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SNPPLTAIHLGGPDDGPLLLLGPSLGTTTATLWTGVAQRLVDHVRVVGWDLPGHGRGRRAHPFTIADLAA AVLVIADDLNVETFHYAGDSVGGCVGLQLLLDAPQRVSSATLLCTGAAIGTPDGWLARAATVRAGGVDTM LTGAAERWFAPGFVDREPGTASALLDALSHTDAESYAQVCEALAVFDVTDRLSEIVTPVLAVAGSADSPT PPESLRRIASDVKDGDVVVLEGVGHLAPAEAPERVAGLIAEIVGVPQPPSKTLEDVHRAGMAVRREVLGH AHVDRAVAGTTDLTADFQHMITQYAWGSIWTRPGLDFRSRSMITLTALVARGHHEELAMHLRAARRNGLS NDEIKELLLQTAIYCGVPDANSAFRIAAEVLPEFDEHPGAPS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0527 | - | - | 100% (393) | 4-carboxymuconolactone decarboxylase |
| M. gilvum PYR-GCK | Mflv_1348 | - | 4e-40 | 36.51% (241) | 3-oxoadipate enol-lactonase |
| M. gilvum PYR-GCK | Mflv_1912 | - | 3e-23 | 37.19% (121) | carboxymuconolactone decarboxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0794 | - | 2e-08 | 35.48% (93) | 4-carboxymuconolactone decarboxylase |
| M. tuberculosis H37Rv | Rv0771 | - | 2e-08 | 35.48% (93) | 4-carboxymuconolactone decarboxylase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0349c | - | 3e-19 | 26.38% (254) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_3948 | - | 4e-11 | 28.19% (259) | hydrolase |
| M. avium 104 | MAV_4589 | - | 2e-11 | 27.65% (217) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_2604 | pcaC | 1e-49 | 73.81% (126) | 4-carboxymuconolactone decarboxylase |
| M. thermoresistible (build 8) | TH_0621 | - | 1e-14 | 44.71% (85) | 4-carboxymuconolactone decarboxylase |
| M. ulcerans Agy99 | MUL_3358 | - | 3e-10 | 25.00% (308) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_0563 | - | 0.0 | 97.20% (393) | 4-carboxymuconolactone decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0527|M.gilvum_PYR-GCK --------------------MSNPPLTAIHLGGPDDGPLLLLGPSLGTTT
Mvan_0563|M.vanbaalenii_PYR-1 --------------------MSNPPLTAIHLGGPDDGPLLLLGPSLGTTT
MSMEG_2604|M.smegmatis_MC2_155 --------------------------------------------------
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
MAB_0349c|M.abscessus_ATCC_199 -----------MGSAALQDRYLQSCLGGLHVRIGGEGPVILFWPSLLMTG
MAV_4589|M.avium_104 -------------------------MINLAYDDRGSGEPVVFIAGHGGAG
MMAR_3948|M.marinum_M ------------------MPIATINGQKIHYTDAGAGPPVLATHATLMDL
MUL_3358|M.ulcerans_Agy99 MTERKRNLRPVREVTAPSLQFRTIHGYKRAFRIAGSGPAILLIHGIGDNS
Mflv_0527|M.gilvum_PYR-GCK ATLWTGVAQRLVDH-VRVVGWDLPGHGRGRRAH-PFTIADLAAAVLVIAD
Mvan_0563|M.vanbaalenii_PYR-1 ATLWTGVAQRLVDH-VRVVGWDLPGHGRGRRAH-PFTIADLAAAVLVIAD
MSMEG_2604|M.smegmatis_MC2_155 --------------------------------------------------
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
MAB_0349c|M.abscessus_ATCC_199 -SMWAAQAEYFADR-YTVILVDPPGHGDSQSLTRMFRFEDCAHAITQILD
MAV_4589|M.avium_104 RTWHPYQVPAFLAAGYRVITFDNRGIG-ATENAQGFTTETMVADTAALIE
MMAR_3948|M.marinum_M ISLEP-VTTKLVDAGYRVIAFDLRGHGETVYDQQPYTYVDVAGDVIGLAD
MUL_3358|M.ulcerans_Agy99 TTWTG--IHAKLAQRFTVIAPDLLGHGRSDKPRADYSIAAYANGMRDLLS
Mflv_0527|M.gilvum_PYR-GCK DLNVETFHYAGDSVGGCVGLQLLLDAPQRVSSATLLCTGAAIGTPDGWLA
Mvan_0563|M.vanbaalenii_PYR-1 DLNVETFHYAGDSVGGCVGLQLLLDAPQRVSSATLLCTGAAIGTPDGWLA
MSMEG_2604|M.smegmatis_MC2_155 --------------------------------------------------
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
