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M. gilvum PYR-GCK Mflv_5174 (-)

annotation: diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s)
coordinates: 5514892 - 5517003
length: 703

EGQPGIPADLVRTLLGVLRQRLGLDTAWLSSFHDDTQTIEVLDGDAASFGLSPGLRTPLSESYCVRVIDG
RLPSVVPDTSQNQTTHALPVTDEMGLGAYIGVPVPGHAGTTSGMVCLVSQEPKPYLGDDDLRLVRQAAEL
IGTLIESPVRQADSVDRRSAIRRVVSELDFEVVFQAIHDVASGRAVGVEALARFPCEPFRPDAFFAEAAQ
LGIGIQLELAIVRRVLSLLPQLPDDVFVSINISPAAALVAPWSELLADVEPSRIVLEITEHDAVPNYGAL
DDVLEGCRAQGVRVAVDDVGAGFASFSHVLELAPEFVKIDHSIIRHIDVDDARRRLAQAIAEFAGQFGAM
VIAEGVESQRELDAVRAAGIGCAQGFYLSRPKAHGHGFPAATATADPSEPLPTAVDLLGERRFELALAHS
PIGMAVVGLDGSFLRTNRALRAMLGYSRRAMSELTFQDITHPDDLDLDLALVNECLEGRRRSYRIDKRYI
AADGSIVWCALTAVIVHAPRDQPRCFVSQIVDVTADRLREAELVRRASTDPLTSIANRSAAWTRLEQLDQ
SGEGYGVLFCDIERFKSVNDRHGHHAGDQLLVEVAQRLHDTLDPFDLAARWGGDEFLVITRCVEEPALAC
LADRIIDRMDGTPITLPGGAEESVAMTIGFAAHRPGDGRSVDDVLDLADHQMCEQRRRRPRVRRRLGVSR
PR*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_5174--100% (703)diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s)
M. gilvum PYR-GCKMflv_4571-1e-4231.50% (381) diguanylate phosphodiesterase
M. gilvum PYR-GCKMflv_2883-3e-2431.77% (299) diguanylate cyclase with PAS/PAC sensor

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1389c-3e-1626.69% (236) hypothetical protein Mb1389c
M. tuberculosis H37RvRv1354c-4e-1626.69% (236) hypothetical protein Rv1354c
M. leprae Br4923MLBr_01750-8e-2028.90% (218) hypothetical protein MLBr_01750
M. abscessus ATCC 19977MAB_3940c-1e-1236.30% (135) hypothetical protein MAB_3940c
M. marinum M-----
M. avium 104MAV_3132-3e-2028.57% (217) GGDEF domain-containing protein
M. smegmatis MC2 155MSMEG_2196-5e-1727.98% (218) sensory box/response regulator
M. thermoresistible (build 8)TH_0811-8e-1829.36% (218) sensory box/response regulator
M. ulcerans Agy99-----
M. vanbaalenii PYR-1Mvan_1152-0.075.51% (690) diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_2196|M.smegmatis_MC2_155      ------------MSESLDVLVTSVATQLMAVEAATSVSVSQQVLAELVSF
TH_0811|M.thermoresistible__bu      ------------VSTELDLLVTGVATKLMAADAATARDVSRRVLADLVRA
MLBr_01750|M.leprae_Br4923          ------------MTRSLDELVTRVASKLMAATAATAVTISEGVLAILVEH
MAV_3132|M.avium_104                ------------MSGTLDHLVTAAAAELMAATAADAAQISERVLADLVSH
Mb1389c|M.bovis_AF2122/97           -------MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQ
Rv1354c|M.tuberculosis_H37Rv        -------MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQ
Mflv_5174|M.gilvum_PYR-GCK          MEG-QPGIPADLVRTLLGVLRQRLGLDTAWLSSFHDDTQTIEVLDGDAAS
Mvan_1152|M.vanbaalenii_PYR-1       MTGDQPELPVDLVRTLLGVLRQRLGLDAAWLSSFDDGMQVIEVLDGNADG
MAB_3940c|M.abscessus_ATCC_199      ----------------MIVSYIRSTAWMGFLRQWWTEPVPTGWLRGFLHA
                                                    :                          *      

