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QKPPVAGMEHDSTGKLPQYPIESVDNALRLILLLGDRSEIRLTDASEYLHVASSTAHRLLSMLQYRGFVR QDPISRAYQPGPSLTNVAFAVHSRMDIPRTAAPILRRLADTLQETVHVGTLDGRLVRFIAALESPSAVRV ISRLGGTRPAHCTSTGKVLLAGLSDDELDQLYPDPHLEPLTEHSVRTLTELRTQLAEVRKSGFAISNQES EEGVASVAVAVPQGGSGIRLALALNASAPSYRFRPSDVRKACSALKDAAAELARNLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0462 | - | - | 100% (268) | regulatory proteins, IclR |
| M. vanbaalenii PYR-1 | Mvan_4411 | - | 5e-23 | 29.46% (241) | regulatory proteins, IclR |
| M. vanbaalenii PYR-1 | Mvan_1018 | - | 4e-22 | 32.28% (254) | regulatory proteins, IclR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1748 | - | 3e-19 | 29.50% (200) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0596 | - | 1e-141 | 97.35% (264) | regulatory protein, IclR |
| M. tuberculosis H37Rv | Rv1719 | - | 3e-19 | 29.50% (200) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4493 | - | 9e-15 | 25.11% (227) | IclR family transcriptional regulator |
| M. marinum M | MMAR_4423 | - | 1e-29 | 34.92% (252) | transcriptional regulatory protein |
| M. avium 104 | MAV_3513 | - | 3e-78 | 60.16% (251) | transcriptional regulator, IclR family protein |
| M. smegmatis MC2 155 | MSMEG_4174 | - | 8e-22 | 29.57% (230) | transcriptional regulator, IclR family protein |
| M. thermoresistible (build 8) | TH_3647 | - | 6e-33 | 41.95% (205) | PUTATIVE putative transcriptional regulator, IclR family |
| M. ulcerans Agy99 | MUL_1967 | - | 2e-15 | 30.74% (244) | transcriptional regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0462|M.vanbaalenii_PYR-1 ----------------------------MQKPPVAG---MEHDSTGKLPQ
Mflv_0596|M.gilvum_PYR-GCK MKASFRRRWLSVAILRAAFGFHRGKVSVMQKPPVAG---MEHDSTGKLPQ
MAV_3513|M.avium_104 --------------------------MPAKRARVAGPAAAAPAADALAPQ
TH_3647|M.thermoresistible__bu -----------------------------VRKRARG--------AIERPT
Mb1748|M.bovis_AF2122/97 ----------------------------------------MSAEEQDTRS
Rv1719|M.tuberculosis_H37Rv ----------------------------------------MSAEEQDTRS
MAB_4493|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4423|M.marinum_M --------------------------MSSGISSMIMGTGNDGGASESDPA
MSMEG_4174|M.smegmatis_MC2_155 -----------------------------------------------MEI
