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MRLTRQIFIQMAIFAIVATTALLIMVFGYMRVPAMVGIGQYRVTVELPEAGGLYPRSNVTYRGVEVGTVK SVHLTNTGVAAVLSLNSDVKIPADVEAEVHSVSSVGEQYVQLLPRSGQGPSLKDGDVIPSSRTRVPTDIN TILDETNRGLQAIPRENLKTVVDEAAVAVGGLGPELRRLITGSSKLAIDARANLDELTLLIDQSKPVLDT QTDTAGAIRSWASNLASITDQLQRQDSSLAGLLDQGPGAADEVRALFNRLRPTLPIVLANLVSVGEVAVA YHPSLEQLLVLFPQGTAVTQAVGVAKRNTIQDYKGDYLVFNLNLNLPPPCTTGFLPAQQQRVPTFEDYPN RAPGDLYCRVPQDAPFNVRGARNLPCVTVPGKRAPTAKLCESNEVYVPLNDGYNWKGDPNSTLSGQPIPQ LPPEPPLEQSAPPGPAPPAPIAAAEYDPATGTYMGPDGHLYTQANLGQTVPEEQTWQTMLLPPKK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3923 | mce3F_1 | - | 100% (485) | MCE-family protein Mce3F_1 |
| M. ulcerans Agy99 | MUL_2865 | mce3F | 0.0 | 64.88% (484) | MCE-family protein Mce3F |
| M. ulcerans Agy99 | MUL_1067 | mce1F | 3e-89 | 36.93% (528) | MCE-family protein Mce1F |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0180 | mce1F | 1e-99 | 39.12% (524) | MCE-family protein MCE1F |
| M. gilvum PYR-GCK | Mflv_2106 | - | 0.0 | 72.78% (485) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1971 | mce3F | 1e-150 | 60.83% (434) | MCE-family protein MCE3F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 5e-91 | 36.57% (525) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4148c | - | 5e-92 | 38.52% (514) | MCE-family protein |
| M. marinum M | MMAR_4056 | mce3F_1 | 0.0 | 100.00% (485) | MCE-family protein Mce3F_1 |
| M. avium 104 | MAV_2537 | - | 0.0 | 64.08% (490) | virulence factor mce family protein |
| M. smegmatis MC2 155 | MSMEG_0351 | - | 1e-166 | 59.43% (488) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3681 | - | 1e-171 | 60.41% (485) | PUTATIVE virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_4599 | - | 0.0 | 74.04% (497) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3923|M.ulcerans_Agy99 -MRLTRQIFIQMAIFAIVATTALLIMVFGYMRVP-AMVGIGQYRVTVELP
MMAR_4056|M.marinum_M -MRLTRQIFIQMAIFAIVATTALLIMVFGYMRVP-AMVGIGQYRVTVELP
Mvan_4599|M.vanbaalenii_PYR-1 -MRLTRQILIQMAIFAVIATTALVIMVFAYMRLP-AFLGIGQYRVTLELP
Mflv_2106|M.gilvum_PYR-GCK -MRVTRQMLIQLLIFSLLAVTALGIMVFGYMRLP-EMIGIGQYKVTLELP
MAV_2537|M.avium_104 MLHLTRRTKIQLAIFTVISLSAASLMFFDYMQIPTVFFGVDRYTVTVELP
Rv1971|M.tuberculosis_H37Rv MLHLPRRVIVQLAVFTVIAVGVLAITFLHFVRLPAMLFGVGRYTVTMELV
MSMEG_0351|M.smegmatis_MC2_155 MIH--RRTKIQLAIFCVIAVVFGTVMIFGYMRLPAHLFGIGLYTVNLDLD
TH_3681|M.thermoresistible__bu -MNLTRRILLQLAVFVGVAVIAGSVMIVGVIKLPALALGVGRYTVTVELP