MSMEG_2196|M.smegmatis_MC2_155      FDVDVS----FLRHNDHRAHATRLVAEWPPRPVDAATDPIAVVHFADADP
TH_0811|M.thermoresistible__bu      FELDFS----FLRHNDHEIRASKLIAEWPVRENVPDPDPIGVVHFEGADP
MLBr_01750|M.leprae_Br4923          FGVDVS----FLRHNNHDIHETKLIVEWPPRDYVPDPDPIGVVYFADADP
MAV_3132|M.avium_104                FGVNFG----FLRHNDHSIRATVLVAEWPPRN--VDPDPLGVIYFADADS
Mb1389c|M.bovis_AF2122/97           LGVDVS----FLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADP
Rv1354c|M.tuberculosis_H37Rv        LGVDVS----FLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADP
Mflv_5174|M.gilvum_PYR-GCK          FGLSPGLRTPLSESYCVRVIDGRLPSVVPDTSQNQTTHALPVTDEMGLGA
Mvan_1152|M.vanbaalenii_PYR-1       LGVSPGQRIGLPESYCVRVIDGRLPAVIPDTSADQTTAALPITRESGVGA
MAB_3940c|M.abscessus_ATCC_199      RKLDRT--------------------------------------------
                                      :.                                              

MSMEG_2196|M.smegmatis_MC2_155      VFAMAEHLK--------EPAVFRPEP---LYDDYQRTIEAGRHIPATSMA
TH_0811|M.thermoresistible__bu      VFALAEHAK--------EIHIFRPEP---ATDEFQRLIEESSGVPASTVA
MLBr_01750|M.leprae_Br4923          VFAMAEYLK--------EPAVLRPEP---ANADYQRRIEEGASVPAVSLA
MAV_3132|M.avium_104                VFARVETMK--------EPDVLRPEP---ANADYQRNIEDGTGIPEVSLA
Mb1389c|M.bovis_AF2122/97           VFALCEHAK--------EPLVFRPEP---ATEDYQRLIEEARGVPVTSAA
Rv1354c|M.tuberculosis_H37Rv        VFALCEHAK--------EPLVFRPEP---ATEDYQRLIEEARGVPVTSAA
Mflv_5174|M.gilvum_PYR-GCK          YIG--VPVPGHAGTTSGMVCLVSQEPKPYLGDDDLRLVRQAAELIGTLIE
Mvan_1152|M.vanbaalenii_PYR-1       YVGVPVPVPGHGDATAGMVCVVSREPKPDLTDEDLQIVKQVADLIGTLID
MAB_3940c|M.abscessus_ATCC_199      ----------------------------------VRNLIGGYALIFAAIC
                                                                       : :     :      

MSMEG_2196|M.smegmatis_MC2_155      CVPLLSGDVTTGVLGFVKFGDREWLPAELNALKAIAS-------------
TH_0811|M.thermoresistible__bu      AVPLVSGEITTGVLGFVKYGDRQWHPDELNALKAIAS-------------
MLBr_01750|M.leprae_Br4923          CVPLLSGEITTGVLGFVKYGDREWHDDELRALQAIAT-------------
MAV_3132|M.avium_104                AVPLLSGDVTTGTLGFVKFGDREWLSEELNALQAIAA-------------
Mb1389c|M.bovis_AF2122/97           AVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIAT-------------
Rv1354c|M.tuberculosis_H37Rv        AVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIAT-------------
Mflv_5174|M.gilvum_PYR-GCK          SPVRQAD-SVDRRSAIRRVVSELDFEVVFQAIHDVASGRAVGVEALARFP
Mvan_1152|M.vanbaalenii_PYR-1       SPAPGADPTADQRKAIRRVLAERDFEVVFQAVHDAATGKVVGVEALARFP
MAB_3940c|M.abscessus_ATCC_199      IAVQFSDTGPRSMIGRVIVG-----------LCAVGS-------------
                                         :.       .                :   .:             

MSMEG_2196|M.smegmatis_MC2_155      -------LFAQVQARIEAEERLRYLADHDHLTGLYNR-RALMAHLEARLA
TH_0811|M.thermoresistible__bu      -------LFAQVQARVEAEERLRYLAEHDDLTGLHNR-RALLAHLDARLA
MLBr_01750|M.leprae_Br4923          -------LFAQLQARIVAEEQLRYLAEHDDLTGLLNR-RALIAHLDERLA
MAV_3132|M.avium_104                -------LFAQLQARVVAEEQIHYLAEHDELTGLLNR-RALIAHLDKRLA
Mb1389c|M.bovis_AF2122/97           -------LFAQVQARVAAEARLRYLADHDDLTGLHNR-RALLQHLDQRLA
Rv1354c|M.tuberculosis_H37Rv        -------LFAQVQARVAAEARLRYLADHDDLTGLHNR-RALLQHLDQRLA
Mflv_5174|M.gilvum_PYR-GCK          CEPFRPDAFFAEAAQLGIGIQLELAIVRRVLSLLPQLPDDVFVSINISPA
Mvan_1152|M.vanbaalenii_PYR-1       CEPFRPDAFFQQAAQLGLDIELETAIVRRVLSMIPQLPDDVFVAMNISPA
MAB_3940c|M.abscessus_ATCC_199      -----------------LGWALRWAVGP----------WPSLREAVAFVA
                                                         :.                  :       *

