVFVAMNISPA
MAB_3940c|M.abscessus_ATCC_199 -----------------LGWALRWAVGP----------WPSLREAVAFVA
:. : *
MSMEG_2196|M.smegmatis_MC2_155 PGQPGPVAVMFFDLDRLKAINDYLGHTAGDAFISILAQRLQRGDDAPKLI
TH_0811|M.thermoresistible__bu AGQPGPVSALYFDLDRLKAVNDYLGHTVGDWFIRVLAERLREGAGPDDLI
MLBr_01750|M.leprae_Br4923 DGQRGPVTLLFLGLDRLKAVNDYLGHNAGDRLIEVFADRLREAAESLTVI
MAV_3132|M.avium_104 PGQPGPVPVVFLAIDRFKVINGRLGQDAGDRFIDAFAALLREATEIPSVI
Mb1389c|M.bovis_AF2122/97 PGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLI
Rv1354c|M.tuberculosis_H37Rv PGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLI
Mflv_5174|M.gilvum_PYR-GCK AALVAPWSELLADVEPSRIVLEITEHDAVPNYGALDDVLEGCRAQGVRVA
Mvan_1152|M.vanbaalenii_PYR-1 AALAAPWHELLVDVDPSRIVLEITEHVAVGNYGALDDALESCRARGMRIA
MAB_3940c|M.abscessus_ATCC_199 FADIGIAVACWQDSDPLAGLVGTVLFTPVGAYVSFFLANR----------
. . : :
MSMEG_2196|M.smegmatis_MC2_155 ARLGGDEFVVVP----------DDPMSLDEATALAYRLQSVLRERVTVDG
TH_0811|M.thermoresistible__bu ARLGGDEFVVVP----------SGPVDADAALELANRLRSRLQQQVCVDG
MLBr_01750|M.leprae_Br4923 ARFGGDEFVVVP----------AESVSVDVAESFAHRLQTRLQKQVVIDG
MAV_3132|M.avium_104 ARFGGDEFGVVP----------AAPMDVEAAESFAHSLHERLHHPIAIDD
Mb1389c|M.bovis_AF2122/97 ARLGGDEFVLIP----------ASPMSADAAQPLAERLRDQLKDHVAIGG
Rv1354c|M.tuberculosis_H37Rv ARLGGDEFVLIP----------ASPMSADAAQPLAERLRDQLKDHVAIGG
Mflv_5174|M.gilvum_PYR-GCK VDDVGAGFASFSHVLELAPEFVKIDHSIIRHIDVDDARRRLAQAIAEFAG
Mvan_1152|M.vanbaalenii_PYR-1 VDDVGAGFASFSHVLELTPEFVKIDQSITRHIDVDDARRRLAQAIAEFAG
MAB_3940c|M.abscessus_ATCC_199 ----------------------------------------LLVAHVAWCA
MSMEG_2196|M.smegmatis_MC2_155 EMLTRTVSIGIAQGIPGKDSTSDVLNRADHAVLTAKGSGGNRVAVFSDAM
TH_0811|M.thermoresistible__bu EMLTRTASIGVAQGTPGRDTTSDLLRRADQAVLTAKSAGGNQITVFTDDM
MLBr_01750|M.leprae_Br4923 EILTRTVSIGVATGLPGRDTTSDLLRWADHAALSAKSDG-SKVVVLDHGI
MAV_3132|M.avium_104 EMLSRTVSIGVAAGIPGDESTSDLLRRVDQATRSAKAAGGNNVATFRPEM
Mb1389c|M.bovis_AF2122/97 EVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADM
Rv1354c|M.tuberculosis_H37Rv EVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADM
Mflv_5174|M.gilvum_PYR-GCK QFGAMVIAEGVESQRELDAVRAAGIGCAQGFYLSRPKAHGHGFPAATATA
Mvan_1152|M.vanbaalenii_PYR-1 QIGATVIAEGVESQGELDAVVAAGITWAQGFCLSRPKPHAHGFPPSFATA
MAB_3940c|M.abscessus_ATCC_199 PMIIALSSRLFAEGTVG-AAMTALVKVTSMLLVVVLIPAVIQFGIAVVRW
. : . : : .. .
