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VRLTRRIKIQLLVFAVASLIAGLVMSIGYMGLPSLLFGIGRYQVAMELPTTGGLYKTGNVTYRGQEVGRV VDVRMTDTGIEAVLSLRSQVRVPKDLDAQVHSRSAIGEQYVELIPRPGGDMTPLRDGDVIPADRTSVPPD INTLLDETNTGLQAIPPGNLKTAIDEGAAALAGLGPDLARLVKGSTTLAIDARTNLPALTNLIDNAGPIL DTQSDTSDAIRSWAAHMADISGQIRAQDPAVRTLLPDGAAAAEESRKLVERLRPSLPVLLANLTGIADVA LTYHASVEQLLVLLPQSVSVLNSALVPNLGNESPYAGVFTTFDLNINVPPPCLTGYLPPTQQRSFAFEDY PERPAGDLYCRVPQDSQFNVRGARNLPCVNKPGKRAPTARMCESLEEYVPLNDGYNWKGDPNATLSGQDV PQLPPGTEPVQSEPGAAPPAPPAPPAAAPLPIAVAEYDPATGTYVGPDGRVYTQSNLAEHGGAQTWQSML TPPGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0927 | - | - | 100% (495) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0368 | - | e-165 | 58.10% (494) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0518 | - | e-164 | 56.80% (493) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0180 | mce1F | 3e-93 | 39.16% (526) | MCE-family protein MCE1F |
| M. gilvum PYR-GCK | Mflv_0647 | - | 1e-164 | 56.80% (493) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1971 | mce3F | 1e-142 | 56.52% (437) | MCE-family protein MCE3F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 2e-87 | 37.22% (540) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4148c | - | 2e-94 | 38.60% (513) | MCE-family protein |
| M. marinum M | MMAR_4056 | mce3F_1 | 1e-167 | 59.11% (494) | MCE-family protein Mce3F_1 |
| M. avium 104 | MAV_2537 | - | 1e-164 | 57.49% (494) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_0351 | - | 1e-165 | 58.87% (496) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3681 | - | 1e-165 | 58.27% (496) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_3923 | mce3F_1 | 1e-167 | 59.11% (494) | MCE-family protein Mce3F_1 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4056|M.marinum_M -MRLTRQIFIQMAIFAIVATTALLIMVFGYMRVP-AMVGIGQYRVTVELP
MUL_3923|M.ulcerans_Agy99 -MRLTRQIFIQMAIFAIVATTALLIMVFGYMRVP-AMVGIGQYRVTVELP
MAV_2537|M.avium_104 MLHLTRRTKIQLAIFTVISLSAASLMFFDYMQIPTVFFGVDRYTVTVELP
Rv1971|M.tuberculosis_H37Rv MLHLPRRVIVQLAVFTVIAVGVLAITFLHFVRLPAMLFGVGRYTVTMELV
MSMEG_0351|M.smegmatis_MC2_155 MIH--RRTKIQLAIFCVIAVVFGTVMIFGYMRLPAHLFGIGLYTVNLDLD
TH_3681|M.thermoresistible__bu -MNLTRRILLQLAVFVGVAVIAGSVMIVGVIKLPALALGVGRYTVTVELP
Mflv_0647|M.gilvum_PYR-GCK -MYLSKRVRLQLAIFAMVTVLAGGSMAFAYLRLPSLLFGVGRYQVTMKLQ