MSMEG_2196|M.smegmatis_MC2_155      PGQPGPVAVMFFDLDRLKAINDYLGHTAGDAFISILAQRLQRGDDAPKLI
TH_0811|M.thermoresistible__bu      AGQPGPVSALYFDLDRLKAVNDYLGHTVGDWFIRVLAERLREGAGPDDLI
MLBr_01750|M.leprae_Br4923          DGQRGPVTLLFLGLDRLKAVNDYLGHNAGDRLIEVFADRLREAAESLTVI
MAV_3132|M.avium_104                PGQPGPVPVVFLAIDRFKVINGRLGQDAGDRFIDAFAALLREATEIPSVI
Mb1389c|M.bovis_AF2122/97           PGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLI
Rv1354c|M.tuberculosis_H37Rv        PGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLI
Mflv_5174|M.gilvum_PYR-GCK          AALVAPWSELLADVEPSRIVLEITEHDAVPNYGALDDVLEGCRAQGVRVA
Mvan_1152|M.vanbaalenii_PYR-1       AALAAPWHELLVDVDPSRIVLEITEHVAVGNYGALDDALESCRARGMRIA
MAB_3940c|M.abscessus_ATCC_199      FADIGIAVACWQDSDPLAGLVGTVLFTPVGAYVSFFLANR----------
                                     .  .         :    :                              

MSMEG_2196|M.smegmatis_MC2_155      ARLGGDEFVVVP----------DDPMSLDEATALAYRLQSVLRERVTVDG
TH_0811|M.thermoresistible__bu      ARLGGDEFVVVP----------SGPVDADAALELANRLRSRLQQQVCVDG
MLBr_01750|M.leprae_Br4923          ARFGGDEFVVVP----------AESVSVDVAESFAHRLQTRLQKQVVIDG
MAV_3132|M.avium_104                ARFGGDEFGVVP----------AAPMDVEAAESFAHSLHERLHHPIAIDD
Mb1389c|M.bovis_AF2122/97           ARLGGDEFVLIP----------ASPMSADAAQPLAERLRDQLKDHVAIGG
Rv1354c|M.tuberculosis_H37Rv        ARLGGDEFVLIP----------ASPMSADAAQPLAERLRDQLKDHVAIGG
Mflv_5174|M.gilvum_PYR-GCK          VDDVGAGFASFSHVLELAPEFVKIDHSIIRHIDVDDARRRLAQAIAEFAG
Mvan_1152|M.vanbaalenii_PYR-1       VDDVGAGFASFSHVLELTPEFVKIDQSITRHIDVDDARRRLAQAIAEFAG
MAB_3940c|M.abscessus_ATCC_199      ----------------------------------------LLVAHVAWCA
                                                                                      

MSMEG_2196|M.smegmatis_MC2_155      EMLTRTVSIGIAQGIPGKDSTSDVLNRADHAVLTAKGSGGNRVAVFSDAM
TH_0811|M.thermoresistible__bu      EMLTRTASIGVAQGTPGRDTTSDLLRRADQAVLTAKSAGGNQITVFTDDM
MLBr_01750|M.leprae_Br4923          EILTRTVSIGVATGLPGRDTTSDLLRWADHAALSAKSDG-SKVVVLDHGI
MAV_3132|M.avium_104                EMLSRTVSIGVAAGIPGDESTSDLLRRVDQATRSAKAAGGNNVATFRPEM
Mb1389c|M.bovis_AF2122/97           EVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADM
Rv1354c|M.tuberculosis_H37Rv        EVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADM
Mflv_5174|M.gilvum_PYR-GCK          QFGAMVIAEGVESQRELDAVRAAGIGCAQGFYLSRPKAHGHGFPAATATA
Mvan_1152|M.vanbaalenii_PYR-1       QIGATVIAEGVESQGELDAVVAAGITWAQGFCLSRPKPHAHGFPPSFATA
MAB_3940c|M.abscessus_ATCC_199      PMIIALSSRLFAEGTVG-AAMTALVKVTSMLLVVVLIPAVIQFGIAVVRW
                                     .     :  .          :  :  ..             .       

