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AINGKVALVTGAARGIGRGIALRLARDGADVALVDVHQDGLDDVAAEIAEIGSKTTTFVADVSDRDQVFA AVRHASSALGGFDIMVNNAGIALVGPISEVTPAEIQKLWSINVDGVLWGIQAAVAQFTTLHNKEQGKISK IINASSIAGHDGFAMLGPYSATKFAVRALTQAAAKEHAADGITVNAYCPGVVGTDMWVEIDKRFAELTGA AEGETYDKFVGGIALGRAETPDDVAGFVSYLAGPDSDYMTGQAGLIDGGLVYR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0124 | - | - | 100% (264) | acetoin reductase |
| M. gilvum PYR-GCK | Mflv_4505 | - | 4e-32 | 37.21% (258) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_3281 | - | 1e-30 | 35.00% (260) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2025 | fabG3 | 9e-35 | 38.85% (260) | 20-beta-hydroxysteroid dehydrogenase |
| M. tuberculosis H37Rv | Rv2002 | fabG3 | 9e-35 | 38.85% (260) | 20-beta-hydroxysteroid dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 2e-22 | 33.51% (188) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0827 | - | 8e-37 | 40.08% (262) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_2981 | fabG3_1 | 3e-35 | 39.31% (262) | 20-beta-hydroxysteroid dehydrogenase FabG3_1 |
| M. avium 104 | MAV_2509 | - | 8e-35 | 38.76% (258) | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5020 | - | 1e-114 | 77.27% (264) | acetoin(diacetyl) reductase |
| M. thermoresistible (build 8) | TH_2435 | - | 4e-29 | 33.60% (253) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1037 | fabG3 | 3e-32 | 36.40% (261) | 20-beta-hydroxysteroid dehydrogenase FabG3 |
| M. vanbaalenii PYR-1 | Mvan_0789 | - | 1e-131 | 87.12% (264) | acetoin reductases |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2981|M.marinum_M --------------------------------------------------
MAV_2509|M.avium_104 --------------------------------------------------
MUL_1037|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0124|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5020|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0827|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2435|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2981|M.marinum_M --------------------------------------------------
MAV_2509|M.avium_104 --------------------------------------------------
MUL_1037|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0124|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5020|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0827|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2435|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2981|M.marinum_M --------------------------------------------------
MAV_2509|M.avium_104 --------------------------------------------------
MUL_1037|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0124|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5020|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0827|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2435|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2981|M.marinum_M --------------------------------------------------
MAV_2509|M.avium_104 --------------------------------------------------
MUL_1037|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0124|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5020|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0827|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2435|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2981|M.marinum_M --------------------------------------------------