Mvan_0927|M.vanbaalenii_PYR-1 -MRLTRRIKIQLLVFAVASLIAGLVMSIGYMGLPSLLFGIGRYQVAMELP
MAB_4148c|M.abscessus_ATCC_199 ---MERLIKIQLAIFAAVTVISVALMAIFYLRVP-TALGIGKHDVKAQFV
Mb0180|M.bovis_AF2122/97 --MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIP-SLVGIGQYTLKADLP
MLBr_02594|M.leprae_Br4923 --MLTPLIRRQLVLFAILTVISLTVLGVYYLQIP-SLVGIGRYSLKAELS
*: :* : : :* .*:. : : .:
MMAR_4056|M.marinum_M EAGGLYPRSNVTYRGVEVGTVKSVHLTNTG-VAAVLSLNSDVKIPADVEA
MUL_3923|M.ulcerans_Agy99 EAGGLYPRSNVTYRGVEVGTVKSVHLTNTG-VAAVLSLNSDVKIPADVEA
MAV_2537|M.avium_104 QAGGLYPGGNVTYRGVEVGRVQAVKLTATG-AEAVLQLNSDVHIPANLNA
Rv1971|M.tuberculosis_H37Rv EAGGLYRTGNVTYRGFEVGRVAAVRLTDTG-VQAVLALKSGIDIPSDLKA
MSMEG_0351|M.smegmatis_MC2_155 RTGGLYPTGNVTYRGTEVGRVESVGLSENGGVRAVLKLKSGIDIPSDLRA
TH_3681|M.thermoresistible__bu EAAGLYEGGNVTYRGTTVGRIRDVRLTDTG-VEAVLSLDSGIDIPSNLRA
Mflv_0647|M.gilvum_PYR-GCK DAASLYRDANVTYRGTTVGRVSDVRLSDAG-VDAMLSLQSDTKIPADLDA
Mvan_0927|M.vanbaalenii_PYR-1 TTGGLYKTGNVTYRGQEVGRVVDVRMTDTG-IEAVLSLRSQVRVPKDLDA
MAB_4148c|M.abscessus_ATCC_199 ASGGLYQNANVTFRGVQIGRVTDVELTPEG-VTATMRLNDNVKVPGNVVA
Mb0180|M.bovis_AF2122/97 ASGGLYPTANVTYRGITIGKVTAVEPTDQG-ARVTMSIASNYKIPVDASA
MLBr_02594|M.leprae_Br4923 ATGGLYPTANVTYRGIAIGKVTDVEPTATG-AEATMSIDSRYKIPIDSAA
:..** .***:** :* : * : * . : : . :* : *
MMAR_4056|M.marinum_M EVHSVSSVGEQYVQLLPR-SGQGPSLKDGDVIPSSRTRVPTDINTILDET
MUL_3923|M.ulcerans_Agy99 EVHSVSSVGEQYVQLLPR-SGQGPSLKDGDVIPSSRTRVPTDINTILDET
MAV_2537|M.avium_104 QVHSVSAVGEQYVELLPR-GGQGPSLKNGDVIPVDRSYVPPDINSLLAAT
Rv1971|M.tuberculosis_H37Rv EVHSHTAIGETYVELLPR-NAASPPLKNGDVIALADTSVPPDINDLLSAA
MSMEG_0351|M.smegmatis_MC2_155 EVHSQSAIGEQYVELLPR-SAAAPPLQDGDVIAAKDVFIPPDINSLLDAA
TH_3681|M.thermoresistible__bu EVHSQSAVGEQYVALLPR-DGESPPLRDGDVVSRENVKVPPNINALVAAT
Mflv_0647|M.gilvum_PYR-GCK HVGSQTAVGELFVDLVPR-SGDGAPLKNGDVIPADRTSVPPDINALLRAV
Mvan_0927|M.vanbaalenii_PYR-1 QVHSRSAIGEQYVELIPRPGGDMTPLRDGDVIPADRTSVPPDINTLLDET
MAB_4148c|M.abscessus_ATCC_199 AVKSVSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQA
Mb0180|M.bovis_AF2122/97 NVHSVSAVGEQYIDLVST-GAPGKYFSSGQTIT--KGTVPSEIGPALDNS
MLBr_02594|M.leprae_Br4923 NVHSVSAVGEQYLDLVSS-GNPGKYLAPGQTIT--KSKIPIEIGPALDSV
* * :::** :: *:. : *:.: :* ::. :
MMAR_4056|M.marinum_M NRGLQAIPRENLKTVVDEAAVAVGGLGPELRRLITGSSKLAIDARANLDE
