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MGSSTLIIDTDTHITEPPDLWTSRMSKSRWGNLIPEVKWVEEKQGEYWCMDGQPVFTVGTCIMVPGEDGK PVRSPRFPDYADRFSSMHPSAYDAKARLEVMDAYGIQAAAIFPNLGFVGPNIFAAAGPDALEFQTAALQA YNDFLLDWSSIAPDRLLSLALIPYWDVDAAVAEIERCAAAGHKGLVSTGKPHEHGYKLLADRYWDPMWAA AQDANLSISFHVGGGNLSRHLNDERTSVEGWRATLARLTTSFFLESGITLADLLMSGVLARYPKLRFVSV ESAVGWIPFLLESLDFHYKKYEPWLERPEFAGNDMLPSDYFHRQVYANYWYEDLQPWHVAAIGEDNLMFE TDYPHQTCLDKEEIQHSINEGLSGVSETTKEKILWRNAASLFNMDIAKLEKLT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0901 | - | - | 100% (403) | amidohydrolase 2 |
| M. vanbaalenii PYR-1 | Mvan_4275 | - | 3e-38 | 29.15% (398) | amidohydrolase 2 |
| M. vanbaalenii PYR-1 | Mvan_4211 | - | 4e-31 | 26.07% (399) | amidohydrolase 2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2371 | - | 1e-36 | 28.39% (398) | amidohydrolase 2 |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0299 | - | 7e-09 | 24.36% (312) | putative amidohydrolase (aminocarboxymuconate-semialdehyde |
| M. marinum M | MMAR_2618 | - | 5e-36 | 29.44% (394) | amidohydrolase |
| M. avium 104 | MAV_2591 | - | 2e-37 | 30.75% (322) | amidohydrolase 2 |
| M. smegmatis MC2 155 | MSMEG_6547 | - | 2e-37 | 28.93% (394) | amidohydrolase 2 |
| M. thermoresistible (build 8) | TH_2339 | - | 5e-36 | 28.61% (395) | amidohydrolase 2 |
| M. ulcerans Agy99 | MUL_3143 | - | 4e-35 | 29.19% (394) | amidohydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2618|M.marinum_M MKSIDELASDLSFTTAKTGADRSVTFLPDPPRARRRYTVISVDDHIVEPP
MUL_3143|M.ulcerans_Agy99 --------------------------MTDPPRARRRYTVISVDDHIVEPP
MAV_2591|M.avium_104 --------------------------------------------------
Mflv_2371|M.gilvum_PYR-GCK -------------------------------MREDDLILVSIDDHVVEPP
MSMEG_6547|M.smegmatis_MC2_155 -------------------------------MQTDDLILVSIDDHVVEPP
TH_2339|M.thermoresistible__bu ---------------------------MSHDLRPEDLILVSIDDHVVEPP
Mvan_0901|M.vanbaalenii_PYR-1 --------------------------------MGSSTLIIDTDTHITEPP
MAB_0299|M.abscessus_ATCC_1997 --------------------------------------------MTSVRI
MMAR_2618|M.marinum_M DTFTGRLPQRFAD--RAPRVVETDDGGQVWVYDGQVLPNVGFNAVVGRPV
MUL_3143|M.ulcerans_Agy99 DTFTGRLPQRFAD--RAPRVVETDDGGQVWVYDGQVLPNVGFNAVVGRPV
MAV_2591|M.avium_104 -MWQDRLPQKYLE--QGPRIVE-ENGMHLWHYDGQVFPTIGLNAVAGKPP
Mflv_2371|M.gilvum_PYR-GCK DMFLRHVPEKYKE--EAPIVVTDEKGVDQWMYQGRPQGVSGLNAVVSWPA
MSMEG_6547|M.smegmatis_MC2_155 DMFLRHVPAKYRD--EAPIVVTDEKGVDQWMYQGRPQGVSGLNAVVSWPA
TH_2339|M.thermoresistible__bu DMFLRHVPAKYRD--EAPIVVTDENGVDQWMYQGRPQGVSGLNAVVSWPP
Mvan_0901|M.vanbaalenii_PYR-1 DLWTSRMSKSRWGNLIPEVKWVEEKQGEYWCMDGQPVFTVGTCIMVPGED
MAB_0299|M.abscessus_ATCC_1997 DIHAHLWSDEYLS-----------------LLDGYGRPATDVHRGLGAGA
. :* .
