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VPEMSPVAEFDFIIVGAGSAGCLLANRLSANPDHRVLLIEAGGKDDWFWIKVPVGYLYTIANPRTDWCFT TEPDPGLAGRSIIYARGRVIGGCSSINAMIHMRGQASDYELWARATGDERWLWGGPDRAGETLEIYKELE DYFGGADEWHGADGEIRVERPRVRWKILDAWQNAAAQLGIEPIDEFNRGDNSGSAYFHVNQRRGRRWSMA DAFLHPVTHRPNLTVYAQTQALQLLTDDQVHEDQRRGAWTTAQRRVTGLRLLKEGQIVDVRARREVILSA GAIGSPHLMQVSGLGPAGLLTQHQVPVVVDLPGVGENLQDHLQLRTVYRVRGARTVNTLYRNWITRAGMG IQYLLLRSGPMTMPPSTLGAFAKSDPALASPDLEWHVQPLSLPKFGEPLHPFGAITPSVCNLRPTSRGYV RIADADPLSHPKIFCNYLSTDADRDAAVRGLRMTRQIMAAPSLARYCPEEMLPGPQLVSDDDLQAAAREL GTTIFHPVGTCAMGAFDARGLPRSAATVLDTDCRVFRVAGLRVADASAMPTITSGNTNAPVMLIAERAAR AILK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2938 | - | - | 100% (564) | glucose-methanol-choline oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_5894 | - | 7e-71 | 34.09% (572) | glucose-methanol-choline oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1606 | - | 4e-63 | 33.33% (561) | glucose-methanol-choline oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1310 | - | 3e-72 | 35.27% (567) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. gilvum PYR-GCK | Mflv_3230 | - | 0.0 | 91.02% (557) | glucose-methanol-choline oxidoreductase |
| M. tuberculosis H37Rv | Rv1279 | - | 3e-72 | 35.27% (567) | dehydrogenase FAD flavoprotein GMC oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0250 | - | 8e-79 | 35.97% (556) | GMC-type oxidoreductase |
| M. marinum M | MMAR_2954 | - | 0.0 | 89.64% (560) | dehydrogenase fad flavoprotein GMC oxidoreductase |
| M. avium 104 | MAV_4980 | - | 2e-52 | 34.16% (483) | choline dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3375 | - | 0.0 | 90.84% (557) | alcohol dehydrogenase |
| M. thermoresistible (build 8) | TH_4204 | - | 7e-81 | 34.22% (561) | PUTATIVE glucose-methanol-choline oxidoreductase |
| M. ulcerans Agy99 | MUL_4004 | - | 1e-78 | 35.35% (563) | dehydrogenase fad flavoprotein GMC oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1310|M.bovis_AF2122/97 -----MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFI
Rv1279|M.tuberculosis_H37Rv -----MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFI
MUL_4004|M.ulcerans_Agy99 -----MDIECDYVVVGTGSAGAAVVNRLSADSGTSVVALEAGPSDKNRFI
MAB_0250|M.abscessus_ATCC_1997 ---MVEDLAADFVIVGAGSAGAPLATRLSERTNDQVLVLEAGPKDKDMGI
Mvan_2938|M.vanbaalenii_PYR-1 MPEMSPVAEFDFIIVGAGSAGCLLANRLSANPDHRVLLIEAGGKDDWFWI
MSMEG_3375|M.smegmatis_MC2_155 ------MAEFDYVIVGAGSAGCLLANRLSANPDHRVLLIEAGGKDNWFWI
MMAR_2954|M.marinum_M ---MSPVAEFDFIIVGAGSAGCLLANRLSANPDHRVLVIEAGGKDNWFWI
Mflv_3230|M.gilvum_PYR-GCK ------MPEYDYIIVGAGSAGCLLANRLSADPDHRVLLIEAGGKDDWFWI
