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EGQPGIPADLVRTLLGVLRQRLGLDTAWLSSFHDDTQTIEVLDGDAASFGLSPGLRTPLSESYCVRVIDG RLPSVVPDTSQNQTTHALPVTDEMGLGAYIGVPVPGHAGTTSGMVCLVSQEPKPYLGDDDLRLVRQAAEL IGTLIESPVRQADSVDRRSAIRRVVSELDFEVVFQAIHDVASGRAVGVEALARFPCEPFRPDAFFAEAAQ LGIGIQLELAIVRRVLSLLPQLPDDVFVSINISPAAALVAPWSELLADVEPSRIVLEITEHDAVPNYGAL DDVLEGCRAQGVRVAVDDVGAGFASFSHVLELAPEFVKIDHSIIRHIDVDDARRRLAQAIAEFAGQFGAM VIAEGVESQRELDAVRAAGIGCAQGFYLSRPKAHGHGFPAATATADPSEPLPTAVDLLGERRFELALAHS PIGMAVVGLDGSFLRTNRALRAMLGYSRRAMSELTFQDITHPDDLDLDLALVNECLEGRRRSYRIDKRYI AADGSIVWCALTAVIVHAPRDQPRCFVSQIVDVTADRLREAELVRRASTDPLTSIANRSAAWTRLEQLDQ SGEGYGVLFCDIERFKSVNDRHGHHAGDQLLVEVAQRLHDTLDPFDLAARWGGDEFLVITRCVEEPALAC LADRIIDRMDGTPITLPGGAEESVAMTIGFAAHRPGDGRSVDDVLDLADHQMCEQRRRRPRVRRRLGVSR PR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_5174 | - | - | 100% (703) | diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) |
M. gilvum PYR-GCK | Mflv_4571 | - | 1e-42 | 31.50% (381) | diguanylate phosphodiesterase |
M. gilvum PYR-GCK | Mflv_2883 | - | 3e-24 | 31.77% (299) | diguanylate cyclase with PAS/PAC sensor |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1389c | - | 3e-16 | 26.69% (236) | hypothetical protein Mb1389c |
M. tuberculosis H37Rv | Rv1354c | - | 4e-16 | 26.69% (236) | hypothetical protein Rv1354c |
M. leprae Br4923 | MLBr_01750 | - | 8e-20 | 28.90% (218) | hypothetical protein MLBr_01750 |
M. abscessus ATCC 19977 | MAB_3940c | - | 1e-12 | 36.30% (135) | hypothetical protein MAB_3940c |
M. marinum M | - | - | - | - | - |
M. avium 104 | MAV_3132 | - | 3e-20 | 28.57% (217) | GGDEF domain-containing protein |
M. smegmatis MC2 155 | MSMEG_2196 | - | 5e-17 | 27.98% (218) | sensory box/response regulator |
M. thermoresistible (build 8) | TH_0811 | - | 8e-18 | 29.36% (218) | sensory box/response regulator |
M. ulcerans Agy99 | - | - | - | - | - |
M. vanbaalenii PYR-1 | Mvan_1152 | - | 0.0 | 75.51% (690) | diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_2196|M.smegmatis_MC2_155 ------------MSESLDVLVTSVATQLMAVEAATSVSVSQQVLAELVSF TH_0811|M.thermoresistible__bu ------------VSTELDLLVTGVATKLMAADAATARDVSRRVLADLVRA MLBr_01750|M.leprae_Br4923 ------------MTRSLDELVTRVASKLMAATAATAVTISEGVLAILVEH MAV_3132|M.avium_104 ------------MSGTLDHLVTAAAAELMAATAADAAQISERVLADLVSH Mb1389c|M.bovis_AF2122/97 -------MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQ Rv1354c|M.tuberculosis_H37Rv -------MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQ Mflv_5174|M.gilvum_PYR-GCK MEG-QPGIPADLVRTLLGVLRQRLGLDTAWLSSFHDDTQTIEVLDGDAAS