MAB_0349c|M.abscessus_ATCC_199 SLGIERAHVVGNSWGGMIGGTFTAMYPHRAGASVLMNATASR--------
MAV_4589|M.avium_104 GLNAAPARIVGMSMGAFIAQELMLARPELVSAAVLMGT------------
MMAR_3948|M.marinum_M YLGVDRFIFVAEGQGAVVALRTALLAPQRVRALALIGP------------
MUL_3358|M.ulcerans_Agy99 VLDIERVTIIGHSLGGGVAMQFAYQFPQLVDRLILVGAGG----------
Mflv_0527|M.gilvum_PYR-GCK RAATVRAGGVDTMLTGAAERWFAPGFVDREPGTASALLDALSHTDAESYA
Mvan_0563|M.vanbaalenii_PYR-1 RAATVRAGGVDTMLAGAAERWFAPGFVDREPGTASALLDALSHTDAESYA
MSMEG_2604|M.smegmatis_MC2_155 --------------------------------------------------
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
MAB_0349c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4589|M.avium_104 --------------------------------------------------
MMAR_3948|M.marinum_M --------------------------------------------------
MUL_3358|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0527|M.gilvum_PYR-GCK QVCEALAVFDVTDRLSEIVTPVLAVAGSADSPTPPESLRRIASDVKDGDV
Mvan_0563|M.vanbaalenii_PYR-1 QVCEALAVFDVTNQLSEIVTPVLAVAGSVDVPTPPESLRRIASDVKDGDL
MSMEG_2604|M.smegmatis_MC2_155 --------------------------------------------------
Mb0794|M.bovis_AF2122/97 --------------------------------------------------
Rv0771|M.tuberculosis_H37Rv --------------------------------------------------
TH_0621|M.thermoresistible__bu --------------------------------------------------
MAB_0349c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4589|M.avium_104 --------------------------------------------------
MMAR_3948|M.marinum_M --------------------------------------------------
MUL_3358|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0527|M.gilvum_PYR-GCK VVLEGVGHLAPAEAPERVAGLIAEIVGVPQPPSKTLEDVHRAGMAVRREV
Mvan_0563|M.vanbaalenii_PYR-1 VVLEGVGHLAPAEAPQRVAGLIAEIVGVPQPPSKTLEDVHRAGMAVRREV
MSMEG_2604|M.smegmatis_MC2_155 -------------------------------MTTMRDETHAAGSQVRRAV
Mb0794|M.bovis_AF2122/97 ----------------------------------MMDELRRTGLDKMNEV
Rv0771|M.tuberculosis_H37Rv ----------------------------------MMDELRRTGLDKMNEV
TH_0621|M.thermoresistible__bu --------------------------------------MREQGLQVFREL
MAB_0349c|M.abscessus_ATCC_199 --------------------------------ASMRQRVEFRLLTEIVRI
MAV_4589|M.avium_104 --------------------------------RGRMDRARQFFRDAEAEL
MMAR_3948|M.marinum_M --------------------------------------TAEAALDGENAA
MUL_3358|M.ulcerans_Agy99 ---------------------------VTKDVNVVFRLASLPMGAEALAL
Mflv_0527|M.gilvum_PYR-GCK LGHAHVDRAVAGTTD-LTADFQHMIT---QYAWGSIWTRPGLDFRSRS-M
Mvan_0563|M.vanbaalenii_PYR-1 LGEAHVDRAVAGTTD-LTADFQHMIT---QYAWGTIWTRPGLDLRSRS-M
MSMEG_2604|M.smegmatis_MC2_155 LGDDHVDRAVAATTG-FTADFQDLIT---RYAWGEIWTRPGLDRRSRS-M
Mb0794|M.bovis_AF2122/97 YAWDMPD---------MPGEFFALTV---DHLFGRIWTRPGLSMRDRR-M
Rv0771|M.tuberculosis_H37Rv YAWDMPD---------MPGEFFALTV---DHLFGRIWTRPGLSMRDRR-M
TH_0621|M.thermoresistible__bu LPGVLPDGDVDFRDGSFGDELLEIGI---DNVFGRLWTRDGLSRRDRS-L
MAB_0349c|M.abscessus_ATCC_199 LGRFREPLTTRAVKAFVGPTIMRERP---HVEQSIRAELRDLRVDSVY-W
MAV_4589|M.avium_104 ADGGVALPASYEAKIRLLENFSRKTLNDDTAVADWIAMFSTWPVKSTPGM
MMAR_3948|M.marinum_M LTAAMEIWCTQGPLPDIYRPTAAMATPTPDAADALMERWRCSAWREYR--
MUL_3358|M.ulcerans_Agy99 LRLPMVLPTVQLAGKVLGMALGSTALG--QDLPNVLRILDDLPEPTASSA
.
