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MSNPPLTAIHLGGPDDGPLLLLGPSLGTTTATLWTGVAQRLVDHVRVVGWDLPGHGRGRRAHPFTIADLA AAVLVIADDLNVETFHYAGDSVGGCVGLQLLLDAPQRVSSATLLCTGAAIGTPDGWLARAATVRAGGVDT MLAGAAERWFAPGFVDREPGTASALLDALSHTDAESYAQVCEALAVFDVTNQLSEIVTPVLAVAGSVDVP TPPESLRRIASDVKDGDLVVLEGVGHLAPAEAPQRVAGLIAEIVGVPQPPSKTLEDVHRAGMAVRREVLG EAHVDRAVAGTTDLTADFQHMITQYAWGTIWTRPGLDLRSRSMITLTALVARGHHEELAMHLRAARRNGL SNDEIKELLMQTAIYCGVPDANSAFRIAAEVLPEFDEHPGAPS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0563 | - | - | 100% (393) | 4-carboxymuconolactone decarboxylase |
| M. vanbaalenii PYR-1 | Mvan_4821 | - | 5e-23 | 37.82% (119) | carboxymuconolactone decarboxylase |
| M. vanbaalenii PYR-1 | Mvan_4934 | - | 9e-14 | 35.25% (139) | carboxymuconolactone decarboxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3370 | - | 2e-09 | 28.30% (265) | hypothetical protein Mb3370 |
| M. gilvum PYR-GCK | Mflv_0527 | - | 0.0 | 97.20% (393) | 4-carboxymuconolactone decarboxylase |
| M. tuberculosis H37Rv | Rv0771 | - | 1e-08 | 35.48% (93) | 4-carboxymuconolactone decarboxylase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0349c | - | 4e-18 | 25.98% (254) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_3948 | - | 2e-11 | 28.57% (259) | hydrolase |
| M. avium 104 | MAV_4589 | - | 7e-12 | 28.11% (217) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_2604 | pcaC | 8e-50 | 73.02% (126) | 4-carboxymuconolactone decarboxylase |
| M. thermoresistible (build 8) | TH_0621 | - | 1e-14 | 44.71% (85) | 4-carboxymuconolactone decarboxylase |
| M. ulcerans Agy99 | MUL_3358 | - | 3e-10 | 25.33% (300) | hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0563|M.vanbaalenii_PYR-1 --------------------MSNPPLTAIHLGGPDDGPLLLLGPSLGTTT
Mflv_0527|M.gilvum_PYR-GCK --------------------MSNPPLTAIHLGGPDDGPLLLLGPSLGTTT
MSMEG_2604|M.smegmatis_MC2_155 --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0349c|M.abscessus_ATCC_199 -----------MGSAALQDRYLQSCLGGLHVRIGGEGPVILFWPSLLMTG
MUL_3358|M.ulcerans_Agy99 MTERKRNLRPVREVTAPSLQFRTIHGYKRAFRIAGSGPAILLIHG-IGDN
MAV_4589|M.avium_104 -------------------------MINLAYDDRGSGEPVVFIAGHGGAG
MMAR_3948|M.marinum_M ------------------MPIATINGQKIHYTDAGAGPPVLATHATLMDL
Mb3370|M.bovis_AF2122/97 ---MPSPSTTGHHAACGTGGTGFSVGSMRSPIRVGSGEPVLLLHPFLMSQ
Mvan_0563|M.vanbaalenii_PYR-1 ATLWTGVA-QRLVDHVRVVGWDLPGHGRGRRAH-PFTIADLAAAVLV-IA
Mflv_0527|M.gilvum_PYR-GCK ATLWTGVA-QRLVDHVRVVGWDLPGHGRGRRAH-PFTIADLAAAVLV-IA
MSMEG_2604|M.smegmatis_MC2_155 --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0349c|M.abscessus_ATCC_199 -SMWAAQA-EYFADRYTVILVDPPGHGDSQSLTRMFRFEDCAHAITQ-IL
MUL_3358|M.ulcerans_Agy99 STTWTGIH-AKLAQRFTVIAPDLLGHGRSDKPRADYSIAAYANGMRD-LL
MAV_4589|M.avium_104 RTWHPYQVPAFLAAGYRVITFDNRGIG-ATENAQGFTTETMVADTAA-LI
MMAR_3948|M.marinum_M ISLEPVTT-KLVDAGYRVIAFDLRGHGETVYDQQPYTYVDVAGDVIG-LA