TH_4204|M.thermoresistible__bu ------MSSYDYIIAGSGSAGCVLANRLSADPKVSVLLIEAGGFDRNPLF
MAV_4980|M.avium_104 --------------------------------------------------
Mb1310|M.bovis_AF2122/97 GVPAAFSKLFRS-EIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMNAMM
Rv1279|M.tuberculosis_H37Rv GVPAAFSKLFRS-EIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMNAMM
MUL_4004|M.ulcerans_Agy99 GIPAAFPKLFRS-EVDWDYTTEPEPQLGGREIYWPRDKVLGGSSSMNAMM
MAB_0250|M.abscessus_ATCC_1997 HIPAAFSKLFRS-DVDWDYLTEPQPQLNNRQIYWPRGKTLGGSSSMNAMM
Mvan_2938|M.vanbaalenii_PYR-1 KVPVGYLYTIANPRTDWCFTTEPDPGLAGRSIIYARGRVIGGCSSINAMI
MSMEG_3375|M.smegmatis_MC2_155 KVPVGYLFTIANPRTDWCFNTEPDPGLAGRSIIYARGRVIGGCSSINAMI
MMAR_2954|M.marinum_M KVPVGYLYTIANPRTDWCFTTEADPGLAGRSIHYARGRVIGGCSSINAMI
Mflv_3230|M.gilvum_PYR-GCK KVPVGYLYTIANPRTDWCYTTEPDPGLAGRSILYARGRVVGGSSSINAMI
TH_4204|M.thermoresistible__bu SIPKGSGKLFDSERHMWHYETTP-FGPGRHTEQWMRGKVLGGSSSVNGMI
MAV_4980|M.avium_104 -----------------------MQTAIGRAVPFARGRGIGGSSTINAMV
: : *.: :**.*::*.*:
Mb1310|M.bovis_AF2122/97 WVRGFASDYDEWAARAGPR-WSYA------DVLGYFRRIENVTAAWHFVS
Rv1279|M.tuberculosis_H37Rv WVRGFASDYDEWAARAGPR-WSYA------DVLGYFRRIENVTAAWHFVS
MUL_4004|M.ulcerans_Agy99 WVRGFAADYDEWARLAGSH-WSYG------ELLGYFRQIEDVTAAWHFVN
MAB_0250|M.abscessus_ATCC_1997 WVRGFAADYDDWAQVAGEQ-WSFA------NIAPYFKRIEAVEG----AT
Mvan_2938|M.vanbaalenii_PYR-1 HMRGQASDYELWARATGDERWLWGGPDRAGETLEIYKELEDYFGG----A
MSMEG_3375|M.smegmatis_MC2_155 HMRGQASDYELWARATGDDRWLWGGPDRPGQTLAIYKELENYFGG----A
MMAR_2954|M.marinum_M HMRGQASDYDLWAQATGDQRWLWGGPDSSGETLAIYKKLENYFGG----A
Mflv_3230|M.gilvum_PYR-GCK HMRGQASDYELWAQATGDERWLWGGPDRPGDTLAIYKDLEDYFGG----A
TH_4204|M.thermoresistible__bu YNRGNRADYDGLEQL-GNKGWGWD------DILPIFKQFEDNEFG----P
MAV_4980|M.avium_104 FARGHRDSYSRWRDNGAAG-WSFD------ELLPYFKRSESTCGK----D
** .*. . * : : :: *
Mb1310|M.bovis_AF2122/97 GDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFA-AARPNSPRPEGFCE
Rv1279|M.tuberculosis_H37Rv GDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFA-AARPNSPRPEGFCE
MUL_4004|M.ulcerans_Agy99 GDDSGVTGPLQISRQRSPSPLTAAWLAATRDCGFA-PVQPNSAEPEGFCE
MAB_0250|M.abscessus_ATCC_1997 ESDEGTDGALKISKQRSPRSSTAAWLEAVKEAGFD-VERANTPEPKGFSE
Mvan_2938|M.vanbaalenii_PYR-1 DEWHGADGEIRVERPRVRWKILDAWQNAAAQLGIEPIDEFNRGDNSGSAY
MSMEG_3375|M.smegmatis_MC2_155 DEWHGADGEIRVERPRVRWKILDAWQAAAAQFGITPIEEFNRGDNSGSAY
MMAR_2954|M.marinum_M DDWHGAGGEIRVERPRVHWKILDAWQAAAAQVGIAPIDEFNRGDNAGSAY
Mflv_3230|M.gilvum_PYR-GCK DDWHGARGEIRVERPRVRWKILDAWQAAAAESGIAPIDEFNRGDNSGSAY
TH_4204|M.thermoresistible__bu SPTRGAGGPLHISVPRDADPLCDEMIDAGTVAGLHRVEDINESDDERIGY
MAV_4980|M.avium_104 PSLRGQDGPMAVAPAAHPNPVLVACLCAAIQQGYPRAADISGGLEVGFGF
* * : : * * .
