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VKASFRRRWLSVAILRAAFGFHRGKVSVMQKPPVAGMEHDSTGKLPQYPIESVDNALRLILLLGDRSEIR LTDASEYLHVASSTAHRLLSMLQYRGFVRQDPISRAYQPGPSLTNVAFAVHSRMDIPRTAAPILRQLVDT LQETVHVGTLDGRLVRFIAALESPSAVRVISRLGSTRPAHCTSTGKVLLAGLSVDELDQLYPDPHLEPLT EHSVRTLTELRTQLAEVRKSGFAISRQESEEGVASVAVAVPQGGSGIRLALNASAPSYRFRPSDVRKACS ALKDAAAELAVLT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0596 | - | - | 100% (293) | regulatory protein, IclR |
| M. gilvum PYR-GCK | Mflv_0686 | - | e-139 | 96.56% (262) | regulatory protein, IclR |
| M. gilvum PYR-GCK | Mflv_3174 | - | 9e-25 | 32.23% (242) | regulatory protein, IclR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1748 | - | 1e-20 | 31.31% (198) | transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv1719 | - | 1e-20 | 31.31% (198) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0077 | - | 5e-15 | 30.32% (188) | IclR family transcriptional regulator |
| M. marinum M | MMAR_4423 | - | 3e-28 | 33.47% (242) | transcriptional regulatory protein |
| M. avium 104 | MAV_3513 | - | 2e-79 | 61.48% (244) | transcriptional regulator, IclR family protein |
| M. smegmatis MC2 155 | MSMEG_4174 | - | 9e-22 | 28.83% (222) | transcriptional regulator, IclR family protein |
| M. thermoresistible (build 8) | TH_3647 | - | 8e-32 | 38.94% (226) | PUTATIVE putative transcriptional regulator, IclR family |
| M. ulcerans Agy99 | MUL_1967 | - | 2e-14 | 29.29% (239) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0462 | - | 1e-140 | 97.35% (264) | regulatory proteins, IclR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1748|M.bovis_AF2122/97 -----------------------------MSAEEQD-----------TRS
Rv1719|M.tuberculosis_H37Rv -----------------------------MSAEEQD-----------TRS
Mflv_0596|M.gilvum_PYR-GCK MKASFRRRWLSVAILRAAFGFHRGKVSVMQKPPVAG---MEHDSTGKLPQ
Mvan_0462|M.vanbaalenii_PYR-1 ----------------------------MQKPPVAG---MEHDSTGKLPQ
MAV_3513|M.avium_104 --------------------------MPAKRARVAGPAAAAPAADALAPQ
TH_3647|M.thermoresistible__bu -----------------------------VRKRARG--------AIERPT
MMAR_4423|M.marinum_M -------------------------MSSGISSMIMG-TGNDGGASESDPA
MUL_1967|M.ulcerans_Agy99 ----------------------------------------------MRQD
MSMEG_4174|M.smegmatis_MC2_155 -----------------------------------------------MEI