MSMEG_2196|M.smegmatis_MC2_155 AMEIDFRNDIELHLQSVIEG--GALVLHYLPEIDMRTGEVLAAEALVRWE
TH_0811|M.thermoresistible__bu SLEAEFRNDIELHLQSVIQD--EALLLHFLPEVDMRTGEILATEALVRWH
MLBr_01750|M.leprae_Br4923 SAQHTLRTEVELHLAGMIDT---DLVLHYLPEVDMSTGKVLGTEALVRWQ
MAV_3132|M.avium_104 STIDTIRNDIELYLEGMIDGGSGALVLHYLPEFDMRTGEILGTEALTRWQ
Mb1389c|M.bovis_AF2122/97 SVSGELRNDIELHLRRGIES--DALRLVYLPEVDLRTGDIVGTEALVRWQ
Rv1354c|M.tuberculosis_H37Rv SVSGELRNDIELHLRRGIES--DALRLVYLPEVDLRTGDIVGTEALVRWQ
Mflv_5174|M.gilvum_PYR-GCK DPSEPLPTAVDLLGERRFELALAHSPIG-MAVVGLDGSFLRTNRALRAML
Mvan_1152|M.vanbaalenii_PYR-1 ASTERVLAPVDLLGDRPFELALTHSPIG-MAVVGLDGGFLRTNRALRAML
MAB_3940c|M.abscessus_ATCC_199 DALAAQRDPLTGLLNR----------------RGIYAEWQRLYGELRREQ
: .: *
MSMEG_2196|M.smegmatis_MC2_155 HPTRGLLSPDSFIGVAESINLAGELG----RWVLRTACAEFSRWRANGVG
TH_0811|M.thermoresistible__bu HPTRGLLAPDTFIGVAESVNLAGELG----RWVMRTACGEFAKWRAEGIG
MLBr_01750|M.leprae_Br4923 HPTRGLLFPDSFIPVAESINLAGKLG----RMVMHSACAEFSRWRSAGVG
MAV_3132|M.avium_104 HPTLGLLMPDSFIQVAESINLGAKLG----RLVMRSACAQFGQWRSRGVG
Mb1389c|M.bovis_AF2122/97 HPTRGLLAPGCFIPVAESINLAGELD----RWVLRRACNEFSEWQSAGLG
Rv1354c|M.tuberculosis_H37Rv HPTRGLLAPGCFIPVAESINLAGELD----RWVLRRACNEFSEWQSAGLG
Mflv_5174|M.gilvum_PYR-GCK GYSRRAMSELTFQDITHPDDLDLDLALVNECLEGRRRSYRIDKRYIAADG
Mvan_1152|M.vanbaalenii_PYR-1 GYSRGTLADMTFQQITHPDDLDADLAMVAECLEGRRRSYRIDKRYIAADG
MAB_3940c|M.abscessus_ATCC_199 PLDGDQVTAAAIVDIDRFKSINDRYG--------------------HGTG
: : : . .: . *
MSMEG_2196|M.smegmatis_MC2_155 RNIVLRINVSPVQLVTDG---FVESVAGIMKEFGLPRGSVCLEITESVVV
TH_0811|M.thermoresistible__bu LDAVLRINVSPVQLVTDG---FVASVADIIDEFGLDGSSVCLEITESVVV
MLBr_01750|M.leprae_Br4923 LDALLRINVSPVQLVAEG---FVDNVAGTLDEFGLDGSMVCLEITENVVV
MAV_3132|M.avium_104 QGTVLRINVSPVQLVTAG---IVDTVAATLDEFGLDPSTVCLEITESVVV
Mb1389c|M.bovis_AF2122/97 HDALLRINVSAGQLVTGG---FVDFVADTIGQHGLDASSVCLEITENVVV
Rv1354c|M.tuberculosis_H37Rv HDALLRINVSAGQLVTGG---FVDFVADTIGQHGLDASSVCLEITENVVV
Mflv_5174|M.gilvum_PYR-GCK SIVWCALTAVIVHAPRDQPRCFVSQIVDVTADRLREAELVRRASTDPLTS
Mvan_1152|M.vanbaalenii_PYR-1 HIVWCALTVVLVHAPRDQPRCFVSQIVDVTADRAREAELARQAATDPLTA
MAB_3940c|M.abscessus_ATCC_199 DRVLIDVAHALTCGTTGT---------SVVGRSGGEEFLVVTVCPASAVA
: . . .