MUL_1967|M.ulcerans_Agy99 ----------------------------------------------MRQD
Mvan_0462|M.vanbaalenii_PYR-1 YPIESVDNALRLILLLGDR-SEIRLTDASEYLHVASSTAHRLLSMLQYRG
Mflv_0596|M.gilvum_PYR-GCK YPIESVDNALRLILLLGDR-SEIRLTDASEYLHVASSTAHRLLSMLQYRG
MAV_3513|M.avium_104 YPIESVDNALKLLLLLGEQ-PEIRLSEATRYLGVASSTAHRLLAMLAYRG
TH_3647|M.thermoresistible__bu YLLESVDNALRLLQMLRDG-GAVRLTEAAEELGVAPSTAHRLLAMLVYRG
Mb1748|M.bovis_AF2122/97 GGIQVIARAAELLRVLQAHPGGLSQAEIGERVGMARSTVSRILNALEDEG
Rv1719|M.tuberculosis_H37Rv GGIQVIARAAELLRVLQAHPGGLSQAEIGERVGMARSTVSRILNALEDEG
MAB_4493|M.abscessus_ATCC_1997 --MSVLTRAAQILDALAESNSGLSVRELAEATGLPKSSVHRIVQELTVSQ
MMAR_4423|M.marinum_M PTVQSVDRALLVLELLADL-GKAGVTEVADELGVHKSTASRLITALEARG
MSMEG_4174|M.smegmatis_MC2_155 AGAQSAYRVLDVLTEVSLN-PGATAGEVAKATNLTAPTAHRLLRVLCDRG
MUL_1967|M.ulcerans_Agy99 SGIGVIDKAVGLLRATAKS--PCGLAELCERTGLPRATAYRLAAALEVHR
.. :: : : .:. *: *
Mvan_0462|M.vanbaalenii_PYR-1 FVRQDPISRAYQPGPSLTNVAFAVHSRMDIPRTAAPILRRLADTLQETVH
Mflv_0596|M.gilvum_PYR-GCK FVRQDPISRAYQPGPSLTNVAFAVHSRMDIPRTAAPILRQLVDTLQETVH
MAV_3513|M.avium_104 FVRQDPVSKAYLPGPSLTGVAFAIFGRLDIARSAAPIMRALSEQLRETVH
TH_3647|M.thermoresistible__bu FAVQD-EKRTYLPGPALRAGPAERGWTREFTDVCLPHLEALSTVCGETVN
Mb1748|M.bovis_AF2122/97 LVASRGARGPYRLGPEITRMATTV--RLGVVTEMHPFLTELSRELDETVD
Rv1719|M.tuberculosis_H37Rv LVASRGARGPYRLGPEITRMATTV--RLGVVTEMHPFLTELSRELDETVD
MAB_4493|M.abscessus_ATCC_1997 YVMAGGRGGSYQLGPGLLKLGLNN--RRQFVAPMRKAIATVAREVNENID
MMAR_4423|M.marinum_M YVEQLSDRGKYQLGIGVSRLARARSGHSDLVKLSQDACDKLAADLGETAN
MSMEG_4174|M.smegmatis_MC2_155 FAIQN-DAGKYVPGPQMRVLAGDRVDRAILEELGRPLLARLRDESTETVF
MUL_1967|M.ulcerans_Agy99 LLGRD-EDGRWGLGPAITELAAHVD--DPLLTAGATVLPRLCETTGESVQ
: * : . : *.
Mvan_0462|M.vanbaalenii_PYR-1 VGTLDGRLVRFIAALESPSAVRVISRLGGTRPAHCTSTGKVLLAGLSDDE
Mflv_0596|M.gilvum_PYR-GCK VGTLDGRLVRFIAALESPSAVRVISRLGSTRPAHCTSTGKVLLAGLSVDE
MAV_3513|M.avium_104 VGMLDGASVRFVAAVEGPAAVRVASRLGRALPAHCTSTGKVMLAQLSAAE
TH_3647|M.thermoresistible__bu LVIRVGTGVRFLTSVESTAMLRVGDRRGQVLPAERTAGGRALLAELDDEV
Mb1748|M.bovis_AF2122/97 LSILDGDRADVVDQVVPPQRLRAVSAVGESFPLYCCANGKALLAALPPER
Rv1719|M.tuberculosis_H37Rv LSILDGDRADVVDQVVPPQRLRAVSAVGESFPLYCCANGKALLAALPPER
MAB_4493|M.abscessus_ATCC_1997 LAMLSGGELVIIEQIATVRNLPTVTVVGRTFALHASSIGKALLSQLPPDQ
MMAR_4423|M.marinum_M LAILDENRAVNIVEAVSTAEIALQTWVGQSCPVHATSSGKVLLAGLDADE
