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PTYELLRYHFRSPETAAHFLQTSASHDRRQDRGTETLGISASPSDPTIVVEIVCHTDESGARPATDAPGI QRVETLALEPRAAGVSEASRGRSGQGRLAGKVALITGGARGQGEAEARLFAQHGAHVYICDVLEEEGEKL AAELRGSGLQADFRFLDVTDAEQWSRTVAHIDAGAGRLDVLINNAGINVRHQLTDTTSEEWDRIVAVNTK GQMLGMQACAPLMKRSGNGSIINIGSTAGIMGHPVAAYSASKWAVRGLTKAAAMELASSGIRVNAMHPGV VETPMVDAGSRVFAELRSLTPLGRAAQPSEMASAALFLASDEASFITGIDLAVDGGFSELAAYGEVWKRL NTAL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2477 | - | - | 100% (355) | cyclopentanol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3515 | - | 3e-54 | 48.76% (242) | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3009 | - | 1e-45 | 42.68% (246) | 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2025 | fabG3 | 3e-52 | 47.33% (243) | 20-beta-hydroxysteroid dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4505 | - | 4e-55 | 49.79% (243) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2002 | fabG3 | 3e-52 | 47.33% (243) | 20-beta-hydroxysteroid dehydrogenase |
| M. leprae Br4923 | MLBr_01740 | - | 2e-26 | 32.22% (270) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4680c | - | 3e-51 | 45.27% (243) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0387 | fabG3 | 3e-54 | 48.35% (242) | 20-beta-hydroxysteroid dehydrogenase FabG3 |
| M. avium 104 | MAV_2509 | - | 4e-53 | 47.11% (242) | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase |
| M. thermoresistible (build 8) | TH_4254 | - | 3e-47 | 42.06% (252) | PUTATIVE putative 2,5-dichloro-2,5-cyclohexadiene-1,4-diol |
| M. ulcerans Agy99 | MUL_1037 | fabG3 | 6e-54 | 47.93% (242) | 20-beta-hydroxysteroid dehydrogenase FabG3 |
| M. vanbaalenii PYR-1 | Mvan_3000 | - | 2e-53 | 45.97% (248) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2025|M.bovis_AF2122/97 --------------------------------------------------
Rv2002|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2509|M.avium_104 --------------------------------------------------
Mflv_4505|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0387|M.marinum_M --------------------------------------------------
MUL_1037|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3000|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2477|M.smegmatis_MC2_155 MPTYELLRYHFRSPETAAHFLQTSASHDRRQDRGTETLGISASPSDPTIV
TH_4254|M.thermoresistible__bu --------------------------------------------------
MAB_4680c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01740|M.leprae_Br4923 --------------------------------------------------
Mb2025|M.bovis_AF2122/97 --------------------------------------------MSGRLI
Rv2002|M.tuberculosis_H37Rv --------------------------------------------MSGRLI
MAV_2509|M.avium_104 --------------------------------------------MAERLA
Mflv_4505|M.gilvum_PYR-GCK --------------------------------------------MTGRLA
MMAR_0387|M.marinum_M ---------------------------------------------MGRVD
MUL_1037|M.ulcerans_Agy99 ---------------------------------------------MGRVD
Mvan_3000|M.vanbaalenii_PYR-1 ---------------------------------------------MGRVD
MSMEG_2477|M.smegmatis_MC2_155 VEIVCHTDESGARPATDAPGIQRVETLALEPRAAGVSEASRGRSGQGRLA
TH_4254|M.thermoresistible__bu -----------------------------------------MTAGSTRLA
MAB_4680c|M.abscessus_ATCC_199 -----------------------------------------MNGNSALLQ
MLBr_01740|M.leprae_Br4923 -----------------------------------------MVKTAQYFV
.
