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MTSVRIDIHAHLWSDEYLSLLDGYGRPATDVHRGLGAGATRDDLDGRFELMDEAGVDLQILTATPASPHF EDQAAAVASARFINDEYAKLSSEYPGRFGALASLPLPHVPAALEELARAIDELGMYGASITTSVLGRSIA DPIFDPLYAELNRRRAVLFVHPAGCGAESSLITDHSLTWSIGAPIEDTVAIMHLIVAGVPSRYPDMKIVT CHLGGALPMVLERAHRQVTEWEATQCPEAPRDAARRLWYDTVGHDHTPALRAAVASLGVDRLIFGSDFPY QAGPRYVSSATYIEEGLSAEDASAILDHNGAELLGLTGV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0299 | - | - | 100% (319) | putative amidohydrolase (aminocarboxymuconate-semialdehyde decarboxylase) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2325c | - | 1e-06 | 22.75% (189) | antibiotic-resistance protein |
| M. gilvum PYR-GCK | Mflv_3792 | - | 1e-09 | 27.34% (267) | amidohydrolase 2 |
| M. tuberculosis H37Rv | Rv2303c | - | 1e-06 | 22.75% (189) | antibiotic-resistance protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_1500 | - | 7e-25 | 30.82% (279) | hypothetical protein MMAR_1500 |
| M. avium 104 | MAV_2515 | - | 2e-24 | 29.39% (279) | amidohydrolase 2 |
| M. smegmatis MC2 155 | MSMEG_6813 | - | 7e-31 | 32.27% (282) | amidohydrolase 2 |
| M. thermoresistible (build 8) | TH_0554 | - | 6e-14 | 28.43% (299) | amidohydrolase family protein |
| M. ulcerans Agy99 | MUL_2437 | - | 2e-24 | 30.47% (279) | hypothetical protein MUL_2437 |
| M. vanbaalenii PYR-1 | Mvan_2602 | - | 1e-09 | 26.44% (261) | amidohydrolase 2 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1500|M.marinum_M --------------------------------------------------
MUL_2437|M.ulcerans_Agy99 MGTRLEPHRGRRIHLGADDLPGNQHLGPYSRGTAHHRQVGPVQDGGAFVA
MAV_2515|M.avium_104 --------------------------------------------------
MSMEG_6813|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_3792|M.gilvum_PYR-GCK ---MPSRSLDYPVFDADNHFYEPKEALTQFLPDHRKGVIDYIDVHGRTKI
Mvan_2602|M.vanbaalenii_PYR-1 ---MPSRILDYPVFDADNHFYEPKEALTKFLPDKRKGVIDYIDVHGRTKI
TH_0554|M.thermoresistible__bu ---MSPRSLPYPVFDIDNHMYETTDALIKFLPREHRGKVGYVELNGRKKL
Mb2325c|M.bovis_AF2122/97 ------------------------------------------MTAPEPRV
Rv2303c|M.tuberculosis_H37Rv ------------------------------------------MTAPEPRV
MAB_0299|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_1500|M.marinum_M -----------------MWRIDTHHHMIPPDYRRALR----NAGVDGAGG
MUL_2437|M.ulcerans_Agy99 AARGQRGAALRPGKEFAIWRIDTHHHMIPPDYRRALR----NAGVDGAGG
MAV_2515|M.avium_104 -----------------MLRIDTHHHLIPPDYRKALQ----QKGIDEAGG
MSMEG_6813|M.smegmatis_MC2_155 ---------------MNQARIDVHHHVVPPQYRELLA----AQTTN-AGG
Mflv_3792|M.gilvum_PYR-GCK VVRNHISDYIPNPTFEVVARPGAQEEYFK-HGSGGKS----FREVMGKPM
Mvan_2602|M.vanbaalenii_PYR-1 MVRNHISDYIPNPTFEVVARPGAQEEYFR-HGSGGKS----FREVMGKPM
TH_0554|M.thermoresistible__bu MVKDRISHMIPNPTFEKVARPGSAEDYFLGNNPEGLN----FREFVGEPM
Mb2325c|M.bovis_AF2122/97 PVIDMWAPFVPSAEVIDDLREGFPVELLSYFEVFTKT----TISAEQFGA
Rv2303c|M.tuberculosis_H37Rv PVIDMWAPFVPSAEVIDDLREGFPVELLSYFEVFTKT----TISAEQFGA
MAB_0299|M.abscessus_ATCC_1997 ---------------MTSVRIDIHAHLWSDEYLSLLDGYGRPATDVHRGL
* . .
