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TKSVFITGAATGIGRATALLFAQRGYRVGGYDIDEAGLRLLAADITAVGGRPVVGRLDVTDADEVAHRLA EFVDAAGGRLDVLINNAGLLQAGRFEDIPLPVHHRAIEVNVKGVVNGLHAAFPYLRDTPDAVVVNLSSAS AIYGQVELANYSATKFYVRAITEALNLEWAQHGIRVIDMWPLYVNTAMTQGVKTGTTQSLGIRLTAQDIA RDIVTAVEATWPRRLVKQVHFPVGGQAKALALGSRFSPAWLTRLINKRLAGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0267 | - | - | 100% (263) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3576 | - | 2e-23 | 34.62% (260) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3101 | - | 2e-22 | 34.67% (199) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1914c | - | 2e-37 | 43.09% (188) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0407 | - | 1e-123 | 83.65% (263) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv1882c | - | 2e-37 | 43.09% (188) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01094 | - | 3e-23 | 31.91% (257) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4335 | - | 1e-26 | 35.29% (255) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_2770 | - | 2e-38 | 45.21% (188) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_2820 | - | 6e-37 | 35.40% (274) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2477 | - | 1e-25 | 39.57% (187) | cyclopentanol dehydrogenase |
| M. thermoresistible (build 8) | TH_3493 | - | 1e-101 | 68.97% (261) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2977 | - | 1e-37 | 44.15% (188) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0267|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0407|M.gilvum_PYR-GCK --------------------------------------------------
TH_3493|M.thermoresistible__bu --------------------------------------------------
Mb1914c|M.bovis_AF2122/97 --------------------------------------------------
Rv1882c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2770|M.marinum_M --------------------------------------------------
MUL_2977|M.ulcerans_Agy99 --------------------------------------------------
MAV_2820|M.avium_104 --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
MSMEG_2477|M.smegmatis_MC2_155 MPTYELLRYHFRSPETAAHFLQTSASHDRRQDRGTETLGISASPSDPTIV
Mvan_0267|M.vanbaalenii_PYR-1 -------------------------------------------------M
Mflv_0407|M.gilvum_PYR-GCK -------------------------------------------------M
TH_3493|M.thermoresistible__bu -----------------------------------------------MRN
Mb1914c|M.bovis_AF2122/97 --------------------------------------------------
Rv1882c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2770|M.marinum_M --------------------------------------------------
MUL_2977|M.ulcerans_Agy99 --------------------------------------------------