MUL_3923|M.ulcerans_Agy99 NRGLQAIPRENLKTVVDEAAVAVGGLGPELRRLITGSSKLAIDARANLDE
MAV_2537|M.avium_104 NRGLTVIPRDNLKTVVDESYTAVGGLGPELSRLVSGTAKLATDSRQNLDA
Rv1971|M.tuberculosis_H37Rv NTALEAIPHENLQTVIDESYTAVAGLGLELSRLIKGSAELAIDARANLDP
MSMEG_0351|M.smegmatis_MC2_155 NTGLQAIPQDNLKTAIDESYAAVGGLGPAISRLVRGSTALASDARKNLGS
TH_3681|M.thermoresistible__bu NRGLQAIPRENLETVVDESYNAVGGLGPELARLVSGSASLAIEARKNLDS
Mflv_0647|M.gilvum_PYR-GCK NTGVQAIPRDNLTTVIDESYIAFGGLGPDLARLTRGATTLAIDTRNNLPA
Mvan_0927|M.vanbaalenii_PYR-1 NTGLQAIPPGNLKTAIDEGAAALAGLGPDLARLVKGSTTLAIDARTNLPA
MAB_4148c|M.abscessus_ATCC_199 DGLVNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDS
Mb0180|M.bovis_AF2122/97 NRGLAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGD
MLBr_02594|M.leprae_Br4923 NRGLAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITD
: : .:. .: : * *. * * : ** .: : . *
MMAR_4056|M.marinum_M LTLLIDQSKPVLDTQTDTAGAIRSWASNLASITDQLQRQDSSLAGLLDQG
MUL_3923|M.ulcerans_Agy99 LTLLIDQSKPVLDTQTDTAGAIRSWASNLASITDQLQRQDSSLAGLLDQG
MAV_2537|M.avium_104 LVNLIDGSKPLLDSQTQSADSVQAWAAHLATITSELRDNDSSVAGLLREG
Rv1971|M.tuberculosis_H37Rv LVALIDRAGPVLDSQTHTSDAIAAWAAQLAAVTGQLQTHDSAVGDLIDRG
MSMEG_0351|M.smegmatis_MC2_155 LTTLIDLWQPVAESQIGTADSIEAWAANLAAVTGQLKQHNADVVGLIEQG
TH_3681|M.thermoresistible__bu LTALIDQSQPVLDSQVDTSDSIARWARNLAALTAQLKIHDPAVRGLLDNG
Mflv_0647|M.gilvum_PYR-GCK LTTLIDDAKPILDTQTETSDSIQTWASNLAQVTNQLQLQDESVQGLLVNG
Mvan_0927|M.vanbaalenii_PYR-1 LTNLIDNAGPILDTQSDTSDAIRSWAAHMADISGQIRAQDPAVRTLLPDG
MAB_4148c|M.abscessus_ATCC_199 TTKLIDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVA
Mb0180|M.bovis_AF2122/97 VNDIIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRDQNVRSILSQA
MLBr_02594|M.leprae_Br4923 VNDIIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQA
:*: *: ::* : . : . : :: . : : :: .
MMAR_4056|M.marinum_M PGAADEVRALFNRLRPTLPIVLANLVSVGEVAVAYHPSLEQLLVLFPQGT
MUL_3923|M.ulcerans_Agy99 PGAADEVRALFNRLRPTLPIVLANLVSVGEVAVAYHPSLEQLLVLFPQGT
MAV_2537|M.avium_104 GPAAAEARQLFDRLSPTLPIVLANLVSVGQVGVTYRDNLESLLVELPQGV
Rv1971|M.tuberculosis_H37Rv GPALGETRQLLERLQPTVPILLANLVSVGQVALTYHNDIEQLLVVFPMAI
MSMEG_0351|M.smegmatis_MC2_155 APAAEEARRLFERVQPTLPILLANLVSINEVAVTYQPGIEQILVLLPQGI
TH_3681|M.thermoresistible__bu AGAGEQGRLLFERLKPTLPVLMANLVSVGEVAVTYNAGIEQLLVLLPPSV