MMAR_1500|M.marinum_M RALPDWS-PAGSLQAMAELTVGAAILSVSAPATAFLPQASD---AAALAR
MUL_2437|M.ulcerans_Agy99 RALPDWS-PAGSLQAMAELTVGAAILSVSAPATAFLPQASD---AAALAR
MAV_2515|M.avium_104 RALPDWS-PEASLQTMAELDVGTAILSVSTPGTTFLSEPAD---AAALAR
MSMEG_6813|M.smegmatis_MC2_155 RATPDWS-VDSALGLMDSIGVETAILSITTPG-VEPAERAQ---RPAVAR
Mflv_3792|M.gilvum_PYR-GCK KAIPAFRNPEARLEVLDGLGLDYTIMFPTLASLVEERMKDDPDLILDIVH
Mvan_2602|M.vanbaalenii_PYR-1 KAIPAFRNPEARLEVMDGLGLDYTLMFPTLASLVEERLKDDPELIHDIIH
TH_0554|M.thermoresistible__bu EVIPAFQHPAPRLELMDELGIDRCVMYPTLASLIEERTTDDVVLTHAVMH
Mb2325c|M.bovis_AF2122/97 YAESLRRTDDQILDSLDDAGITRSLITG-----FDERSTCG-------VT
Rv2303c|M.tuberculosis_H37Rv YAESLRRTDDQILDSLDDAGITRSLITG-----FDERSTCG-------VT
MAB_0299|M.abscessus_ATCC_1997 GAGATRDDLDGRFELMDEAGVDLQILTATPASPHFEDQAAA----VASAR
. . : : : ::
MMAR_1500|M.marinum_M DINDYAADIVAGRPT-QFGFFATVPMPHLDQSVAETVRALDDLKADGVVL
MUL_2437|M.ulcerans_Agy99 DINDYAADVVAGRPA-QFGFFATVPMPHLDQSVAETVRALDDLKADGVVL
MAV_2515|M.avium_104 DLNDYTAELAAAQPD-RFGFFATVPMPHVDAAVAETVRALDELSADGVVL
MSMEG_6813|M.smegmatis_MC2_155 DLNEFCADVVRSAPD-RFGFWATLTLPDVDSAIGEAAYALDELHADGVVL
Mflv_3792|M.gilvum_PYR-GCK ALNQWMYETWQFDYQGRILSTPVINLSVVDRALEELQWCLERGARTVLVR
Mvan_2602|M.vanbaalenii_PYR-1 ALNEWMYETWQFDYEGRIFSTPVITLPIVDRALEELEWCLERGAKTVLVR
TH_0554|M.thermoresistible__bu ALNQWMHEHWSFDYEGRIFATPVITLPIVEEAIRELHWCLERGMRTFLVR
Mb2325c|M.bovis_AF2122/97 FVHNASVAAVAARYPDRFLPFAGADILAGDSAVDEFERWVVEHGFRGLSL
Rv2303c|M.tuberculosis_H37Rv FVHNASVAAVAARYPDRFLPFAGADILAGDSAVDEFERWVVEHGFRGLSL
MAB_0299|M.abscessus_ATCC_1997 FINDEYAKLSSEYPG-RFGALASLPLPHVPAALEELARAIDELGMYGASI
::: :: . : :: * :
MMAR_1500|M.marinum_M LANHAGVYLGEDGQ-----DDLFTALNSRAAVVFVHPAEL----------
MUL_2437|M.ulcerans_Agy99 LANHAGVYLGEDGQ-----DDLFTALNSRAAVVFVHPAEL----------
MAV_2515|M.avium_104 LANNAGVYVGQDGQ-----DALFDALNHRSAVVFIHPAEL----------
MSMEG_6813|M.smegmatis_MC2_155 LANSERTYLGDRRF-----DPLMEELDRRGATIFVHPSHL----------
Mflv_3792|M.gilvum_PYR-GCK PAPVPG-YRGSRSLGLPEFDPFWDACVQAGIPVCMHASDSGYAQYLNDWE