MMAR_2618|M.marinum_M SEYGFEP------VRFDEMRRGAWDIHERIKDMDLNGVYASLNFPSFLPG
MUL_3143|M.ulcerans_Agy99 SEYGFEP------VRFDEMRRGAWDIHERIKDMDLNGVYASLNFPSFLPG
MAV_2591|M.avium_104 EEWGMDP------VRYEDMIPGCYDPVARVADMDLDGVQSALCFPSF-PG
Mflv_2371|M.gilvum_PYR-GCK EEWGRDP------AGFAEMRPGVYDVHERVRDMNRNGILASMCFPTF-TG
MSMEG_6547|M.smegmatis_MC2_155 EEWGRDP------AGFAEMRPGVYDVHERVRDMNRNGILASMCFPTF-TG
TH_2339|M.thermoresistible__bu EEWGRNP------ARFAEMRPGVYDVHERVRDMNRNGILASMCFPTF-TG
Mvan_0901|M.vanbaalenii_PYR-1 GKPVRSPRFPDYADRFSSMHPSAYDAKARLEVMDAYGIQAAAIFPNLGFV
MAB_0299|M.abscessus_ATCC_1997 TRDDLDG---------------------RFELMDEAGVDLQILTATP---
. . *. *: *: ..
MMAR_2618|M.marinum_M FAGQRLQQVTKDPELAWAAVRAWNDWHLEAWAGPYPERIIPCQLPWLLDP
MUL_3143|M.ulcerans_Agy99 FAGQRLQQVTKDPELAWAAVRAWNDWHLEAWAGPYPERIIPCQLPWLLDP
MAV_2591|M.avium_104 FGGGTFQRAE-DKDLALLCVKAWNDFYIDEWCAVAPERYIPLAILPTWDI
Mflv_2371|M.gilvum_PYR-GCK FSARHLNMTR--EDVTLVMVSAYNDWHIDEWAGSYPDRFIPIAILPTWTP
MSMEG_6547|M.smegmatis_MC2_155 FSARHLNMHR--EEATLVMVSAYNDWHIDEWAGSYPDRFIPIAILPTWNP
TH_2339|M.thermoresistible__bu FSARHLNMHR--EHVTLIMVSAYNDWHIDEWAGSYPGRFIPIAILPTWNP
Mvan_0901|M.vanbaalenii_PYR-1 GPNIFAAAGPDALEFQTAALQAYNDFLLD-WSSIAPDRLLSLALIPYWDV
MAB_0299|M.abscessus_ATCC_1997 ------ASPHFEDQAAAVASARFINDEYAKLSSEYPGRFGALASLPLPHV
. : : .. * * .
MMAR_2618|M.marinum_M SAGAQLIHENAERGFRAVSFSENPAMLGLPSIHSG-HWDPMMAACAETGT
MUL_3143|M.ulcerans_Agy99 SAGAQLIHENAERGFRAVSFSENPAMLGLPSIHSG-HWDPMMAACAETGT
MAV_2591|M.avium_104 DACVAEAERVAAKGARTISFPDSPVPLGLPSFHSD-HWDGLWRVCSDAKM
Mflv_2371|M.gilvum_PYR-GCK EGMCNEIRRVAAKGCRAVTMPELPHLEGLPSYHDEDYWGPVFRTLSEENV
MSMEG_6547|M.smegmatis_MC2_155 EAMCREIRRVAAKGCRAVTMPELPHLEGLPSYHDDDYWGPVFTTLSEENV
TH_2339|M.thermoresistible__bu EAMCAEIRRVAAKGCRAVTMPELPHLEGLPSYHDEDYWGPVFRTLSEENV
Mvan_0901|M.vanbaalenii_PYR-1 DAAVAEIERCAAAGHKGLVSTGKPHEHGYKLLADR-YWDPMWAAAQDANL
MAB_0299|M.abscessus_ATCC_1997 PAALEELARAIDELG---MYGASITTSVLGRSIADPIFDPLYAELNRRRA
. . :. :
MMAR_2618|M.marinum_M VVNLHIGS----SGSSPSTTD---------DAPADVPGVLFFAYAISAAV
MUL_3143|M.ulcerans_Agy99 VVNLHIGS----SGSSPSTTD---------DAPADVPGVLFFAYAISAAV
MAV_2591|M.avium_104 PVSLHFGSGSFVPGFSFSTIKPVPGQMAVPDAPFAVATALFSTNLMWSTV
Mflv_2371|M.gilvum_PYR-GCK VMCLHIGT-----GFGAISMAP--------NAPIDNLIILATQVSAMCAQ
MSMEG_6547|M.smegmatis_MC2_155 VMCLHIGT-----GFGAISMAP--------NAPIDNLIILATQVSAMCAQ
TH_2339|M.thermoresistible__bu VMCLHIGT-----GFGAISMAP--------DAPIDNMIILATQVSAMCAQ
Mvan_0901|M.vanbaalenii_PYR-1 SISFHVGG-----GNLSRHLNDERTSVEGWRATLARLTTSFFLESGITLA
MAB_0299|M.abscessus_ATCC_1997 VLFVHPAG----CGAESSLITD----------HSLTWSIGAPIEDTVAIM
: .* . *
MMAR_2618|M.marinum_M DWLYSGLPSRFPDLKICLSEGGIGWVAGLLDRLDHMLSYHEMYGTW-RAM
MUL_3143|M.ulcerans_Agy99 DWLYSGLPSRFPDLKICLSEGRIGWVAGLLDRLDHMLSYHEMYGTW-RAM
MAV_2591|M.avium_104 DLLFSGKLQQFPDLQISLAEGGIGWVPYILERTDYVWERHRYY----QKI
Mflv_2371|M.gilvum_PYR-GCK DLLWGPAMRNYPDLKFAFSEGGIGWIPFYLDRSDRHYTNQKWLR---RDF
MSMEG_6547|M.smegmatis_MC2_155 DLLWGPAMRNYPDLKFAFSEGGIGWIPFYLDRSDRHYTNQKWLR---RDF
TH_2339|M.thermoresistible__bu DLLWGPAMRNYPDLKFAFSEGGIGWIPFYLDRCDRHYTNQKWLR---RDF
Mvan_0901|M.vanbaalenii_PYR-1 DLLMSGVLARYPKLRFVSVESAVGWIPFLLESLDFHYKKYEPWLERPEFA
MAB_0299|M.abscessus_ATCC_1997 HLIVAGVPSRYPDMKIVTCHLG-GALPMVLERAHRQVTEWEATQCP----
. : . .:*.::: . * :. *: . .
