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LNQASIAIDPVRSSEHDSIHQSPTNSVRRTLQVLAAFDGSRTVLGVSEVAARADVPKSTAHRLLNVMSQQ GFVRREGNRYRLGERLFELGARALEPRGLRERAIPFMAELHHSTLETIHLAVLRGDQVLYVEKIYGHGAA PCPTTVGGRNPATCTGLGKAILSSCSEEAVDAILGSRLPRPTRNSLHTRQALHRNLTISREEGVAVDYEE LRMGLACVSAPIIDRSTGAAVAALSISAPTSRFNRRRFTVQLLKATEALSLGSLRSA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4411 | - | - | 100% (267) | regulatory proteins, IclR |
| M. vanbaalenii PYR-1 | Mvan_2889 | - | 3e-39 | 40.35% (228) | regulatory proteins, IclR |
| M. vanbaalenii PYR-1 | Mvan_0559 | - | 2e-31 | 32.91% (237) | regulatory proteins, IclR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1748 | - | 1e-20 | 28.81% (236) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_4551 | - | 2e-33 | 39.64% (222) | regulatory protein, IclR |
| M. tuberculosis H37Rv | Rv1719 | - | 1e-20 | 28.81% (236) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0077 | - | 1e-34 | 39.82% (221) | IclR family transcriptional regulator |
| M. marinum M | MMAR_4423 | - | 6e-19 | 31.98% (247) | transcriptional regulatory protein |
| M. avium 104 | MAV_3024 | - | 2e-36 | 40.99% (222) | transcriptional regulator, IclR family protein |
| M. smegmatis MC2 155 | MSMEG_2890 | - | 3e-38 | 37.79% (262) | putative transcriptional regulator |
| M. thermoresistible (build 8) | TH_3251 | - | 4e-39 | 40.65% (246) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_1967 | - | 2e-12 | 28.44% (225) | transcriptional regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2890|M.smegmatis_MC2_155 -MEDLMTITVESPVT-SGKGAAADTPSAVIDRISLVLDAFDGP-GRLTLA
TH_3251|M.thermoresistible__bu MTATLDQPTPNTTVKRTGTERTGETPSAVLDRISLVLDAFDGP-GRLTLA
Mflv_4551|M.gilvum_PYR-GCK ------------------MTTPVETPSAVIDRVSLVLDAFDGP-GRLTLA
MAV_3024|M.avium_104 ------------------MPAPAETPTAVIDRISLVLDAFDGP-GRLTLA
MAB_0077|M.abscessus_ATCC_1997 ----------------MTITADSATPSAVIDRVSLLLDAFDGP-GRLTLA
Mvan_4411|M.vanbaalenii_PYR-1 ---MNQASIAIDPVRSSEHDSIHQSPTNSVRRTLQVLAAFDGSRTVLGVS
Mb1748|M.bovis_AF2122/97 --------------MSAEEQDTRSGGIQVIARAAELLRVLQAHPGGLSQA
Rv1719|M.tuberculosis_H37Rv --------------MSAEEQDTRSGGIQVIARAAELLRVLQAHPGGLSQA
MUL_1967|M.ulcerans_Agy99 --------------------MRQDSGIGVIDKAVGLLRATAKS--PCGLA
MMAR_4423|M.marinum_M MSSGISSMIMGTGNDGGASESDPAPTVQSVDRALLVLELLADL-GKAGVT
: : :* :
MSMEG_2890|M.smegmatis_MC2_155 QVVRRTGLPRSSAHRMLERLVQLRWLRRNGRD--YELGMRLVELGSLAVH
TH_3251|M.thermoresistible__bu QVVRRTGLPRSSAHRMLERLVQLRWLRRDGRD--YELGMRLVELGSLAVH
Mflv_4551|M.gilvum_PYR-GCK QIVRRTGLPRSSAHRMLERLVQLRWLRRTGRD--YELGMRLVELGSLAVH
MAV_3024|M.avium_104 QIVRRTGLPRSSAHRMLERLVQLRWLRRSGRD--YELGMRLVELGSLAVH
MAB_0077|M.abscessus_ATCC_1997 QLVRRTGLPRSSVHRMLERLVQLRWLRRDGRD--YELGTRLVELGSLAVH
Mvan_4411|M.vanbaalenii_PYR-1 EVAARADVPKSTAHRLLNVMSQQGFVRREGNR--YRLGERLFELGARALE
Mb1748|M.bovis_AF2122/97 EIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVRL
Rv1719|M.tuberculosis_H37Rv EIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTVRL
MUL_1967|M.ulcerans_Agy99 ELCERTGLPRATAYRLAAALEVHRLLGRDEDGR-WGLGPAITELAAHVDD
MMAR_4423|M.marinum_M EVADELGVHKSTASRLITALEARGYVEQLSDRGKYQLGIGVSRLARARSG
:: . .: :::. *: : : : ** : .:.
