For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
GSAALQDRYLQSCLGGLHVRIGGEGPVILFWPSLLMTGSMWAAQAEYFADRYTVILVDPPGHGDSQSLTR MFRFEDCAHAITQILDSLGIERAHVVGNSWGGMIGGTFTAMYPHRAGASVLMNATASRASMRQRVEFRLL TEIVRILGRFREPLTTRAVKAFVGPTIMRERPHVEQSIRAELRDLRVDSVYWAVNSVVPARPDQRELLGR ITTPILVIAGREDPTFPVAETELMAEAIPGAELVIMENTGHLAALERPEEVNALIDDFLKRHPIED*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0349c | - | - | 100% (277) | putative hydrolase, alpha/beta fold |
| M. abscessus ATCC 19977 | MAB_3034 | - | 3e-17 | 26.24% (263) | hydrolase |
| M. abscessus ATCC 19977 | MAB_0139c | - | 1e-12 | 25.37% (272) | alpha/beta fold family hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2734 | - | 4e-15 | 25.10% (263) | hydrolase |
| M. gilvum PYR-GCK | Mflv_1348 | - | 2e-23 | 31.60% (250) | 3-oxoadipate enol-lactonase |
| M. tuberculosis H37Rv | Rv2715 | - | 4e-15 | 25.10% (263) | hydrolase |
| M. leprae Br4923 | MLBr_01899 | lipG | 9e-11 | 28.50% (207) | putative hydrolase |
| M. marinum M | MMAR_5064 | bphD | 4e-18 | 29.55% (264) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. avium 104 | MAV_2517 | - | 4e-16 | 27.38% (252) | 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase |
| M. smegmatis MC2 155 | MSMEG_1897 | pcaD | 4e-20 | 30.04% (253) | 3-oxoadipate enol-lactonase |
| M. thermoresistible (build 8) | TH_2963 | - | 1e-23 | 31.35% (252) | PUTATIVE putative 3-oxoadipate enol-lactonase |
| M. ulcerans Agy99 | MUL_4140 | bphD | 4e-18 | 29.55% (264) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. vanbaalenii PYR-1 | Mvan_0563 | - | 3e-18 | 25.98% (254) | 4-carboxymuconolactone decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1348|M.gilvum_PYR-GCK -----------------------MSAVDVHVIESGLPD-GPAVVLSNSLG
MSMEG_1897|M.smegmatis_MC2_155 -----------------------MSSVAVHHVVTGRSD-GPAVVFSNSLG
Mvan_0563|M.vanbaalenii_PYR-1 -----------------------MSNPPLTAIHLGGPDDGPLLLLGPSLG
Mb2734|M.bovis_AF2122/97 MTERKRNLRPVRDVAPPTLQFRTVHG-YRRAFRIAGSG--PAILLIHGIG
Rv2715|M.tuberculosis_H37Rv MTERKRNLRPVRDVAPPTLQFRTVHG-YRRAFRIAGSG--PAILLIHGIG
MMAR_5064|M.marinum_M MTVTQSKTAEHTFESTSRYAEVDVDGPLKLHYHEAGVGNDQTVVLLHGGG
MUL_4140|M.ulcerans_Agy99 MTVTQSKTAEHTFESTSRYAEVDVDGPLKLHYHEAGVGNDQTVVLLHGGG
MAV_2517|M.avium_104 --MTTSNMADH---------AVTVNG-KSIFFAEKGTG--APVLLLHGGG
MAB_0349c|M.abscessus_ATCC_199 ------------MGSAALQDRYLQSCLGGLHVRIGGEG--PVILFWPSLL
TH_2963|M.thermoresistible__bu ---------------MPRFSRAGTTIDYTDTGAPAGRLEAPTILFGHGLL
MLBr_01899|M.leprae_Br4923 ---------------MEVRSGYATSGDLKLYYEDMGNVDDPPVLLIMGLG
::: .