MAB_4148c|M.abscessus_ATCC_199 ---MERLIKIQLAIFAAVTVISVALMAIFYLRVP-TALGIGKHDVKAQFV
Mb0180|M.bovis_AF2122/97 --MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIP-SLVGIGQYTLKADLP
MLBr_02594|M.leprae_Br4923 --MLTPLIRRQLVLFAILTVISLTVLGVYYLQIP-SLVGIGRYSLKAELS
*: :* :: : :::* .*:. : :. ::
MUL_3923|M.ulcerans_Agy99 EAGGLYPRSNVTYRGVEVGTVKSVHLTNTG-VAAVLSLNSDVKIPADVEA
MMAR_4056|M.marinum_M EAGGLYPRSNVTYRGVEVGTVKSVHLTNTG-VAAVLSLNSDVKIPADVEA
Mvan_4599|M.vanbaalenii_PYR-1 ETGGLYPRGNVTYRGVEVGEVKSVQLTDTG-VEAVLSLNDNVEIPANLEA
Mflv_2106|M.gilvum_PYR-GCK ETGGLYERSNVTYRGSQVGIVESVGLTDRG-VAAELSLNSDVSIPADLIA
MAV_2537|M.avium_104 QAGGLYPGGNVTYRGVEVGRVQAVKLTATG-AEAVLQLNSDVHIPANLNA
Rv1971|M.tuberculosis_H37Rv EAGGLYRTGNVTYRGFEVGRVAAVRLTDTG-VQAVLALKSGIDIPSDLKA
MSMEG_0351|M.smegmatis_MC2_155 RTGGLYPTGNVTYRGTEVGRVESVGLSENGGVRAVLKLKSGIDIPSDLRA
TH_3681|M.thermoresistible__bu EAAGLYEGGNVTYRGTTVGRIRDVRLTDTG-VEAVLSLDSGIDIPSNLRA
MAB_4148c|M.abscessus_ATCC_199 ASGGLYQNANVTFRGVQIGRVTDVELTPEG-VTATMRLNDNVKVPGNVVA
Mb0180|M.bovis_AF2122/97 ASGGLYPTANVTYRGITIGKVTAVEPTDQG-ARVTMSIASNYKIPVDASA
MLBr_02594|M.leprae_Br4923 ATGGLYPTANVTYRGIAIGKVTDVEPTATG-AEATMSIDSRYKIPIDSAA
:.*** .***:** :* : * : * . . : : . :* : *
MUL_3923|M.ulcerans_Agy99 EVHSVSSVGEQYVQLLPR-SGQGPSLKDGDVIPSSRTRVPTDINTILDET
MMAR_4056|M.marinum_M EVHSVSSVGEQYVQLLPR-SGQGPSLKDGDVIPSSRTRVPTDINTILDET
Mvan_4599|M.vanbaalenii_PYR-1 EVHSVSSVGEQFVQLLPR-SADGPVLKDGDVIPINRTTVPTDINGVLDAT
Mflv_2106|M.gilvum_PYR-GCK SVRSQSAVGEQFVELVPQ-SGDGPALRNGDVISRDRARVPADVNTVLELT
MAV_2537|M.avium_104 QVHSVSAVGEQYVELLPR-GGQGPSLKNGDVIPVDRSYVPPDINSLLAAT
Rv1971|M.tuberculosis_H37Rv EVHSHTAIGETYVELLPR-NAASPPLKNGDVIALADTSVPPDINDLLSAA
MSMEG_0351|M.smegmatis_MC2_155 EVHSQSAIGEQYVELLPR-SAAAPPLQDGDVIAAKDVFIPPDINSLLDAA
TH_3681|M.thermoresistible__bu EVHSQSAVGEQYVALLPR-DGESPPLRDGDVVSRENVKVPPNINALVAAT
MAB_4148c|M.abscessus_ATCC_199 AVKSVSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQA
Mb0180|M.bovis_AF2122/97 NVHSVSAVGEQYIDLVST-GAPGKYFSSGQTITKG--TVPSEIGPALDNS
MLBr_02594|M.leprae_Br4923 NVHSVSAVGEQYLDLVSS-GNPGKYLAPGQTITKS--KIPIEIGPALDSV
*:* :::** :: *:. . : *:.: :* ::. :
MUL_3923|M.ulcerans_Agy99 NRGLQAIPRENLKTVVDEAAVAVGGLGPELRRLITGSSKLAIDARANLDE
MMAR_4056|M.marinum_M NRGLQAIPRENLKTVVDEAAVAVGGLGPELRRLITGSSKLAIDARANLDE
Mvan_4599|M.vanbaalenii_PYR-1 NAGLEAIPQENLQTVIDEAYTAVGGLGPELRRLVTGSTALAIDARKNLES
Mflv_2106|M.gilvum_PYR-GCK NEGLRAIPQDNLRTVVDEAYEAVGGLGPELRRLVNGSSQLAIDARANLDS
