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MKSGFVTGAGSGMGREGAKLFHAKGWRVAAVDRDGAGLDALGAELGTERLWTRVVDVTDRDALDRALADF CAGTSHGGLDMMWNNAGIGEGGWFEDVPYDAAMRVVDVNFKAVLTGAYGALPYLRKAPGSLMFSTSSSSA TYGMPRLAVYSATKHAVKGLTEALSAEWRRHGVRVADVLPGLIDTAILTSTRQHSDASAPTLSSEQIRAA APKKGMFRLLPASSVAEAAWHAYQHPTRLHWYVPPSIRWIDRLKGVSPEFVRSRILKSLPTFGTGQQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2977 | - | - | 100% (277) | short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_4501 | - | 3e-21 | 39.49% (195) | short-chain type dehydrogenase/reductase |
| M. ulcerans Agy99 | MUL_3160 | - | 1e-20 | 33.85% (257) | short-chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1914c | - | 1e-130 | 83.03% (271) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0407 | - | 2e-37 | 42.25% (213) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv1882c | - | 1e-130 | 83.03% (271) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01094 | - | 6e-20 | 36.92% (195) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4335 | - | 5e-24 | 34.92% (189) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_2770 | - | 1e-158 | 98.19% (277) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_2820 | - | 1e-124 | 79.26% (270) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2872 | - | 2e-21 | 40.98% (183) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_1963 | - | 2e-97 | 65.70% (277) | PROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE |
| M. vanbaalenii PYR-1 | Mvan_0267 | - | 2e-37 | 44.15% (188) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0407|M.gilvum_PYR-GCK -------MTKSVFITGAATGIGRATALLFAGRGYRVGGYDLDEDGLAVLA
Mvan_0267|M.vanbaalenii_PYR-1 -------MTKSVFITGAATGIGRATALLFAQRGYRVGGYDIDEAGLRLLA
MUL_2977|M.ulcerans_Agy99 --------MKSGFVTGAGSGMGREGAKLFHAKGWRVAAVDRDGAGLDALG
MMAR_2770|M.marinum_M --------MKSVFITGAGSGMGREGAKLFHAKGWRVAAVDRDGAGLDALG
Mb1914c|M.bovis_AF2122/97 --------MKAIFITGAGSGMGREGATLFHANGWRVGAIDRNEDGLAALR
Rv1882c|M.tuberculosis_H37Rv --------MKAIFITGAGSGMGREGATLFHANGWRVGAIDRNEDGLAALR
MAV_2820|M.avium_104 --------MKSIFITGAGSGMGREGAKLFHAKGWRVGAVDRNDDGLATLQ
TH_1963|M.thermoresistible__bu ---VTRQTARAVFITGAGSGMGRAGAELFHARGWRVGAVDRNAEGLSGLR
MLBr_01094|M.leprae_Br4923 ---MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEGLAQTE
MSMEG_2872|M.smegmatis_MC2_155 ----MRIADRVFVVTGAGNGMGREVALGLARRGAHVAAVDLDEAGLAGTA
MAB_4335|M.abscessus_ATCC_1997 MGTAVQLAGKVVAVTGGARGIGRAIATAFAAEGAKVAIGDIDKKLCENTA
: :**.. *:*: * : * ::. * :
Mflv_0407|M.gilvum_PYR-GCK ADITAVGGTPVVAHLDVTDPDEVARRLAEFAEG-SGGRIDVLINNAGLLN
Mvan_0267|M.vanbaalenii_PYR-1 ADITAVGGRPVVGRLDVTDADEVAHRLAEFVDA-AGGRLDVLINNAGLLQ
MUL_2977|M.ulcerans_Agy99 AELGTE--RLWTRVVDVTDRDALDRALADFCAGTSHGGLDMMWNNAGIGE
MMAR_2770|M.marinum_M AELGTE--RLWTRVVDVTDRDALDRALADFCAGTSHGGLDMMWNNAGIGE
Mb1914c|M.bovis_AF2122/97 VQLGAE--RLWARAVDVTDKAALEGALADFCAGNVGGGLDMMWNNAGIGE
Rv1882c|M.tuberculosis_H37Rv VQLGAE--RLWARAVDVTDKAALEGALADFCAGNVGGGLDMMWNNAGIGE
