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VQPSRSGWCVKAMKRLLAFGTALTTIGAAGCLGFGIAAADEAPAVPPSPTPADAPPPLGTPGRAYALGGA HVLGIPYDEYIMRTGADWFPGLDRQIVDYPAGQVQGHTLERLFPGIGRLDDSFPGIGIDGPSVGESVDVG TPNVITAIREGGRGTAIGLSEGAMVLNDVQAKLAYDPAAPPPDQLSFAMYGDPVARHAFGESFLTQNFPV GSVVPSLDYRIPPPVESQYDTYQFVSAYDSIADWPDRPDNWISVANAIVGLATGHTAVAFTEPSMVPPQN IRTTVNSRGAKTTTYMIPEEHLPLVLPFKYLGVPTETLIELDAVLKPFVDAGYSRNDDPLTAPITVDPVN GYDPAEVTAPATQAAFGGAADPVSQLLSGLQYVLNNPP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0276 | - | - | 100% (388) | hypothetical protein Mvan_0276 |
| M. vanbaalenii PYR-1 | Mvan_1838 | - | 4e-31 | 31.89% (301) | hypothetical protein Mvan_1838 |
| M. vanbaalenii PYR-1 | Mvan_4723 | - | 2e-30 | 32.85% (277) | hypothetical protein Mvan_4723 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1216c | - | 6e-88 | 46.45% (366) | hypothetical protein Mb1216c |
| M. gilvum PYR-GCK | Mflv_0401 | - | 0.0 | 84.47% (380) | hypothetical protein Mflv_0401 |
| M. tuberculosis H37Rv | Rv1184c | - | 7e-88 | 46.45% (366) | hypothetical protein Rv1184c |
| M. leprae Br4923 | MLBr_01232 | - | 3e-78 | 44.48% (344) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_0936c | - | 1e-138 | 64.04% (381) | hypothetical protein MAB_0936c |
| M. marinum M | MMAR_4939 | - | 2e-26 | 29.74% (343) | PE-PGRS family protein |
| M. avium 104 | MAV_1760 | - | 1e-146 | 68.17% (377) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_0412 | - | 0.0 | 83.82% (377) | hypothetical protein MSMEG_0412 |
| M. thermoresistible (build 8) | TH_3724 | - | 9e-18 | 29.23% (325) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_1034 | - | 2e-13 | 31.82% (220) | PE family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1216c|M.bovis_AF2122/97 -----------------------------------MKRVIAGAFAVWLVG
Rv1184c|M.tuberculosis_H37Rv -----------------------------------MKRVIAGAFAVWLVG
MLBr_01232|M.leprae_Br4923 -----------------------------------MKRLLATTLAALTVG
Mflv_0401|M.gilvum_PYR-GCK -----------------------------------MRRHLAFATAITTLG
MSMEG_0412|M.smegmatis_MC2_155 ----------------------------------MRRRLLAFGTAFTTIG
Mvan_0276|M.vanbaalenii_PYR-1 -----------------------MQPSRSGWCVKAMKRLLAFGTALTTIG
MAV_1760|M.avium_104 -----------------------------------MKQLLAGVTALLSVS
MAB_0936c|M.abscessus_ATCC_199 -----------------------------------MRNLLAGTAVLVVAC
MMAR_4939|M.marinum_M MSYVVAAPDFLSTAAEDLAAMGSAVSTATAAAARSTTLLLAAGADEVSTH
TH_3724|M.thermoresistible__bu ---------------------------------------------VVAVG
MUL_1034|M.ulcerans_Agy99 MSYVLTAPDLLASAATDVDGIAATLQVANSAAAALTSGLLAAAQDEVSAA
Mb1216c|M.bovis_AF2122/97 WAGGFGTA--------------------IAASEPAY----PWAPGPPPSP
Rv1184c|M.tuberculosis_H37Rv WAGGFGTA--------------------IAASEPAY----PWAPGPPPSP
MLBr_01232|M.leprae_Br4923 TVSGFGST--------------------VASSEPGE----PWLP---PSP
Mflv_0401|M.gilvum_PYR-GCK ATGILGLG--------------------IAAAQPAPAPPPPPAPGAAAGA
MSMEG_0412|M.smegmatis_MC2_155 TAGFLGFG--------------------VAAADDT--KPVDPAPGGAHAE
Mvan_0276|M.vanbaalenii_PYR-1 AAGCLGFG--------------------IAAADEAPAVPPSPTP---ADA
MAV_1760|M.avium_104 TAGYFGIG--------------------TAAADGGP-----------IGG
MAB_0936c|M.abscessus_ATCC_199 VTGCFGIP--------------------SAVADDPQVPGPPIPGIAPDGT
MMAR_4939|M.marinum_M IAALFSTHGLQYQLASAQAAEFHERFVLTLAADANTYLTTEIANAQRCLA
TH_3724|M.thermoresistible__bu ALTWGGXG----------------------------------------VA
MUL_1034|M.ulcerans_Agy99 IAKVFSAYG---------------QEYQAAIAQASAFHTEFTRALAAAGA
.