MAV_2537|M.avium_104 NRGLTVIPRDNLKTVVDESYTAVGGLGPELSRLVSGTAKLATDSRQNLDA
Rv1971|M.tuberculosis_H37Rv NTALEAIPHENLQTVIDESYTAVAGLGLELSRLIKGSAELAIDARANLDP
MSMEG_0351|M.smegmatis_MC2_155 NTGLQAIPQDNLKTAIDESYAAVGGLGPAISRLVRGSTALASDARKNLGS
TH_3681|M.thermoresistible__bu NRGLQAIPRENLETVVDESYNAVGGLGPELARLVSGSASLAIEARKNLDS
MAB_4148c|M.abscessus_ATCC_199 DGLVNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDS
Mb0180|M.bovis_AF2122/97 NRGLAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGD
MLBr_02594|M.leprae_Br4923 NRGLAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITD
: : .:. .: : *: *. * * : **: .: : . *
MUL_3923|M.ulcerans_Agy99 LTLLIDQSKPVLDTQTDTAGAIRSWASNLASITDQLQRQDSSLAGLLDQG
MMAR_4056|M.marinum_M LTLLIDQSKPVLDTQTDTAGAIRSWASNLASITDQLQRQDSSLAGLLDQG
Mvan_4599|M.vanbaalenii_PYR-1 LTTLIDQSKPVLDSQTETGDSIQAWAANLASISGQLQSQDPAVAGILDKG
Mflv_2106|M.gilvum_PYR-GCK LTTVIDESKPVLDSQIETSGSIRAWASNLADLTGQLQSQDAAVSGILSNG
MAV_2537|M.avium_104 LVNLIDGSKPLLDSQTQSADSVQAWAAHLATITSELRDNDSSVAGLLREG
Rv1971|M.tuberculosis_H37Rv LVALIDRAGPVLDSQTHTSDAIAAWAAQLAAVTGQLQTHDSAVGDLIDRG
MSMEG_0351|M.smegmatis_MC2_155 LTTLIDLWQPVAESQIGTADSIEAWAANLAAVTGQLKQHNADVVGLIEQG
TH_3681|M.thermoresistible__bu LTALIDQSQPVLDSQVDTSDSIARWARNLAALTAQLKIHDPAVRGLLDNG
MAB_4148c|M.abscessus_ATCC_199 TTKLIDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVA
Mb0180|M.bovis_AF2122/97 VNDIIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRDQNVRSILSQA
MLBr_02594|M.leprae_Br4923 VNDIIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQA
:*: *: ::* : . : . * :: . : : :: .
MUL_3923|M.ulcerans_Agy99 PGAADEVRALFNRLRPTLPIVLANLVSVGEVAVAYHPSLEQLLVLFPQGT
MMAR_4056|M.marinum_M PGAADEVRALFNRLRPTLPIVLANLVSVGEVAVAYHPSLEQLLVLFPQGT
Mvan_4599|M.vanbaalenii_PYR-1 PGGAEEVRALFDRLQPTLPIVLANLVSIGEVAVTYQPSLEQLLVLLPQGT
Mflv_2106|M.gilvum_PYR-GCK PGAAEETRALFDRIKPTLPIVLANLISVGEVAVAYQPNLEQLLVLLPQGT
MAV_2537|M.avium_104 GPAAAEARQLFDRLSPTLPIVLANLVSVGQVGVTYRDNLESLLVELPQGV
Rv1971|M.tuberculosis_H37Rv GPALGETRQLLERLQPTVPILLANLVSVGQVALTYHNDIEQLLVVFPMAI
MSMEG_0351|M.smegmatis_MC2_155 APAAEEARRLFERVQPTLPILLANLVSINEVAVTYQPGIEQILVLLPQGI
TH_3681|M.thermoresistible__bu AGAGEQGRLLFERLKPTLPVLMANLVSVGEVAVTYNAGIEQLLVLLPPSV
MAB_4148c|M.abscessus_ATCC_199 PGASEQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALF
Mb0180|M.bovis_AF2122/97 APTADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVEQLLVFLPQGA
MLBr_02594|M.leprae_Br4923 APTADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQGA
: :: : :.* *.: : : *. .:*. ** :*
MUL_3923|M.ulcerans_Agy99 AVTQAVGVAKRNTI-QDYKGDYLVFNLNLN--------------LPPPCT
MMAR_4056|M.marinum_M AVTQAVGVAKRNTI-QDYKGDYLVFNLNLN--------------LPPPCT
Mvan_4599|M.vanbaalenii_PYR-1 AVTQAVGVHKRNTK-QDYMGDALVFNLNLAIPLLPAPIPLPPQQLPPPCT
Mflv_2106|M.gilvum_PYR-GCK AVTQAVGVAKNGTK-QDYMGDYLVFNLNLN--------------VPPPCT
MAV_2537|M.avium_104 AEIQATGVANRNTK-QDYNGAFLSFNLNLN--------------WPPPCT
Rv1971|M.tuberculosis_H37Rv AAEQAGILANLNTK-QAYRGQYLSFNLNLN--------------LPPPCT
MSMEG_0351|M.smegmatis_MC2_155 AQLQGPNLANRDNKDTAHKGMFLAFNTNIN--------------LPPPCT
TH_3681|M.thermoresistible__bu AALQAAGVANFNTK-QDYKGAYLNFNLNVN--------------LPPPCV
MAB_4148c|M.abscessus_ATCC_199 SALLTVAGGAPMDE-----GAKLDFRLNLG--------------DPPPCL
Mb0180|M.bovis_AF2122/97 AIAQTVLTPTPGAA-------QLPLAPAIN--------------YPPPCL
MLBr_02594|M.leprae_Br4923 SIAQTASATFPNMA-------ALDLALSIN--------------QPPPCL
: * : : ****
MUL_3923|M.ulcerans_Agy99 TGFLPAQQQRVPTFEDYPNRAPGDLYCRVPQDA-PFNVRGARNLPCVTVP
MMAR_4056|M.marinum_M TGFLPAQQQRVPTFEDYPNRAPGDLYCRVPQDA-PFNVRGARNLPCVTVP
Mvan_4599|M.vanbaalenii_PYR-1 TGFLPAQQRRVPTFEDYPDRPVGNLYCRVPQDA-PFNVRGARNLPCISVP
Mflv_2106|M.gilvum_PYR-GCK TGFLPAQQQRAPTFEDAPDRPRGDLYCRVPQDS-AFNVRGARNIPCATVP
MAV_2537|M.avium_104 TGFLPIQQQRAASYEDYPDSPNGDIYCRVPQDS-VLNVRGARNMPCETRP
Rv1971|M.tuberculosis_H37Rv TGFLPAQQRRIPTFEDYPDRPAGDLYCRVPQDS-PFNVRGARNIPCETVP
MSMEG_0351|M.smegmatis_MC2_155 TGFLPAQQRRPPSFEDYPERPAGDLYCRTPQDS-PFNARGARNIPCETVP
TH_3681|M.thermoresistible__bu TGYFPTQQRRSPALVDSPDLPPGDVYCRVPQDSTVLAVRGARNIPCLNKP
MAB_4148c|M.abscessus_ATCC_199 TGFVPPPLMRTPADETLRELPR-DMYCKTAQND-PSAVRGARNYPCQEFP
Mb0180|M.bovis_AF2122/97 TGFLPASEWRSPADTSPRPLPS-GTYCKIPQDAQLQ-VRGARNIPCVDVP
MLBr_02594|M.leprae_Br4923 TGFIPAAEWRSPADTSLQPLPV-GTYCKIPMDTPANSVRGSRNIPCVDVP
**:.* * .: . . **: . : .**:** ** *
MUL_3923|M.ulcerans_Agy99 GKRAPTAKLCESNEVYVPLNDGYNWKG----------DPNSTLSGQP---
MMAR_4056|M.marinum_M GKRAPTAKLCESNEVYVPLNDGYNWKG----------DPNSTLSGQP---
Mvan_4599|M.vanbaalenii_PYR-1 GKRAPTWQDCESNEVYVPLNDGYNWKG----------DPNATLSGEP---
Mflv_2106|M.gilvum_PYR-GCK GKRAPSAAMCESGEVYVPLNEGYIWKG----------DPNATLSGQA---
MAV_2537|M.avium_104 GKRAPTVKMCESDQTYVPLNDGFNWKG----------DPNATYSGQD---
Rv1971|M.tuberculosis_H37Rv GKRAPTVKLCESDAPYLPLNDGYNWKG----------DPNATVPG-----
MSMEG_0351|M.smegmatis_MC2_155 GKRAPTVKLCESDENFVPLNDGYNWKG----------DPNATLSGQS---
TH_3681|M.thermoresistible__bu GKRAPTAQLCESDEEYTPLNDGMNWKG----------DPNATLSGQD---