MAV_2509|M.avium_104 --------------------------------------------------
MUL_1037|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0124|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5020|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0827|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2435|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2981|M.marinum_M --------------------------------------------------
MAV_2509|M.avium_104 --------------------------------------------------
MUL_1037|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0124|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0789|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5020|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0827|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2435|M.thermoresistible__bu --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Mb2025|M.bovis_AF2122/97 ---------------------MSGRLIGKVALVSGGARGMGASHVRAMVA
Rv2002|M.tuberculosis_H37Rv ---------------------MSGRLIGKVALVSGGARGMGASHVRAMVA
MMAR_2981|M.marinum_M ---------------------MAGRLTGKVALVSGGARGMGASHVRALVA
MAV_2509|M.avium_104 ---------------------MAERLAGKVALVSGGARGMGASHVRSLVA
MUL_1037|M.ulcerans_Agy99 ----------------------MGRVDGKVALISGGARGMGASHARLLVQ
Mflv_0124|M.gilvum_PYR-GCK ---------------------MA--INGKVALVTGAARGIGRGIALRLAR
Mvan_0789|M.vanbaalenii_PYR-1 ---------------------MT--LNGKVALVTGAARGIGRGIALRLAR
MSMEG_5020|M.smegmatis_MC2_155 ---------------------MS--LQGKVALVTGAGRGIGRGIALRLAQ
MAB_0827|M.abscessus_ATCC_1997 ---------------------MTSPLKSRRAFVTGGSRGIGAGIVRRLAE
TH_2435|M.thermoresistible__bu --------------------------------VTGGASGLGRAIAARLGD
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
::*.. *:* . :
Mb2025|M.bovis_AF2122/97 EGAKVVFGD-ILDEEGKAVAAEL---ADAARYVHLDVTQPAQWTAAVDTA
Rv2002|M.tuberculosis_H37Rv EGAKVVFGD-ILDEEGKAVAAEL---ADAARYVHLDVTQPAQWTAAVDTA
MMAR_2981|M.marinum_M EGAHVVLGD-ILDDEGRAVAAEL---GDAARYVHLDVTQPEQWTAAVDTA
MAV_2509|M.avium_104 EGAKVVFGD-ILDDEGKAVAAEV---GEATRYLHLDVTKPEDWDAAVATA
MUL_1037|M.ulcerans_Agy99 EGAKVVIGD-ILDEEGKALAEEI---GDAARYVHLDVTQPDQWEAAVATA
Mflv_0124|M.gilvum_PYR-GCK DGADVALVD-VHQDGLDDVAAEIAEIGSKTTTFVADVSDRDQVFAAVRHA
Mvan_0789|M.vanbaalenii_PYR-1 DGADIALVD-VLPEGLDGVADKIAGIGGKTTMFVADVSDREQVFAAVDHA
MSMEG_5020|M.smegmatis_MC2_155 DGADIALVD-VTADGIDAVADEVAAIGSKATTFVADVSDRDAVFAAVEHA
MAB_0827|M.abscessus_ATCC_1997 DGARVVFTYSSSVQQAADVVDDINEDGGWARAVKADVADPDQLGAAIGQA
TH_2435|M.thermoresistible__bu DGHRVAVLD-IDHAAAEQTAAELRAHGGDAVAVGADVADQDAVHDAFAAI
MLBr_00862|M.leprae_Br4923 RGAEVVVSD-IDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQV
* :.. . .: . : **:.
Mb2025|M.bovis_AF2122/97 VTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVK
Rv2002|M.tuberculosis_H37Rv VTAFGGLHVLVNNAGILNIGTIEDYALTEWQRILDVNLTGVFLGIRAVVK
MMAR_2981|M.marinum_M VNEFGGLHVLVNNAGILNIGTIEDYALSEWQRILDINVTGVFLGIRAAVK
MAV_2509|M.avium_104 LAEFGRIDVLVNNAGIINIGTLEDYALSEWQRILDINLTGVFLGIRAVVK
MUL_1037|M.ulcerans_Agy99 VDEFGKLDVLVNNVGIVALGQLKKFDLGKWQKVIDVNLTGTFLGMRAAVE
Mflv_0124|M.gilvum_PYR-GCK SSALGGFDIMVNNAGIALVGPISEVTPAEIQKLWSINVDGVLWGIQAAVA
Mvan_0789|M.vanbaalenii_PYR-1 AAALGGFDIMVNNAGIALVGPISDVTPEQIEKLWAINVNGVLWGTQAAVA
MSMEG_5020|M.smegmatis_MC2_155 QSALGGFDIMVNNAGVALVGPVAEVTPDDAARVWGVNVNGVLWGIQAAAA