Mb1216c|M.bovis_AF2122/97 SPVGDASTAKVVYALGGARMPGIPWYEYTNQAGSQYFPNAKHDLIDYPAG
Rv1184c|M.tuberculosis_H37Rv SPVGDASTAKVVYALGGARMPGIPWYEYTNQAGSQYFPNAKHDLIDYPAG
MLBr_01232|M.leprae_Br4923 VPVRENSPAKIVYALGGARPPTFDWDYYTIRAGDEFFPDVNRKLIDYPAR
Mflv_0401|M.gilvum_PYR-GCK PTPLGTPG--RGYALGGAHVLGIPYDEYIMRTGADWFPGLDREIVDYPAG
MSMEG_0412|M.smegmatis_MC2_155 APSMGTPG--RGYALGGAHVLGIPYDEYIMRTGADWFPGLDRQIVDYPAG
Mvan_0276|M.vanbaalenii_PYR-1 PPPLGTPG--RAYALGGAHVLGIPYDEYIMRTGADWFPGLDRQIVDYPAG
MAV_1760|M.avium_104 PPTPGAPGDQTAYALGGAHVLGIPYDQYIRMEGADWFPGQQRQIVRYPAG
MAB_0936c|M.abscessus_ATCC_199 VKAAPSAPDRTAYALGGAHVLGIPYDEYIRMTGKDWFPNMKRENVWYPAG
MMAR_4939|M.marinum_M GAINAPATALLGHPLLGADPTASASTAATPAGGASMAPAAAGTRITVPGA
TH_3724|M.thermoresistible__bu SPAGQPERAAALRLTATADAIIMPGTKIGYIPSQDEFTAYATAVIGATAG
MUL_1034|M.ulcerans_Agy99 AYAQAEAANASLITAGVSDALTAITTPIQSLLGPAAIGTGGAGSAGALTA
: .
Mb1216c|M.bovis_AF2122/97 ---------------------AAFSWWPTMLLPPGSHQDNMT--------
Rv1184c|M.tuberculosis_H37Rv ---------------------AAFSWWPTMLLPPGSHQDNMT--------
MLBr_01232|M.leprae_Br4923 ---------------------APFRYVPTFLVP--GPRDEVT--------
Mflv_0401|M.gilvum_PYR-GCK ---------------------QVQGHTLERLFPGIGAFGDRIAP------
MSMEG_0412|M.smegmatis_MC2_155 ---------------------QVQGHTLERLFPGIGALGERFMP------
Mvan_0276|M.vanbaalenii_PYR-1 ---------------------QVQGHTLERLFPGIGRLDDSF-P------
MAV_1760|M.avium_104 ---------------------QVQGHVLERLFPGIGKLDESF-P------
MAB_0936c|M.abscessus_ATCC_199 ---------------------QVQGHTLERFFPGIGPIGEKILP------
MMAR_4939|M.marinum_M GPLYYPRFLTELPYLGQALLLGIPGPSSASILQGYDLINHAIGENWFPDT
TH_3724|M.thermoresistible__bu ----------------------APGAVDYLGVPGEFWPATGLDS------
MUL_1034|M.ulcerans_Agy99 VSSTLMADP----------VVALIMGGTSVPLPGPGYVSDINNNYIQPLF
.
