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EIAGAQSAYRVLDVLTEVSLNPGATAGEVAKATNLTAPTAHRLLRVLCDRGFAIQNDAGKYVPGPQMRVL AGDRVDRAILEELGRPLLARLRDESTETVFLAVREGLQLTYLVVMTSSHSVQMYGEVGQQIPLHATSQGK VVLAFLPPGVGERIIDQLELARYTPSTITTAKELHEAMYEIRRDGYALNLEERELGVRSVAAPVLDPSGN VVASVCVGGPIFRFSEDDLRGKFARMVCGTAEAITAELRRRVKPVDVLDERPAQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4174 | - | - | 100% (265) | transcriptional regulator, IclR family protein |
| M. smegmatis MC2 155 | MSMEG_2507 | - | 2e-26 | 36.65% (221) | IclR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_3784 | - | 2e-24 | 30.09% (216) | transcriptional regulator, IclR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1748 | - | 2e-16 | 29.87% (231) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0686 | - | 1e-23 | 30.16% (252) | regulatory protein, IclR |
| M. tuberculosis H37Rv | Rv1719 | - | 2e-16 | 29.87% (231) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3295 | - | 5e-18 | 30.13% (239) | IclR family transcriptional regulator |
| M. marinum M | MMAR_4423 | - | 2e-22 | 33.47% (245) | transcriptional regulatory protein |
| M. avium 104 | MAV_3513 | - | 6e-22 | 30.50% (200) | transcriptional regulator, IclR family protein |
| M. thermoresistible (build 8) | TH_3647 | - | 6e-22 | 29.60% (250) | PUTATIVE putative transcriptional regulator, IclR family |
| M. ulcerans Agy99 | MUL_1967 | - | 6e-17 | 32.65% (196) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0462 | - | 7e-22 | 29.57% (230) | regulatory proteins, IclR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0686|M.gilvum_PYR-GCK --MQKPSLAG---MERDSTGKPPQYPIESVDNALRLLLLLGER-SEIRLT
Mvan_0462|M.vanbaalenii_PYR-1 --MQKPPVAG---MEHDSTGKLPQYPIESVDNALRLILLLGDR-SEIRLT
MAV_3513|M.avium_104 MPAKRARVAGPAAAAPAADALAPQYPIESVDNALKLLLLLGEQ-PEIRLS
TH_3647|M.thermoresistible__bu ---VRKRARG--------AIERPTYLLESVDNALRLLQMLRDG-GAVRLT
MAB_3295|M.abscessus_ATCC_1997 --------------------MRQHSGIGVLDKAVQVLTAIGD--SPCGLA
MUL_1967|M.ulcerans_Agy99 --------------------MRQDSGIGVIDKAVGLLRATAK--SPCGLA
Mb1748|M.bovis_AF2122/97 --------------MSAEEQDTRSGGIQVIARAAELLRVLQAHPGGLSQA
Rv1719|M.tuberculosis_H37Rv --------------MSAEEQDTRSGGIQVIARAAELLRVLQAHPGGLSQA
MMAR_4423|M.marinum_M MSSGISSMIMGTGNDGGASESDPAPTVQSVDRALLVLELLADL-GKAGVT
MSMEG_4174|M.smegmatis_MC2_155 ---------------------MEIAGAQSAYRVLDVLTEVSLN-PGATAG
.. ::
Mflv_0686|M.gilvum_PYR-GCK DASEYLRVASSTAHRLLSMLQYRGFVRQDPASKAYQPGPSLTNVAFAVHS
Mvan_0462|M.vanbaalenii_PYR-1 DASEYLHVASSTAHRLLSMLQYRGFVRQDPISRAYQPGPSLTNVAFAVHS
MAV_3513|M.avium_104 EATRYLGVASSTAHRLLAMLAYRGFVRQDPVSKAYLPGPSLTGVAFAIFG
TH_3647|M.thermoresistible__bu EAAEELGVAPSTAHRLLAMLVYRGFAVQD-EKRTYLPGPALRAGPAERGW
MAB_3295|M.abscessus_ATCC_1997 ELCERTGLPRATAHRLAAGLEVHRLLSRD-GDGQWQLGAGLTELAAHVN-
MUL_1967|M.ulcerans_Agy99 ELCERTGLPRATAYRLAAALEVHRLLGRD-EDGRWGLGPAITELAAHVD-
Mb1748|M.bovis_AF2122/97 EIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVR-
Rv1719|M.tuberculosis_H37Rv EIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVR-
MMAR_4423|M.marinum_M EVADELGVHKSTASRLITALEARGYVEQLSDRGKYQLGIGVSRLARARSG
MSMEG_4174|M.smegmatis_MC2_155 EVAKATNLTAPTAHRLLRVLCDRGFAIQN-DAGKYVPGPQMRVLAGDRVD
: : .*. *: * . : * : .