Mflv_1348|M.gilvum_PYR-GCK ---ATHRMWDAQLDALERRFRVLRYDTRGHGA------------------
MSMEG_1897|M.smegmatis_MC2_155 ---STHRMWDPQLAAFEERFRVVRYDTRGHGQ------------------
Mvan_0563|M.vanbaalenii_PYR-1 T--TTATLWTGVAQRLVDHVRVVGWDLPGHGR------------------
Mb2734|M.bovis_AF2122/97 DNSTTWN---GVHAKLAQRFTVIAPDLLGHGQ------------------
Rv2715|M.tuberculosis_H37Rv DNSTTWN---GVHAKLAQRFTVIAPDLLGHGQ------------------
MMAR_5064|M.marinum_M PGASSWSNFARNIEVLAQQFHVLAVDQPGYGH------------------
MUL_4140|M.ulcerans_Agy99 PGASSWSNFARNIEVLAQQFHVLAVDQPGYGH------------------
MAV_2517|M.avium_104 PGASGVSNYSRNIDPLAEKFRVIVPDMPGYGR------------------
MAB_0349c|M.abscessus_ATCC_199 ---MTGSMWAAQAEYFADRYTVILVDPPGHGD------------------
TH_2963|M.thermoresistible__bu ---FSGWQFNLQIYALRRYYRCLAIDWRGQGA------------------
MLBr_01899|M.leprae_Br4923 -AQLVLWRTAFCEKLVAQGLRVVRYDNRDVGLSSRTDSTEQPCPSQPLTA
. : * . *
Mflv_1348|M.gilvum_PYR-GCK -------SPVPDGPYSIDDLAD-DVVGILDRRGIDTAHLVGLSLGGMTAM
MSMEG_1897|M.smegmatis_MC2_155 -------SPVPEGPYTIDDLAD-DVVALLDTLGIERAHVVGLSLGGMTAM
Mvan_0563|M.vanbaalenii_PYR-1 -------GRR-AHPFTIADLAA-AVLVIADDLNVETFHYAGDSVGGCVGL
Mb2734|M.bovis_AF2122/97 -------SDKPRADYSVAAYAN-GMRDLLSVLDIERVTIVGHSLGGGVAM
Rv2715|M.tuberculosis_H37Rv -------SDKPRADYSVAAYAN-GMRDLLSVLDIERVTIVGHSLGGGVAM
MMAR_5064|M.marinum_M -------SDKRAEHGQFNHYAARALKELFDQLGLGRVPLVGNSLGGGTAV
MUL_4140|M.ulcerans_Agy99 -------SDKRAEHGQFNHYAARALKELFDQLGLGRVLLVGNSLGGGTAV
MAV_2517|M.avium_104 -------SAKGVDQSDPFGYLADTMRGLLDELGIDSAHLVGNSYGGSCAL
MAB_0349c|M.abscessus_ATCC_199 -------SQSLTRMFRFEDCAH-AITQILDSLGIERAHVVGNSWGGMIGG
TH_2963|M.thermoresistible__bu -------SSGAARPYDMDTLTE-DAAHLVRSLGVAPAHYVGLSMGGFVGI
MLBr_01899|M.leprae_Br4923 RLIRFWLGQRNACAYTLEDMTD-DAVALLDHLSIERAHIVGASMGGMIAQ
. : .: .* * ** .
Mflv_1348|M.gilvum_PYR-GCK RVAARNPDRVNRMVLLCTAAELAPAQAWTDRAAAVR-------------A
MSMEG_1897|M.smegmatis_MC2_155 RLSARNPQRVDRIALLCTATHLPPSSAWTERAAAVR-------------T
Mvan_0563|M.vanbaalenii_PYR-1 QLLLDAPQRVSSATLLCTGAAIGTPDGWLARAATVR-------------A
Mb2734|M.bovis_AF2122/97 QFAYQFPQLVDRLILVSAGGVTKDVNIVFRLASLPMGSEAMALLRLP-LV
Rv2715|M.tuberculosis_H37Rv QFAYQFPQLVDRLILVSAGGVTKDVNIVFRLASLPMGSEAMALLRLP-LV
MMAR_5064|M.marinum_M RFALDYPDRAGRLVLMGPGGLSINLFAPDPTEGVKR------LGKFS--V
MUL_4140|M.ulcerans_Agy99 RFALDYPDRAGRLVLMGPGGLSINLFAPDPTEGVKR------LGKFS--V
MAV_2517|M.avium_104 RLALDNPRRVGKLVLMGPGGIGTTRGLP--TAGLNS------LLAYYGGR
MAB_0349c|M.abscessus_ATCC_199 TFTAMYPHRAGASVLMNATASRASMRQRVEFRLLTEIVR----------I
TH_2963|M.thermoresistible__bu RLAARHPELVRSLVLMNTSAGPEDPAKADRYRTMARIYR----------F
MLBr_01899|M.leprae_Br4923 IFAARFPTRTRSLAVFFSSNNRPFLPPPAPRALLALLTG-------PPTG
. * . :. .