Mvan_2602|M.vanbaalenii_PYR-1 PAPVPG-FRGTRSFGTEEFDPFWDACVKAGIPVAMHASDSGYAQYLNDWE
TH_0554|M.thermoresistible__bu PAPVPSRFGGSRSMGLPEFDPFWQEVVNAGIPVTMHASDSGYQKHLMEWE
Mb2325c|M.bovis_AF2122/97 RPFMIGRPASDPAY-----FPCYAKCVELGVPVSIHTSAD----------
Rv2303c|M.tuberculosis_H37Rv RPFMIGRPASDPAY-----FPCYAKCVELGVPVSIHTSAD----------
MAB_0299|M.abscessus_ATCC_1997 TTSVLGRSIADPIF-----DPLYAELNRRRAVLFVHPAGCG---------
. . : :*.:
MMAR_1500|M.marinum_M PGPAVPGVAPWAGDFLLDTTR----AAHLLVRNGIRQRYPDIKFVLSHAG
MUL_2437|M.ulcerans_Agy99 PGPAVPGVAPWAGDFLLDTTR----AAHLLVRNGIRQRYPDINFVLSHAG
MAV_2515|M.avium_104 PGPTVPGVAPFAADFLLDTTR----SAYLLVRNGIRNRYPNIRFLLSHAG
MSMEG_6813|M.smegmatis_MC2_155 PGGSIPGINAYFADFLLDTTR----AAINMVLNGTLDRYPNLRVILSHAG
Mflv_3792|M.gilvum_PYR-GCK PADEFLPFRPTAFRMVAMGKRPIEDTMAALVCHGALTRNPDLRILSIENG
Mvan_2602|M.vanbaalenii_PYR-1 PADEFLPFRPTAFRMVAMGKRPIEDTMAALVCHGAFTRNPDLRILSIENG
TH_0554|M.thermoresistible__bu GGDEYLSFKPSALREVVMGHRAIEDTLAAMICHGALSRFPDLKILCVENG
Mb2325c|M.bovis_AF2122/97 -------WTRTRLSDLGHPRH----------IDDVACRFPELTILMSHGG
Rv2303c|M.tuberculosis_H37Rv -------WTRTRLSDLGHPRH----------IDDVACRFPELTILMSHGG
MAB_0299|M.abscessus_ATCC_1997 --AESSLITDHSLTWSIGAPIEDTVAIMHLIVAGVPSRYPDMKIVTCHLG
. * *:: .: . *
MMAR_1500|M.marinum_M -GFVPYASHRLALAITADT-GRSPADVLEEFSSFYFDTALSSSAAALPTL
MUL_2437|M.ulcerans_Agy99 -GFVPYASHRLALVITADT-GRSPADVLEEFSSFYFDTALSSSAAALPTL
MAV_2515|M.avium_104 -GFVPYASHRMAMAIMADT-GRSFADVLDDFSSFYFDTALSSSAAALPSL
MSMEG_6813|M.smegmatis_MC2_155 -GFVPFIAERIATCVPIEHPDVSVESILDGLRKFYFDTALSASESALPSL
Mflv_3792|M.gilvum_PYR-GCK ASWVPYLFYQFEDVYKKMP-QEFPENPIDAFRRGVYVAPF--WEDDFGKM
Mvan_2602|M.vanbaalenii_PYR-1 ASWVPYLFYQFKDVYSKMP-QEFPEDPIEAFRRCVYVAPF--WEDDFKKM
TH_0554|M.thermoresistible__bu SGWVRNLLEQLDTAYRIMP-KEFDEHPVEVFKRNIYIHPF--LEDDVPGL
Mb2325c|M.bovis_AF2122/97 ---YPWVLQACLIAWKHPN----VYLELAAHRPKYFASPGAGWEPLMR--
Rv2303c|M.tuberculosis_H37Rv ---YPWVLQACLIAWKHPN----VYLELAAHRPKYFASPGAGWEPLMR--
MAB_0299|M.abscessus_ATCC_1997 -GALPMVLERAHRQVTEWEATQCPEAPRDAARRLWYDTVGHDHTPALRAA
: .