Mb3370|M.bovis_AF2122/97 TVWEKVAQQLADTGRFEVFAPTMAGHNGGPASGTRFLSSAVLADHVERQL
Mvan_0563|M.vanbaalenii_PYR-1 DDLNVETFHYAGDSVGGCVGLQLLLDAPQRVSSATLLCTGAAIGTPDGWL
Mflv_0527|M.gilvum_PYR-GCK DDLNVETFHYAGDSVGGCVGLQLLLDAPQRVSSATLLCTGAAIGTPDGWL
MSMEG_2604|M.smegmatis_MC2_155 --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0349c|M.abscessus_ATCC_199 DSLGIERAHVVGNSWGGMIGGTFTAMYPHRAGASVLMNATASR-------
MUL_3358|M.ulcerans_Agy99 SVLDIERVTIIGHSLGGGVAMQFAYQFPQLVDRLILVGAGGVTKDVN---
MAV_4589|M.avium_104 EGLNAAPARIVGMSMGAFIAQELMLARPELVSAAVLMGTRGRMDR-----
MMAR_3948|M.marinum_M DYLGVDRFIFVAEGQGAVVALRTALLAPQRVRALALIGP-----------
Mb3370|M.bovis_AF2122/97 DELGWETSHIVGNSLGGWVAFELERRGRARSVTGIAPAGGWTRWSP----
Mvan_0563|M.vanbaalenii_PYR-1 ARAATVRAGGVDTMLAGAAERWFAPGFVDREPGTASALLDALSHTDAESY
Mflv_0527|M.gilvum_PYR-GCK ARAATVRAGGVDTMLTGAAERWFAPGFVDREPGTASALLDALSHTDAESY
MSMEG_2604|M.smegmatis_MC2_155 --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0349c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_3358|M.ulcerans_Agy99 --------------------------------------------------
MAV_4589|M.avium_104 --------------------------------------------------
MMAR_3948|M.marinum_M --------------------------------------------------
Mb3370|M.bovis_AF2122/97 --------------------------------------------------
Mvan_0563|M.vanbaalenii_PYR-1 AQVCEALAVFDVTNQLSEIVTPVLAVAGSVDVPTPPESLRRIASDVKDGD
Mflv_0527|M.gilvum_PYR-GCK AQVCEALAVFDVTDRLSEIVTPVLAVAGSADSPTPPESLRRIASDVKDGD
MSMEG_2604|M.smegmatis_MC2_155 --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0349c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_3358|M.ulcerans_Agy99 --------------------------------------------------
MAV_4589|M.avium_104 --------------------------------------------------
MMAR_3948|M.marinum_M --------------------------------------------------
Mb3370|M.bovis_AF2122/97 --------------------------------------------------
Mvan_0563|M.vanbaalenii_PYR-1 LVVLEGVGHLAPAEAPQRVAGLIAEIVGVPQPPSKTLEDVHRAGMAVRRE
Mflv_0527|M.gilvum_PYR-GCK VVVLEGVGHLAPAEAPERVAGLIAEIVGVPQPPSKTLEDVHRAGMAVRRE
MSMEG_2604|M.smegmatis_MC2_155 --------------------------------MTTMRDETHAAGSQVRRA
TH_0621|M.thermoresistible__bu ---------------------------------------MREQGLQVFRE
Rv0771|M.tuberculosis_H37Rv -----------------------------------MMDELRRTGLDKMNE
MAB_0349c|M.abscessus_ATCC_199 ---------------------------------ASMRQRVEFRLLTEIVR
MUL_3358|M.ulcerans_Agy99 ------------------------------VVFRLASLPMGAEALALLRL
MAV_4589|M.avium_104 -----------------------------------ARQFFRDAEAELADG
MMAR_3948|M.marinum_M -----------------------------------TAEAALDGENAALTA
Mb3370|M.bovis_AF2122/97 ------------------------------VKFEVIAKFIAGAPILAVAH
Mvan_0563|M.vanbaalenii_PYR-1 VLGEAHVDRAVAGTTD-LTADFQHMITQYAWGTIWTRPGLDLRSRSMITL
