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PIATINGQKIHYTDAGAGPPVLATHATLMDLISLEPVTTKLVDAGYRVIAFDLRGHGETVYDQQPYTYVD VAGDVIGLADYLGVDRFIFVAEGQGAVVALRTALLAPQRVRALALIGPTAEAALDGENAALTAAMEIWCT QGPLPDIYRPTAAMATPTPDAADALMERWRCSAWREYRAAADALATRPTFIAELSTVACPALVVHSTQDV FVPMFLGKEVADSLGGPTAFVPVDTGHHAITCAFHPQIGAEILAWLPSVEDHPE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3948 | - | - | 100% (265) | hydrolase |
| M. marinum M | MMAR_2866 | ephB | 1e-11 | 36.36% (110) | epoxide hydrolase EphB |
| M. marinum M | MMAR_0900 | bpoC | 6e-11 | 26.89% (238) | bromoperoxidase BpoC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0569 | bpoC | 1e-09 | 27.32% (205) | peroxidase BpoC |
| M. gilvum PYR-GCK | Mflv_3121 | - | 1e-14 | 29.32% (266) | transcriptional regulator, CadC |
| M. tuberculosis H37Rv | Rv0554 | bpoC | 1e-09 | 27.32% (205) | peroxidase BpoC |
| M. leprae Br4923 | MLBr_02269 | - | 7e-10 | 27.31% (238) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2289 | - | 7e-14 | 27.80% (259) | putative hydrolase, alpha/beta hydrolase fold |
| M. avium 104 | MAV_4589 | - | 4e-13 | 30.83% (240) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_3856 | - | 5e-12 | 27.03% (259) | transcriptional regulator, CadC |
| M. thermoresistible (build 8) | TH_3727 | - | 1e-12 | 25.75% (233) | PUTATIVE Chloride peroxidase |
| M. ulcerans Agy99 | MUL_0653 | bpoC | 2e-11 | 26.89% (238) | bromoperoxidase BpoC |
| M. vanbaalenii PYR-1 | Mvan_4002 | - | 3e-12 | 36.36% (110) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3121|M.gilvum_PYR-GCK MTSADALSSSPRVWRWDDYVLDLGRYELRAGDSVIRVEPQVFDVLTQLVS
MSMEG_3856|M.smegmatis_MC2_155 ------------MWRFDDFVLDTGRFELRRGDEVIRVEPQVFDVLTQLIV
Mb0569|M.bovis_AF2122/97 --------------------------------------------------
Rv0554|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0653|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02269|M.leprae_Br4923 --------------------------------------------------
MAV_4589|M.avium_104 --------------------------------------------------
TH_3727|M.thermoresistible__bu --------------------------------------------------
MMAR_3948|M.marinum_M --------------------------------------------------
MAB_2289|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_4002|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3121|M.gilvum_PYR-GCK HHDRCVSKEELFDTVWGGRFVGEAALTSRIKAVRRALGDDGEAQRYIRTV
MSMEG_3856|M.smegmatis_MC2_155 NHERVVTKVELFDTVWGGRFVGEAALTSRIKAARRALGDDGESQRYIRTI
Mb0569|M.bovis_AF2122/97 --------------------------------------------------
Rv0554|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0653|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02269|M.leprae_Br4923 --------------------------------------------------
MAV_4589|M.avium_104 --------------------------------------------------
TH_3727|M.thermoresistible__bu --------------------------------------------------
MMAR_3948|M.marinum_M --------------------------------------------------
MAB_2289|M.abscessus_ATCC_1997 ------------------------------------MGVAAHQQIYRPVS
Mvan_4002|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3121|M.gilvum_PYR-GCK RGRGYRFVGTLHGEDS-----------------------ATPDEASVEHV
MSMEG_3856|M.smegmatis_MC2_155 RGRGYQFVGTLLPDDAGDGVNAPMRAQPLQQHEAVALDTADTAEGSAEPV
