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VTKSVFITGAATGIGRATALLFAGRGYRVGGYDLDEDGLAVLAADITAVGGTPVVAHLDVTDPDEVARRL AEFAEGSGGRIDVLINNAGLLNAGRFEEIPLEVHHREIEVNVKGVVNGLHAAFPYLKGTPGAVVVNLASA SAIYGQAELANYSATKFFVRAITEALNLEWGHYGIRVIDMWPLYVNTAMTKDVKTGTTQSLGIRLTAQDI ANDIVAAVDATWARKALAQVHFPVGLQAKALALGARFSPAWLTRLVNKGLAGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0407 | - | - | 100% (263) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4505 | - | 2e-30 | 39.53% (215) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_3779 | - | 7e-23 | 38.02% (192) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1914c | - | 3e-39 | 43.92% (189) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv1882c | - | 3e-39 | 43.92% (189) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01094 | - | 4e-21 | 31.77% (192) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4335 | - | 6e-27 | 34.65% (254) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_2770 | - | 3e-38 | 43.19% (213) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_2820 | - | 1e-37 | 42.33% (189) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4280 | - | 8e-24 | 37.97% (187) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3493 | - | 5e-99 | 66.67% (261) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2977 | - | 1e-37 | 42.25% (213) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_0267 | - | 1e-123 | 83.65% (263) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 MYTFVTSQDGTRIAVYQQGDPERPTLVMAHGWPDSHVLWDGVVGELGDRY
Mflv_0407|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0267|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3493|M.thermoresistible__bu --------------------------------------------------
Mb1914c|M.bovis_AF2122/97 --------------------------------------------------
Rv1882c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2770|M.marinum_M --------------------------------------------------
MUL_2977|M.ulcerans_Agy99 --------------------------------------------------
MAV_2820|M.avium_104 --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 RIVRYDNRGAGASDVPKATSAYTMERFADDFSAVIDAVSPDAPVHVLAHD
Mflv_0407|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0267|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3493|M.thermoresistible__bu --------------------------------------------------
Mb1914c|M.bovis_AF2122/97 --------------------------------------------------
Rv1882c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2770|M.marinum_M --------------------------------------------------
MUL_2977|M.ulcerans_Agy99 --------------------------------------------------
MAV_2820|M.avium_104 --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 WGSVGIWEYLSRQGSAARMVSFTSVSGPSTDHYGAYVRRGLARPYRPVQF
Mflv_0407|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0267|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3493|M.thermoresistible__bu --------------------------------------------------
Mb1914c|M.bovis_AF2122/97 --------------------------------------------------
Rv1882c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2770|M.marinum_M --------------------------------------------------
MUL_2977|M.ulcerans_Agy99 --------------------------------------------------
MAV_2820|M.avium_104 --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 ARAVNLASRFSYWIPFSIPVLAPALMRRGAARRLQAIDTPGPKFQSENLD
Mflv_0407|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0267|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3493|M.thermoresistible__bu --------------------------------------------------
