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STAAGNPARTRDEDAIGVPPASPTLVPAQRYHSPAFAQLEIERMWPKVWQLACMLDHVAAPGDYFEYRCG PYSVLIVHDCDGVLRAFQNVCRHRGNSLCAGSGSGLRELKCGYHGWTWDLTGELRRVPNRKGFGSLHMPD FPLLPVRVETWEGLVFVSLDVTAMPLMDYLDPIPEDIAWCGLSDFRCYATLTVEVDANWKTIADGYSETY HIQTLHPELLRCVDDIHAPQQIWRHAGKSDQPYGVPSPRFEGTLSDQEVWDAYVYTQGALMGAAEGTPLP ADERRPGQSVQDLIAARTRAFAATRGVDLEWADTDRITRLHQYNVFPNMTFLANADHLTIMCSRPQPEHF ADPDKGEMVMFLMTRMPPDAPHNKPTDVRMAADQAEPGIVLTQDIRVLPGVQRGLHQPGFTHLVLSGEER RIINMHRNLERYLDLPEPERMSGGGLRPGPGAPRV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0212 | - | - | 100% (456) | oxidoreductase |
| M. marinum M | MMAR_0307 | - | 4e-33 | 26.98% (467) | dioxygenase |
| M. marinum M | MMAR_4744 | - | 1e-24 | 30.57% (193) | dioxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3186c | - | 1e-25 | 32.67% (202) | dioxygenase |
| M. gilvum PYR-GCK | Mflv_2328 | - | 8e-40 | 27.77% (443) | Rieske (2Fe-2S) domain-containing protein |
| M. tuberculosis H37Rv | Rv3161c | - | 7e-26 | 33.17% (202) | dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4370c | - | 7e-21 | 29.49% (234) | putative large terminal subunit of phenylpropionate dioxygenase |
| M. avium 104 | MAV_5278 | - | 0.0 | 83.15% (445) | Rieske (2Fe-2S) domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_5627 | - | 2e-35 | 27.78% (450) | Rieske (2Fe-2S) domain-containing protein |
| M. thermoresistible (build 8) | TH_4380 | - | 1e-42 | 28.15% (444) | PUTATIVE putative Rieske (2Fe-2S) domain protein |
| M. ulcerans Agy99 | MUL_3820 | - | 4e-17 | 31.03% (145) | ring-hydroxylating dioxygenase, large terminal subunit |
| M. vanbaalenii PYR-1 | Mvan_0908 | - | 6e-47 | 30.99% (426) | Rieske (2Fe-2S) domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0212|M.marinum_M -------MSTAAGNPAR----TRDEDAIGVPPASP-TLVPAQRYHSPAFA
MAV_5278|M.avium_104 -------MAAAAGNPAR----TRDEDAIGTPPPGP-TLVPAERYYSPAFA
Mb3186c|M.bovis_AF2122/97 -------MLSTDNRAELGDILTDIGDYLDDNPPAL-SLPPAA-YTSSELW
Rv3161c|M.tuberculosis_H37Rv -------MLSTDNRAELGDILTDIGDYLDDNPPAL-SLPPAA-YTSSELW
Mvan_0908|M.vanbaalenii_PYR-1 -------MTSTAEPRTN----------PEYRSKNK-EFGISERYTSAEFA
MSMEG_5627|M.smegmatis_MC2_155 -------MTDTQP-------------RTDEALATP-MTIGVEAYTSEAYA
TH_4380|M.thermoresistible__bu -------MTDLTAQRVP-----------QKYACGE-TFVPKSRYIDPEFL
Mflv_2328|M.gilvum_PYR-GCK -------MPATRPGEWVDADSGLGLGLDDVAPGTFNMTIPTDRYTCPDYA
MUL_3820|M.ulcerans_Agy99 -------MDRDQLIDLTRRALKLARDKTTDLAPHQ-HAVDAREYTSLDRH