Mb1310|M.bovis_AF2122/97 TVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVIDG--------
Rv1279|M.tuberculosis_H37Rv TVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVIDG--------
MUL_4004|M.ulcerans_Agy99 TIVTQRRGSRWSTVDAYLRPAMGRRNLSILTGATATRIVIHG--------
MAB_0250|M.abscessus_ATCC_1997 TMVCQHGGRRWSTADGYLKPGLRRRNLNVVTDAQARRVLFDG--------
Mvan_2938|M.vanbaalenii_PYR-1 FHVNQRRGRRWSMADAFLHPVTHRPNLTVYAQTQALQLLTDDQVHEDQRR
MSMEG_3375|M.smegmatis_MC2_155 FHVNQRRGRRWSMADAFLHPVAHRRNLTVYTQTRALRLLMDDQVSEEQRR
MMAR_2954|M.marinum_M FHVNQRRGRRWSMADAFLHPVAHRPNLTIYTQTQALKLLVDNQVREDQRR
Mflv_3230|M.gilvum_PYR-GCK FHVNQRRGRRWSMADAFLHPVAHRPNLTVYTQTQALRLLTDDQVRDDQRC
TH_4204|M.thermoresistible__bu ATATIKNGRRVSAARAFLKPALRRANLSVRTRAVAQRILLAG--------
MAV_4980|M.avium_104 TDLNIVDGKRQSAADAYLLPALDRPNLEFHSGATVHRLRIRG--------
* * * . .:* * * ** . : : . :: .
Mb1310|M.bovis_AF2122/97 -------DRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGD
Rv1279|M.tuberculosis_H37Rv -------DRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGD
MUL_4004|M.ulcerans_Agy99 -------TRATGVEYQREGQHCTVHARREVVLCGGAVNSPQLLMLSGIGD
MAB_0250|M.abscessus_ATCC_1997 -------IRAVGVEYVRDGITHTVHARREVILSGGAINSPQLLMLSGIGE
Mvan_2938|M.vanbaalenii_PYR-1 GAWTTAQRRVTGLRLLKEGQIVDVRARREVILSAGAIGSPHLMQVSGLGP
MSMEG_3375|M.smegmatis_MC2_155 GAWTTAQHRVTGVRLLKDGQIVDVRARREVILSAGAIGSPHLMQVSGLGP
MMAR_2954|M.marinum_M GAWATAQHRATGVRLLKDGQIVDVRARREVILSAGAIGSPQLMQASGLGP
Mflv_3230|M.gilvum_PYR-GCK GAWTTATHRATGLRVLKDGQIVDVRARREVILSAGAIGSPHLMQVSGLGP
TH_4204|M.thermoresistible__bu -------GRAVGLEIASRGRTGKVYATREVIIAMGSLNTPKLLQLSGIGP
MAV_4980|M.avium_104 -------SRCTGVEYTTAEGRQVTAAAREIILCAGAIGSPHLLLASGIGP
* .*:. . * **:::. *::.:*:*: **:*
Mb1310|M.bovis_AF2122/97 RDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKD----SLFA--AEK
Rv1279|M.tuberculosis_H37Rv RDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKD----SLFA--AEK
MUL_4004|M.ulcerans_Agy99 RSHLADHGIETVYHAPEVGQNLLDHLITPLGFDVAGD----SLAA--AEK
MAB_0250|M.abscessus_ATCC_1997 ATRLGELGIPVVHDAPQVGQNLLDHLCCPVGYAVKSD----SLFG--AEK
