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TEPDISVRKVKSAVRTVELLEYLAARPDDPARLREISDALDMPRSSAHALLRTLVCQGWVRSDPTGTLYG IGIRALLVGTSYLDSDPYLPLITPFLEDLRAEQDETFHLGRLDGTDIVYLATRESTQYTRTSSRVGRRLP AYATSLGKALLAERFGTERDEHVPAALKSLTPHTITDRTELDHALDEVRIRGYACDDEENTTGLRCFAVP LRYCRPAQDAISASVPVERLDPQRQREIIDALRAVGDKVSRVVRPLANGDKWFAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1018 | - | - | 100% (266) | regulatory proteins, IclR |
| M. vanbaalenii PYR-1 | Mvan_0462 | - | 4e-22 | 32.28% (254) | regulatory proteins, IclR |
| M. vanbaalenii PYR-1 | Mvan_2889 | - | 9e-22 | 30.26% (228) | regulatory proteins, IclR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1748 | - | 9e-21 | 32.08% (265) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0686 | - | 4e-22 | 32.67% (251) | regulatory protein, IclR |
| M. tuberculosis H37Rv | Rv1719 | - | 1e-20 | 32.08% (265) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4493 | - | 7e-20 | 28.95% (228) | IclR family transcriptional regulator |
| M. marinum M | MMAR_4423 | - | 2e-16 | 29.37% (252) | transcriptional regulatory protein |
| M. avium 104 | MAV_3513 | - | 8e-27 | 33.06% (242) | transcriptional regulator, IclR family protein |
| M. smegmatis MC2 155 | MSMEG_6118 | - | 1e-114 | 76.52% (264) | IclR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_3251 | - | 2e-20 | 34.13% (208) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_1967 | - | 9e-11 | 29.57% (230) | transcriptional regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1018|M.vanbaalenii_PYR-1 ----------------MTEPDISVRKVKSAVRTVELLEYLAARPDDPARL
MSMEG_6118|M.smegmatis_MC2_155 ---------------MSTDDAVSVRKVKSAVRTVELLEYLAARPDRPTRI
Mb1748|M.bovis_AF2122/97 --------------MSAEEQDTRSGGIQVIARAAELLRVLQAHPGG-LSQ
Rv1719|M.tuberculosis_H37Rv --------------MSAEEQDTRSGGIQVIARAAELLRVLQAHPGG-LSQ
MAB_4493|M.abscessus_ATCC_1997 --------------------------MSVLTRAAQILDALAESNSG-LSV
Mflv_0686|M.gilvum_PYR-GCK --MQKPSLAG---MERDSTGKPPQYPIESVDNALRLLLLLGERSE--IRL
MAV_3513|M.avium_104 MPAKRARVAGPAAAAPAADALAPQYPIESVDNALKLLLLLGEQPE--IRL
MMAR_4423|M.marinum_M MSSGISSMIMGTGNDGGASESDPAPTVQSVDRALLVLELLADLGK--AGV
MUL_1967|M.ulcerans_Agy99 --------------------MRQDSGIGVIDKAVGLLRATAKSPCG---L
TH_3251|M.thermoresistible__bu MTATLDQPTPNTTVKRTGTERTGETPSAVLDRISLVLDAFDGPGR--LTL
. :*
Mvan_1018|M.vanbaalenii_PYR-1 REISDALDMPRSSAHALLRTLVCQGWVRSDPTGTLYGIGIRALLVGTSYL
MSMEG_6118|M.smegmatis_MC2_155 REICAALDMPRSSAHALLRTLVAQGWVRSDEAGTQYSIGIRALLVGTSYL
Mb1748|M.bovis_AF2122/97 AEIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTV-
Rv1719|M.tuberculosis_H37Rv AEIGERVGMARSTVSRILNALEDEGLVASRGARGPYRLGPEITRMATTV-
MAB_4493|M.abscessus_ATCC_1997 RELAEATGLPKSSVHRIVQELTVSQYVMAGGRGGSYQLGPGLLKLGLNN-
Mflv_0686|M.gilvum_PYR-GCK TDASEYLRVASSTAHRLLSMLQYRGFVRQDPASKAYQPGPSLTNVAFAVH
MAV_3513|M.avium_104 SEATRYLGVASSTAHRLLAMLAYRGFVRQDPVSKAYLPGPSLTGVAFAIF
MMAR_4423|M.marinum_M TEVADELGVHKSTASRLITALEARGYVEQLSDRGKYQLGIGVSRLARARS
MUL_1967|M.ulcerans_Agy99 AELCERTGLPRATAYRLAAALEVHRLLGRDED-GRWGLGPAITELAAHVD
TH_3251|M.thermoresistible__bu AQVVRRTGLPRSSAHRMLERLVQLRWLR--RDGRDYELGMRLVELGSLAV
: : ::. : * : : * :.