Mflv_1348|M.gilvum_PYR-GCK GGAESVAPAVIA--RWFTLSHLETHPAE--RAEWVDMIAATPAEG-----
MSMEG_1897|M.smegmatis_MC2_155 HGSAAVAESVVG--RWFTPGFLAADPGR--KAAYQQMIAATPAEG-----
Mvan_0563|M.vanbaalenii_PYR-1 GGVDTMLAGAAE--RWFAPGFVDREPGT--ASALLDALSHTDAES-----
Mb2734|M.bovis_AF2122/97 LPAVQIAGRIVG--KAIGTTSLGHDLPN--VLRILDDLPEPTASAAFGRT
Rv2715|M.tuberculosis_H37Rv LPAVQIAGRIVG--KAIGTTSLGHDLPN--VLRILDDLPEPTASAAFGRT
MMAR_5064|M.marinum_M APTRENLEAFLR-VMVYDQKLITPELVD--QRFELARTPESLAAT---RA
MUL_4140|M.ulcerans_Agy99 APTRENLEAFLR-VMVYDQKLITPELVD--QRFELARTPESLAAT---RA
MAV_2517|M.avium_104 GPSRDKLEAFIRNYLVYDGASVPDELID--LRYQASVDPEVVADPPLRRP
MAB_0349c|M.abscessus_ATCC_199 LGRFREPLTTRAVKAFVGPTIMRERPHV--EQSIRAELRDLRVDS-----
TH_2963|M.thermoresistible__bu TGIGPLRRAVLP--LMFGPAFLADPDSEDVIDEWERRLRRYPRSS-----
MLBr_01899|M.leprae_Br4923 SRRDVVVDNVVRVTKITGSPLYRMPEEQ--VRTNAAEIYDRSFYP-----
Mflv_1348|M.gilvum_PYR-GCK ---YASCCEAIAELDLREQLPTITAPTLAIAGADDPATPPAKLEQIVSAI
MSMEG_1897|M.smegmatis_MC2_155 ---YAGCCEAIAALDLRADLARITAPTLAIAGTDDPATPPDRLAEITAAV
Mvan_0563|M.vanbaalenii_PYR-1 ---YAQVCEALAVFDVTNQLSEIVTPVLAVAGSVDVPTPPESLRRIASDV
Mb2734|M.bovis_AF2122/97 LR-AVVDWRGQMVTMLDRCYLTEAIPVQIIWGTKDVVLPVRHAHMAHAAM
Rv2715|M.tuberculosis_H37Rv LR-AVVDWRGQMVTMLDRCYLTEAIPVQIIWGTKDVVLPVRHAHMAHAAM
MMAR_5064|M.marinum_M MGKSFAAADFELGMMW-REVYKLRQPVLLIWGREDRVNPLDGALVALKTI
MUL_4140|M.ulcerans_Agy99 MGKSFAAADFELGMMW-REVYKLRQPVLLIWGREDRVNPLDGALVALKTI
MAV_2517|M.avium_104 SGPMALRTLWRMDLARDRRLKRLRTPTLVLWGRDDKVNRPAGGPMLLNLM
MAB_0349c|M.abscessus_ATCC_199 -VYWAVNSVVPARPDQRELLGRITTPILVIAGREDPTFPVAETELMAEAI
TH_2963|M.thermoresistible__bu --VRDAVLAVANRAGVEDELAAIDVPTLVIGGAQDAATPPAHAQALAAGI
MLBr_01899|M.leprae_Br4923 LGVSRQFSAILGSGSLLHYNQRIIAPTVVIHGRADKLVRPSSGRAVARAI
* : * * :
Mflv_1348|M.gilvum_PYR-GCK PGARLLVVDGAAHLANAEQPEQITPAIIEHL--EQR--------------
MSMEG_1897|M.smegmatis_MC2_155 RGARLVQVTPGAHLANVEQADAITPTLLEHLGTEQS--------------
Mvan_0563|M.vanbaalenii_PYR-1 KDGDLVVLEGVGHLAPAEAPQRVAGLIAEIVGVPQPPSKTLEDVHRAGMA
Mb2734|M.bovis_AF2122/97 PGSQLEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQAALRALLRR
Rv2715|M.tuberculosis_H37Rv PGSQLEIFEGSGHFPFHDDPARFIDIVERFMDTTEPAEYDQAALRALLRR
MMAR_5064|M.marinum_M PRAQLHVFGQCGHWAQVEKFDEFNRLTIDFLGGAR---------------
MUL_4140|M.ulcerans_Agy99 PRAQLHVFGQCGHWAQVEKFDEFNRLTIDFLGGAR---------------
MAV_2517|M.avium_104 PNAELVMTSRTGHWVQWERADLFNKLVTEFLHNTSVFAQ-----------