MMAR_1500|M.marinum_M IAFAKPGHITFGSDWPFAPTAAGKLFAAGLETYPALDAAARG-AIDRGSA
MUL_2437|M.ulcerans_Agy99 IAFAKPGHITFGSDWPFAPTAAGKLFAAGLETYPALDAAARG-AIDRGSA
MAV_2515|M.avium_104 LAFARPGHITFGSDWPFAPVAVGKLFAAGLETYPALDTSTRG-AIEHTNA
MSMEG_6813|M.smegmatis_MC2_155 LAFARPDHILFGSDFPYATAEIATRFAKNLDAYLADHQDVDGVAVNRDNA
Mflv_3792|M.gilvum_PYR-GCK ADLLGIDRVIFGSDWPHPEGLADPITLVDQLEENGLDEDGIR-KVMGGNL
Mvan_2602|M.vanbaalenii_PYR-1 ADLCGIDRVIFGSDWPHPEGLADPINLVADLEAHGLDQEGVR-KVMGKNM
TH_0554|M.thermoresistible__bu IEIMGADHVLFGSDYPHPEGIGDPLSFVDRLE--GVSEADKA-KIMGGNA
Mb2325c|M.bovis_AF2122/97 ----------FGQTTIRNKIVYGTGGFLINRPYLQLCDEMRALPVPREVL
Rv2303c|M.tuberculosis_H37Rv ----------FGQTTIRNKIVYGTGGFLINRPYLQLCDEMRALPVPREVL
MAB_0299|M.abscessus_ATCC_1997 VASLGVDRLIFGSDFPYQAGPRYVSSATYIEEGLSAEDASAILDHNGAEL
**.
MMAR_1500|M.marinum_M LSLFPRFGVAAPPPQPSAAQRIRHTLSRTAMRGVARLMNSGG
MUL_2437|M.ulcerans_Agy99 LSLFPRFGVAAPPPQPSAAQRIRHTLSRTAMRGVARLMNSGG
MAV_2515|M.avium_104 LALFPRLGTPPHPIPQSPAQRIRHSLSRGAMRVVARMTSTS-
MSMEG_6813|M.smegmatis_MC2_155 LKLLPRLAVGAAR-----------------------------
Mflv_3792|M.gilvum_PYR-GCK VDLFKVPNKVVHKPDAPALVIA--------------------
Mvan_2602|M.vanbaalenii_PYR-1 VDLFRVENKVVYKPDVPALVIA--------------------
TH_0554|M.thermoresistible__bu MGLLGIR--------VPA------------------------
Mb2325c|M.bovis_AF2122/97 EDWLWRNATRVLRLDT--------------------------
Rv2303c|M.tuberculosis_H37Rv EDWLWRNATRVLRLDT--------------------------
MAB_0299|M.abscessus_ATCC_1997 LGLTGV------------------------------------