Mflv_0686|M.gilvum_PYR-GCK RMDIPRTAAPILRQLVDTLQETVHVGTLDGRLVRFIAALESPSAVRVISR
Mvan_0462|M.vanbaalenii_PYR-1 RMDIPRTAAPILRRLADTLQETVHVGTLDGRLVRFIAALESPSAVRVISR
MAV_3513|M.avium_104 RLDIARSAAPIMRALSEQLRETVHVGMLDGASVRFVAAVEGPAAVRVASR
TH_3647|M.thermoresistible__bu TREFTDVCLPHLEALSTVCGETVNLVIRVGTGVRFLTSVESTAMLRVGDR
MAB_3295|M.abscessus_ATCC_1997 -DPLLSASAQVLPKLREITGESVQLYRREGTVRICVAALEPPAGLRDTVP
MUL_1967|M.ulcerans_Agy99 -DPLLTAGATVLPRLCETTGESVQLYRREGTSRVCVAALEPPAGLRDTVP
Mb1748|M.bovis_AF2122/97 -LGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVSA
Rv1719|M.tuberculosis_H37Rv -LGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVSA
MMAR_4423|M.marinum_M HSDLVKLSQDACDKLAADLGETANLAILDENRAVNIVEAVSTAEIALQTW
MSMEG_4174|M.smegmatis_MC2_155 RAILEELGRPLLARLRDESTETVFLAVREGLQLTYLVVMTSSHSVQMYGE
. * *:. : : . :
Mflv_0686|M.gilvum_PYR-GCK LGSTRPAHCTSTGKVLLAGLSVDELDQLYPDPHLEPLTEHSVRTLTELRT
Mvan_0462|M.vanbaalenii_PYR-1 LGGTRPAHCTSTGKVLLAGLSDDELDQLYPDPHLEPLTEHSVRTLTELRT
MAV_3513|M.avium_104 LGRALPAHCTSTGKVMLAQLSAAELRALLPRERLKRITAHSIGSRAALET
TH_3647|M.thermoresistible__bu RGQVLPAERTAGGRALLAELDDEVVERLYADR--------SAGQRAELLT
MAB_3295|M.abscessus_ATCC_1997 VGSRLPMSAGSGAKVLLAHSDPGTQAAVLPGA-------------TFTER
MUL_1967|M.ulcerans_Agy99 VGARLPMTAGSGAKVLLAHSDPATQQAVLPTA-------------KFTDR
Mb1748|M.bovis_AF2122/97 VGESFPLYCCANGKALLAALPPERQARALPSR-LAPLTANTITDRAALRD
Rv1719|M.tuberculosis_H37Rv VGESFPLYCCANGKALLAALPPERQARALPSR-LAPLTANTITDRAALRD
MMAR_4423|M.marinum_M VGQSCPVHATSSGKVLLAGLDADEVRQRVGAT-LDSFTENTIVTIDALEA
MSMEG_4174|M.smegmatis_MC2_155 VGQQIPLHATSQGKVVLAFLPPGVGERIIDQLELARYTPSTITTAKELHE
* * : .:.:**
Mflv_0686|M.gilvum_PYR-GCK QLAEVRKSGFAISRQESEEGVASVAVAVPQG-GSGIR--LALNASAPSYR
Mvan_0462|M.vanbaalenii_PYR-1 QLAEVRKSGFAISNQESEEGVASVAVAVPQG-GSGIRLALALNASAPSYR
MAV_3513|M.avium_104 ELAAIRERGYATNREESEEGVASVAVPIPTR-APGLR--LALNAAAPQNR
TH_3647|M.thermoresistible__bu ELAAVREVGFGLNVEHTEEGVAAFGAVVRNRLGRAVG---AVTVAVPIVR
MAB_3295|M.abscessus_ATCC_1997 ALADVRKRGWAQSAAEREAGVASVSAPVRDRHGNVIA---AISVSGPIDR
MUL_1967|M.ulcerans_Agy99 VLAEVRRRGWAQSVAEREPGVASVSAPVRDGRGVVVA---AISVSGPIDR
Mb1748|M.bovis_AF2122/97 ELNRIRVDGVAYDREEQTEGICAVGAVLRGVSVELVA----VSVPVPAQR
Rv1719|M.tuberculosis_H37Rv ELNRIRVDGVAYDREEQTEGICAVGAVLRGVSVELVA----VSVPVPAQR
MMAR_4423|M.marinum_M QLAATRAAGWASAREELEIGLNAVAAPVYDSTGRVAA---ALSVSGPAYR
MSMEG_4174|M.smegmatis_MC2_155 AMYEIRRDGYALNLEERELGVRSVAAPVLDPSGNVVAS---VCVGGPIFR
: * * . . *: :... : : . * *
Mflv_0686|M.gilvum_PYR-GCK FRPSDVRKACSALKD-AAAELARNLG---------------
Mvan_0462|M.vanbaalenii_PYR-1 FRPSDVRKACSALKD-AAAELARNLG---------------
MAV_3513|M.avium_104 LDAARYPAVAAALVA-AAKEIGDQLG---------------
TH_3647|M.thermoresistible__bu YQRHARGDLVRQLFR-TADEISVDLDGRFDSLEP-------
MAB_3295|M.abscessus_ATCC_1997 MGRRPGARWAADLVA-ASEAITARL----------------
MUL_1967|M.ulcerans_Agy99 IGRRPGARWAADLLA-AADELARRL----------------
Mb1748|M.bovis_AF2122/97 FYGR-EAELAGALLA-WVSKVDAWFNGTEDRK---------
Rv1719|M.tuberculosis_H37Rv FYGR-EAELAGALLA-WVSKVDAWFNGTEDRK---------
MMAR_4423|M.marinum_M LPAADFEEVAQQTIA-AADAVSRGLGWTDRIS---------
MSMEG_4174|M.smegmatis_MC2_155 FSEDDLRGKFARMVCGTAEAITAELRRRVKPVDVLDERPAQ
: :