MAB_4370c|M.abscessus_ATCC_199 MASLPRPVAVAQGALCRPQALVRDIDVSGLVDSHG-GLLDRVIFTDGELY
: :
MMAR_0212|M.marinum_M QLEIERMWPKVWQLACMLDHVAAPGDYFEYRCGPYSVLIVHD----CDGV
MAV_5278|M.avium_104 ALEVERMWPRVWQLACMVDHVATPGDYFEYRCGPYGVLIVRD----DDGA
Mb3186c|M.bovis_AF2122/97 QLERERIFNRSWMLVAHVDQLAKTGDYVTVSVAGEPVMVVRD----VDGQ
Rv3161c|M.tuberculosis_H37Rv QLERERIFNRSWMLVAHVDQVAKTGDYVTVSVAGEPVMVVRD----VDGQ
Mvan_0908|M.vanbaalenii_PYR-1 RLENEKLWPKVWQVACRVEEVPNPGDYCEYTIADETILITRT----REGD
MSMEG_5627|M.smegmatis_MC2_155 RAERDRLWRRVWQQVGRVEELPEVGSYLTYDILDDSILVVRTGPGDSGGS
TH_4380|M.thermoresistible__bu QLELDRLFTQVWQPACREEEIPDPGSYYEYCIGRQSIMVVRQ----KDRS
Mflv_2328|M.gilvum_PYR-GCK AREREAIWTRIWQIAGRAEDIPKPGDWKRYEILDQSFIIVRG----KDEQ
MUL_3820|M.ulcerans_Agy99 ERDRAMVLD-SPQLVGYSSELPGPDTYRTKTIMGRSILLTRA----ADRA
MAB_4370c|M.abscessus_ATCC_199 RQELRRVFAPSWLFLAHADQFHRPGDFFTTYMGEDPVIVSMD----KNRR
: : ... . : .::
MMAR_0212|M.marinum_M LRAFQNVCRHRGNSLCAG-------SGSGLRELKCGYHGWTWDLTGELRR
MAV_5278|M.avium_104 LRAFQNVCRHRGNSLCSG-------SGSGLRELKCGYHGWTWDLAGALKR
Mb3186c|M.bovis_AF2122/97 LHALSPICRHRLMLMVEP-------GAGRIDTLTCQYHLWRYGLDGRLRG
Rv3161c|M.tuberculosis_H37Rv LHALSPICRHRLMLMVEP-------GAGRIDTLTCQYHLWRYGLDGRLRG
Mvan_0908|M.vanbaalenii_PYR-1 VKALFNACQHRGMRLKEG-------RGS-CSEIRCPSHSWCWNLDGSLNE
MSMEG_5627|M.smegmatis_MC2_155 FAAHHNVCMHRGRRLVDTPAGAKNACARTRKSFMCGFHGWTYDLTGACTH
TH_4380|M.thermoresistible__bu IKAFHNTCAHRGMKIVCG------TGVEAEGELRCRFHGWRYSLDGRSSF
Mflv_2328|M.gilvum_PYR-GCK LRGFVNACRHRGNALCVT------DTGNAKRGFLCQYHLWSYDLEGTLKG
MUL_3820|M.ulcerans_Agy99 VRAFDNVCLHRQSRVATG--------CGTALRFTCPYHGWTYDNGGRLVG
MAB_4370c|M.abscessus_ATCC_199 IRAFLNSCRHRGARVCRA-------DYGVTRGFTCTYHGWAYDLEGKLIS
. . * ** : : * * * :. *
MMAR_0212|M.marinum_M VPNRKGFG--SLHMPDFPLLPV-RVETWEGLVFVSLDVTAMPLMDYL---
MAV_5278|M.avium_104 VPDRKGFG--SLRLSDYPLIPA-RVDTWAGLVFVNLDPDAMPLPEYL---
Mb3186c|M.bovis_AF2122/97 APHMAANL--DFNRRECRLPQF-AVATWNGLVWINLDADAEPIAAHL---
Rv3161c|M.tuberculosis_H37Rv APHMAANL--DFNRRECRLPQF-AVATWNGLVWINLDADAEPIAAHL---
Mvan_0908|M.vanbaalenii_PYR-1 VIDPQDFDPEAISPDALRLPEC-KVEVWAGFVFINMDPDAVPLTEYL---
MSMEG_5627|M.smegmatis_MC2_155 IREQDDWQG-TLTPENTHLPRV-HVDTWGGWLFINMDPDPEPLADYL---
TH_4380|M.thermoresistible__bu VPGREEFAN--RPREQWGLRPV-HVGTWGGWVFISMADEPPELLEWL---
Mflv_2328|M.gilvum_PYR-GCK LLRENLAG--SIDKAENSLLPV-SVDTFAGFIFLNPDPHAAPLREYLG--
MUL_3820|M.ulcerans_Agy99 LPGREGFPG--IAVGSDGLTEL-PATEFAGFLWVSLHPAARLDVPAHL--
MAB_4370c|M.abscessus_ATCC_199 VPNEEGYPD-SFSTDDWGLVEVPHVDSYHGLIFGTWNPAPVGLRESLGDM
* . : * :: . .