Mflv_0647|M.gilvum_PYR-GCK PPAADQVRQLFERVQPTLPILLANLVSLGQVALTYQPNLEQILALYPIEI
Mvan_0927|M.vanbaalenii_PYR-1 AAAAEESRKLVERLRPSLPVLLANLTGIADVALTYHASVEQLLVLLPQSV
MAB_4148c|M.abscessus_ATCC_199 PGASEQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALF
Mb0180|M.bovis_AF2122/97 APTADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVEQLLVFLPQGA
MLBr_02594|M.leprae_Br4923 APTADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQGA
: : :. : :.* *.: : : *. .:*. *. *
MMAR_4056|M.marinum_M AVTQAVGVAKRNTI-QDYKGDYLVFNLNLNLPPPCTTGFLPAQQQRVPTF
MUL_3923|M.ulcerans_Agy99 AVTQAVGVAKRNTI-QDYKGDYLVFNLNLNLPPPCTTGFLPAQQQRVPTF
MAV_2537|M.avium_104 AEIQATGVANRNTK-QDYNGAFLSFNLNLNWPPPCTTGFLPIQQQRAASY
Rv1971|M.tuberculosis_H37Rv AAEQAGILANLNTK-QAYRGQYLSFNLNLNLPPPCTTGFLPAQQRRIPTF
MSMEG_0351|M.smegmatis_MC2_155 AQLQGPNLANRDNKDTAHKGMFLAFNTNINLPPPCTTGFLPAQQRRPPSF
TH_3681|M.thermoresistible__bu AALQAAGVANFNTK-QDYKGAYLNFNLNVNLPPPCVTGYFPTQQRRSPAL
Mflv_0647|M.gilvum_PYR-GCK AGLQGAALANRNTK-QDYKGLFLSFNLNLNVPPPCRTGYLPAQQQRAPSE
Mvan_0927|M.vanbaalenii_PYR-1 SVLNSALVPNLGNE-SPYAGVFTTFDLNINVPPPCLTGYLPPTQQRSFAF
MAB_4148c|M.abscessus_ATCC_199 SALLTVAGGAPMDE-----GAKLDFRLNLGDPPPCLTGFVPPPLMRTPAD
Mb0180|M.bovis_AF2122/97 AIAQTVLTPTPGAA-------QLPLAPAINYPPPCLTGFLPASEWRSPAD
MLBr_02594|M.leprae_Br4923 SIAQTASATFPNMA-------ALDLALSINQPPPCLTGFIPAAEWRSPAD
: : :. **** **:.* * :
MMAR_4056|M.marinum_M EDYPNRAPGDLYCRVPQDA-PFNVRGARNLPCVTVPGKRAPTAKLCESNE
MUL_3923|M.ulcerans_Agy99 EDYPNRAPGDLYCRVPQDA-PFNVRGARNLPCVTVPGKRAPTAKLCESNE
MAV_2537|M.avium_104 EDYPDSPNGDIYCRVPQDS-VLNVRGARNMPCETRPGKRAPTVKMCESDQ
Rv1971|M.tuberculosis_H37Rv EDYPDRPAGDLYCRVPQDS-PFNVRGARNIPCETVPGKRAPTVKLCESDA
MSMEG_0351|M.smegmatis_MC2_155 EDYPERPAGDLYCRTPQDS-PFNARGARNIPCETVPGKRAPTVKLCESDE
TH_3681|M.thermoresistible__bu VDSPDLPPGDVYCRVPQDSTVLAVRGARNIPCLNKPGKRAPTAQLCESDE
Mflv_0647|M.gilvum_PYR-GCK VDYPPKPPGDLYCRIPQESGLTNVRGARNLPCVTRPGKRAPTVKMCESDE
Mvan_0927|M.vanbaalenii_PYR-1 EDYPERPAGDLYCRVPQDS-QFNVRGARNLPCVNKPGKRAPTARMCESLE
MAB_4148c|M.abscessus_ATCC_199 ETLRELPR-DMYCKTAQND-PSAVRGARNYPCQEFPGKRAPTIQLCRDPR
Mb0180|M.bovis_AF2122/97 TSPRPLPS-GTYCKIPQDAQLQ-VRGARNIPCVDVPGKRAATPKECRSKD
MLBr_02594|M.leprae_Br4923 TSLQPLPV-GTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECRDSK
. . **: . : .**:** ** *****.: : *..