MAV_2820|M.avium_104 QELGDD--RLWTRAVDVTDKAALDGALADFCAGNTGGGLDMMWNNAGIGE
TH_1963|M.thermoresistible__bu AQLGPE--RLFTGQVDVTDRSALEAGLARFCADNTGGGLDMMWNNAGIGA
MLBr_01094|M.leprae_Br4923 GQLKAIGASARTDRLDVTEREAFLTYADVVHEN--FGKVNQIYNNAGIAF
MSMEG_2872|M.smegmatis_MC2_155 ERARGTGARMSTHVLNVTDRDAVAGLPDAVLDV--HGQIDGLVNIAGIAQ
MAB_4335|M.abscessus_ATCC_1997 AEIGNS---AIGLPLDVTDHGSFEAFFDTIAAT--VGPVDVIVNNAGIMP
::**: . . * :: : * **:
Mflv_0407|M.gilvum_PYR-GCK -AGRFEEIPLEVHHREIEVNVKGVVNGLHAAFPYLKGTPGAVVVNLASAS
Mvan_0267|M.vanbaalenii_PYR-1 -AGRFEDIPLPVHHRAIEVNVKGVVNGLHAAFPYLRDTPDAVVVNLSSAS
MUL_2977|M.ulcerans_Agy99 -GGWFEDVPYDAAMRVVDVNFKAVLTGAYGALPYLRKAPGSLMFSTSSSS
MMAR_2770|M.marinum_M -GGWFEDVPYDAAMRVVDVNFKAVLTGAYGALPYLRKAPGSLMFSTSSSS
Mb1914c|M.bovis_AF2122/97 -GGWFEDVPYEAAVRVVDVNFKAVLTGAYAALPYLKKAPGSLMFSTSSSS
Rv1882c|M.tuberculosis_H37Rv -GGWFEDVPYEAAVRVVDVNFKAVLTGAYAALPYLKKAPGSLMFSTSSSS
MAV_2820|M.avium_104 -SGWFEDVPYDAAMRVVDVNYKAVLTGAYGALPYLKKSAGSLMFSTSSSS
TH_1963|M.thermoresistible__bu -SGWFEDVPHEAALRVVAINFTAVLTGAYAALPYLRRTPGSLMFSTSSSS
MLBr_01094|M.leprae_Br4923 TGDVEVS-HFKDIERVMDVDYWGVVNGTKAFLPYLISSGDGHVINISSVF
MSMEG_2872|M.smegmatis_MC2_155 RFALFTDLEADQIDRVTTVNFLGTVQMCRAFLPVLRQRPEANITNMSSLS
MAB_4335|M.abscessus_ATCC_1997 -ITPFDDESLESIQRQLDINVRGVMWGSQLAIKRMKPRGGGVIVNIASAA
. * :: ..: : : . : . :*
Mflv_0407|M.gilvum_PYR-GCK AIYGQAELANYSATKFFVRAITEALNLEWGHYG--IRVIDMWPLYVNTAM
Mvan_0267|M.vanbaalenii_PYR-1 AIYGQVELANYSATKFYVRAITEALNLEWAQHG--IRVIDMWPLYVNTAM
MUL_2977|M.ulcerans_Agy99 ATYGMPRLAVYSATKHAVKGLTEALSAEWRRHG--VRVADVLPGLIDTAI
MMAR_2770|M.marinum_M ATYGMPRLAVYSATKHAVKGLTEALSAEWRRHG--VRVADVLPGLIDTAI
Mb1914c|M.bovis_AF2122/97 GTYGMPRIAVYSATKHAVKGLTEALSVEWQRHG--VRVADVLPGLIDTAI
Rv1882c|M.tuberculosis_H37Rv GTYGMPRIAVYSATKHAVKGLTEALSVEWQRHG--VRVADVLPGLIDTAI
MAV_2820|M.avium_104 ATYGMPRLAVYSSTKHAVKGLTEALSVEWQRHG--VRVADVLPGLIDTAI
TH_1963|M.thermoresistible__bu ATYGMPQLAVYSATKHAVKGLTEALSVEWQRHG--VRVADIA--------
MLBr_01094|M.leprae_Br4923 GLFSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGGIKTAI
MSMEG_2872|M.smegmatis_MC2_155 ALVPFASQVLYSASKAAVQQFSEGLDAELADTN--VRVVTVFPGQVSTNL
MAB_4335|M.abscessus_ATCC_1997 GKAGFPGLATYCATKHAVVGLSESLSLEYEPAG--ISVVCVMPGMVNTEL
. . * ::* * ::*.* * . : * :
Mflv_0407|M.gilvum_PYR-GCK TKD----------------VKTGTTQSLGIRLTAQDIANDIVAAVDATWA
Mvan_0267|M.vanbaalenii_PYR-1 TQG----------------VKTGTTQSLGIRLTAQDIARDIVTAVEATWP
MUL_2977|M.ulcerans_Agy99 LTSTRQHSDASAPTLSSEQIRAAAPKKGMFRLLPASSVAEAAWHAYQHPT
MMAR_2770|M.marinum_M LTSTRQHSDASAPTLSSEQIRAAAPKKGMFRLLPASSVAEAAWQAYQHPT
Mb1914c|M.bovis_AF2122/97 LTSTRQHSDEGPYTISAEQIRAAAPKKGMFRLMPSSSVAEAAWRAYQHPT
Rv1882c|M.tuberculosis_H37Rv LTSTRQHSDEGPYTISAEQIRAAAPKKGMFRLMPSSSVAEAAWRAYQHPT
MAV_2820|M.avium_104 LTTTTNHSNDGAAPMTAEELRATAPKKGMLRLMPASSVAEVAWRAYNHPR
TH_1963|M.thermoresistible__bu ---------------------ARAPRRGMFRLLPPSSVAETAWAAYHDTG
MLBr_01094|M.leprae_Br4923 ARNAT----------AAEGLDVSKIASRFDTWVAHTSPQHAARIILKAVR