MSMEG_2890|M.smegmatis_MC2_155 QDRLHKAAIPKLHELHAATGLVVHLAVLDGPDVVFMEKVGNRMAAAIPTR
TH_3251|M.thermoresistible__bu QDRLHRAAIPRLHELHAATGLVVHLAVLDGSDVVYLEKVGSRLAAAIPTR
Mflv_4551|M.gilvum_PYR-GCK QDRVHRAATPLLHDLHRATGLVVHLAVLDGSDVVYLDKIGDGMASAIPTR
MAV_3024|M.avium_104 QDRLVRAATPLLVELHRATGLVVHLAVLDGPDVVYLEKVGDRLNSVIPSR
MAB_0077|M.abscessus_ATCC_1997 QDRLHAAALPMLHELHRATGLVVHLSILDGADVVYLEKIGAGIGAAVATR
Mvan_4411|M.vanbaalenii_PYR-1 PRGLRERAIPFMAELHHSTLETIHLAVLRGDQVLYVEKIYGHGAAPCPTT
Mb1748|M.bovis_AF2122/97 G--VVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVSA
Rv1719|M.tuberculosis_H37Rv G--VVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVSA
MUL_1967|M.ulcerans_Agy99 P--LLTAGATVLPRLCETTGESVQLYRREGTSRVCVAALEPPAGLRDTVP
MMAR_4423|M.marinum_M HSDLVKLSQDACDKLAADLGETANLAILDENRAVNIVEAVSTAEIALQTW
: * .* :
MSMEG_2890|M.smegmatis_MC2_155 VGGRQPAHCAAVGKAVLAYADDCDVEALTDDVLARRTKYSITNSGRLRSE
TH_3251|M.thermoresistible__bu VGGRRPANCAAVGKAILAYAEDDGVLSGTG-PLPRNTKYSISDPARLRAE
Mflv_4551|M.gilvum_PYR-GCK VGGRQPAHCTAVGKAMLAFNDD-VDVDLQ----SRMTKYSIGTAAQLAAE
MAV_3024|M.avium_104 VGGRQPAHCTAVGKAILAYRDEATDLDLG----ARPTKYSISSAPQLAAE
MAB_0077|M.abscessus_ATCC_1997 IGGRQPAHCTASGKAILAYRAQILDGCTAL---ARKTRYSIGSAAQLRPE
Mvan_4411|M.vanbaalenii_PYR-1 VGGRNPATCTGLGKAILSSCSEEAVDAILGSRLPRPTRNSLHTRQALHRN
Mb1748|M.bovis_AF2122/97 VGESFPLYCCANGKALLAALPPERQARALPSRLAPLTANTITDRAALRDE
Rv1719|M.tuberculosis_H37Rv VGESFPLYCCANGKALLAALPPERQARALPSRLAPLTANTITDRAALRDE
MUL_1967|M.ulcerans_Agy99 VGARLPMTAGSGAKVLLAHSDPATQQAVLP------------TAKFTDRV
MMAR_4423|M.marinum_M VGQSCPVHATSSGKVLLAGLDADEVRQRVGATLDSFTENTIVTIDALEAQ
:* * . . .*.:*:
MSMEG_2890|M.smegmatis_MC2_155 LAKVRAHGIAFDREESFPGLGCVAAPIGD--PGQAVAAVSVCGPMNRMVF
TH_3251|M.thermoresistible__bu LAKVRAHGVAFDREESLPGIGCVAAPIGD--PGEAVAAISVCGPMNQMAF
Mflv_4551|M.gilvum_PYR-GCK LAKVRAHGVAYEREESLPGFGCVAAAIGR--PGEAVAAVSVCGPMNRMAF