MAB_0077|M.abscessus_ATCC_1997 -------------------------------------------MTITADS
Mb1748|M.bovis_AF2122/97 GGIQVIARAAELLRVLQAHPGGLSQAEIGERVGMARSTVSRILNALEDEG
Rv1719|M.tuberculosis_H37Rv GGIQVIARAAELLRVLQAHPGGLSQAEIGERVGMARSTVSRILNALEDEG
Mflv_0596|M.gilvum_PYR-GCK YPIESVDNALRLILLLGDRSE-IRLTDASEYLHVASSTAHRLLSMLQYRG
Mvan_0462|M.vanbaalenii_PYR-1 YPIESVDNALRLILLLGDRSE-IRLTDASEYLHVASSTAHRLLSMLQYRG
MAV_3513|M.avium_104 YPIESVDNALKLLLLLGEQPE-IRLSEATRYLGVASSTAHRLLAMLAYRG
TH_3647|M.thermoresistible__bu YLLESVDNALRLLQMLRDGGA-VRLTEAAEELGVAPSTAHRLLAMLVYRG
MMAR_4423|M.marinum_M PTVQSVDRALLVLELLADLGK-AGVTEVADELGVHKSTASRLITALEARG
MUL_1967|M.ulcerans_Agy99 SGIGVIDKAVGLLRATAKSPC--GLAELCERTGLPRATAYRLAAALEVHR
MSMEG_4174|M.smegmatis_MC2_155 AGAQSAYRVLDVLTEVSLNPG-ATAGEVAKATNLTAPTAHRLLRVLCDRG
MAB_0077|M.abscessus_ATCC_1997 ATPSAVIDRVSLLLDAFDGPGRLTLAQLVRRTGLPRSSVHRMLERLVQLR
:: : : .:. *: *
Mb1748|M.bovis_AF2122/97 LVASRGARGPYRLGPEITRMATTVR--LGVVTEMHPFLTELSRELDETVD
Rv1719|M.tuberculosis_H37Rv LVASRGARGPYRLGPEITRMATTVR--LGVVTEMHPFLTELSRELDETVD
Mflv_0596|M.gilvum_PYR-GCK FVRQDPISRAYQPGPSLTNVAFAVHSRMDIPRTAAPILRQLVDTLQETVH
Mvan_0462|M.vanbaalenii_PYR-1 FVRQDPISRAYQPGPSLTNVAFAVHSRMDIPRTAAPILRRLADTLQETVH
MAV_3513|M.avium_104 FVRQDPVSKAYLPGPSLTGVAFAIFGRLDIARSAAPIMRALSEQLRETVH
TH_3647|M.thermoresistible__bu FAVQD-EKRTYLPGPALRAGPAERGWTREFTDVCLPHLEALSTVCGETVN
MMAR_4423|M.marinum_M YVEQLSDRGKYQLGIGVSRLARARSGHSDLVKLSQDACDKLAADLGETAN
MUL_1967|M.ulcerans_Agy99 LLGRD-EDGRWGLGPAITELAAHVD--DPLLTAGATVLPRLCETTGESVQ
MSMEG_4174|M.smegmatis_MC2_155 FAIQN-DAGKYVPGPQMRVLAGDRVDRAILEELGRPLLARLRDESTETVF
MAB_0077|M.abscessus_ATCC_1997 WLRRD--GRDYELGTRLVELGSLAVHQDRLHAAALPMLHELHRATGLVVH
: * : . * .
Mb1748|M.bovis_AF2122/97 LSILDGDRADVVDQVVPPQRLRAVSAVGESFPLYCCANGKALLAALPPER
Rv1719|M.tuberculosis_H37Rv LSILDGDRADVVDQVVPPQRLRAVSAVGESFPLYCCANGKALLAALPPER
Mflv_0596|M.gilvum_PYR-GCK VGTLDGRLVRFIAALESPSAVRVISRLGSTRPAHCTSTGKVLLAGLSVDE
Mvan_0462|M.vanbaalenii_PYR-1 VGTLDGRLVRFIAALESPSAVRVISRLGGTRPAHCTSTGKVLLAGLSDDE
MAV_3513|M.avium_104 VGMLDGASVRFVAAVEGPAAVRVASRLGRALPAHCTSTGKVMLAQLSAAE
TH_3647|M.thermoresistible__bu LVIRVGTGVRFLTSVESTAMLRVGDRRGQVLPAERTAGGRALLAELDDEV
MMAR_4423|M.marinum_M LAILDENRAVNIVEAVSTAEIALQTWVGQSCPVHATSSGKVLLAGLDADE
MUL_1967|M.ulcerans_Agy99 LYRREGTSRVCVAALEPPAGLRDTVPVGARLPMTAGSGAKVLLAHSDPAT
MSMEG_4174|M.smegmatis_MC2_155 LAVREGLQLTYLVVMTSSHSVQMYGEVGQQIPLHATSQGKVVLAFLPPGV