MMAR_0212|M.marinum_M -DPIPEDIAWCGLSDFRCYATLTVEVDANWKTIADGYSET-YHIQTLHPE
MAV_5278|M.avium_104 -EAIPEDIAWCRLDEFRCYATLTVEVDANWKTIADGYSET-YHIQTLHPE
Mb3186c|M.bovis_AF2122/97 -DLTDDEFAGYRLGEMVQVESWSHEWRANWKVAAENGHEN-YHVLGLHRQ
Rv3161c|M.tuberculosis_H37Rv -DLTDDEFAGYRLGEMVQVESWSHEWRANWKVAAENGHEN-YHVLGLHRQ
Mvan_0908|M.vanbaalenii_PYR-1 -GEAGPRVENFGVHKMVCTRLRSTVIKANWKLCHEAFIET-YHAIGTHPQ
MSMEG_5627|M.smegmatis_MC2_155 -FPAAKILDPFGLENMRYKWRKWLYFDCNWKVALEAFNET-YHVFTTHPE
TH_4380|M.thermoresistible__bu -DPLPTALAPFRLQDMRFRWRKRTTLPANYKTVIDAFIEG-YHTPGTHPQ
Mflv_2328|M.gilvum_PYR-GCK -EEVVSLLEPYNIEQFTTVMDVTEAIECNWKVVMDAFEEG-YHINGIHPQ
MUL_3820|M.ulcerans_Agy99 -GPLAGELQSWGIGRWSPLGEKVLGSPIDWKLATDTFAEN-YHFATVHRR
MAB_4370c|M.abscessus_ATCC_199 AWYMDAMLDHDSEGTVVVGGVHKWVLDGNWKLAAEQFATDWYHVNMSHAS
. ::* : ** *
MMAR_0212|M.marinum_M LLRCVDDI-----------------------------HAPQQIWRHAGKS
MAV_5278|M.avium_104 LLRCVDDI-----------------------------HAPQQIWRHTGKS
Mb3186c|M.bovis_AF2122/97 TLEPFVPG-----------------------------GGDLDVRQYSR--
Rv3161c|M.tuberculosis_H37Rv TLEPFVPG-----------------------------GGDLDVRQYSR--
Mvan_0908|M.vanbaalenii_PYR-1 SLRYLDDTGMIFEQYG---------------DHGMHRIAPGHMGKPSARL
MSMEG_5627|M.smegmatis_MC2_155 FNKFGEFKGWAKAQGK---------------HSNIGYDAPKDMEATKSKI
TH_4380|M.thermoresistible__bu TLRTAQSPHPSTEPAKPQEYVYAPYTPTIAYKNHSRFIYTQRPETAERDK
Mflv_2328|M.gilvum_PYR-GCK LLQVLHINPKTAR---------------------YRFFESHSVAMAPFEV
MUL_3820|M.ulcerans_Agy99 TFATIARS-------------------------------NCTVFDSYG--
MAB_4370c|M.abscessus_ATCC_199 ALMVMAPQ-----------------------------GKAPKDEIVHRTG
MMAR_0212|M.marinum_M DQPYGVPSPRFEGTLSDQEVWDAYVYTQGALMGAAEGTPLPADERRPGQS
MAV_5278|M.avium_104 DQPYGVPSPRFEGALSDEEVWDAYVSTQGALMGAAEGTPFPAADRRPGQT
Mb3186c|M.bovis_AF2122/97 --------------------WALRLRVPFTVPVEAKSLQLNEVQK-----
Rv3161c|M.tuberculosis_H37Rv --------------------WALRLRVPFTVPVEAKSLQLNEVQK-----
Mvan_0908|M.vanbaalenii_PYR-1 DGDDIDRRDVLMALMGDLAEFDFYNEEDVAQANALIETVMDLPEEVTVG-
MSMEG_5627|M.smegmatis_MC2_155 RLGTGDDPRVSTAEMQMYTWEQTNATTTETLVNAAKRLVDELPEGTPPDK
TH_4380|M.thermoresistible__bu GRQEQASRPEVFANAMQYNYIGVNALVTERDYRAAQKLATMEPSEVPP--
Mflv_2328|M.gilvum_PYR-GCK VGAGVQDQVAGILALPETFPGTVAVIPRFQELIAPYQDEDGNVDFPDGLT
MUL_3820|M.ulcerans_Agy99 --------------------PHHRLIFPLNTILELENVPEGQWDP-----
MAB_4370c|M.abscessus_ATCC_199 RQYVDPNGHGAGFPVHPKNRFDARVVHQWTDYGALRERLGEARVQGPLTN
MMAR_0212|M.marinum_M VQDLIAARTRAFAATRGVDLEWADTDRI-TRLHQYNVFPNMTFLANADHL
MAV_5278|M.avium_104 VADLIADRTRAFAATRGVDLGWADTDRI-TRLHQYNVFPNMTFLTNADHL
Mb3186c|M.bovis_AF2122/97 -----------------------------SNLVVLWTFPNSALAIAGERV
Rv3161c|M.tuberculosis_H37Rv -----------------------------SNLVVLWTFPNSALAIAGERV
Mvan_0908|M.vanbaalenii_PYR-1 --TFFAGLRRQQAEAEGVDLSVYSDADL-LAGELWNIFPNVTIPCNAGNA
MSMEG_5627|M.smegmatis_MC2_155 VLEHWLASARRDDEARGVIWPTIPADILGQAGTAWQIFPNFQIGQGLTTA
TH_4380|M.thermoresistible__bu -FVLYHQLCEELALAEGVDFPRMSMEEYFAGNGDWHIFPTMVILVEKSCL
Mflv_2328|M.gilvum_PYR-GCK ARLLLQQATREVLTGMGLDVSGLTDSQM-VDNQGWVLFPNYFMTVRAGEC
MUL_3820|M.ulcerans_Agy99 ---------------------------FHHMVVIYALFPNVVLSVTIANG
MAB_4370c|M.abscessus_ATCC_199 ----------------GHATVFPNLSYLPVNGSVRIWHPKGPDKMEVWAW
.*.