MAB_0349c|M.abscessus_ATCC_199 PGAELVIMENTGHLAALERPEEVNALIDDFLKRHPIED------------
TH_2963|M.thermoresistible__bu RGARLEIIDDCGHSSPLERPDVVTELLRGFLLEHT---------------
MLBr_01899|M.leprae_Br4923 TGARLVLFDGMGHDLPQQLWDQAVGVLMSNFAKAS---------------
. * .* : .
Mflv_1348|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1897|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0563|M.vanbaalenii_PYR-1 VRREVLGEAHVDRAVAGTTDLTADFQHMITQYAWGTIWTRPGLDLRSRSM
Mb2734|M.bovis_AF2122/97 GGGEATVTGSADTRVAVLNAIGSNERSAT---------------------
Rv2715|M.tuberculosis_H37Rv GGGEATVTGSADTRVAVLNAIGSNERSAT---------------------
MMAR_5064|M.marinum_M --------------------------------------------------
MUL_4140|M.ulcerans_Agy99 --------------------------------------------------
MAV_2517|M.avium_104 --------------------------------------------------
MAB_0349c|M.abscessus_ATCC_199 --------------------------------------------------
TH_2963|M.thermoresistible__bu --------------------------------------------------
MLBr_01899|M.leprae_Br4923 --------------------------------------------------
Mflv_1348|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1897|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0563|M.vanbaalenii_PYR-1 ITLTALVARGHHEELAMHLRAARRNGLSNDEIKELLMQTAIYCGVPDANS
Mb2734|M.bovis_AF2122/97 --------------------------------------------------
Rv2715|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5064|M.marinum_M --------------------------------------------------
MUL_4140|M.ulcerans_Agy99 --------------------------------------------------
MAV_2517|M.avium_104 --------------------------------------------------
MAB_0349c|M.abscessus_ATCC_199 --------------------------------------------------
TH_2963|M.thermoresistible__bu --------------------------------------------------
MLBr_01899|M.leprae_Br4923 --------------------------------------------------
Mflv_1348|M.gilvum_PYR-GCK --------------------
MSMEG_1897|M.smegmatis_MC2_155 --------------------
Mvan_0563|M.vanbaalenii_PYR-1 AFRIAAEVLPEFDEHPGAPS
Mb2734|M.bovis_AF2122/97 --------------------
Rv2715|M.tuberculosis_H37Rv --------------------
MMAR_5064|M.marinum_M --------------------
MUL_4140|M.ulcerans_Agy99 --------------------
MAV_2517|M.avium_104 --------------------
MAB_0349c|M.abscessus_ATCC_199 --------------------
TH_2963|M.thermoresistible__bu --------------------
MLBr_01899|M.leprae_Br4923 --------------------