MSMEG_2872|M.smegmatis_MC2_155 AQNS-----------------GVKMLDAGGRRAPVTTPEAAGRKIVTGIA
MAB_4335|M.abscessus_ATCC_1997 ISGLDTHWLLKTVEPEDIANAVVKAVRRGVFPVFVPKMFGGMYRTMSVLP
Mflv_0407|M.gilvum_PYR-GCK R-----KALAQVHFPVGLQAKALALGARFSPAWLTRLVNKGLAGS-----
Mvan_0267|M.vanbaalenii_PYR-1 R-----RLVKQVHFPVGGQAKALALGSRFSPAWLTRLINKRLAGS-----
MUL_2977|M.ulcerans_Agy99 R----------LHWYVPPSIRWIDRLKGVSPEFVRSRILKSLPTFGTGQQ
MMAR_2770|M.marinum_M R----------LHWYVPPSVRWIDRLKGVSPEFVRSRILKSLPTFGAGQQ
Mb1914c|M.bovis_AF2122/97 R----------LHWYVPRSIRWIDRLKGVSPEFVRRHIAKSLATLEPKRK
Rv1882c|M.tuberculosis_H37Rv R----------LHWYVPRSIRWIDRLKGVSPEFVRRHIAKSLATLEPKRK
MAV_2820|M.avium_104 R----------LHWYVPRSIRLIDVFKGLSPEFVRRSIVKSLPALMPKRQ
TH_1963|M.thermoresistible__bu RSRWGRTRAGRLHWYVPDSLKWIDRLKGVSAEFVRGRIVKQLPALIEEDD
MLBr_01094|M.leprae_Br4923 K--------KKARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQ
MSMEG_2872|M.smegmatis_MC2_155 K--------DRYRVIIGTDAHVLYTLSRLAPRRTARMVAKQIKSVL----
MAB_4335|M.abscessus_ATCC_1997 R---------STGKFLTRKLGIQDFMLNAHGSDARKAYEDRASHSGPSTE
: : .
Mflv_0407|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0267|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_2977|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2770|M.marinum_M --------------------------------------------------
Mb1914c|M.bovis_AF2122/97 --------------------------------------------------
Rv1882c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2820|M.avium_104 --------------------------------------------------
TH_1963|M.thermoresistible__bu RMKSPADIEGFEIDSRARQVYGEPHVTADGTTIVPVARVSRRGTGDAARV
MLBr_01094|M.leprae_Br4923 R-------------------------------------------------
MSMEG_2872|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0407|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0267|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_2977|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2770|M.marinum_M --------------------------------------------------
Mb1914c|M.bovis_AF2122/97 --------------------------------------------------
Rv1882c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2820|M.avium_104 --------------------------------------------------
TH_1963|M.thermoresistible__bu TARPVGVLVIKDGRATWKPTVDSTRIALFSQLIGLVAAALAGLAMVRRPP
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
MSMEG_2872|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0407|M.gilvum_PYR-GCK -----------------------
Mvan_0267|M.vanbaalenii_PYR-1 -----------------------
MUL_2977|M.ulcerans_Agy99 -----------------------
MMAR_2770|M.marinum_M -----------------------
Mb1914c|M.bovis_AF2122/97 -----------------------
Rv1882c|M.tuberculosis_H37Rv -----------------------
MAV_2820|M.avium_104 -----------------------
TH_1963|M.thermoresistible__bu WPDLHGDISSRPRPARPARSGRR
MLBr_01094|M.leprae_Br4923 -----------------------
MSMEG_2872|M.smegmatis_MC2_155 -----------------------
MAB_4335|M.abscessus_ATCC_1997 -----------------------