MMAR_0212|M.marinum_M TIMCSRPQPEHFADPDKGEMVMFLMTRMPPDAPHNKPTDVRMAADQAEPG
MAV_5278|M.avium_104 TVMCSRPAPDPAAAPDKGELVMFLTTRMPPGAPRTKPTDVRMSAGEAEPG
Mb3186c|M.bovis_AF2122/97 VWFGFIPQSIDRVQVLGGVLTTPELAADAAATAQTSQFVMAMINDEDRLG
Rv3161c|M.tuberculosis_H37Rv VWFGFIPQSIDRVQVLGGVLTTPELAADAAATAQTSQFVMAMINDEDRLG
Mvan_0908|M.vanbaalenii_PYR-1 LTLRFRPNGLNHEECIFDIFYLKVFPEGATIPPMEHEFYPDWQETK-VWG
MSMEG_5627|M.smegmatis_MC2_155 LCYSAKPHPSYNPDKCIFEVATFELFPKGQEPRTEWEYTP---ADSPNWL
TH_4380|M.thermoresistible__bu LGYRMLPDAED-PDKCTFEMFTLEHFAPGEVPETSWQVFER-WQDHDGWG
Mflv_2328|M.gilvum_PYR-GCK HVIMSRPHPSGDPNRCIWHVASYMYVPQEFRDAVRAESIVVDTPGSHKYF
MUL_3820|M.ulcerans_Agy99 ELFRIYPGDRPGSSITVHQNSTPLDLSDESVATGAQAVFDYAHATVRDED
MAB_4370c|M.abscessus_ATCC_199 TIVDRSMPEEVRDAQRLYNLRTFGPTGIFEQDDGENWSEVQSISRGFVTN
MMAR_0212|M.marinum_M IVLTQDIRVLPGVQRGLHQPGFTHLV-LSGEERRIINMHRNLERYLDLPE
MAV_5278|M.avium_104 LVLTQDIAVLAGLQRGMHQPGFTHLV-LSSEERRVINMHRNLERYLDLPA
Mb3186c|M.bovis_AF2122/97 LEAVQVGAGSRFAERGHLS---------SKEWPGMLAFYRNLAMALVGDH
Rv3161c|M.tuberculosis_H37Rv LEAVQVGAGSRFAERGHLS---------SKEWPGMLAFYRNLAMALVGDH
Mvan_0908|M.vanbaalenii_PYR-1 TIVTQDFTNLPKWQAGVHSRGYRGPV-WGRPDGNVSNLHRVISEYLAQ--
MSMEG_5627|M.smegmatis_MC2_155 SVLPQDFSNMAAVQQGMKSMGFPGTKPNPYRERSTVNLHYQLSKYMGTGE
TH_4380|M.thermoresistible__bu ELPTQDLQNIEAIHAGMHSHGFEGLWLNTAQEMSIRNEHAIADRFIFGLD
Mflv_2328|M.gilvum_PYR-GCK EALQQDYEQMPRQQKGLRNDRLDHMS-LVKEEVVIAHYHSVVDRYMAASE
MUL_3820|M.ulcerans_Agy99 YRLAETLQTN--LESGARQR-----LVFGRNEPGLQHRHITWAQALETPG
MAB_4370c|M.abscessus_ATCC_199 SVALNYQMGLDSEREDGRHPGLTSELYSDAAGRSFYARWRDLMNTKAWHE
: . .
MMAR_0212|M.marinum_M PERMSGGGLRPGPGAPRV
MAV_5278|M.avium_104 AQRMSGG-----AGT---
Mb3186c|M.bovis_AF2122/97 PGAS--------------
Rv3161c|M.tuberculosis_H37Rv PGAS--------------
Mvan_0908|M.vanbaalenii_PYR-1 ------------------
MSMEG_5627|M.smegmatis_MC2_155 PRDLQENA----------
TH_4380|M.thermoresistible__bu KQ----------------
Mflv_2328|M.gilvum_PYR-GCK VKA---------------
MUL_3820|M.ulcerans_Agy99 ------------------
MAB_4370c|M.abscessus_ATCC_199 EHV---------------