Mb1216c|M.bovis_AF2122/97 -------------------------VGVAVKDGTNSLDNAIH-----HGT
Rv1184c|M.tuberculosis_H37Rv -------------------------VGVAVKDGTNSLDNAIH-----HGT
MLBr_01232|M.leprae_Br4923 -------------------------IGEAIAVATKNLNQAIH-----RGT
Mflv_0401|M.gilvum_PYR-GCK -----------------GLGLDGPSYGESIDVGAPNLIGAIR-----RGG
MSMEG_0412|M.smegmatis_MC2_155 -----------------GLGLDGPSYGESIDVGAPNLINAIR-----QGG
Mvan_0276|M.vanbaalenii_PYR-1 -----------------GIGIDGPSVGESVDVGTPNVITAIR-----EGG
MAV_1760|M.avium_104 -----------------GLGMDGPSVGESVAEGIDNLDAAIR-----TTG
MAB_0936c|M.abscessus_ATCC_199 -----------------GLGLDGPSIGESIDIGEPNLENAIR-----SGG
MMAR_4939|M.marinum_M I---ASVINYPASIGILSGSLAAPDTNTAVAIGARMLHEQIMSAVTNGSG
TH_3724|M.thermoresistible__bu -----------------------LTFDASVAXGQAMLTPMVDG--AIESD
MUL_1034|M.ulcerans_Agy99 SGAIPQALFTPEQFWPVTPGLGNLTFNQSVAQGVTLLNDAIN--TQLALG
. :: . : :
Mb1216c|M.bovis_AF2122/97 DPAAAVGLSQGSLVLDQEQARLANDPTAP-APDKLQFTTFGDPTGRHAFG
Rv1184c|M.tuberculosis_H37Rv DPAAAVGLSQGSLVLDQEQARLANDPTAP-APDKLQFTTFGDPTGRHAFG
MLBr_01232|M.leprae_Br4923 EPAAVVGLSQGSLALDTEQEQLATDPTAP-PPDQLTFNTFGDPSGYHGFG
Mflv_0401|M.gilvum_PYR-GCK -PGTAIGLSEGASVLDEVQARLAYDPAAP-PPDQLSFATYGNPVGKHAFG
MSMEG_0412|M.smegmatis_MC2_155 -PGTVIGLSEGASVLDEVQARLAYDPAAP-PPDSLSFATYGNPVGKHAFG
Mvan_0276|M.vanbaalenii_PYR-1 -RGTAIGLSEGAMVLNDVQAKLAYDPAAP-PPDQLSFAMYGDPVARHAFG
MAV_1760|M.avium_104 RPGTAIGLSEGAFVVDGEQARLANDPTAP-PPNTLNFATFGDPIGRHAFG
MAB_0936c|M.abscessus_ATCC_199 -PGTAMGLSEGALVLNAVKNALATDPTAP-EPESLTFATFGDPIAKSPFS
MMAR_4939|M.marinum_M LPVHVATLSQGTIVANRELAYLATDPNAP-PAHALEFALFGSP------E
TH_3724|M.thermoresistible__bu TPIVVFGHSQSAVIATKEKQRLLAEYPDPDTAPDVTFVMVANPNRPNGGL
MUL_1034|M.ulcerans_Agy99 NKVVAFGYSQSATIVNNEILALMAMGTGAPDPGDLSFIMVGAPNNPDGGL
. *:.: * . . : * . *
Mb1216c|M.bovis_AF2122/97 ASFLARIFPPGSHIPIPFIEYTMPQQVDSQYDTNHVVTAYDGFSDFPDRP
Rv1184c|M.tuberculosis_H37Rv ASFLARIFPPGSHIPIPFIEYTMPQQVDSQYDTNHVVTAYDGFSDFPDRP
MLBr_01232|M.leprae_Br4923 KSVLASIFRPGDYIPL--IDYTMPQRMDSQYDSNRVVAAYDGLSEFPDRA
Mflv_0401|M.gilvum_PYR-GCK ESFLTQNFPVGSVVPS--LDYRIPAPVESQYDTYKFVSAYDSIADWPDRP
MSMEG_0412|M.smegmatis_MC2_155 ESFLTQMFPVGSVVPS--LDYRIPAPVESQYDTYQFVSAYDSIADWPDRP