Mb0569|M.bovis_AF2122/97 --------------------------------------------------
Rv0554|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0653|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02269|M.leprae_Br4923 --------------------------------------------------
MAV_4589|M.avium_104 --------------------------------------------------
TH_3727|M.thermoresistible__bu --------------------------------------------------
MMAR_3948|M.marinum_M --------------------------------------------------
MAB_2289|M.abscessus_ATCC_1997 GHGGAMSLG-----------------------------------------
Mvan_4002|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3121|M.gilvum_PYR-GCK VRETPRQHIAFARAADGVRLAYAESGDGPPLVKAANWMTHLGYDSESPVW
MSMEG_3856|M.smegmatis_MC2_155 E-PPPRQHIAFCRAGDGVRLAYAVVGEGPPLVRAANWMTHLGYDIESPVW
Mb0569|M.bovis_AF2122/97 ----------------MINLAYDDNGTGDPVVFIA------GRGGAGRTW
Rv0554|M.tuberculosis_H37Rv ----------------MINLAYDDNGTGDPVVFIA------GRGGAGRTW
MUL_0653|M.ulcerans_Agy99 ----------------MINLAYDDKGTGEPVLFIA------GRGGAGRTW
MLBr_02269|M.leprae_Br4923 ----------------MINLAYEDRGTGEPVVFIA------GRGGAGRTW
MAV_4589|M.avium_104 ----------------MINLAYDDRGSGEPVVFIA------GHGGAGRTW
TH_3727|M.thermoresistible__bu --------MATITTSDGVEIFYRDWGSGQPIVFSH------GWPLTADDW
MMAR_3948|M.marinum_M ---------MPIATINGQKIHYTDAGAGPPVLATH-------ATLMDLIS
MAB_2289|M.abscessus_ATCC_1997 -----LEKHRRSVDIERGRISYLDIGAGSPTVFVHG-------VLTNSLL
Mvan_4002|M.vanbaalenii_PYR-1 -----MSQIHRMLNCRGTRIHAVEEGEGPLVVLIHG-------FPESWYS
.: * * :
Mflv_3121|M.gilvum_PYR-GCK R--HGVREMSLRYRFIRYDERGCGLS--DWDVGDFTFDDWVADLETVVDA
MSMEG_3856|M.smegmatis_MC2_155 S--HWVRDLSRNHTFIRYDERGCGLS--DWEAADFSFDDWVADLESVVEA
Mb0569|M.bovis_AF2122/97 HPHQVPAFLAAGYRCITFDNRGIGAT--ENAEG-FTTQTMVADTAALIET
Rv0554|M.tuberculosis_H37Rv HPHQVPAFLAAGYRCITFDNRGIGAT--ENAEG-FTTQTMVADTAALIET
MUL_0653|M.ulcerans_Agy99 QPHQVPAFLAAGYRCITFDNRGIGAT--ENAEG-FTTQTMVNDTAALIES
MLBr_02269|M.leprae_Br4923 QPHQVPAFLAAGYRVITFDNRGIGAT--ENTEG-FTTQTMVADTAVLIES
MAV_4589|M.avium_104 HPYQVPAFLAAGYRVITFDNRGIGAT--ENAQG-FTTETMVADTAALIEG
TH_3727|M.thermoresistible__bu DP-QMLFFLNAGYRVIAHDRRGHGRS--SPVPDGHDMDHYADDLAALVEH
MMAR_3948|M.marinum_M LEPVTTKLVDAGYRVIAFDLRGHGET--VYDQQPYTYVDVAGDVIGLADY
MAB_2289|M.abscessus_ATCC_1997 WRDVVTAVAATGRRCIALDLPGHGHSPVPADGIDVTLSGLAQLIAEFLDS
Mvan_4002|M.vanbaalenii_PYR-1 WRHQIPALAAAGYRVVAIDQRGYGRSSKYRVQKAYRIKELVGDIVGVIDA
: * * * : . . :
Mflv_3121|M.gilvum_PYR-GCK VGLDRFHLMGVSQGGAVAVAYAARHP----DKVSRLVLCGAYARGRAVRA
MSMEG_3856|M.smegmatis_MC2_155 LGLERFPLLGVSQGGAVAVAYAARHP----ERVSRLVLCGAYARGRAVRA
Mb0569|M.bovis_AF2122/97 LDIAPARVVGVSMGAFIAQELMVVAP----ELVSSAVLMATRGRLDRARQ
Rv0554|M.tuberculosis_H37Rv LDIAPARVVGVSMGAFIAQELMVVAP----ELVSSAVLMATRGRLDRARQ
MUL_0653|M.ulcerans_Agy99 LGIGPVRIVAVSMGSFIAQELMVVRP----ELVNSAVLMATRGRLDRARK
MLBr_02269|M.leprae_Br4923 LGAVPARIVGVSMGSFIAQELMVARP----ELVRAAVLMATRGRLDRTRQ
MAV_4589|M.avium_104 LNAAPARIVGMSMGAFIAQELMLARP----ELVSAAVLMGTRGRMDRARQ
TH_3727|M.thermoresistible__bu LGLRDAVHVGHSTGGGVVVRYLARHGE---ERTAKAVLIAAVPPLMVRTD
MMAR_3948|M.marinum_M LGVDRFIFVAEGQGAVVALRTALLAP----QRVRALALIGP------TAE
MAB_2289|M.abscessus_ATCC_1997 IGIDEFDLVANDTGGAVAQIMVARQP----DRIRTLALTNCDTEGHVPPK
Mvan_4002|M.vanbaalenii_PYR-1 YGVERAVVVGHDWGAPVAWTFAWLHPQRCAGVAGISVPFAGRGVIGLPGS
. :. . *. :. .
