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AQLSGKVVFITGGASGIGAALTARLGAAGAQVWIADRQFGVAEELAQRLRDTGARVHAVELDVRDPAAFA TAIAATVQTAGRIDYLFNNAGIGIGGEVDTLTLDDWNDIIDVNLRGVVHGIQAAYPIMIRQGSGHIVNTA SMAGLVTTSAQAGYSATKHAVVALSKTMRVEAATHGVRVSVLCPGVVRTPILSGGAYGRNKSVSREDLVK LGEALRPMDADDFADRALRAVLRNEAIIVVPRWWKALWYLERLSPALSMRTAAAALKRTREVQSAVPPQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3101 | - | - | 100% (280) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4644 | - | 4e-59 | 49.45% (273) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_0852 | - | 1e-42 | 41.67% (252) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3083c | - | 8e-34 | 37.45% (259) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3370 | - | 1e-132 | 84.59% (279) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv3057c | - | 8e-34 | 37.45% (259) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01740 | - | 9e-32 | 34.36% (259) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4022c | - | 3e-36 | 35.27% (275) | oxidoreductase |
| M. marinum M | MMAR_2600 | - | 7e-39 | 36.26% (273) | short-chain dehydrogenase |
| M. avium 104 | MAV_0895 | - | 7e-32 | 33.88% (242) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5235 | - | 2e-57 | 46.49% (271) | short chain dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_2445 | - | 1e-61 | 49.82% (273) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3160 | - | 2e-38 | 35.90% (273) | short-chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3083c|M.bovis_AF2122/97 ---MLQRGAGQYFAGKRCFVTGAASGIGRATALRLAAQGAELYLTDRDRD
Rv3057c|M.tuberculosis_H37Rv ---MLQRGAGQYFAGKRCFVTGAASGIGRATALRLAAQGAELYLTDRDRD
MLBr_01740|M.leprae_Br4923 ---MVKT--AQYFVGKRCFVTGAASGIGRATALRLAAYGAELYLTDRHCD
Mvan_3101|M.vanbaalenii_PYR-1 ---------MAQLSGKVVFITGGASGIGAALTARLGAAGAQVWIADRQFG
Mflv_3370|M.gilvum_PYR-GCK ----MASTDTAQLSGKVAFVTGGASGIGAALVAKLATAGTEVWIADRQIA
MSMEG_5235|M.smegmatis_MC2_155 ----------MSFTGKTAIVTGAGSGIGATLCRALVDAGADVLCTDVDAD
TH_2445|M.thermoresistible__bu ----------MTFAGKHALVTGAGSGIGAALCRALAAAGAEVMCTDIDG-
MMAR_2600|M.marinum_M MFKLNSGTNTSDLAGRVVAITGAGSGIGRELALLCAQRGADLALCDINDT
MUL_3160|M.ulcerans_Agy99 MFKLNSGTNTSDLAGRVVAITGAGSGIGRELALLCAQRGADLALCDINDT
MAB_4022c|M.abscessus_ATCC_199 MVKLN------QLQPQLVVVTGAGSGIGRATAIRFAKRGAHVVVSDMDLD
MAV_0895|M.avium_104 -----MDGFLSGFDGRAAVVTGGASGIGLATATEFARRGARLVLSDVDQP
: : :**..**** *: : * .
Mb3083c|M.bovis_AF2122/97 GLAQTVCDARALGAQVPEHRVLDVSDYQDVAAFAADIHARHPSMDVVLNI
Rv3057c|M.tuberculosis_H37Rv GLAQTVCDARALGAQVPEHRVLDVSDYQDVAAFAADIHARHPSMDVVLNI
MLBr_01740|M.leprae_Br4923 GLAQTVSEARALGAQVPEYRALDISDYDEVAAFGADIHARHPSMDIVMNI
Mvan_3101|M.vanbaalenii_PYR-1 VAEELAQRLRDTGARV-HAVELDVRDPAAFATAIAATVQTAGRIDYLFNN
Mflv_3370|M.gilvum_PYR-GCK PAEELAAQLRATGAVA-HAVELDVRDPAAFAHAVHTAVDTSGRLDYLFNN
MSMEG_5235|M.smegmatis_MC2_155 AAARTAAARTAAALGA-RSARLDVTDAAAVQTTVDDVVARAGRLDLMFNN
TH_2445|M.thermoresistible__bu ----AAAERTAQSIGG-RWAALDVTDAAAVQAAVDGVVDRAGRLDLLFNN
MMAR_2600|M.marinum_M AVADTAQTARGFGHDV-ITRRVDVSDPEQMTAFADATLGHFGGVDLLVNN
MUL_3160|M.ulcerans_Agy99 AVADTAQTARGFGHDV-ITRRVDVSDPEQMTAFADATLGHFGGVDLLVNN
MAB_4022c|M.abscessus_ATCC_199 SAHATTAMIQADGNTA-SAVQLDVTDPDQWETFARDVLADHGVADVLVNN
MAV_0895|M.avium_104 ALEQAVNGLRGQGFDA-HGVVCDVRHLDEMVRLADEAFRLLGGVDVVFSN
. . *: . * :..