Mvan_2938|M.vanbaalenii_PYR-1 AGLLTQHQVPVVVDLPGVGENLQDHLQLRTVYRVRGARTVNTLYRNWITR
MSMEG_3375|M.smegmatis_MC2_155 AGLLAEHQVPVAVDLPGVGENLQDHLQLRTVFRVRGARTVNTLYRNWITR
MMAR_2954|M.marinum_M AGLLAEHQVPVAVDLPGVGENLQDHLQLRTIYRVRGARTVNTLYRNWISR
Mflv_3230|M.gilvum_PYR-GCK AELLARHDVPVTVDLPGVGENLQDHLQLRTVYRVRGARTVNTLYRNWITR
TH_4204|M.thermoresistible__bu REVLDAAGVPVYLDRANVGRRMREHRCATLRFDLREDLGYNRLLATGTGQ
MAV_4980|M.avium_104 PNHLRSFRVDVALELPGVGANLQDHPIVPLVYRAARP-------------
* : . . . ** .: :* :
Mb1310|M.bovis_AF2122/97 PGQLISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAPAPFYDEA
Rv1279|M.tuberculosis_H37Rv PGQLISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAPAPFYDEA
MUL_4004|M.ulcerans_Agy99 PMQLINYLLRRRGMLTSNVGEAYGFVRSRPGLDLPDLELIFAPAPFYDEG
MAB_0250|M.abscessus_ATCC_1997 PLQLANYFLRHRGMLTSNVGEAYGFLRSHPNLTLPDLELIFAPAPFFDEG
Mvan_2938|M.vanbaalenii_PYR-1 AGMGIQYLLLRSGPMTMPPSTLGAFAKSDPALASPDLEWHVQPLSLPKFG
MSMEG_3375|M.smegmatis_MC2_155 AGMGIQYLLLRSGPMTMPPSTLGAFAKSDPTLASPDLEWHVQPLSLPKFG
MMAR_2954|M.marinum_M AGMGLQYLLLRSGPLTMPPSTLGAFAKSDPALASPDLEWHVQPLSLPKFG
Mflv_3230|M.gilvum_PYR-GCK AGMGIQYLLLRSGPLTMPPSTLGAFAKSDPVLASPDLEWHVQPLSLTKFG
TH_4204|M.thermoresistible__bu ALTGAKYLATRKGPLAAPSFDVVGFVKTQPGLDRPDGQIMLGPWTIPPYN
MAV_4980|M.avium_104 -----------VPAGRYNHGELLGLIRRHATGGPPEIQIFGVDSADVPGL
.: : . *: : .
Mb1310|M.bovis_AF2122/97 LVP-----PAGHGVVFGPILVAPQSRGQITLRSADPHAKPVIEPRYLSDL
Rv1279|M.tuberculosis_H37Rv LVP-----PAGHGVVFGPILVAPQSRGQITLRSADPHAKPVIEPRYLSDL
MUL_4004|M.ulcerans_Agy99 LPAH----PPGHGVVFGPILVAPQSRGQITLRSADPHAKPIIEARYLSDP
MAB_0250|M.abscessus_ATCC_1997 IGV-----ATEHAIVMGPILLKPESSGEITLTSPDPLAKPRIDPRYLSDP
Mvan_2938|M.vanbaalenii_PYR-1 EP-----LHPFGAITPSVCNLRPTSRGYVRIADADPLSHPKIFCNYLSTD
MSMEG_3375|M.smegmatis_MC2_155 EP-----LHPFAAITPSVCNLRPTSRGHVRMATADPLADPKILCNYLSTD
MMAR_2954|M.marinum_M EP-----LHRFGAITPSVCNLRPSSRGHVRITSGDPLTKPKILCNYLSTD
Mflv_3230|M.gilvum_PYR-GCK EP-----LHPYGAITPSVCNLRPTSRGHVRLADADPLTHPKIFCNYLSTD
TH_4204|M.thermoresistible__bu QSGEPVVIPRQAGVSALGMALRPTSEGTVEITAVDPAAPLRIDPNYLGSD
MAV_4980|M.avium_104 GG--------ADGYVLGVSVMQPVSRGRVGLSGPTIQEPPAIDPNYLSDD
. : * * * : : * .**.