Mvan_1018|M.vanbaalenii_PYR-1 DSDPYLPLITPFLEDLRAEQDETFHLGRLDGTDIVYLATRESTQYTRTSS
MSMEG_6118|M.smegmatis_MC2_155 DADPYLPLITPFLDDLRGELDETFHLARLDGYDVVYLATRESRQYVRTTN
Mb1748|M.bovis_AF2122/97 -RLGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVS
Rv1719|M.tuberculosis_H37Rv -RLGVVTEMHPFLTELSRELDETVDLSILDGDRADVVDQVVPPQRLRAVS
MAB_4493|M.abscessus_ATCC_1997 -RRQFVAPMRKAIATVAREVNENIDLAMLSGGELVIIEQIATVRNLPTVT
Mflv_0686|M.gilvum_PYR-GCK SRMDIPRTAAPILRQLVDTLQETVHVGTLDGRLVRFIAALESPSAVRVIS
MAV_3513|M.avium_104 GRLDIARSAAPIMRALSEQLRETVHVGMLDGASVRFVAAVEGPAAVRVAS
MMAR_4423|M.marinum_M GHSDLVKLSQDACDKLAADLGETANLAILDENRAVNIVEAVSTAEIALQT
MUL_1967|M.ulcerans_Agy99 --DPLLTAGATVLPRLCETTGESVQLYRREGTSRVCVAALEPPAGLRDTV
TH_3251|M.thermoresistible__bu HQDRLHRAAIPRLHELHAATGLVVHLAVLDGSDVVYLEKVGSRLAAAIPT
: .: . :
Mvan_1018|M.vanbaalenii_PYR-1 RVGRRLPAYATSLGKALLAERFGTERDEHVP-AALKSLTPHTITDRTELD
MSMEG_6118|M.smegmatis_MC2_155 KVGRRLPAYTTALGKALLAERFGADLDAHVP-QTLTPMTPHTITDRAVLD
Mb1748|M.bovis_AF2122/97 AVGESFPLYCCANGKALLAALPPERQARALP-SRLAPLTANTITDRAALR
Rv1719|M.tuberculosis_H37Rv AVGESFPLYCCANGKALLAALPPERQARALP-SRLAPLTANTITDRAALR
MAB_4493|M.abscessus_ATCC_1997 VVGRTFALHASSIGKALLSQLPPDQVRNMLP-ADLEVFTTNTITDVTALL
Mflv_0686|M.gilvum_PYR-GCK RLGSTRPAHCTSTGKVLLAGLSVDELDQLYPDPHLEPLTEHSVRTLTELR
MAV_3513|M.avium_104 RLGRALPAHCTSTGKVMLAQLSAAELRALLPRERLKRITAHSIGSRAALE
MMAR_4423|M.marinum_M WVGQSCPVHATSSGKVLLAGLDADEVRQRVG-ATLDSFTENTIVTIDALE
MUL_1967|M.ulcerans_Agy99 PVGARLPMTAGSGAKVLLAHSDPATQQAVLP-------------TAKFTD
TH_3251|M.thermoresistible__bu RVGGRRPANCAAVGKAILAYAEDDGVLSGTG--PLPRNTKYSISDPARLR
:* . : .*.:*:
Mvan_1018|M.vanbaalenii_PYR-1 HALDEVRIRGYACDDEENTTGLRCFAVPLR-YCRPAQDAISASVPV----
MSMEG_6118|M.smegmatis_MC2_155 DALGEARVRGYATENEENTLGTKCFAVALR-YRQPAQDAISASVPL----
Mb1748|M.bovis_AF2122/97 DELNRIRVDGVAYDREEQTEGICAVGAVLR-GVSVELVAVSVPVPA----