Mflv_0527|M.gilvum_PYR-GCK VLGHAHVDRAVAGTTD-LTADFQHMITQYAWGSIWTRPGLDFRSRSMITL
MSMEG_2604|M.smegmatis_MC2_155 VLGDDHVDRAVAATTG-FTADFQDLITRYAWGEIWTRPGLDRRSRSMITL
TH_0621|M.thermoresistible__bu LLPGVLPDGDVDFRDGSFGDELLEIGIDNVFGRLWTRDGLSRRDRSLVTL
Rv0771|M.tuberculosis_H37Rv VYAWDMPD---------MPGEFFALTVDHLFGRIWTRPGLSMRDRRMAVI
MAB_0349c|M.abscessus_ATCC_199 ILGRFREPLTTRAVKAFVGPTIMRERPHVEQSIRAELRDLRVDSVYWAVN
MUL_3358|M.ulcerans_Agy99 PMVLPTVQLAGKVLGMALGSTALGQDLPNVLRILDDLPEPTASSAFTRTL
MAV_4589|M.avium_104 GVALPASYEAKIRLLENFSRKTLNDDTAVADWIAMFSTWPVKSTPGMRAQ
MMAR_3948|M.marinum_M AMEIWCTQGPLPDIYR--PTAAMATPTPDAADALMERWRCSAWREYRAAA
Mb3370|M.bovis_AF2122/97 ILGQRALRLPFSRLLATLPISATPDGVSERELSGIIDDAAHCPAYFQLLV
Mvan_0563|M.vanbaalenii_PYR-1 TALVARG-----HHEELAMHLRAARR-NGLSNDEIKELLMQTAIYCGVPD
Mflv_0527|M.gilvum_PYR-GCK TALVARG-----HHEELAMHLRAARR-NGLSNDEIKELLLQTAIYCGVPD
MSMEG_2604|M.smegmatis_MC2_155 TAMIARG-----HHDELAMHVRAARR-NGLSVDEIKEVLLQSAIYCGVPE
TH_0621|M.thermoresistible__bu GILIALR-----ATDELRFHVQIARN-NGLTEDEIAEVIYHATGYAGFPN
Rv0771|M.tuberculosis_H37Rv AVLTAQG-----QSDLLEVQVNAVLHNDELTIDELRELAVFITHYVGFPL
MAB_0349c|M.abscessus_ATCC_199 SVVPARP-----DQRELLGRITTPILVIAGREDPTFPVAETELMAEAIPG
MUL_3358|M.ulcerans_Agy99 RAVVDWRGQIVTMLDRCYLTQAIPVQIIWGSRDAVVPVRHAEMAHAAMPG
MAV_4589|M.avium_104 LDVAPYT-----NRLSAYRSIATPVLVIGFSDDVLTPPYLGREVADALPN
MMAR_3948|M.marinum_M DALATRP-----TFIAELSTVACPALVVHSTQDVFVPMFLGKEVADSLGG
Mb3370|M.bovis_AF2122/97 KALVLPG------LQELEHTAVPSHVVLCEQDRVVPPSRFSRHFTDSLPA
: ..
Mvan_0563|M.vanbaalenii_PYR-1 ANSAFRIAAEVLPE-FDEHPGAPS--------------------------
Mflv_0527|M.gilvum_PYR-GCK ANSAFRIAAEVLPE-FDEHPGAPS--------------------------
MSMEG_2604|M.smegmatis_MC2_155 ANTAFRIAGAVLAE-EAQEPGDER--------------------------
TH_0621|M.thermoresistible__bu ASTAMKVAKEVLAE-EHSRAADADKQSRLGESNP----------------
Rv0771|M.tuberculosis_H37Rv GSRLNSAIERVAAK-RKQAAENGSLPDTKANVAEVLAKESGKSS------
MAB_0349c|M.abscessus_ATCC_199 AELVIMENTGHLAA-LERPEEVNALIDDFLKRHPIED-------------
MUL_3358|M.ulcerans_Agy99 SKLEVFEGSGHFPF-HDDPARFIDIVLRFIDSTQPPEYDQAALRELLRTG
MAV_4589|M.avium_104 GRYVQIPDTGHLGF-FERPDAVNAAMLKFFGEQH----------------
MMAR_3948|M.marinum_M PTAFVPVDTGHHAITCAFHPQIGAEILAWLPSVEDHPE------------
Mb3370|M.bovis_AF2122/97 GHRLTVLDGVGHVPMFEAPGRITELITSFIEECCPHVRAS----------
Mvan_0563|M.vanbaalenii_PYR-1 ----------------------------
Mflv_0527|M.gilvum_PYR-GCK ----------------------------
MSMEG_2604|M.smegmatis_MC2_155 ----------------------------
TH_0621|M.thermoresistible__bu ----------------------------
Rv0771|M.tuberculosis_H37Rv ----------------------------
MAB_0349c|M.abscessus_ATCC_199 ----------------------------
MUL_3358|M.ulcerans_Agy99 GGERTVSDPADTRVAVLSAMGSDERSAT
MAV_4589|M.avium_104 ----------------------------
MMAR_3948|M.marinum_M ----------------------------
Mb3370|M.bovis_AF2122/97 ----------------------------