MSMEG_2196|M.smegmatis_MC2_155 QDIETTRTTLTGLHNVG---VQVAIDDFGTGYSVLSLLKSLPVDTLKIDR
TH_0811|M.thermoresistible__bu QDIKTTRITLEGLNEVG---VQVAIDDFGTGYSVLSHLKTLPVDTLKIDK
MLBr_01750|M.leprae_Br4923 QNIDATRKTLAGLKEVG---VHLAIDDFGTGYSVLTHLKSLPVDTIKIDK
MAV_3132|M.avium_104 QDIDATRQTLFGLKDIG---VQIAIDDFGTGYSVLTYLKSLPVDSLKIDK
Mb1389c|M.bovis_AF2122/97 QDLHTARATLARLKEVG---VHIAIDDFGTGYSAISLLQTLPIDTLKIDK
Rv1354c|M.tuberculosis_H37Rv QDLHTARATLARLKEVG---VHIAIDDFGTGYSAISLLQTLPIDTLKIDK
Mflv_5174|M.gilvum_PYR-GCK IANRSAAWTRLEQLDQSGEGYGVLFCDIERFKSVNDRHGHHAGDQLLVEV
Mvan_1152|M.vanbaalenii_PYR-1 IANRSAAFRRLEQLDAGHDGYGVLFCDIERFKSVNDWCGHHAGDQLLVEV
MAB_3940c|M.abscessus_ATCC_199 EFATRLRQAVTASMPAG---IAVTASVGVAAQAVSRVVSATSQEAIEVLT
. : :. . : : :
MSMEG_2196|M.smegmatis_MC2_155 SFVAELGSNPGDLPIVRA------VIALAGAFGLQLVAEGVETERAALTL
TH_0811|M.thermoresistible__bu GFVQDLGNSPGDLAIVRA------IIALAEAFGLQLVAEGVETEAAALTL
MLBr_01750|M.leprae_Br4923 SFVAELGSNASDLAIVRA------IMALAKEFELEVVAEGVETAVAAQVL
MAV_3132|M.avium_104 GFVQSLDTNPGDLAIVRS------TLALADAFGLDVVAEGVETVAAAETL
Mb1389c|M.bovis_AF2122/97 TFVRQLGTNTSDLVIVRG------IMTLAEGFQLDVVAEGVETEAAARIL
Rv1354c|M.tuberculosis_H37Rv TFVRQLGTNTSDLVIVRG------IMTLAEGFQLDVVAEGVETEAAARIL
Mflv_5174|M.gilvum_PYR-GCK AQRLHDTLDPFDLAARWGGDEFLVITRCVEEPALACLADRIIDRMDGTPI
Mvan_1152|M.vanbaalenii_PYR-1 AARLLAAVDEGALVARWGGDEFLVVTDTVEEHELARLATRITEEVDRTPV
MAB_3940c|M.abscessus_ATCC_199 ACAD------------------------------RAMYEAKHDGGDQSRI
: :
MSMEG_2196|M.smegmatis_MC2_155 LRHG-----CYRAQGFLLSKPILGSEMQTLLAKGRVPVHFS--AAPRM--
TH_0811|M.thermoresistible__bu LRHG-----CHRAQGFLLSRPIPSNEMRELLARGRIPMRFS--ATP----
MLBr_01750|M.leprae_Br4923 LELG-----CNRAQGFLLSRPVDGAAMESLLAKGVIPMALGTCQSPEPSE
MAV_3132|M.avium_104 LSLG-----CHRAQGFLLSRPLDSAGMEALLIKGAIPMRFSDGGAPE-NQ
Mb1389c|M.bovis_AF2122/97 LDQR-----CYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-
Rv1354c|M.tuberculosis_H37Rv LDQR-----CYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-
Mflv_5174|M.gilvum_PYR-GCK TLPGGAEESVAMTIGFAAHRPGDGRSVDDVLDLADHQMCEQRRRRPRVRR
Mvan_1152|M.vanbaalenii_PYR-1 TLADGTQMPVAMTIGFAAHRPGDGRSIDAVLDCADQAMYEQRRQRRNTVL
MAB_3940c|M.abscessus_ATCC_199 LHAD------DDSEGRYLWRSGA---------------------------
: * :.
MSMEG_2196|M.smegmatis_MC2_155 -----------
TH_0811|M.thermoresistible__bu -----------
MLBr_01750|M.leprae_Br4923 HQIHRS-----
MAV_3132|M.avium_104 HVV--------
Mb1389c|M.bovis_AF2122/97 -----------
Rv1354c|M.tuberculosis_H37Rv -----------
Mflv_5174|M.gilvum_PYR-GCK RLGVSRPR---
Mvan_1152|M.vanbaalenii_PYR-1 HKGNEAIGLVE
MAB_3940c|M.abscessus_ATCC_199 -----------