Mflv_3121|M.gilvum_PYR-GCK LSDDEKRAAALDLELAR--------------VGWGRDDPAFRQVFAAQFL
MSMEG_3856|M.smegmatis_MC2_155 VGDEEKRAAALDLELAR--------------VGWGRDDPAFRQVFAAQFL
Mb0569|M.bovis_AF2122/97 FFNKAEAELYDSGVQLP--------------PTYDARARLLENFSRKTLN
Rv0554|M.tuberculosis_H37Rv FFNKAEAELYDSGVQLP--------------PTYDARARLLENFSRKTLN
MUL_0653|M.ulcerans_Agy99 FFHDAEAELYDSGARMP--------------STYDVKDRLLENFSRKTLN
MLBr_02269|M.leprae_Br4923 FFHAAEAEFHDSGIQLP--------------SGYNAKVRLLENLSRKTLN
MAV_4589|M.avium_104 FFRDAEAELADGGVALP--------------ASYEAKIRLLENFSRKTLN
TH_3727|M.thermoresistible__bu ANPGGLPKSVFDDFQAQ--------------LAANRSE-FYRALASGPFY
MMAR_3948|M.marinum_M AALDGENAALTAAMEIW--------------CTQGPLPDIYRPTAAMATP
MAB_2289|M.abscessus_ATCC_1997 LFKPVVALARPPLMALIG-------------PRLFARRKVLRALLGAGYR
Mvan_4002|M.vanbaalenii_PYR-1 PFGEHRPDDYHLELAGPGRVWYQDYFSAQDGIIAEIEEDLRGWLWGLTYT
Mflv_3121|M.gilvum_PYR-GCK ---------PDGTRADWAAFDQLQRRTTSPENAVHFLE------------
MSMEG_3856|M.smegmatis_MC2_155 ---------PDGTRADWAAFDQLQRRTTSPENAVRFLE------------
Mb0569|M.bovis_AF2122/97 ---------DDVAVGDWIAMFSMWPIKSTPG-LRCQLD------------
Rv0554|M.tuberculosis_H37Rv ---------DDVAVGDWIAMFSMWPIKSTPG-LRCQLD------------
MUL_0653|M.ulcerans_Agy99 ---------DDAAVGDWLAMFSMWPIKQTPG-LRCQLD------------
MLBr_02269|M.leprae_Br4923 ---------DDVAVADWIAMFNMWPIKSTPG-LRCQTD------------
MAV_4589|M.avium_104 ---------DDTAVADWIAMFSTWPVKSTPG-MRAQLD------------
TH_3727|M.thermoresistible__bu G-------FNRDGVEPSEALIANWWRQGMMGDAKAHYDGI----------
MMAR_3948|M.marinum_M ------------TPDAADALMERWRCSAWREYRAAADA------------
MAB_2289|M.abscessus_ATCC_1997 ---------KPGRLPDSIVESYGQPVFGTAESSRFLSKML----------
Mvan_4002|M.vanbaalenii_PYR-1 VSGDGMIAATKAAVAAGVDLESMDPIDVIRAGPLCMAEGARLKDAFSYPE
Mflv_3121|M.gilvum_PYR-GCK ----------------EFARIDVRDLCA------------------RVQC
MSMEG_3856|M.smegmatis_MC2_155 ----------------AFGRIDVRDEAR------------------EVRC
Mb0569|M.bovis_AF2122/97 ----------------CAPQTNRLPAYR------------------NIAA
Rv0554|M.tuberculosis_H37Rv ----------------CAPQTNRLPAYR------------------NIAA