Mb1310|M.bovis_AF2122/97 GGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALA
Rv1279|M.tuberculosis_H37Rv GGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALA
MUL_4004|M.ulcerans_Agy99 GGVDRAAMMEGLRICARIAQAPALRGLLGPVARPHNSSELDEATLELALT
MAB_0250|M.abscessus_ATCC_1997 AGRDRAAMMFGLRTTARIAETPSMRAVLGKILRPRNPSDDLEETLVAALE
Mvan_2938|M.vanbaalenii_PYR-1 A--DRDAAVRGLRMTRQIMAAPSLARYCPEEMLP-GPQLVSDDDLQAAAR
MSMEG_3375|M.smegmatis_MC2_155 D--DRQKAVRGLRMTRQIMSAPALARYSPEEMLP-GPQLASDDDLQQAAR
MMAR_2954|M.marinum_M Q--DRQLAVRGLRMTRQIMAAPSLARYCPEELLP-GPQLVSDEDLQKAAR
Mflv_3230|M.gilvum_PYR-GCK A--DRDIAVRGLRMTRKIMASPVLARYRPEEMLP-GPHLVSDDDLQAAAR
TH_4204|M.thermoresistible__bu A--DRETTANLLRRMRSVFEQSPIAERISHETFP-GPHIRSDDELVDAAL
MAV_4980|M.avium_104 R--DMGLMIEGLRIGRKIGMSQALDPWRAEELAP-GDDAVDDAALRSYIQ
* ** : : * . : *
Mb1310|M.bovis_AF2122/97 TCSHTLYHPMGTCRMGSDEA--------SVVDPQLRVRGVDGLRVADASV
Rv1279|M.tuberculosis_H37Rv TCSHTLYHPMGTCRMGSDEA--------SVVDPQLRVRGVDGLRVADASV
MUL_4004|M.ulcerans_Agy99 TCSHTLYHPLGTCRMGSDEA--------SVVDRQLRVRGVDGLRVADASV
MAB_0250|M.abscessus_ATCC_1997 NNSHTLYHPVGTCRMGADDA--------SVVTPDLTVRGVQGLRVVDASV
Mvan_2938|M.vanbaalenii_PYR-1 ELGTTIFHPVGTCAMGAFDARGLPRSAATVLDTDCRVFRVAGLRVADASA
MSMEG_3375|M.smegmatis_MC2_155 ELGTTIFHPVGTCAMGAFDTHGLPTSATTVLDTDLRVFRVAGLRVADASA
MMAR_2954|M.marinum_M ELGTTIFHPVGTCAMGAFDARGRPRSAATVLDTDCRVYRVAGLRVADASA
Mflv_3230|M.gilvum_PYR-GCK ELGTTIFHPVGTCAMGAFDARGLPRSATTVLDTDCRVFRVAGLRVVDASA
TH_4204|M.thermoresistible__bu DGGYCGYHAIGTCAMGPSDD--------DVVDPQLRVRGVDGLRVVDCSV
MAV_4980|M.avium_104 RSVASYFHPVGTCAMGTGPE--------SVVDNQLRLHGIDNLRVIDASV
:*.:*** **. *: : : : .*** *.*.
Mb1310|M.bovis_AF2122/97 MPSTVRGHTHAPSVLIGEKAADLIRS---
Rv1279|M.tuberculosis_H37Rv MPSTVRGHTHAPSVLIGEKAADLIRS---
MUL_4004|M.ulcerans_Agy99 MPSTVRGHTHAPSVLIGAKAADLIRN---
MAB_0250|M.abscessus_ATCC_1997 IPSLIRGHTHAPSVLLGEKAADLILSPQP
Mvan_2938|M.vanbaalenii_PYR-1 MPTITSGNTNAPVMLIAERAARAILK---
MSMEG_3375|M.smegmatis_MC2_155 MPNITSGNTNAPVMLIAERAARAILG---
MMAR_2954|M.marinum_M MPTITSGNTNAPVMLVAERAARAILG---
Mflv_3230|M.gilvum_PYR-GCK MPTITSGNTNAPVMLIAERAARAILH---
TH_4204|M.thermoresistible__bu LPVMVAGNLNGPIMAVAWRAADLIRQDL-
MAV_4980|M.avium_104 MPSLPSNNTAATVYAIAERGADLVRLG--
:* .: .. :. :.* :