Mvan_0276|M.vanbaalenii_PYR-1 ESFLTQNFPVGSVVPS--LDYRIPPPVESQYDTYQFVSAYDSIADWPDRP
MAV_1760|M.avium_104 QSFLTAMFGVGSVVPA--LDYTMPPPYESQYDTNRFVAAYDSIADFPDRP
MAB_0936c|M.abscessus_ATCC_199 ESFLTQNFAPGSVVPF--MDYPVPARVDSQYHTDQFISAYDSIADWPDRP
MMAR_4939|M.marinum_M LGLAHIYLPDGLTVPL--INYTVHGLSNTQYDVSVVNGQYDFWGNPPDRP
TH_3724|M.thermoresistible__bu LARFPGLYIPILGVTF---NGATPAPADGPFDSYDVAREFDGWADFPRYP
MUL_1034|M.ulcerans_Agy99 LARFPGFYIPFLDVSFN-----GATPAANPYPTSIFTAQYDGIAHAPQYR
. :. : . :* .. *
Mb1216c|M.bovis_AF2122/97 DNLLAVANAAIGAAIAHT--PIGFTGPGDVPPQNIRTTVNSRGATTTTYL
Rv1184c|M.tuberculosis_H37Rv DNLLAVANAAIGAAIAHT--PIGFTGPGDVPPQNIRTTVNSRGATTTTYL
MLBr_01232|M.leprae_Br4923 DNLLAQLNCFAGGAISHT--PSGFFNPEDVPPQNIRTTVNSRGAKTTTYL
Mflv_0401|M.gilvum_PYR-GCK DNWLSVANAIVGLATGHT--AVAFTDPSMVPERNIRTTVNSRGATTTTYM
MSMEG_0412|M.smegmatis_MC2_155 DNWISVANAIVGLATGHT--AVAFTNPSMVPPQNIRTTVNSRGAKDTTIM
Mvan_0276|M.vanbaalenii_PYR-1 DNWISVANAIVGLATGHT--AVAFTEPSMVPPQNIRTTVNSRGAKTTTYM
MAV_1760|M.avium_104 DNMFALANTLMGLATGHT--AVAFTNPSMVPPQNIRTTINSRGAKDTTIM
MAB_0936c|M.abscessus_ATCC_199 DNLFALANAIAGLATGHT--AVAFTNPKMVPARNIVTETNSRGGTTTTYF
MMAR_4939|M.marinum_M WNLPAWVNSLFGAAYYHN--TSSFASLS--DAVEVSSVTTSLGGTITTYL
TH_3724|M.thermoresistible__bu LNLVATANAILGIYYLHGGYYELLTENPDILDDPERTIVQQYG-DTTYYL
MUL_1034|M.ulcerans_Agy99 LNILSDINAIMGYFYVHG----NYPDLMSGQAIQLPTSPGYTG-NTDYYM
* : * * * : * :
Mb1216c|M.bovis_AF2122/97 VPVNHLPLTLPLRYLGMS-DAEVDQIDSVLQPQIDAAYARNDNWFTRPVS
Rv1184c|M.tuberculosis_H37Rv VPVNHLPLTLPLRYLGMS-DAEVDQIDSVLQPQIDAAYARNDNWFTRPVS
MLBr_01232|M.leprae_Br4923 IPVNHLPLTLPLRYLGWS-DALVDQIDAVLQPKIDAAYAYNDNPLNKPIS
Mflv_0401|M.gilvum_PYR-GCK IPEEHLPLVLPFKYLGVP-KDTLMELDKVLLPYVDAGYSRNDDPATAPIT
MSMEG_0412|M.smegmatis_MC2_155 IPEEHLPLVLPFKYLGVD-KDTLNKLDGVLKPYVDAGYSRNDDPLTAPIT
Mvan_0276|M.vanbaalenii_PYR-1 IPEEHLPLVLPFKYLGVP-TETLIELDAVLKPFVDAGYSRNDDPLTAPIT
MAV_1760|M.avium_104 IPEKHLPLVMPLKYIGID-ENTLNKLDAILTPRVNAGYSRNDDPATAPVQ
MAB_0936c|M.abscessus_ATCC_199 IPEQHLPLVMGFKYLGVP-EETLNRLDAILQPRVDAGYSRNDDPATAPIA
MMAR_4939|M.marinum_M IPSPTLPMLLPLEQIGVP-APIVAGLNSVLAPIVNDGYSSLTPNAGPYFS