MSMEG_2196|M.smegmatis_MC2_155      AMEIDFRNDIELHLQSVIEG--GALVLHYLPEIDMRTGEVLAAEALVRWE
TH_0811|M.thermoresistible__bu      SLEAEFRNDIELHLQSVIQD--EALLLHFLPEVDMRTGEILATEALVRWH
MLBr_01750|M.leprae_Br4923          SAQHTLRTEVELHLAGMIDT---DLVLHYLPEVDMSTGKVLGTEALVRWQ
MAV_3132|M.avium_104                STIDTIRNDIELYLEGMIDGGSGALVLHYLPEFDMRTGEILGTEALTRWQ
Mb1389c|M.bovis_AF2122/97           SVSGELRNDIELHLRRGIES--DALRLVYLPEVDLRTGDIVGTEALVRWQ
Rv1354c|M.tuberculosis_H37Rv        SVSGELRNDIELHLRRGIES--DALRLVYLPEVDLRTGDIVGTEALVRWQ
Mflv_5174|M.gilvum_PYR-GCK          DPSEPLPTAVDLLGERRFELALAHSPIG-MAVVGLDGSFLRTNRALRAML
Mvan_1152|M.vanbaalenii_PYR-1       ASTERVLAPVDLLGDRPFELALTHSPIG-MAVVGLDGGFLRTNRALRAML
MAB_3940c|M.abscessus_ATCC_199      DALAAQRDPLTGLLNR----------------RGIYAEWQRLYGELRREQ
                                             :                       .:          *    

MSMEG_2196|M.smegmatis_MC2_155      HPTRGLLSPDSFIGVAESINLAGELG----RWVLRTACAEFSRWRANGVG
TH_0811|M.thermoresistible__bu      HPTRGLLAPDTFIGVAESVNLAGELG----RWVMRTACGEFAKWRAEGIG
MLBr_01750|M.leprae_Br4923          HPTRGLLFPDSFIPVAESINLAGKLG----RMVMHSACAEFSRWRSAGVG
MAV_3132|M.avium_104                HPTLGLLMPDSFIQVAESINLGAKLG----RLVMRSACAQFGQWRSRGVG
Mb1389c|M.bovis_AF2122/97           HPTRGLLAPGCFIPVAESINLAGELD----RWVLRRACNEFSEWQSAGLG
Rv1354c|M.tuberculosis_H37Rv        HPTRGLLAPGCFIPVAESINLAGELD----RWVLRRACNEFSEWQSAGLG
Mflv_5174|M.gilvum_PYR-GCK          GYSRRAMSELTFQDITHPDDLDLDLALVNECLEGRRRSYRIDKRYIAADG
Mvan_1152|M.vanbaalenii_PYR-1       GYSRGTLADMTFQQITHPDDLDADLAMVAECLEGRRRSYRIDKRYIAADG
MAB_3940c|M.abscessus_ATCC_199      PLDGDQVTAAAIVDIDRFKSINDRYG--------------------HGTG
                                          :    :  : .  .:                          . *

MSMEG_2196|M.smegmatis_MC2_155      RNIVLRINVSPVQLVTDG---FVESVAGIMKEFGLPRGSVCLEITESVVV
TH_0811|M.thermoresistible__bu      LDAVLRINVSPVQLVTDG---FVASVADIIDEFGLDGSSVCLEITESVVV
MLBr_01750|M.leprae_Br4923          LDALLRINVSPVQLVAEG---FVDNVAGTLDEFGLDGSMVCLEITENVVV
MAV_3132|M.avium_104                QGTVLRINVSPVQLVTAG---IVDTVAATLDEFGLDPSTVCLEITESVVV
Mb1389c|M.bovis_AF2122/97           HDALLRINVSAGQLVTGG---FVDFVADTIGQHGLDASSVCLEITENVVV
Rv1354c|M.tuberculosis_H37Rv        HDALLRINVSAGQLVTGG---FVDFVADTIGQHGLDASSVCLEITENVVV
Mflv_5174|M.gilvum_PYR-GCK          SIVWCALTAVIVHAPRDQPRCFVSQIVDVTADRLREAELVRRASTDPLTS
Mvan_1152|M.vanbaalenii_PYR-1       HIVWCALTVVLVHAPRDQPRCFVSQIVDVTADRAREAELARQAATDPLTA
MAB_3940c|M.abscessus_ATCC_199      DRVLIDVAHALTCGTTGT---------SVVGRSGGEEFLVVTVCPASAVA
                                          :                                .    .   . 