MUL_0653|M.ulcerans_Agy99 ----------------AAPLTNRLPAYR------------------NIAA
MLBr_02269|M.leprae_Br4923 ----------------VAPQNNRLPAYR------------------SIAA
MAV_4589|M.avium_104 ----------------VAPYTNRLSAYR------------------SIAT
TH_3727|M.thermoresistible__bu ---------------VAFSQTDFTEDLT------------------KITV
MMAR_3948|M.marinum_M ----------------LATRPTFIAELS------------------TVAC
MAB_2289|M.abscessus_ATCC_1997 ---------------RAMHTRDLEAARAGLV---------------TFTK
Mvan_4002|M.vanbaalenii_PYR-1 TMPDWFTEDDLDFYTAEFERSGFGGPLSFYHNIDNDWHDLAEQAGTPLTP
.
Mflv_3121|M.gilvum_PYR-GCK PTLVLHSRDDH--RVPMRYGEELASLIPDARLVALSSNNHLLTATEPAWQ
MSMEG_3856|M.smegmatis_MC2_155 PTLVMHSRDDH--RVPVRFGEELAALIEDARMVALDSNNHLLTGTEPAWQ
Mb0569|M.bovis_AF2122/97 PVLVIGFADDV--VTPPYLGREVADALPNGRYLQIPDAGHLGFFERPE-A
Rv0554|M.tuberculosis_H37Rv PVLVIGFADDV--VTPPYLGREVADALPNGRYLQIPDAGHLGFFERPE-A
MUL_0653|M.ulcerans_Agy99 PVLVIGFSDDI--VTPPYLGREVADSLSNGRYLQIPDAGHLGFFERPE-A
MLBr_02269|M.leprae_Br4923 PVLVIGFAEDV--VTPPSLGREVADVLPNGRYLQIPDAGHLGFFERPE-A
MAV_4589|M.avium_104 PVLVIGFSDDV--LTPPYLGREVADALPNGRYVQIPDTGHLGFFERPD-A
TH_3727|M.thermoresistible__bu PVLVMHGDDDQ--VVPYANSGPLTAELLRNAKLKTYQGFPHGMMTTHAEV
MMAR_3948|M.marinum_M PALVVHSTQDV--FVPMFLGKEVADSLGGPTAFVPVDTGHHAITCAFHPQ
MAB_2289|M.abscessus_ATCC_1997 PTLIAWGLGDY--FFPLKYGQRLAELFGGPVTFETVPDGRLYFPDEDADR
Mvan_4002|M.vanbaalenii_PYR-1 PAVFIGGQYDVGTTWGAEALERAPEVMPNYCGTHMVPDVGHWIQQEAPEE
*.:. * . :
Mflv_3121|M.gilvum_PYR-GCK VFCAEVAAFLV------------
MSMEG_3856|M.smegmatis_MC2_155 VFRQELEGFLALDGS--------
Mb0569|M.bovis_AF2122/97 VNTAMLKFFASVKA---------
Rv0554|M.tuberculosis_H37Rv VNTAMLKFFASVKA---------
MUL_0653|M.ulcerans_Agy99 VNTAALKFFAGTRG---------
MLBr_02269|M.leprae_Br4923 VNAAALQFFAGVKGEWP------
MAV_4589|M.avium_104 VNAAMLKFFGEQH----------
TH_3727|M.thermoresistible__bu VNADILEFLRS------------
MMAR_3948|M.marinum_M IGAEILAWLPSVEDHPE------
MAB_2289|M.abscessus_ATCC_1997 LLPLLYRHWHSAGRQESSTEVGS
Mvan_4002|M.vanbaalenii_PYR-1 TNRLLLDFLRGLG----------