Mb2025|M.bovis_AF2122/97 GKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAVAAELA----
Rv2002|M.tuberculosis_H37Rv GKVALVSGGARGMGASHVRAMVAEGAKVVFGDILDEEGKAVAAELA----
MAV_2509|M.avium_104 GKVALVSGGARGMGASHVRSLVAEGAKVVFGDILDDEGKAVAAEVG----
Mflv_4505|M.gilvum_PYR-GCK GKVALISGAARGMGASHARVMAGHGAKVVCGDILDSDGEAVAAELG----
MMAR_0387|M.marinum_M GKVALISGGARGMGASHARLLVQEGAKVVIGDILDEEGKALAEEIG----
MUL_1037|M.ulcerans_Agy99 GKVALISGGARGMGASHARLLVQEGAKVVIGDILDEEGKALAEEIG----
Mvan_3000|M.vanbaalenii_PYR-1 GKVALISGGAQGMGAADARALIAEGAKVVIGDILDDKGKALADEINAETP
MSMEG_2477|M.smegmatis_MC2_155 GKVALITGGARGQGEAEARLFAQHGAHVYICDVLEEEGEKLAAELRG-SG
TH_4254|M.thermoresistible__bu GKVVLVTGAGGGLGTAIARRLADEGARLVLADLQESQCAALADELPAP-A
MAB_4680c|M.abscessus_ATCC_199 GKNVIVTGGARGLGAAFSRHIVSQGGRVVIADVLDGDGRQLAAELG----
MLBr_01740|M.leprae_Br4923 GKRCFVTGAASGIGRATALRLAAYGAELYLTDRHCDGLAQTVSEARALGA
** :::*.. * * : : *..: * . *
Mb2025|M.bovis_AF2122/97 DAARYVHLDVTQPAQWTAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYAL
Rv2002|M.tuberculosis_H37Rv DAARYVHLDVTQPAQWTAAVDTAVTAFGGLHVLVNNAGILNIGTIEDYAL
MAV_2509|M.avium_104 EATRYLHLDVTKPEDWDAAVATALAEFGRIDVLVNNAGIINIGTLEDYAL
Mflv_4505|M.gilvum_PYR-GCK DAARYVHLDVTSPDDWDRAVAAAVADFGGLDVLVNNAGILNIGTVEDYEL
MMAR_0387|M.marinum_M DAARYVHLDVTQPDQWEAAVATAVDEFGKLDVLVNNAGIVALGQLKKFDL
MUL_1037|M.ulcerans_Agy99 DAARYVHLDVTQPDQWEAAVATAVDEFGKLDVLVNNVGIVALGQLKKFDL
Mvan_3000|M.vanbaalenii_PYR-1 DSIRYVHLDVTQADQWEAAVATAVDAFGKLNVLVNNAGTVALGQIGQFDM
MSMEG_2477|M.smegmatis_MC2_155 LQADFRFLDVTDAEQWSRTVAHIDAGAGRLDVLINNAGINVRHQLTDTTS
TH_4254|M.thermoresistible__bu GAHHPLGFDVADETAWISAISTVSAQYGALHALVNNAAIGALGNVAEERL
MAB_4680c|M.abscessus_ATCC_199 DAARFTHLDVTDAEQWRELIDTTLAGFGTITGLVNNAGISSAAMVADEPL
MLBr_01740|M.leprae_Br4923 QVPEYRALDISDYDEVAAFGADIHARHPSMDIVMNIAGVSVWGTVDRLTH
:*::. : ::* .. :
Mb2025|M.bovis_AF2122/97 TEWQRILDVNLTGVFLGIRAVVKPMKEAG-RGSIINISSIEG-LAGTVAC
Rv2002|M.tuberculosis_H37Rv TEWQRILDVNLTGVFLGIRAVVKPMKEAG-RGSIINISSIEG-LAGTVAC
MAV_2509|M.avium_104 SEWQRILDINLTGVFLGIRAVVKPMKKAG-RGSIINISSIEG-MAGTIAC
Mflv_4505|M.gilvum_PYR-GCK SEWHRILDVNLTGVFLGIRAATPTMKAAG-RGSIINIASIEG-MAGTVGC
MMAR_0387|M.marinum_M GKWQKVIDVNLTGTFLGMRAAVEPMTAAG-SGSIINVSSIEG-LRGAPAV
MUL_1037|M.ulcerans_Agy99 GKWQKVIDVNLTGTFLGMRAAVEPMTAAG-SGSIINVSSIEG-LRGAPAV
Mvan_3000|M.vanbaalenii_PYR-1 AKWQKVIDVNLTGTFLGMQASVEAMKTAG-GGSIINISSIEG-LRGAVMV
MSMEG_2477|M.smegmatis_MC2_155 EEWDRIVAVNTKGQMLGMQACAPLMKRSG-NGSIINIGSTAG-IMGHP-V
TH_4254|M.thermoresistible__bu ERWDRILDVGATGVWLGMKHAVPLIRRSG-GGSVVNICSIFGTVGGFGDS
MAB_4680c|M.abscessus_ATCC_199 EHFRKVIEINLVGVFIGMQAVIPAMRAHG-CGSIVNISSAAG-LVGLALT
MLBr_01740|M.leprae_Br4923 DQWSNVVAINLMGPIHIIETFVPAILAAGRGGHLVNVSSAAG-LVALPWH
.: .:: :. * :. : * * ::*: * * : .