MSMEG_2196|M.smegmatis_MC2_155      QDIETTRTTLTGLHNVG---VQVAIDDFGTGYSVLSLLKSLPVDTLKIDR
TH_0811|M.thermoresistible__bu      QDIKTTRITLEGLNEVG---VQVAIDDFGTGYSVLSHLKTLPVDTLKIDK
MLBr_01750|M.leprae_Br4923          QNIDATRKTLAGLKEVG---VHLAIDDFGTGYSVLTHLKSLPVDTIKIDK
MAV_3132|M.avium_104                QDIDATRQTLFGLKDIG---VQIAIDDFGTGYSVLTYLKSLPVDSLKIDK
Mb1389c|M.bovis_AF2122/97           QDLHTARATLARLKEVG---VHIAIDDFGTGYSAISLLQTLPIDTLKIDK
Rv1354c|M.tuberculosis_H37Rv        QDLHTARATLARLKEVG---VHIAIDDFGTGYSAISLLQTLPIDTLKIDK
Mflv_5174|M.gilvum_PYR-GCK          IANRSAAWTRLEQLDQSGEGYGVLFCDIERFKSVNDRHGHHAGDQLLVEV
Mvan_1152|M.vanbaalenii_PYR-1       IANRSAAFRRLEQLDAGHDGYGVLFCDIERFKSVNDWCGHHAGDQLLVEV
MAB_3940c|M.abscessus_ATCC_199      EFATRLRQAVTASMPAG---IAVTASVGVAAQAVSRVVSATSQEAIEVLT
                                                    .     :         :.       . : : :  

MSMEG_2196|M.smegmatis_MC2_155      SFVAELGSNPGDLPIVRA------VIALAGAFGLQLVAEGVETERAALTL
TH_0811|M.thermoresistible__bu      GFVQDLGNSPGDLAIVRA------IIALAEAFGLQLVAEGVETEAAALTL
MLBr_01750|M.leprae_Br4923          SFVAELGSNASDLAIVRA------IMALAKEFELEVVAEGVETAVAAQVL
MAV_3132|M.avium_104                GFVQSLDTNPGDLAIVRS------TLALADAFGLDVVAEGVETVAAAETL
Mb1389c|M.bovis_AF2122/97           TFVRQLGTNTSDLVIVRG------IMTLAEGFQLDVVAEGVETEAAARIL
Rv1354c|M.tuberculosis_H37Rv        TFVRQLGTNTSDLVIVRG------IMTLAEGFQLDVVAEGVETEAAARIL
Mflv_5174|M.gilvum_PYR-GCK          AQRLHDTLDPFDLAARWGGDEFLVITRCVEEPALACLADRIIDRMDGTPI
Mvan_1152|M.vanbaalenii_PYR-1       AARLLAAVDEGALVARWGGDEFLVVTDTVEEHELARLATRITEEVDRTPV
MAB_3940c|M.abscessus_ATCC_199      ACAD------------------------------RAMYEAKHDGGDQSRI
                                                                        :            :

MSMEG_2196|M.smegmatis_MC2_155      LRHG-----CYRAQGFLLSKPILGSEMQTLLAKGRVPVHFS--AAPRM--
TH_0811|M.thermoresistible__bu      LRHG-----CHRAQGFLLSRPIPSNEMRELLARGRIPMRFS--ATP----
MLBr_01750|M.leprae_Br4923          LELG-----CNRAQGFLLSRPVDGAAMESLLAKGVIPMALGTCQSPEPSE
MAV_3132|M.avium_104                LSLG-----CHRAQGFLLSRPLDSAGMEALLIKGAIPMRFSDGGAPE-NQ
Mb1389c|M.bovis_AF2122/97           LDQR-----CYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-
Rv1354c|M.tuberculosis_H37Rv        LDQR-----CYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS-
Mflv_5174|M.gilvum_PYR-GCK          TLPGGAEESVAMTIGFAAHRPGDGRSVDDVLDLADHQMCEQRRRRPRVRR
Mvan_1152|M.vanbaalenii_PYR-1       TLADGTQMPVAMTIGFAAHRPGDGRSIDAVLDCADQAMYEQRRQRRNTVL
MAB_3940c|M.abscessus_ATCC_199      LHAD------DDSEGRYLWRSGA---------------------------
                                                : *    :.                             

MSMEG_2196|M.smegmatis_MC2_155      -----------
TH_0811|M.thermoresistible__bu      -----------
MLBr_01750|M.leprae_Br4923          HQIHRS-----
MAV_3132|M.avium_104                HVV--------
Mb1389c|M.bovis_AF2122/97           -----------
Rv1354c|M.tuberculosis_H37Rv        -----------
Mflv_5174|M.gilvum_PYR-GCK          RLGVSRPR---
Mvan_1152|M.vanbaalenii_PYR-1       HKGNEAIGLVE
MAB_3940c|M.abscessus_ATCC_199      -----------