Mvan_1152|M.vanbaalenii_PYR-1 MTGDQPELPVDLVRTLLGVLRQRLGLDAAWLSSFDDGMQVIEVLDGNADG MAB_3940c|M.abscessus_ATCC_199 ----------------MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHA : * MSMEG_2196|M.smegmatis_MC2_155 FDVDVS----FLRHNDHRAHATRLVAEWPPRPVDAATDPIAVVHFADADP TH_0811|M.thermoresistible__bu FELDFS----FLRHNDHEIRASKLIAEWPVRENVPDPDPIGVVHFEGADP MLBr_01750|M.leprae_Br4923 FGVDVS----FLRHNNHDIHETKLIVEWPPRDYVPDPDPIGVVYFADADP MAV_3132|M.avium_104 FGVNFG----FLRHNDHSIRATVLVAEWPPRN--VDPDPLGVIYFADADS Mb1389c|M.bovis_AF2122/97 LGVDVS----FLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADP Rv1354c|M.tuberculosis_H37Rv LGVDVS----FLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADP Mflv_5174|M.gilvum_PYR-GCK FGLSPGLRTPLSESYCVRVIDGRLPSVVPDTSQNQTTHALPVTDEMGLGA Mvan_1152|M.vanbaalenii_PYR-1 LGVSPGQRIGLPESYCVRVIDGRLPAVIPDTSADQTTAALPITRESGVGA MAB_3940c|M.abscessus_ATCC_199 RKLDRT-------------------------------------------- :. MSMEG_2196|M.smegmatis_MC2_155 VFAMAEHLK--------EPAVFRPEP---LYDDYQRTIEAGRHIPATSMA TH_0811|M.thermoresistible__bu VFALAEHAK--------EIHIFRPEP---ATDEFQRLIEESSGVPASTVA MLBr_01750|M.leprae_Br4923 VFAMAEYLK--------EPAVLRPEP---ANADYQRRIEEGASVPAVSLA MAV_3132|M.avium_104 VFARVETMK--------EPDVLRPEP---ANADYQRNIEDGTGIPEVSLA Mb1389c|M.bovis_AF2122/97 VFALCEHAK--------EPLVFRPEP---ATEDYQRLIEEARGVPVTSAA Rv1354c|M.tuberculosis_H37Rv VFALCEHAK--------EPLVFRPEP---ATEDYQRLIEEARGVPVTSAA Mflv_5174|M.gilvum_PYR-GCK YIG--VPVPGHAGTTSGMVCLVSQEPKPYLGDDDLRLVRQAAELIGTLIE Mvan_1152|M.vanbaalenii_PYR-1 YVGVPVPVPGHGDATAGMVCVVSREPKPDLTDEDLQIVKQVADLIGTLID MAB_3940c|M.abscessus_ATCC_199 ----------------------------------VRNLIGGYALIFAAIC : : : MSMEG_2196|M.smegmatis_MC2_155 CVPLLSGDVTTGVLGFVKFGDREWLPAELNALKAIAS------------- TH_0811|M.thermoresistible__bu AVPLVSGEITTGVLGFVKYGDRQWHPDELNALKAIAS------------- MLBr_01750|M.leprae_Br4923 CVPLLSGEITTGVLGFVKYGDREWHDDELRALQAIAT------------- MAV_3132|M.avium_104 AVPLLSGDVTTGTLGFVKFGDREWLSEELNALQAIAA------------- Mb1389c|M.bovis_AF2122/97 AVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIAT------------- Rv1354c|M.tuberculosis_H37Rv AVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIAT------------- Mflv_5174|M.gilvum_PYR-GCK SPVRQAD-SVDRRSAIRRVVSELDFEVVFQAIHDVASGRAVGVEALARFP Mvan_1152|M.vanbaalenii_PYR-1 SPAPGADPTADQRKAIRRVLAERDFEVVFQAVHDAATGKVVGVEALARFP MAB_3940c|M.abscessus_ATCC_199 IAVQFSDTGPRSMIGRVIVG-----------LCAVGS------------- :. . : .: MSMEG_2196|M.smegmatis_MC2_155 -------LFAQVQARIEAEERLRYLADHDHLTGLYNR-RALMAHLEARLA