MMAR_2618|M.marinum_M GESLTPAEVFTRNFWFCAVEDKS--SFVQHHRIGTENIMVESDYPHCDST
MUL_3143|M.ulcerans_Agy99 GESLTSAEVFTRNFWFCAVEDKS--SFVQHYRIGTENIMVESDYPHCDST
MAV_2591|M.avium_104 DFDTRPSDLFRKHFWGCFIDDEH--GLTNRHSIGIDRIMLEIDFPHSDSN
Mflv_2371|M.gilvum_PYR-GCK GDKL-PSDVFREHSLACYVTDKT--SLKLRHEIGIDIIAWECDYPHSDCF
MSMEG_6547|M.smegmatis_MC2_155 GDKL-PSDVFREHSLACYVTDKT--SLKLRHEIGIDIIAWECDYPHSDCF
TH_2339|M.thermoresistible__bu GDKL-PSDVFREHSLACYVTDKT--SLKLRHEIGIDIIAWECDYPHSDCF
Mvan_0901|M.vanbaalenii_PYR-1 GNDMLPSDYFHRQVYANYWYEDL--QPWHVAAIGEDNLMFETDYPHQTCL
MAB_0299|M.abscessus_ATCC_1997 ---EAPRDAARRLWYDTVGHDHTPALRAAVASLGVDRLIFGSDFPYQAGP
. : . :. :* : : *:*:
MMAR_2618|M.marinum_M -WPHTQQTMHEQLDGLPADV--IRKITWENAARLYQHPVPVAIAQNPEAF
MUL_3143|M.ulcerans_Agy99 -WPHTQQTMHEQLDGLPADV--IRKITWENAARLYQHPVPVAIAQNPEAF
MAV_2591|M.avium_104 -WPNSRKRAAEVLADVPDDE--CRLIVEENARRMLNFPRVGAVDRQLAGV
Mflv_2371|M.gilvum_PYR-GCK -WPDAPEQVLAELNAAGASDSDINKITWQNSCRFFGWDPFKLTPRDQATA
MSMEG_6547|M.smegmatis_MC2_155 -WPDAPEQVLAELNAAGASDSDIHKITWENACRFFSWDPFARTAREEATV
TH_2339|M.thermoresistible__bu -WPDAPEQVHAELRAAGADDFDINKITWENSCRFFSWDPFEHTPRAEATV
Mvan_0901|M.vanbaalenii_PYR-1 DKEEIQHSINEGLSGVSETT--KEKILWRNAASLFNMDIAKLEKLT----
MAB_0299|M.abscessus_ATCC_1997 RYVSSATYIEEGLSAEDASA-----ILDHNGAELLGLTGV----------
* * .*. :
MMAR_2618|M.marinum_M ---------------------------------
MUL_3143|M.ulcerans_Agy99 ---------------------------------
MAV_2591|M.avium_104 ---------------------------------
Mflv_2371|M.gilvum_PYR-GCK GALRAKAADVDTSIRPRAEWARLYHEKQ-LTKA
MSMEG_6547|M.smegmatis_MC2_155 KALRAKGSDVDVSIRSRAEWRRLYEEKQ-LAKA
TH_2339|M.thermoresistible__bu GALRAKATDVDTTIRSRAEWAQLYEQKQQFAQA
Mvan_0901|M.vanbaalenii_PYR-1 ---------------------------------
MAB_0299|M.abscessus_ATCC_1997 ---------------------------------