Mb2025|M.bovis_AF2122/97 HGYTATKFAVRGLTKSTALELGPSGIRVNSIHPGLVKTPMTDW-------
Rv2002|M.tuberculosis_H37Rv HGYTATKFAVRGLTKSTALELGPSGIRVNSIHPGLVKTPMTDW-------
MAV_2509|M.avium_104 HGYTATKFAVRGLTKSAALELGPSGIRVNSIHPGLIKTPMTEW-------
Mflv_4505|M.gilvum_PYR-GCK HGYTATKFAVRGLTKSTALELGPFGIRVNSVHPGLVKTPMADW-------
MMAR_0387|M.marinum_M HPYVASKWAVRGLTKSAALELAPLNIRVNSIHPGFIRTPMTAN-------
MUL_1037|M.ulcerans_Agy99 HPYVASKWAVRGLTKSAALELAPLNIRVNSIHPGFIRTPMTAN-------
Mvan_3000|M.vanbaalenii_PYR-1 HPYVASKWAVRGLTKSAALELGSHNIRVNSVHPGFIRTPMTKH-------
MSMEG_2477|M.smegmatis_MC2_155 AAYSASKWAVRGLTKAAAMELASSGIRVNAMHPGVVETPMVDAGSR---V
TH_4254|M.thermoresistible__bu AAYHAAKGAVRTLTKNAALHWAPDGVRVNSLHPGFIETPQLRELYKGTER
MAB_4680c|M.abscessus_ATCC_199 SGYGASKWGVRGLSKVAAIELGRERIRVNSVHPGVIYTPMTAKEGFR--E
MLBr_01740|M.leprae_Br4923 AAYSASKYGLRGLSEVLRFDLARYRIGVSVVVPGAVRTPLVDTIEIAGVD
* *:* .:* *:: :. . : *. : ** : **
Mb2025|M.bovis_AF2122/97 VPEDIFQTALGRA-----AEPVEVSNLVVYLASDESSYSTGAEFVVDGG-
Rv2002|M.tuberculosis_H37Rv VPEDIFQTALGRA-----AEPVEVSNLVVYLASDESSYSTGAEFVVDGG-
MAV_2509|M.avium_104 VPEDIFQSALGRA-----AEPKEVSNLVVYLASDESSYSTGSEFVVDGG-
Mflv_4505|M.gilvum_PYR-GCK VPEDIFQSALGRI-----AQPHEVSNLVVYLASDESSYSTGAEFVVDGG-
MMAR_0387|M.marinum_M LPDDMVTIPLGRP-----AESREVSTFVVFLASDDASYATGSEFVMDGG-
MUL_1037|M.ulcerans_Agy99 LPDDMVTIPLGRP-----AESREVSTFVVFLASDDASYATGSEFVMDGG-
Mvan_3000|M.vanbaalenii_PYR-1 FPDNMLRIPLGRP-----GQPEEVATFVVFLASDESRYATGAEFVMDGG-
MSMEG_2477|M.smegmatis_MC2_155 FAELRSLTPLGRA-----AQPSEMASAALFLASDEASFITGIDLAVDGG-
TH_4254|M.thermoresistible__bu YERMLAGTPLGRL-----GRPDEIAAVVAFLVSDDASFITGSEVYADGG-
MAB_4680c|M.abscessus_ATCC_199 GEGNMPIAAMGRV-----GNADEVAGAVAYLLSDAASYVTGAELAVDGG-
MLBr_01740|M.leprae_Br4923 RQDPRFSRWVDRFRGHAVSAERAAEKILAGVAKNRYLIYTSHDIRVLYGF
:.* . : .: *. :. *
Mb2025|M.bovis_AF2122/97 -----TVAGLAHNDFGAVEVSSQPEWVT----------------------
Rv2002|M.tuberculosis_H37Rv -----TVAGLAHNDFGAVEVSSQPEWVT----------------------
MAV_2509|M.avium_104 -----TTAGLGHKDFSNVETDAQPDWVT----------------------
Mflv_4505|M.gilvum_PYR-GCK -----TLAGLAHKDFSAVDVDQQPEWIT----------------------
MMAR_0387|M.marinum_M -----LVTDVPHKQF-----------------------------------
MUL_1037|M.ulcerans_Agy99 -----LVTDVPHKQF-----------------------------------
Mvan_3000|M.vanbaalenii_PYR-1 -----LTNDVPHK-------------------------------------
MSMEG_2477|M.smegmatis_MC2_155 -----FSELAAYGEVWKRLNTAL---------------------------
TH_4254|M.thermoresistible__bu -----WTAR-----------------------------------------
MAB_4680c|M.abscessus_ATCC_199 -----WTAGPTLTTITGQ--------------------------------
MLBr_01740|M.leprae_Br4923 KRLAWWPYGVVMKQVNVVFTRALRPSPATMRCVEPIKVGVYSQPRSGEGG
Mb2025|M.bovis_AF2122/97 ----
Rv2002|M.tuberculosis_H37Rv ----
MAV_2509|M.avium_104 ----
Mflv_4505|M.gilvum_PYR-GCK ----
MMAR_0387|M.marinum_M ----
MUL_1037|M.ulcerans_Agy99 ----
Mvan_3000|M.vanbaalenii_PYR-1 ----
MSMEG_2477|M.smegmatis_MC2_155 ----
TH_4254|M.thermoresistible__bu ----
MAB_4680c|M.abscessus_ATCC_199 ----
MLBr_01740|M.leprae_Br4923 KSGN