TH_0811|M.thermoresistible__bu -------LFAQVQARVEAEERLRYLAEHDDLTGLHNR-RALLAHLDARLA MLBr_01750|M.leprae_Br4923 -------LFAQLQARIVAEEQLRYLAEHDDLTGLLNR-RALIAHLDERLA MAV_3132|M.avium_104 -------LFAQLQARVVAEEQIHYLAEHDELTGLLNR-RALIAHLDKRLA Mb1389c|M.bovis_AF2122/97 -------LFAQVQARVAAEARLRYLADHDDLTGLHNR-RALLQHLDQRLA Rv1354c|M.tuberculosis_H37Rv -------LFAQVQARVAAEARLRYLADHDDLTGLHNR-RALLQHLDQRLA Mflv_5174|M.gilvum_PYR-GCK CEPFRPDAFFAEAAQLGIGIQLELAIVRRVLSLLPQLPDDVFVSINISPA Mvan_1152|M.vanbaalenii_PYR-1 CEPFRPDAFFQQAAQLGLDIELETAIVRRVLSMIPQLPDDVFVAMNISPA MAB_3940c|M.abscessus_ATCC_199 -----------------LGWALRWAVGP----------WPSLREAVAFVA :. : * MSMEG_2196|M.smegmatis_MC2_155 PGQPGPVAVMFFDLDRLKAINDYLGHTAGDAFISILAQRLQRGDDAPKLI TH_0811|M.thermoresistible__bu AGQPGPVSALYFDLDRLKAVNDYLGHTVGDWFIRVLAERLREGAGPDDLI MLBr_01750|M.leprae_Br4923 DGQRGPVTLLFLGLDRLKAVNDYLGHNAGDRLIEVFADRLREAAESLTVI MAV_3132|M.avium_104 PGQPGPVPVVFLAIDRFKVINGRLGQDAGDRFIDAFAALLREATEIPSVI Mb1389c|M.bovis_AF2122/97 PGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLI Rv1354c|M.tuberculosis_H37Rv PGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLI Mflv_5174|M.gilvum_PYR-GCK AALVAPWSELLADVEPSRIVLEITEHDAVPNYGALDDVLEGCRAQGVRVA Mvan_1152|M.vanbaalenii_PYR-1 AALAAPWHELLVDVDPSRIVLEITEHVAVGNYGALDDALESCRARGMRIA MAB_3940c|M.abscessus_ATCC_199 FADIGIAVACWQDSDPLAGLVGTVLFTPVGAYVSFFLANR---------- . . : : MSMEG_2196|M.smegmatis_MC2_155 ARLGGDEFVVVP----------DDPMSLDEATALAYRLQSVLRERVTVDG TH_0811|M.thermoresistible__bu ARLGGDEFVVVP----------SGPVDADAALELANRLRSRLQQQVCVDG MLBr_01750|M.leprae_Br4923 ARFGGDEFVVVP----------AESVSVDVAESFAHRLQTRLQKQVVIDG MAV_3132|M.avium_104 ARFGGDEFGVVP----------AAPMDVEAAESFAHSLHERLHHPIAIDD Mb1389c|M.bovis_AF2122/97 ARLGGDEFVLIP----------ASPMSADAAQPLAERLRDQLKDHVAIGG Rv1354c|M.tuberculosis_H37Rv ARLGGDEFVLIP----------ASPMSADAAQPLAERLRDQLKDHVAIGG Mflv_5174|M.gilvum_PYR-GCK VDDVGAGFASFSHVLELAPEFVKIDHSIIRHIDVDDARRRLAQAIAEFAG Mvan_1152|M.vanbaalenii_PYR-1 VDDVGAGFASFSHVLELTPEFVKIDQSITRHIDVDDARRRLAQAIAEFAG MAB_3940c|M.abscessus_ATCC_199 ----------------------------------------LLVAHVAWCA MSMEG_2196|M.smegmatis_MC2_155 EMLTRTVSIGIAQGIPGKDSTSDVLNRADHAVLTAKGSGGNRVAVFSDAM TH_0811|M.thermoresistible__bu EMLTRTASIGVAQGTPGRDTTSDLLRRADQAVLTAKSAGGNQITVFTDDM MLBr_01750|M.leprae_Br4923 EILTRTVSIGVATGLPGRDTTSDLLRWADHAALSAKSDG-SKVVVLDHGI MAV_3132|M.avium_104 EMLSRTVSIGVAAGIPGDESTSDLLRRVDQATRSAKAAGGNNVATFRPEM Mb1389c|M.bovis_AF2122/97 EVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADM Rv1354c|M.tuberculosis_H37Rv EVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADM Mflv_5174|M.gilvum_PYR-GCK QFGAMVIAEGVESQRELDAVRAAGIGCAQGFYLSRPKAHGHGFPAATATA Mvan_1152|M.vanbaalenii_PYR-1 QIGATVIAEGVESQGELDAVVAAGITWAQGFCLSRPKPHAHGFPPSFATA MAB_3940c|M.abscessus_ATCC_199 PMIIALSSRLFAEGTVG-AAMTALVKVTSMLLVVVLIPAVIQFGIAVVRW . : . : : .. . MSMEG_2196|M.smegmatis_MC2_155 AMEIDFRNDIELHLQSVIEG--GALVLHYLPEIDMRTGEVLAAEALVRWE TH_0811|M.thermoresistible__bu SLEAEFRNDIELHLQSVIQD--EALLLHFLPEVDMRTGEILATEALVRWH MLBr_01750|M.leprae_Br4923 SAQHTLRTEVELHLAGMIDT---DLVLHYLPEVDMSTGKVLGTEALVRWQ MAV_3132|M.avium_104 STIDTIRNDIELYLEGMIDGGSGALVLHYLPEFDMRTGEILGTEALTRWQ Mb1389c|M.bovis_AF2122/97 SVSGELRNDIELHLRRGIES--DALRLVYLPEVDLRTGDIVGTEALVRWQ Rv1354c|M.tuberculosis_H37Rv SVSGELRNDIELHLRRGIES--DALRLVYLPEVDLRTGDIVGTEALVRWQ Mflv_5174|M.gilvum_PYR-GCK DPSEPLPTAVDLLGERRFELALAHSPIG-MAVVGLDGSFLRTNRALRAML Mvan_1152|M.vanbaalenii_PYR-1 ASTERVLAPVDLLGDRPFELALTHSPIG-MAVVGLDGGFLRTNRALRAML MAB_3940c|M.abscessus_ATCC_199 DALAAQRDPLTGLLNR----------------RGIYAEWQRLYGELRREQ : .: * MSMEG_2196|M.smegmatis_MC2_155 HPTRGLLSPDSFIGVAESINLAGELG----RWVLRTACAEFSRWRANGVG TH_0811|M.thermoresistible__bu HPTRGLLAPDTFIGVAESVNLAGELG----RWVMRTACGEFAKWRAEGIG MLBr_01750|M.leprae_Br4923 HPTRGLLFPDSFIPVAESINLAGKLG----RMVMHSACAEFSRWRSAGVG MAV_3132|M.avium_104 HPTLGLLMPDSFIQVAESINLGAKLG----RLVMRSACAQFGQWRSRGVG Mb1389c|M.bovis_AF2122/97 HPTRGLLAPGCFIPVAESINLAGELD----RWVLRRACNEFSEWQSAGLG Rv1354c|M.tuberculosis_H37Rv HPTRGLLAPGCFIPVAESINLAGELD----RWVLRRACNEFSEWQSAGLG Mflv_5174|M.gilvum_PYR-GCK GYSRRAMSELTFQDITHPDDLDLDLALVNECLEGRRRSYRIDKRYIAADG Mvan_1152|M.vanbaalenii_PYR-1 GYSRGTLADMTFQQITHPDDLDADLAMVAECLEGRRRSYRIDKRYIAADG MAB_3940c|M.abscessus_ATCC_199 PLDGDQVTAAAIVDIDRFKSINDRYG--------------------HGTG : : : . .: . * MSMEG_2196|M.smegmatis_MC2_155 RNIVLRINVSPVQLVTDG---FVESVAGIMKEFGLPRGSVCLEITESVVV TH_0811|M.thermoresistible__bu LDAVLRINVSPVQLVTDG---FVASVADIIDEFGLDGSSVCLEITESVVV MLBr_01750|M.leprae_Br4923 LDALLRINVSPVQLVAEG---FVDNVAGTLDEFGLDGSMVCLEITENVVV MAV_3132|M.avium_104 QGTVLRINVSPVQLVTAG---IVDTVAATLDEFGLDPSTVCLEITESVVV Mb1389c|M.bovis_AF2122/97 HDALLRINVSAGQLVTGG---FVDFVADTIGQHGLDASSVCLEITENVVV Rv1354c|M.tuberculosis_H37Rv HDALLRINVSAGQLVTGG---FVDFVADTIGQHGLDASSVCLEITENVVV Mflv_5174|M.gilvum_PYR-GCK SIVWCALTAVIVHAPRDQPRCFVSQIVDVTADRLREAELVRRASTDPLTS Mvan_1152|M.vanbaalenii_PYR-1 HIVWCALTVVLVHAPRDQPRCFVSQIVDVTADRAREAELARQAATDPLTA MAB_3940c|M.abscessus_ATCC_199 DRVLIDVAHALTCGTTGT---------SVVGRSGGEEFLVVTVCPASAVA : . . . MSMEG_2196|M.smegmatis_MC2_155 