MAV_2820|M.avium_104 --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 ------------------------------------------MGTAVQLA
MLBr_01094|M.leprae_Br4923 ---------------------------------------------MEGFA
MSMEG_2477|M.smegmatis_MC2_155 VEIVCHTDESGARPATDAPGIQRVETLALEPRAAGVSEASRGRSGQGRLA
Mvan_0267|M.vanbaalenii_PYR-1 TKSVFITGAATGIGRATALLFAQRGYRVGGYDIDEAGLRLLAADITAVGG
Mflv_0407|M.gilvum_PYR-GCK TKSVFITGAATGIGRATALLFAGRGYRVGGYDLDEDGLAVLAADITAVGG
TH_3493|M.thermoresistible__bu DKAIFITGAAAGIGRATALTFARKGYTVGAYDIDEAGLGTLAEEIGRLGA
Mb1914c|M.bovis_AF2122/97 MKAIFITGAGSGMGREGATLFHANGWRVGAIDRNEDGLAALRVQLGAE--
Rv1882c|M.tuberculosis_H37Rv MKAIFITGAGSGMGREGATLFHANGWRVGAIDRNEDGLAALRVQLGAE--
MMAR_2770|M.marinum_M MKSVFITGAGSGMGREGAKLFHAKGWRVAAVDRDGAGLDALGAELGTE--
MUL_2977|M.ulcerans_Agy99 MKSGFVTGAGSGMGREGAKLFHAKGWRVAAVDRDGAGLDALGAELGTE--
MAV_2820|M.avium_104 MKSIFITGAGSGMGREGAKLFHAKGWRVGAVDRNDDGLATLQQELGDD--
MAB_4335|M.abscessus_ATCC_1997 GKVVAVTGGARGIGRAIATAFAAEGAKVAIGDIDKKLCENTAAEIGNS--
MLBr_01094|M.leprae_Br4923 GKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEGLAQTEGQLKAIGA
MSMEG_2477|M.smegmatis_MC2_155 GKVALITGGARGQGEAEARLFAQHGAHVYICDVLEEEGEKLAAELRGSGL
* :**.. * *. * : * : * ::
Mvan_0267|M.vanbaalenii_PYR-1 RPVVGRLDVTDADEVAHRLAEFVDA-AGGRLDVLINNAGLLQAGRFEDIP
Mflv_0407|M.gilvum_PYR-GCK TPVVAHLDVTDPDEVARRLAEFAEG-SGGRIDVLINNAGLLNAGRFEEIP
TH_3493|M.thermoresistible__bu TVHTGHLDVTDTDEMATRVSEFATQ-AGNRLDVMVNNAGILKAGRFEDID
Mb1914c|M.bovis_AF2122/97 RLWARAVDVTDKAALEGALADFCAGNVGGGLDMMWNNAGIGEGGWFEDVP
Rv1882c|M.tuberculosis_H37Rv RLWARAVDVTDKAALEGALADFCAGNVGGGLDMMWNNAGIGEGGWFEDVP
MMAR_2770|M.marinum_M RLWTRVVDVTDRDALDRALADFCAGTSHGGLDMMWNNAGIGEGGWFEDVP
MUL_2977|M.ulcerans_Agy99 RLWTRVVDVTDRDALDRALADFCAGTSHGGLDMMWNNAGIGEGGWFEDVP
MAV_2820|M.avium_104 RLWTRAVDVTDKAALDGALADFCAGNTGGGLDMMWNNAGIGESGWFEDVP
MAB_4335|M.abscessus_ATCC_1997 -AIGLPLDVTDHGSFEAFFDTIAAT--VGPVDVIVNNAGIMPITPFDDES
MLBr_01094|M.leprae_Br4923 SARTDRLDVTEREAFLTYADVVHEN--FGKVNQIYNNAGIAFTGDVEVSH
MSMEG_2477|M.smegmatis_MC2_155 QADFRFLDVTDAEQWSRTVAHIDAG--AGRLDVLINNAGINVRHQLTDTT
:***: . . :: : ****: .
Mvan_0267|M.vanbaalenii_PYR-1 LPVHHRAIEVNVKGVVNGLHAAFPYLRDTPDAVVVNLSSASAIYGQVELA
Mflv_0407|M.gilvum_PYR-GCK LEVHHREIEVNVKGVVNGLHAAFPYLKGTPGAVVVNLASASAIYGQAELA
TH_3493|M.thermoresistible__bu VRAHFAEIDVNTKGVVNGLHAAFPHLRATPDSVVVNLASASAIYGQPELA
Mb1914c|M.bovis_AF2122/97 YEAAVRVVDVNFKAVLTGAYAALPYLKKAPGSLMFSTSSSSGTYGMPRIA
Rv1882c|M.tuberculosis_H37Rv YEAAVRVVDVNFKAVLTGAYAALPYLKKAPGSLMFSTSSSSGTYGMPRIA
MMAR_2770|M.marinum_M YDAAMRVVDVNFKAVLTGAYGALPYLRKAPGSLMFSTSSSSATYGMPRLA
MUL_2977|M.ulcerans_Agy99 YDAAMRVVDVNFKAVLTGAYGALPYLRKAPGSLMFSTSSSSATYGMPRLA
MAV_2820|M.avium_104 YDAAMRVVDVNYKAVLTGAYGALPYLKKSAGSLMFSTSSSSATYGMPRLA