TH_3724|M.thermoresistible__bu IRTEQLPLLRPLRDLGVP-EEFVDALEPYVRRIVDLGYDRN-TPYGEPAP
MUL_1034|M.ulcerans_Agy99 YLTQDLPLVQPIRDIPYAGPPLADLIQPQLRVLVDLGYSDYGPGLSYADV
**: :. : :: : :: .*
Mb1216c|M.bovis_AF2122/97 VDPVRGLDPLTAPGSIVEG----------------ARGLLGSPAFGG---
Rv1184c|M.tuberculosis_H37Rv VDPVRGLDPLTAPGSIVEG----------------ARGLLGSPAFGG---
MLBr_01232|M.leprae_Br4923 VDPVNGMDPIAGIDAELRDSI--------LNVFAQLRSILPPPPG-----
Mflv_0401|M.gilvum_PYR-GCK VDPVNGYDPAEVTAPATQAAFGGGADPV-SQLLSGLQYILNNPP------
MSMEG_0412|M.smegmatis_MC2_155 VDPVNGYDPAAVTAPATQAAFGGGTDPV-SQLLAGLQYVVNNQPAPKP--
Mvan_0276|M.vanbaalenii_PYR-1 VDPVNGYDPAEVTAPATQAAFGGAADPV-SQLLSGLQYVLNNPP------
MAV_1760|M.avium_104 VDPVHGFDPAEVTAPANQATFGGGADPL-SQIMAGAMSVLSHGAGEADH-
MAB_0936c|M.abscessus_ATCC_199 VDPRRGFDPAEVTAPASQATFGGGSDPI-SQITSGALAVLGNGTRPTPPN
MMAR_4939|M.marinum_M QGALVGLPSAADVLGSWPWP--------------ALGSVTAHIC------
TH_3724|M.thermoresistible__bu VRVLPPLTPAPGPATQHNAGQGITVASA-TSTPDKRTPVVEAPVEEPPVQ
MUL_1034|M.ulcerans_Agy99 PTPAGLLSVPNPFAVSYYLLKGSLQAPYGAAVEIGVEAGLLGPESFPDTY
Mb1216c|M.bovis_AF2122/97 --------------------------------------------------
Rv1184c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_0401|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0412|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0276|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4939|M.marinum_M --------------------------------------------------
TH_3724|M.thermoresistible__bu TGRSTLKREKPVSARHLVRNSLRAVPGLRRGEPAATPTPDVTPDVTPDAP
MUL_1034|M.ulcerans_Agy99 PWVPSLNPGLNFYLGQPSVTLLSLLSGGLGDIFHLIPPPVFP--------
Mb1216c|M.bovis_AF2122/97 --------------------------
Rv1184c|M.tuberculosis_H37Rv --------------------------
MLBr_01232|M.leprae_Br4923 --------------------------
Mflv_0401|M.gilvum_PYR-GCK --------------------------
MSMEG_0412|M.smegmatis_MC2_155 --------------------------
Mvan_0276|M.vanbaalenii_PYR-1 --------------------------
MAV_1760|M.avium_104 --------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------
MMAR_4939|M.marinum_M --------------------------
TH_3724|M.thermoresistible__bu AGQPEPAEPNESAAPPAAAEADDASE
MUL_1034|M.ulcerans_Agy99 --------------------------