MAB_0827|M.abscessus_ATCC_1997 AEELGGLDILVNNAGILSIGDVDTATLADFDEIVAVNVRAVFAGIKAASP
TH_2435|M.thermoresistible__bu RGSLGPVHILVTSAAIAGFTRFDEITLDEWNRYLAVNLTGTFLCVQAALT
MLBr_00862|M.leprae_Br4923 SAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQ
* .::*....: . . . :*: ... :*
Mb2025|M.bovis_AF2122/97 PMKEAGR------GSIINISSIEGLAGTVACHG-YTATKFAVRGLTKSTA
Rv2002|M.tuberculosis_H37Rv PMKEAGR------GSIINISSIEGLAGTVACHG-YTATKFAVRGLTKSTA
MMAR_2981|M.marinum_M PMKEAGR------GSIINISSIEGLAGTIASHG-YTVSKFAVRGLTKSTA
MAV_2509|M.avium_104 PMKKAGR------GSIINISSIEGMAGTIACHG-YTATKFAVRGLTKSAA
MUL_1037|M.ulcerans_Agy99 PMTAAGS------GSIINVSSIEGLRGAPAVHP-YVASKWAVRGLTKSAA
Mflv_0124|M.gilvum_PYR-GCK QFTTLHNKEQGKISKIINASSIAGHDG-FAMLGPYSATKFAVRALTQAAA
Mvan_0789|M.vanbaalenii_PYR-1 KFKELKNKDKGRVSRIINASSIAGHDG-FAMLGPYSATKFAVRALTQAAA
MSMEG_5020|M.smegmatis_MC2_155 KFVEL-----GVPGRIINASSIAGHDG-FAMLGVYSASKFAVRALTQAAA
MAB_0827|M.abscessus_ATCC_1997 HLTEG--------GRIVTIGSINGDSSPTANLSLYSMTKAAVAGLTRGLA
TH_2435|M.thermoresistible__bu DMVADGW------GRIVTISSAAGQQG-AHRQGHYAATKGGVIALTKTVA
MLBr_00862|M.leprae_Br4923 RLVERGTG-----GHIVNVSSMAAYAP-LQSLSAYCTSKAATYMFSDCLR
: . *:. .* . * :* .. ::
Mb2025|M.bovis_AF2122/97 LELGPSGIRVNSIHPGLVKTPMTDWVP--------------EDIFQ--TA
Rv2002|M.tuberculosis_H37Rv LELGPSGIRVNSIHPGLVKTPMTDWVP--------------EDIFQ--TA
MMAR_2981|M.marinum_M LELGPSGIRVNSIHPGLVKTPMTEWVP--------------EDLFQ--TA
MAV_2509|M.avium_104 LELGPSGIRVNSIHPGLIKTPMTEWVP--------------EDIFQ--SA
MUL_1037|M.ulcerans_Agy99 LELAPLNIRVNSIHPGFIRTPMTANLP--------------DDMVT--IP
Mflv_0124|M.gilvum_PYR-GCK KEHAADGITVNAYCPGVVGTDMWVEIDKRFAELTGAAEGETYDKFVGGIA
Mvan_0789|M.vanbaalenii_PYR-1 KEHAADGITVNAYCPGVVGTDMWVEIDKRFAELTGAAEGETYDKFVGGIA
MSMEG_5020|M.smegmatis_MC2_155 KEYASSGITVNAYCPGVVGTDMWVEIDQRFADLTGAEVGATFDQFVGGIA
MAB_0827|M.abscessus_ATCC_1997 REFGPRGITINNVQPGPIGTDMNPE------------DGQLADILRPNIA
TH_2435|M.thermoresistible__bu LDYAAKGITANTVPPFVIDSPMLREQQRR-------GTLPPAEYLTRAIP
MLBr_00862|M.leprae_Br4923 AELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFR
: . .: . * : : : .
Mb2025|M.bovis_AF2122/97 LGRAAEPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEV
Rv2002|M.tuberculosis_H37Rv LGRAAEPVEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHNDFGAVEV
MMAR_2981|M.marinum_M LGRAAEPMEVSNLVVYLASDESSYSTGAEFVVDGGTVAGLAHKDFSAVDV
MAV_2509|M.avium_104 LGRAAEPKEVSNLVVYLASDESSYSTGSEFVVDGGTTAGLGHKDFSNVET
MUL_1037|M.ulcerans_Agy99 LGRPAESREVSTFVVFLASDDASYATGSEFVMDGGLVTDVPHKQF-----
Mflv_0124|M.gilvum_PYR-GCK LGRAETPDDVAGFVSYLAGPDSDYMTGQAGLIDGGLVYR-----------
Mvan_0789|M.vanbaalenii_PYR-1 LGRAETPDDVAGFVSYLAGPDADYMTGQSGLIDGGLVYR-----------
MSMEG_5020|M.smegmatis_MC2_155 LGRAETPEDVAAFVSYLAGPDAAYMTGQAPIIDGGLVYR-----------
MAB_0827|M.abscessus_ATCC_1997 VGRYGQPRDIASLVSYLVSDEAWYITGTAINIDGGFTA------------
TH_2435|M.thermoresistible__bu MGRLGVAEDVAAVCSFLCSDAAGYLTGQVIGVNGGAIR------------
MLBr_00862|M.leprae_Br4923 LRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARI
: * . : . .. *
Mb2025|M.bovis_AF2122/97 SSQPEWVT
Rv2002|M.tuberculosis_H37Rv SSQPEWVT
MMAR_2981|M.marinum_M AAQPEWVT
MAV_2509|M.avium_104 DAQPDWVT
MUL_1037|M.ulcerans_Agy99 --------
Mflv_0124|M.gilvum_PYR-GCK --------
Mvan_0789|M.vanbaalenii_PYR-1 --------
MSMEG_5020|M.smegmatis_MC2_155 --------
MAB_0827|M.abscessus_ATCC_1997 --------
TH_2435|M.thermoresistible__bu --------
MLBr_00862|M.leprae_Br4923 RVI-----