MAB_4335|M.abscessus_ATCC_1997 LESIQRQLDINVRGVMWGSQLAIKRMKPRGGGVIVNIASAAGKAGFPGLA
MLBr_01094|M.leprae_Br4923 FKDIERVMDVDYWGVVNGTKAFLPYLISSGDGHVINISSVFGLFSVPGQA
MSMEG_2477|M.smegmatis_MC2_155 SEEWDRIVAVNTKGQMLGMQACAPLMKRSGNGSIINIGSTAGIMGHP-VA
: :: . : * : .. :.. .* . . *
Mvan_0267|M.vanbaalenii_PYR-1 NYSATKFYVRAITEALNLEWAQHG--IRVIDMWPLYVNTAMTQGVKTG--
Mflv_0407|M.gilvum_PYR-GCK NYSATKFFVRAITEALNLEWGHYG--IRVIDMWPLYVNTAMTKDVKTG--
TH_3493|M.thermoresistible__bu NYSATKFFVRGLTEALDLEWGRYG--IRVVAIWPLYVQTPMLTGVDTG--
Mb1914c|M.bovis_AF2122/97 VYSATKHAVKGLTEALSVEWQRHG--VRVADVLPGLIDTAILTSTRQHSD
Rv1882c|M.tuberculosis_H37Rv VYSATKHAVKGLTEALSVEWQRHG--VRVADVLPGLIDTAILTSTRQHSD
MMAR_2770|M.marinum_M VYSATKHAVKGLTEALSAEWRRHG--VRVADVLPGLIDTAILTSTRQHSD
MUL_2977|M.ulcerans_Agy99 VYSATKHAVKGLTEALSAEWRRHG--VRVADVLPGLIDTAILTSTRQHSD
MAV_2820|M.avium_104 VYSSTKHAVKGLTEALSVEWQRHG--VRVADVLPGLIDTAILTTTTNHSN
MAB_4335|M.abscessus_ATCC_1997 TYCATKHAVVGLSESLSLEYEPAG--ISVVCVMPGMVNTELISGLDTHWL
MLBr_01094|M.leprae_Br4923 AYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGGIKTAIARNATAA--
MSMEG_2477|M.smegmatis_MC2_155 AYSASKWAVRGLTKAAAMELASSG--IRVNAMHPGVVETPMVD-------
* ::* * .:::: * * : * : * :.* :
Mvan_0267|M.vanbaalenii_PYR-1 ----TTQSLG-IRLTAQD-----IARDIVTAVEATWPRRLVKQVHFPVGG
Mflv_0407|M.gilvum_PYR-GCK ----TTQSLG-IRLTAQD-----IANDIVAAVDATWARKALAQVHFPVGL
TH_3493|M.thermoresistible__bu ----TTRSLG-VRLTAQD-----VADVIVSAVEPSRLRRTVRQVHYPVGA
Mb1914c|M.bovis_AF2122/97 EGPYTISAEQ-IRAAAPKKGMFRLMPSSSVAEAAWRAYQHPTRLHWYVPR
Rv1882c|M.tuberculosis_H37Rv EGPYTISAEQ-IRAAAPKKGMFRLMPSSSVAEAAWRAYQHPTRLHWYVPR
MMAR_2770|M.marinum_M ASAPTLSSEQ-IRAAAPKKGMFRLLPASSVAEAAWQAYQHPTRLHWYVPP
MUL_2977|M.ulcerans_Agy99 ASAPTLSSEQ-IRAAAPKKGMFRLLPASSVAEAAWHAYQHPTRLHWYVPP
MAV_2820|M.avium_104 DGAAPMTAEE-LRATAPKKGMLRLMPASSVAEVAWRAYNHPRRLHWYVPR
MAB_4335|M.abscessus_ATCC_1997 LKTVEPEDIANAVVKAVRRGVFPVFVPKMFGGMYRTMSVLPRSTGKFLTR
MLBr_01094|M.leprae_Br4923 ------EGLD-VSKIASRFDTWVAHTSPQHAARIILKAVRKKKARVLVGP
MSMEG_2477|M.smegmatis_MC2_155 ---------AGSRVFAELRSLTPLGRAAQPSEMASAALFLASDEASFITG
* . :
Mvan_0267|M.vanbaalenii_PYR-1 QAKALALGSRFSPAWLTRLINKRLAGS------
Mflv_0407|M.gilvum_PYR-GCK QAKALALGARFSPAWLTRLVNKGLAGS------
TH_3493|M.thermoresistible__bu QTKAFALGSRFSPAWLTRALNKRLAGS------
Mb1914c|M.bovis_AF2122/97 SIRWIDRLKGVSPEFVRRHIAKSLATLEPKRK-
Rv1882c|M.tuberculosis_H37Rv SIRWIDRLKGVSPEFVRRHIAKSLATLEPKRK-
MMAR_2770|M.marinum_M SVRWIDRLKGVSPEFVRSRILKSLPTFGAGQQ-
MUL_2977|M.ulcerans_Agy99 SIRWIDRLKGVSPEFVRSRILKSLPTFGTGQQ-
MAV_2820|M.avium_104 SIRLIDVFKGLSPEFVRRSIVKSLPALMPKRQ-
MAB_4335|M.abscessus_ATCC_1997 KLGIQDFMLNAHGSDARKAYEDRASHSGPSTE-
MLBr_01094|M.leprae_Br4923 DAKVANVVVRFSGGAGYQRLFAQVASRLILNQR
MSMEG_2477|M.smegmatis_MC2_155 --IDLAVDGGFSELAAYGEVWKRLNTAL-----