Rv1719|M.tuberculosis_H37Rv DELNRIRVDGVAYDREEQTEGICAVGAVLR-GVSVELVAVSVPVPA----
MAB_4493|M.abscessus_ATCC_1997 RELDDVRSTGVAFDHEEHDVGISSVAVPLP-HPAAIPQAMAIVAPT----
Mflv_0686|M.gilvum_PYR-GCK TQLAEVRKSGFAISRQESEEGVASVAVAVPQGGSGIRLALNASAPS----
MAV_3513|M.avium_104 TELAAIRERGYATNREESEEGVASVAVPIPTRAPGLRLALNAAAPQ----
MMAR_4423|M.marinum_M AQLAATRAAGWASAREELEIGLNAVAAPVYDSTGRVAAALSVSGPA----
MUL_1967|M.ulcerans_Agy99 RVLAEVRRRGWAQSVAEREPGVASVSAPVRDGRGVVVAAISVSGPI----
TH_3251|M.thermoresistible__bu AELAKVRAHGVAFDREESLPGIGCVAAPIG-DPGEAVAAISVCGPMNQMA
* * * * * * .... : *: *
Mvan_1018|M.vanbaalenii_PYR-1 --ERLDPQRQREIIDALRAVGDKVSRVVRPLANGDKWFAS----------
MSMEG_6118|M.smegmatis_MC2_155 --SRLTPEHEREIVDALRMVCDKVSRVVRPVANGDKWFA-----------
Mb1748|M.bovis_AF2122/97 --QRFYGREAELAGALLAWVSKVDAWFNGTEDRK----------------
Rv1719|M.tuberculosis_H37Rv --QRFYGREAELAGALLAWVSKVDAWFNGTEDRK----------------
MAB_4493|M.abscessus_ATCC_1997 --PRFAQRKTKYVAALDSLTKRANST------------------------
Mflv_0686|M.gilvum_PYR-GCK --YRFRPSDVRKACSALKDAAAELARNLG---------------------
MAV_3513|M.avium_104 --NRLDAARYPAVAAALVAAAKEIGDQLG---------------------
MMAR_4423|M.marinum_M --YRLPAADFEEVAQQTIAAADAVSRGLGWTDRIS---------------
MUL_1967|M.ulcerans_Agy99 --DRIGRRPGARWAADLLAAADELARRL----------------------
TH_3251|M.thermoresistible__bu FDHRLVAPVRMAALGIWRAMEGARQRVVPTLQQVRPLRPGPTAQSLSHSA
*:
Mvan_1018|M.vanbaalenii_PYR-1 ---------------------
MSMEG_6118|M.smegmatis_MC2_155 ---------------------
Mb1748|M.bovis_AF2122/97 ---------------------
Rv1719|M.tuberculosis_H37Rv ---------------------
MAB_4493|M.abscessus_ATCC_1997 ---------------------
Mflv_0686|M.gilvum_PYR-GCK ---------------------
MAV_3513|M.avium_104 ---------------------
MMAR_4423|M.marinum_M ---------------------
MUL_1967|M.ulcerans_Agy99 ---------------------
TH_3251|M.thermoresistible__bu LSHPAQSHPARSHRADTRRFA