MAB_4148c|M.abscessus_ATCC_199 GKRAPTIQLCRDPRGYVPIGS-NPWRGPPAPYDTPVEDPRNILPPNK---
Mb0180|M.bovis_AF2122/97 GKRAATPKECRSKDPYVPLGT-NPWFG----------DPNQILTCPAPGA
MLBr_02594|M.leprae_Br4923 GKRAASPRECRDSKPYVPLGT-NPWFG----------DPNQLLTCPAPGA
****.: *.. : *:. * * **. .
MUL_3923|M.ulcerans_Agy99 -------------IPQLPP-EPPLEQSAPP--GPAPP-------------
MMAR_4056|M.marinum_M -------------IPQLPP-EPPLEQSAPP--GPAPP-------------
Mvan_4599|M.vanbaalenii_PYR-1 -------------IPDVPP-DVPVAVTPPP--PGTPP-------------
Mflv_2106|M.gilvum_PYR-GCK -------------VPQLRP-GQQPAQASPP--PGPAP-------------
MAV_2537|M.avium_104 -------------VPQYRPGEEPPGQVPPPSPPGPAP-------------
Rv1971|M.tuberculosis_H37Rv ----------------LGSGQ-----------------------------
MSMEG_0351|M.smegmatis_MC2_155 -------------IPDLGPGQGESAPETSPAPPAPPVEGDP---------
TH_3681|M.thermoresistible__bu -------------IPEVRRGPGAAQVSTSGPVAPP---------------
MAB_4148c|M.abscessus_ATCC_199 -------------FPNIPPGAEPDPGTPTLPPPSPPAPEVPPAGGDVMPV
Mb0180|M.bovis_AF2122/97 RCDQPVKPGLVIPAPSINTGLNPAPADQVQGTPPPVSDPLQRPGSGTVQC
MLBr_02594|M.leprae_Br4923 RCDQPVKPGLVIPAPTVDNGLNPAPADRLPGTPPPVSDPLSQPRSGSVQC
MUL_3923|M.ulcerans_Agy99 ------------APIAAAEYDPATGTYMGPDGHLYTQANLGQTVPEEQTW
MMAR_4056|M.marinum_M ------------APIAAAEYDPATGTYMGPDGHLYTQANLGQTVPEEQTW
Mvan_4599|M.vanbaalenii_PYR-1 ------------LPVAAAEYDPASGEYVGPDGKVYTQSNLADGASGERPW
Mflv_2106|M.gilvum_PYR-GCK ------------PPMAAAEYDPANGTYVGPDGRVYTQSNLAEGATEEQTW
MAV_2537|M.avium_104 ------------PPIAAVQYDPATGMYMGPDGRMYTQTDLAVGTKKGQTW
Rv1971|M.tuberculosis_H37Rv --------------------------------------DIP------QTW
MSMEG_0351|M.smegmatis_MC2_155 ------------VPMAIARYDPATGTYLGPDGQVYTQADLADNGSKEQTW
TH_3681|M.thermoresistible__bu -------------SIAVTEYDPATGTYVGPDGRLYTQSNLVRSAFEVKTW
MAB_4148c|M.abscessus_ATCC_199 SAQ--------SGPMAARAYDPKNGVFLDANNQPSVYAPALDRGTEAETW
Mb0180|M.bovis_AF2122/97 NGQQPNPCVYTPTSGPSAVYSPASGELVGPDGVKYAVANSSTTG--DDGW
MLBr_02594|M.leprae_Br4923 NGQQPNTCVYTPSGPPSAVYSPQSGELVGPDGVAYAVENSTKTG--DDGW
*
MUL_3923|M.ulcerans_Agy99 QTMLLPPKK-
MMAR_4056|M.marinum_M QTMLLPPKK-
Mvan_4599|M.vanbaalenii_PYR-1 QSMLVPPGG-
Mflv_2106|M.gilvum_PYR-GCK QTMLLPPKGN
MAV_2537|M.avium_104 QSMLMPPKRN
Rv1971|M.tuberculosis_H37Rv QTMLLPPGS-
MSMEG_0351|M.smegmatis_MC2_155 QSMLTPHGMN
TH_3681|M.thermoresistible__bu ESLMLPPGG-
MAB_4148c|M.abscessus_ATCC_199 ADLMLGPKPV
Mb0180|M.bovis_AF2122/97 KEMLAPAS--
MLBr_02594|M.leprae_Br4923 KEMLAPAG--
::