Mflv_0527|M.gilvum_PYR-GCK ITLTALVARGHH-------EELAMHLRAARRN-GLSNDEIKELLLQTAIY
Mvan_0563|M.vanbaalenii_PYR-1 ITLTALVARGHH-------EELAMHLRAARRN-GLSNDEIKELLMQTAIY
MSMEG_2604|M.smegmatis_MC2_155 ITLTAMIARGHH-------DELAMHVRAARRN-GLSVDEIKEVLLQSAIY
Mb0794|M.bovis_AF2122/97 AVIAVLTAQGQS-------DLLEVQVNAVLHNDELTIDELRELAVFITHY
Rv0771|M.tuberculosis_H37Rv AVIAVLTAQGQS-------DLLEVQVNAVLHNDELTIDELRELAVFITHY
TH_0621|M.thermoresistible__bu VTLGILIALRAT-------DELRFHV-QIARNNGLTEDEIAEVIYHATGY
MAB_0349c|M.abscessus_ATCC_199 AVNSVVPARPDQ-------RELLGRITTPILVIAGREDPTFPVAETELMA
MAV_4589|M.avium_104 RAQLDVAPYTNR-------LSAYRSIATPVLVIGFSDDVLTPPYLGREVA
MMAR_3948|M.marinum_M AAADALATRPTF-------IAELSTVACPALVVHSTQDVFVPMFLGKEVA
MUL_3358|M.ulcerans_Agy99 FTRTLRAVVDWRGQIVTMLDRCYLTQAIPVQIIWGSRDAVVPVRHAEMAH
. *
Mflv_0527|M.gilvum_PYR-GCK CGVPDANSAFRIAAEVLPE-FDEHPGAPS---------------------
Mvan_0563|M.vanbaalenii_PYR-1 CGVPDANSAFRIAAEVLPE-FDEHPGAPS---------------------
MSMEG_2604|M.smegmatis_MC2_155 CGVPEANTAFRIAGAVLAE-EAQEPGDER---------------------
Mb0794|M.bovis_AF2122/97 VGFPLGSRLNSAIERVAAK-RKQAAENGSLPDTKANVAEVLAKESGKSS-
Rv0771|M.tuberculosis_H37Rv VGFPLGSRLNSAIERVAAK-RKQAAENGSLPDTKANVAEVLAKESGKSS-
TH_0621|M.thermoresistible__bu AGFPNASTAMKVAKEVLAE-EHSRAAD---ADKQSRLGESNP--------
MAB_0349c|M.abscessus_ATCC_199 EAIPGAELVIMENTGHLAA-LERPEEVNALIDDFLKRHPIED--------
MAV_4589|M.avium_104 DALPNGRYVQIPDTGHLGF-FERPDAVNAAMLKFFGEQH-----------
MMAR_3948|M.marinum_M DSLGGPTAFVPVDTGHHAITCAFHPQIGAEILAWLPSVEDHPE-------
MUL_3358|M.ulcerans_Agy99 AAMPGSKLEVFEGSGHFPF-HDDPARFIDIVLRFIDSTQPPEYDQAALRE
..
Mflv_0527|M.gilvum_PYR-GCK ---------------------------------
Mvan_0563|M.vanbaalenii_PYR-1 ---------------------------------
MSMEG_2604|M.smegmatis_MC2_155 ---------------------------------
Mb0794|M.bovis_AF2122/97 ---------------------------------
Rv0771|M.tuberculosis_H37Rv ---------------------------------
TH_0621|M.thermoresistible__bu ---------------------------------
MAB_0349c|M.abscessus_ATCC_199 ---------------------------------
MAV_4589|M.avium_104 ---------------------------------
MMAR_3948|M.marinum_M ---------------------------------
MUL_3358|M.ulcerans_Agy99 LLRTGGGERTVSDPADTRVAVLSAMGSDERSAT