MAV_3024|M.avium_104 LAKVRAHGVAFEREESLLGFGCVAAPIGG--PGEAAAAVSVCGPLQRMAL
MAB_0077|M.abscessus_ATCC_1997 LDKVRGHGVAFDREELQQGIGCVAAPIGS--IGDAVAAVSVCGPMTRMTF
Mvan_4411|M.vanbaalenii_PYR-1 LTISREEGVAVDYEELRMGLACVSAPIIDRSTGAAVAALSISAPTSRFNR
Mb1748|M.bovis_AF2122/97 LNRIRVDGVAYDREEQTEGICAVGAVLRG--VSVELVAVSVPVPAQRFYG
Rv1719|M.tuberculosis_H37Rv LNRIRVDGVAYDREEQTEGICAVGAVLRG--VSVELVAVSVPVPAQRFYG
MUL_1967|M.ulcerans_Agy99 LAEVRRRGWAQSVAEREPGVASVSAPVRD-GRGVVVAAISVSGPIDRIGR
MMAR_4423|M.marinum_M LAATRAAGWASAREELEIGLNAVAAPVYDS-TGRVAAALSVSGPAYRLPA
* * * * * *. .*.* : . .*:*: * ::
MSMEG_2890|M.smegmatis_MC2_155 DHRMAAPVRMTALGIWRAMQGAEMRVAPTLQQMRPLRGGPSGTPAGHPAA
TH_3251|M.thermoresistible__bu DHRLVAPVRMAALGIWRAMEGARQRVVPTLQQVRPLRPGPTAQSLSHSAL
Mflv_4551|M.gilvum_PYR-GCK ER-LAAPVRVTAMGIWRNAEDGPARVTPTLQPLRPLRGGPAARPVA--VR
MAV_3024|M.avium_104 DQRLAAPVRMTAMGVWRNVEGGPQRVAPTLQRLRPLPPMRPQHPVP--KP
MAB_0077|M.abscessus_ATCC_1997 DQRLAAPVRMTAMGIWRNVENGPSRVAPTLQPIRPLRCGPAASSTGREMN
Mvan_4411|M.vanbaalenii_PYR-1 RRFTVQLLKATEALSLGSLRSA----------------------------
Mb1748|M.bovis_AF2122/97 REAELAGALLAWVSKVDAWFNGTEDRK-----------------------
Rv1719|M.tuberculosis_H37Rv REAELAGALLAWVSKVDAWFNGTEDRK-----------------------
MUL_1967|M.ulcerans_Agy99 RPGARWAADLLAAADELARRL-----------------------------
MMAR_4423|M.marinum_M ADFEEVAQQTIAAADAVSRGLGWTDRIS----------------------
MSMEG_2890|M.smegmatis_MC2_155 NLALA---------------
TH_3251|M.thermoresistible__bu SHPAQSHPARSHRADTRRFA
Mflv_4551|M.gilvum_PYR-GCK NDALQYA-------------
MAV_3024|M.avium_104 RPALQYA-------------
MAB_0077|M.abscessus_ATCC_1997 SPALQYA-------------
Mvan_4411|M.vanbaalenii_PYR-1 --------------------
Mb1748|M.bovis_AF2122/97 --------------------
Rv1719|M.tuberculosis_H37Rv --------------------
MUL_1967|M.ulcerans_Agy99 --------------------
MMAR_4423|M.marinum_M --------------------