QDIETTRTTLTGLHNVG---VQVAIDDFGTGYSVLSLLKSLPVDTLKIDR TH_0811|M.thermoresistible__bu QDIKTTRITLEGLNEVG---VQVAIDDFGTGYSVLSHLKTLPVDTLKIDK MLBr_01750|M.leprae_Br4923 QNIDATRKTLAGLKEVG---VHLAIDDFGTGYSVLTHLKSLPVDTIKIDK MAV_3132|M.avium_104 QDIDATRQTLFGLKDIG---VQIAIDDFGTGYSVLTYLKSLPVDSLKIDK Mb1389c|M.bovis_AF2122/97 QDLHTARATLARLKEVG---VHIAIDDFGTGYSAISLLQTLPIDTLKIDK Rv1354c|M.tuberculosis_H37Rv QDLHTARATLARLKEVG---VHIAIDDFGTGYSAISLLQTLPIDTLKIDK Mflv_5174|M.gilvum_PYR-GCK IANRSAAWTRLEQLDQSGEGYGVLFCDIERFKSVNDRHGHHAGDQLLVEV Mvan_1152|M.vanbaalenii_PYR-1 IANRSAAFRRLEQLDAGHDGYGVLFCDIERFKSVNDWCGHHAGDQLLVEV MAB_3940c|M.abscessus_ATCC_199 EFATRLRQAVTASMPAG---IAVTASVGVAAQAVSRVVSATSQEAIEVLT . : :. . : : : MSMEG_2196|M.smegmatis_MC2_155 SFVAELGSNPGDLPIVRA------VIALAGAFGLQLVAEGVETERAALTL TH_0811|M.thermoresistible__bu GFVQDLGNSPGDLAIVRA------IIALAEAFGLQLVAEGVETEAAALTL MLBr_01750|M.leprae_Br4923 SFVAELGSNASDLAIVRA------IMALAKEFELEVVAEGVETAVAAQVL MAV_3132|M.avium_104 GFVQSLDTNPGDLAIVRS------TLALADAFGLDVVAEGVETVAAAETL Mb1389c|M.bovis_AF2122/97 TFVRQLGTNTSDLVIVRG------IMTLAEGFQLDVVAEGVETEAAARIL Rv1354c|M.tuberculosis_H37Rv TFVRQLGTNTSDLVIVRG------IMTLAEGFQLDVVAEGVETEAAARIL Mflv_5174|M.gilvum_PYR-GCK AQRLHDTLDPFDLAARWGGDEFLVITRCVEEPALACLADRIIDRMDGTPI Mvan_1152|M.vanbaalenii_PYR-1 AARLLAAVDEGALVARWGGDEFLVVTDTVEEHELARLATRITEEVDRTPV MAB_3940c|M.abscessus_ATCC_199 ACAD------------------------------RAMYEAKHDGGDQSRI : : MSMEG_2196|M.smegmatis_MC2_155 LRHG-----CYRAQGFLLSKPILGSEMQTLLAKGRVPVHFS--AAPRM-- TH_0811|M.thermoresistible__bu LRHG-----CHRAQGFLLSRPIPSNEMRELLARGRIPMRFS--ATP---- MLBr_01750|M.leprae_Br4923 LELG-----CNRAQGFLLSRPVDGAAMESLLAKGVIPMALGTCQSPEPSE MAV_3132|M.avium_104 LSLG-----CHRAQGFLLSRPLDSAGMEALLIKGAIPMRFSDGGAPE-NQ Mb1389c|M.bovis_AF2122/97 LDQR-----CYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS- Rv1354c|M.tuberculosis_H37Rv LDQR-----CYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS- Mflv_5174|M.gilvum_PYR-GCK TLPGGAEESVAMTIGFAAHRPGDGRSVDDVLDLADHQMCEQRRRRPRVRR Mvan_1152|M.vanbaalenii_PYR-1 TLADGTQMPVAMTIGFAAHRPGDGRSIDAVLDCADQAMYEQRRQRRNTVL MAB_3940c|M.abscessus_ATCC_199 LHAD------DDSEGRYLWRSGA--------------------------- : * :. MSMEG_2196|M.smegmatis_MC2_155 ----------- TH_0811|M.thermoresistible__bu ----------- MLBr_01750|M.leprae_Br4923 HQIHRS----- MAV_3132|M.avium_104 HVV-------- Mb1389c|M.bovis_AF2122/97 ----------- Rv1354c|M.tuberculosis_H37Rv ----------- Mflv_5174|M.gilvum_PYR-GCK RLGVSRPR--- Mvan_1152|M.vanbaalenii_PYR-1 HKGNEAIGLVE MAB_3940c|M.abscessus_ATCC_199 -----------