MAB_0077|M.abscessus_ATCC_1997 LSILDGADVVYLEKIGAGIGAAVATRIGGRQPAHCTASGKAILAYRAQIL
: : * * : .:.:**
Mb1748|M.bovis_AF2122/97 QARALPSR-LAPLTANTITDRAALRDELNRIRVDGVAYDREEQTEGICAV
Rv1719|M.tuberculosis_H37Rv QARALPSR-LAPLTANTITDRAALRDELNRIRVDGVAYDREEQTEGICAV
Mflv_0596|M.gilvum_PYR-GCK LDQLYPDPHLEPLTEHSVRTLTELRTQLAEVRKSGFAISRQESEEGVASV
Mvan_0462|M.vanbaalenii_PYR-1 LDQLYPDPHLEPLTEHSVRTLTELRTQLAEVRKSGFAISNQESEEGVASV
MAV_3513|M.avium_104 LRALLPRERLKRITAHSIGSRAALETELAAIRERGYATNREESEEGVASV
TH_3647|M.thermoresistible__bu VERLYADR--------SAGQRAELLTELAAVREVGFGLNVEHTEEGVAAF
MMAR_4423|M.marinum_M VRQRVGAT-LDSFTENTIVTIDALEAQLAATRAAGWASAREELEIGLNAV
MUL_1967|M.ulcerans_Agy99 QQAVLPTA-------------KFTDRVLAEVRRRGWAQSVAEREPGVASV
MSMEG_4174|M.smegmatis_MC2_155 GERIIDQLELARYTPSTITTAKELHEAMYEIRRDGYALNLEERELGVRSV
MAB_0077|M.abscessus_ATCC_1997 DGCTALAR----KTRYSIGSAAQLRPELDKVRGHGVAFDREELQQGIGCV
: * * . . *: ..
Mb1748|M.bovis_AF2122/97 GAVLRGVSVELVA----VSVPVPAQRFYG------REAELAGALLAWVSK
Rv1719|M.tuberculosis_H37Rv GAVLRGVSVELVA----VSVPVPAQRFYG------REAELAGALLAWVSK
Mflv_0596|M.gilvum_PYR-GCK AVAVPQG-GSGIR--LALNASAPSYRFRPS-----DVRKACSALKDAAAE
Mvan_0462|M.vanbaalenii_PYR-1 AVAVPQG-GSGIRLALALNASAPSYRFRPS-----DVRKACSALKDAAAE
MAV_3513|M.avium_104 AVPIPTR-APGLR--LALNAAAPQNRLDAA-----RYPAVAAALVAAAKE
TH_3647|M.thermoresistible__bu GAVVRNRLGRAVG---AVTVAVPIVRYQRH-----ARGDLVRQLFRTADE
MMAR_4423|M.marinum_M AAPVYDSTGRVAA---ALSVSGPAYRLPAA-----DFEEVAQQTIAAADA
MUL_1967|M.ulcerans_Agy99 SAPVRDGRGVVVA---AISVSGPIDRIGRR-----PGARWAADLLAAADE
MSMEG_4174|M.smegmatis_MC2_155 AAPVLDPSGNVVAS---VCVGGPIFRFSEDD----LRGKFARMVCGTAEA
MAB_0077|M.abscessus_ATCC_1997 AAPIGSIGDAVAA----VSVCGPMTRMTFDQRLAAPVRMTAMGIWRNVEN
.. : : . * * .
Mb1748|M.bovis_AF2122/97 VDAWFNGTEDRK------------------------
Rv1719|M.tuberculosis_H37Rv VDAWFNGTEDRK------------------------
Mflv_0596|M.gilvum_PYR-GCK LAVLT-------------------------------
Mvan_0462|M.vanbaalenii_PYR-1 LARNLG------------------------------
MAV_3513|M.avium_104 IGDQLG------------------------------
TH_3647|M.thermoresistible__bu ISVDLDGRFDSLEP----------------------
MMAR_4423|M.marinum_M VSRGLGWTDRIS------------------------
MUL_1967|M.ulcerans_Agy99 LARRL-------------------------------
MSMEG_4174|M.smegmatis_MC2_155 ITAELRRRVKPVDVLDERPAQ---------------
MAB_0077|M.abscessus_ATCC_1997 GPSRVAPTLQPIRPLRCGPAASSTGREMNSPALQYA