MSMEG_4174|M.smegmatis_MC2_155 LAVREGLQLTYLVVMTSSHSVQMYGEVGQQIPLHATSQGKVVLAFLPPGV
MUL_1967|M.ulcerans_Agy99 LYRREGTSRVCVAALEPPAGLRDTVPVGARLPMTAGSGAKVLLAHSDPAT
: : : * . : .:.:*:
Mvan_0462|M.vanbaalenii_PYR-1 LDQLYPDPHLEPLTEHSVRTLTELRTQLAEVRKSGFAISNQESEEGVASV
Mflv_0596|M.gilvum_PYR-GCK LDQLYPDPHLEPLTEHSVRTLTELRTQLAEVRKSGFAISRQESEEGVASV
MAV_3513|M.avium_104 LRALLPRERLKRITAHSIGSRAALETELAAIRERGYATNREESEEGVASV
TH_3647|M.thermoresistible__bu VERLYADR--------SAGQRAELLTELAAVREVGFGLNVEHTEEGVAAF
Mb1748|M.bovis_AF2122/97 QARALPSR-LAPLTANTITDRAALRDELNRIRVDGVAYDREEQTEGICAV
Rv1719|M.tuberculosis_H37Rv QARALPSR-LAPLTANTITDRAALRDELNRIRVDGVAYDREEQTEGICAV
MAB_4493|M.abscessus_ATCC_1997 VRNMLPAD-LEVFTTNTITDVTALLRELDDVRSTGVAFDHEEHDVGISSV
MMAR_4423|M.marinum_M VRQRVGAT-LDSFTENTIVTIDALEAQLAATRAAGWASAREELEIGLNAV
MSMEG_4174|M.smegmatis_MC2_155 GERIIDQLELARYTPSTITTAKELHEAMYEIRRDGYALNLEERELGVRSV
MUL_1967|M.ulcerans_Agy99 QQAVLPTA-------------KFTDRVLAEVRRRGWAQSVAEREPGVASV
: * * . . *: :.
Mvan_0462|M.vanbaalenii_PYR-1 AVAVPQG-GSGIRLALALNASAPSYRFRPS-DVRKACSALKDAAAELARN
Mflv_0596|M.gilvum_PYR-GCK AVAVPQG-GSGIR--LALNASAPSYRFRPS-DVRKACSALKDAAAELAVL
MAV_3513|M.avium_104 AVPIPTR-APGLR--LALNAAAPQNRLDAA-RYPAVAAALVAAAKEIGDQ
TH_3647|M.thermoresistible__bu GAVVRNRLGRAVG---AVTVAVPIVRYQRH-ARGDLVRQLFRTADEISVD
Mb1748|M.bovis_AF2122/97 GAVLRGVSVELVA----VSVPVPAQRFYG--REAELAGALLAWVSKVDAW
Rv1719|M.tuberculosis_H37Rv GAVLRGVSVELVA----VSVPVPAQRFYG--REAELAGALLAWVSKVDAW
MAB_4493|M.abscessus_ATCC_1997 AVPLPHPAAIPQA----MAIVAPTPRFAQ--RKTKYVAALDSLTKRANST
MMAR_4423|M.marinum_M AAPVYDSTGRVAA---ALSVSGPAYRLPAA-DFEEVAQQTIAAADAVSRG
MSMEG_4174|M.smegmatis_MC2_155 AAPVLDPSGNVVAS---VCVGGPIFRFSEDDLRGKFARMVCGTAEAITAE
MUL_1967|M.ulcerans_Agy99 SAPVRDGRGVVVA---AISVSGPIDRIGRR-PGARWAADLLAAADELARR
.. : : * * .
Mvan_0462|M.vanbaalenii_PYR-1 LG---------------
Mflv_0596|M.gilvum_PYR-GCK T----------------
MAV_3513|M.avium_104 LG---------------
TH_3647|M.thermoresistible__bu LDGRFDSLEP-------
Mb1748|M.bovis_AF2122/97 FNGTEDRK---------
Rv1719|M.tuberculosis_H37Rv FNGTEDRK---------
MAB_4493|M.abscessus_ATCC_1997 -----------------
MMAR_4423|M.marinum_M LGWTDRIS---------
MSMEG_4174|M.smegmatis_MC2_155 LRRRVKPVDVLDERPAQ
MUL_1967|M.ulcerans_Agy99 L----------------