MMAR_4056|M.marinum_M VYVPLNDGYNWKG----------DPNSTLSGQP----------------I
MUL_3923|M.ulcerans_Agy99 VYVPLNDGYNWKG----------DPNSTLSGQP----------------I
MAV_2537|M.avium_104 TYVPLNDGFNWKG----------DPNATYSGQD----------------V
Rv1971|M.tuberculosis_H37Rv PYLPLNDGYNWKG----------DPNATVPG-------------------
MSMEG_0351|M.smegmatis_MC2_155 NFVPLNDGYNWKG----------DPNATLSGQS----------------I
TH_3681|M.thermoresistible__bu EYTPLNDGMNWKG----------DPNATLSGQD----------------I
Mflv_0647|M.gilvum_PYR-GCK NYVPLNEGTNWKG----------DPNATLSGQP----------------V
Mvan_0927|M.vanbaalenii_PYR-1 EYVPLNDGYNWKG----------DPNATLSGQD----------------V
MAB_4148c|M.abscessus_ATCC_199 GYVPIGS-NPWRGPPAPYDTPVEDPRNILPPNK----------------F
Mb0180|M.bovis_AF2122/97 PYVPLGT-NPWFG----------DPNQILTCPAPGARCDQPVKPGLVIPA
MLBr_02594|M.leprae_Br4923 PYVPLGT-NPWFG----------DPNQLLTCPAPGARCDQPVKPGLVIPA
: *:. * * **. .
MMAR_4056|M.marinum_M PQLPP--EPP--LEQSAPPGP------------------------APPAP
MUL_3923|M.ulcerans_Agy99 PQLPP--EPP--LEQSAPPGP------------------------APPAP
MAV_2537|M.avium_104 PQYRPGEEPPGQVPPPSPPGP------------------------APP-P
Rv1971|M.tuberculosis_H37Rv --LGSGQ-------------------------------------------
MSMEG_0351|M.smegmatis_MC2_155 PDLGPGQGESAPETSPAPPAPPV---------------------EGDPVP
TH_3681|M.thermoresistible__bu PEVRRGPGAAQVSTSGPVAPP----------------------------S
Mflv_0647|M.gilvum_PYR-GCK PQPPP---------DPPPPVP-------------------------VTAP
Mvan_0927|M.vanbaalenii_PYR-1 PQLPPGTEPVQSEPGAAPPAPPA-------------------PPAAAPLP
MAB_4148c|M.abscessus_ATCC_199 PNIPPGAEPDPGTPTLPPPSPPAPEVPPA--------GGDVMPVSAQSGP
Mb0180|M.bovis_AF2122/97 PSINTGLNPAPADQVQGTPPPVSDPLQRPGSGTVQCNGQQPNPCVYTPTS
MLBr_02594|M.leprae_Br4923 PTVDNGLNPAPADRLPGTPPPVSDPLSQPRSGSVQCNGQQPNTCVYTPSG
MMAR_4056|M.marinum_M IAAAEYDPATGTYMGPDGHLYTQANLGQTVPEEQTWQTMLLPPKK---
MUL_3923|M.ulcerans_Agy99 IAAAEYDPATGTYMGPDGHLYTQANLGQTVPEEQTWQTMLLPPKK---
MAV_2537|M.avium_104 IAAVQYDPATGMYMGPDGRMYTQTDLAVGTKKGQTWQSMLMPPKRN--
Rv1971|M.tuberculosis_H37Rv ------------------------DIP------QTWQTMLLPPGS---
MSMEG_0351|M.smegmatis_MC2_155 MAIARYDPATGTYLGPDGQVYTQADLADNGSKEQTWQSMLTPHGMN--
TH_3681|M.thermoresistible__bu IAVTEYDPATGTYVGPDGRLYTQSNLVRSAFEVKTWESLMLPPGG---
Mflv_0647|M.gilvum_PYR-GCK IAVAEYDPSTGSYIGPDGKQYRQADLGQNAAGQHTWQDMLLPPKDGDP
Mvan_0927|M.vanbaalenii_PYR-1 IAVAEYDPATGTYVGPDGRVYTQSNLAEHG-GAQTWQSMLTPPGS---
MAB_4148c|M.abscessus_ATCC_199 MAARAYDPKNGVFLDANNQPSVYAPALDRGTEAETWADLMLGPKPV--
Mb0180|M.bovis_AF2122/97 GPSAVYSPASGELVGPDGVKYAVANSSTTG--DDGWKEMLAPAS----
MLBr_02594|M.leprae_Br4923 PPSAVYSPQSGELVGPDGVAYAVENSTKTG--DDGWKEMLAPAG----
. * ::