Mb1914c|M.bovis_AF2122/97 --------------------------------------------------
Rv1882c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2770|M.marinum_M --------------------------------------------------
MUL_2977|M.ulcerans_Agy99 --------------------------------------------------
MAV_2820|M.avium_104 --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 IDAANSLKIYRANAIRSFTHVRRDHYVQVPVQLICNRKDPVVRGEGYRDE
Mflv_0407|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0267|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3493|M.thermoresistible__bu --------------------------------------------------
Mb1914c|M.bovis_AF2122/97 --------------------------------------------------
Rv1882c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2770|M.marinum_M --------------------------------------------------
MUL_2977|M.ulcerans_Agy99 --------------------------------------------------
MAV_2820|M.avium_104 --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 SKWVPLLWRRDLDAGHWAPFSHPRAIAQAVGEFVDHMEGAPPARALRRAE
Mflv_0407|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0267|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3493|M.thermoresistible__bu --------------------------------------------------
Mb1914c|M.bovis_AF2122/97 --------------------------------------------------
Rv1882c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2770|M.marinum_M --------------------------------------------------
MUL_2977|M.ulcerans_Agy99 --------------------------------------------------
MAV_2820|M.avium_104 --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01094|M.leprae_Br4923 ----MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEGLAQT
MSMEG_4280|M.smegmatis_MC2_155 VARPRKAFSDMLVSVTGAASGIGRATALEFARLGAEIVVSDIDEAGAKAT
Mflv_0407|M.gilvum_PYR-GCK --------MTKSVFITGAATGIGRATALLFAGRGYRVGGYDLDEDGLAVL
Mvan_0267|M.vanbaalenii_PYR-1 --------MTKSVFITGAATGIGRATALLFAQRGYRVGGYDIDEAGLRLL
TH_3493|M.thermoresistible__bu ------MRNDKAIFITGAAAGIGRATALTFARKGYTVGAYDIDEAGLGTL
Mb1914c|M.bovis_AF2122/97 ---------MKAIFITGAGSGMGREGATLFHANGWRVGAIDRNEDGLAAL
Rv1882c|M.tuberculosis_H37Rv ---------MKAIFITGAGSGMGREGATLFHANGWRVGAIDRNEDGLAAL
MMAR_2770|M.marinum_M ---------MKSVFITGAGSGMGREGAKLFHAKGWRVAAVDRDGAGLDAL
MUL_2977|M.ulcerans_Agy99 ---------MKSGFVTGAGSGMGREGAKLFHAKGWRVAAVDRDGAGLDAL
MAV_2820|M.avium_104 ---------MKSIFITGAGSGMGREGAKLFHAKGWRVGAVDRNDDGLATL
MAB_4335|M.abscessus_ATCC_1997 -MGTAVQLAGKVVAVTGGARGIGRAIATAFAAEGAKVAIGDIDKKLCENT
:**.. *:*: * : * : * :
MLBr_01094|M.leprae_Br4923 EGQLKAIGASARTDRLDVTEREAFLTYADVVHEN--FGKVNQIYNNAGIA
MSMEG_4280|M.smegmatis_MC2_155 ATAIDEAGGVAHAYGLDVADPDAVQRFVDDVCAT--HGVPDIVVNNAGIG
Mflv_0407|M.gilvum_PYR-GCK AADITAVGGTPVVAHLDVTDPDEVARRLAEFAEG-SGGRIDVLINNAGLL
Mvan_0267|M.vanbaalenii_PYR-1 AADITAVGGRPVVGRLDVTDADEVAHRLAEFVDA-AGGRLDVLINNAGLL
TH_3493|M.thermoresistible__bu AEEIGRLGATVHTGHLDVTDTDEMATRVSEFATQ-AGNRLDVMVNNAGIL
Mb1914c|M.bovis_AF2122/97 RVQLGAE--RLWARAVDVTDKAALEGALADFCAGNVGGGLDMMWNNAGIG
Rv1882c|M.tuberculosis_H37Rv RVQLGAE--RLWARAVDVTDKAALEGALADFCAGNVGGGLDMMWNNAGIG
MMAR_2770|M.marinum_M GAELGTE--RLWTRVVDVTDRDALDRALADFCAGTSHGGLDMMWNNAGIG
MUL_2977|M.ulcerans_Agy99 GAELGTE--RLWTRVVDVTDRDALDRALADFCAGTSHGGLDMMWNNAGIG
MAV_2820|M.avium_104 QQELGDD--RLWTRAVDVTDKAALDGALADFCAGNTGGGLDMMWNNAGIG
MAB_4335|M.abscessus_ATCC_1997 AAEIGNS---AIGLPLDVTDHGSFEAFFDTIAAT--VGPVDVIVNNAGIM
: :**:: . . . : : ****:
MLBr_01094|M.leprae_Br4923 FTGDVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDG-HVINISSV
MSMEG_4280|M.smegmatis_MC2_155 HAGNFLDTPADQYERVLEVNFGGVVNCCRAFGRRLVEQGTGGHIVNVASM
Mflv_0407|M.gilvum_PYR-GCK NAGRFEEIPLEVHHREIEVNVKGVVNGLHAAFPYLK-GTPGAVVVNLASA
Mvan_0267|M.vanbaalenii_PYR-1 QAGRFEDIPLPVHHRAIEVNVKGVVNGLHAAFPYLR-DTPDAVVVNLSSA
TH_3493|M.thermoresistible__bu KAGRFEDIDVRAHFAEIDVNTKGVVNGLHAAFPHLR-ATPDSVVVNLASA
Mb1914c|M.bovis_AF2122/97 EGGWFEDVPYEAAVRVVDVNFKAVLTGAYAALPYLK-KAPGSLMFSTSSS
Rv1882c|M.tuberculosis_H37Rv EGGWFEDVPYEAAVRVVDVNFKAVLTGAYAALPYLK-KAPGSLMFSTSSS
MMAR_2770|M.marinum_M EGGWFEDVPYDAAMRVVDVNFKAVLTGAYGALPYLR-KAPGSLMFSTSSS
MUL_2977|M.ulcerans_Agy99 EGGWFEDVPYDAAMRVVDVNFKAVLTGAYGALPYLR-KAPGSLMFSTSSS
MAV_2820|M.avium_104 ESGWFEDVPYDAAMRVVDVNYKAVLTGAYGALPYLK-KSAGSLMFSTSSS
MAB_4335|M.abscessus_ATCC_1997 PITPFDDESLESIQRQLDINVRGVMWGSQLAIKRMK-PRGGGVIVNIASA
. :::: .*: : . :.. :*
MLBr_01094|M.leprae_Br4923 FGLFSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGGIKTA
MSMEG_4280|M.smegmatis_MC2_155 AAYSPAGSMNAYATSKAAVFMFSDCLRAELAHAG--IGVTTLCPGMIDTG
Mflv_0407|M.gilvum_PYR-GCK SAIYGQAELANYSATKFFVRAITEALNLEWGHYG--IRVIDMWPLYVNTA
Mvan_0267|M.vanbaalenii_PYR-1 SAIYGQVELANYSATKFYVRAITEALNLEWAQHG--IRVIDMWPLYVNTA
TH_3493|M.thermoresistible__bu SAIYGQPELANYSATKFFVRGLTEALDLEWGRYG--IRVVAIWPLYVQTP
Mb1914c|M.bovis_AF2122/97 SGTYGMPRIAVYSATKHAVKGLTEALSVEWQRHG--VRVADVLPGLIDTA
Rv1882c|M.tuberculosis_H37Rv SGTYGMPRIAVYSATKHAVKGLTEALSVEWQRHG--VRVADVLPGLIDTA
MMAR_2770|M.marinum_M SATYGMPRLAVYSATKHAVKGLTEALSAEWRRHG--VRVADVLPGLIDTA
MUL_2977|M.ulcerans_Agy99 SATYGMPRLAVYSATKHAVKGLTEALSAEWRRHG--VRVADVLPGLIDTA
MAV_2820|M.avium_104 SATYGMPRLAVYSSTKHAVKGLTEALSVEWQRHG--VRVADVLPGLIDTA
MAB_4335|M.abscessus_ATCC_1997 AGKAGFPGLATYCATKHAVVGLSESLSLEYEPAG--ISVVCVMPGMVNTE
. * ::* * :::.* * * : * : * :.*
MLBr_01094|M.leprae_Br4923 IARN--------ATAAEGLD-VSKIASRFDTWVAHTSPQHAARIILKAVR
MSMEG_4280|M.smegmatis_MC2_155 IVDTTRFDV--PAHKAGQVE-ARRAQVKKTFQARRYGPEKVAKAVTSAVS
Mflv_0407|M.gilvum_PYR-GCK MTKDVKTG------TTQSLG-IRLTAQD-----IANDIVAAVDATWARKA
Mvan_0267|M.vanbaalenii_PYR-1 MTQGVKTG------TTQSLG-IRLTAQD-----IARDIVTAVEATWPRRL
TH_3493|M.thermoresistible__bu MLTGVDTG------TTRSLG-VRLTAQD-----VADVIVSAVEPSRLRRT
Mb1914c|M.bovis_AF2122/97 ILTSTRQHSDEGPYTISAEQ-IRAAAPKKGMFRLMPSSSVAEAAWRAYQH
Rv1882c|M.tuberculosis_H37Rv ILTSTRQHSDEGPYTISAEQ-IRAAAPKKGMFRLMPSSSVAEAAWRAYQH
MMAR_2770|M.marinum_M ILTSTRQHSDASAPTLSSEQ-IRAAAPKKGMFRLLPASSVAEAAWQAYQH
MUL_2977|M.ulcerans_Agy99 ILTSTRQHSDASAPTLSSEQ-IRAAAPKKGMFRLLPASSVAEAAWHAYQH
MAV_2820|M.avium_104 ILTTTTNHSNDGAAPMTAEE-LRATAPKKGMLRLMPASSVAEVAWRAYNH
MAB_4335|M.abscessus_ATCC_1997 LISGLDTHWLLKTVEPEDIANAVVKAVRRGVFPVFVPKMFGGMYRTMSVL
:
MLBr_01094|M.leprae_Br4923 KKKARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQR
MSMEG_4280|M.smegmatis_MC2_155 RNQALRPVTPEAYVAYGVSRLFPAALRRAARSQVL--------
Mflv_0407|M.gilvum_PYR-GCK LAQVHFPVGLQAKALALGARFSPAWLTRLVNKGLAGS------
Mvan_0267|M.vanbaalenii_PYR-1 VKQVHFPVGGQAKALALGSRFSPAWLTRLINKRLAGS------
TH_3493|M.thermoresistible__bu VRQVHYPVGAQTKAFALGSRFSPAWLTRALNKRLAGS------
Mb1914c|M.bovis_AF2122/97 PTRLHWYVPRSIRWIDRLKGVSPEFVRRHIAKSLATLEPKRK-
Rv1882c|M.tuberculosis_H37Rv PTRLHWYVPRSIRWIDRLKGVSPEFVRRHIAKSLATLEPKRK-
MMAR_2770|M.marinum_M PTRLHWYVPPSVRWIDRLKGVSPEFVRSRILKSLPTFGAGQQ-
MUL_2977|M.ulcerans_Agy99 PTRLHWYVPPSIRWIDRLKGVSPEFVRSRILKSLPTFGTGQQ-
MAV_2820|M.avium_104 PRRLHWYVPRSIRLIDVFKGLSPEFVRRSIVKSLPALMPKRQ-
MAB_4335|M.abscessus_ATCC_1997 PRSTGKFLTRKLGIQDFMLNAHGSDARKAYEDRASHSGPSTE-
: .