Mb3083c|M.bovis_AF2122/97 AGVSAWGTVDQLTHDQWSRMVAINLMGPIHVIETLVPPMVAAGRGGHLVN
Rv3057c|M.tuberculosis_H37Rv AGVSAWGTVDQLTHDQWSRMVAINLMGPIHVIETLVPPMVAAGRGGHLVN
MLBr_01740|M.leprae_Br4923 AGVSVWGTVDRLTHDQWSNVVAINLMGPIHIIETFVPAILAAGRGGHLVN
Mvan_3101|M.vanbaalenii_PYR-1 AGIGIGGEVDTLTLDDWNDIIDVNLRGVVHGIQAAYPIMIRQG-SGHIVN
Mflv_3370|M.gilvum_PYR-GCK AGIGIGGEVDTLTLDDWTDIIDVNLKGVIHGVHAAYPQMIRQG-SGHIVN
MSMEG_5235|M.smegmatis_MC2_155 AGIVWGGDTELLTLDQWNAIIDVNIRGVVHGVAAAYPQMIRQG-HGHIVN
TH_2445|M.thermoresistible__bu AGIVWGGDTELLTLDQWNAIIDVNIRGVVHGVAAAYPLMVRQG-HGHIVN
MMAR_2600|M.marinum_M AGVGLIGGFLDTSRKDWDWLVSINVMGVVHGCEAFLPAMIESGRGGHVVN
MUL_3160|M.ulcerans_Agy99 AGVGLIGGFLDTSRKDWDWLVSINVMGVVHGCEAFLPAMIESGRGGHVVN
MAB_4022c|M.abscessus_ATCC_199 AGIALGGPFLKLTPADWDRLLSVNLMGVVHGCRVFGEQMVERG-SGHIVN
MAV_0895|M.avium_104 AGIVVAGPLAQMNHDDWRWVIDIDLWGSIHAVEAFLPRLLEQGTGGHIAF
**: * . :* :: ::: * :* . :: * **:.
Mb3083c|M.bovis_AF2122/97 VSSAAGLVGLPWHAAYSASKYGLRGLSEVLRFDLARHGIGVSVVVPGAVK
Rv3057c|M.tuberculosis_H37Rv VSSAAGLVGLPWHAAYSASKYGLRGLSEVLRFDLARHGIGVSVVVPGAVK
MLBr_01740|M.leprae_Br4923 VSSAAGLVALPWHAAYSASKYGLRGLSEVLRFDLARYRIGVSVVVPGAVR
Mvan_3101|M.vanbaalenii_PYR-1 TASMAGLVTTSAQAGYSATKHAVVALSKTMRVEAATHGVRVSVLCPGVVR
Mflv_3370|M.gilvum_PYR-GCK TASMAGLITTSAQGGYSATKHAVVALSKTMRVEAATHGVRVSVLCPGVVR
MSMEG_5235|M.smegmatis_MC2_155 TASMAGLAAAGQLTSYVMSKHAVVGLSLALRSEAAAHGVGVLAVCPAAVE
TH_2445|M.thermoresistible__bu TASMAGLAAAGQLTSYVMTKHAVVGLSLALRSEAAAHGVGVLAVCPAAVE
MMAR_2600|M.marinum_M LSSAAGLLANSALSAYSATKFAVLGLSEALRIELEPHRIGVTAICPGVIN
MUL_3160|M.ulcerans_Agy99 LSSAAGLLANPALSAYSATKFAVLGLSEALRIELEPHRIGVTAICPGVIN
MAB_4022c|M.abscessus_ATCC_199 IASAAAFTPTAVMAPYSVSKAGVKMLTECLRLELGPKGVGVSAICPGFIN
MAV_0895|M.avium_104 TASFAGLVPNAGLGTYGVAKYGVVGLAETLAREVKPNGIGVSVLCPMVVE
:* *.: * :* .: *: : : : * .: * :.
Mb3083c|M.bovis_AF2122/97 TPLVNTV--------EIAGVDRDDPRVNRWVERFSGHAVTPEKAADKILA
Rv3057c|M.tuberculosis_H37Rv TPLVNTV--------EIAGVDRDDPRVNRWVERFSGHAVTPEKAADKILA
MLBr_01740|M.leprae_Br4923 TPLVDTI--------EIAGVDRQDPRFSRWVDRFRGHAVSAERAAEKILA
Mvan_3101|M.vanbaalenii_PYR-1 TPILSGG---------AYGRNKSVSREDLVKLGEALRPMDADDFADRALR
Mflv_3370|M.gilvum_PYR-GCK TPILTGG---------AFGRNKSVSREDQLKLGEALRPMDAGVFAQKALR
MSMEG_5235|M.smegmatis_MC2_155 TPILDKG---------AVGG--FVGRDYFLRGQGMKTAYDPDRLAADTLR
TH_2445|M.thermoresistible__bu TPLLDKG---------AVGG--FLGRDYFIRGQGVRSAYDPDRLASDTLR
MMAR_2600|M.marinum_M TAI--------TKASPIRGAGDTEGRRQRLTVTYQRRGYTPARAARNILR
MUL_3160|M.ulcerans_Agy99 TAI--------TKASPIRGAGDTEGRRQRLTVTYQRRGYTPARAARNILR
MAB_4022c|M.abscessus_ATCC_199 TNIGLNGITVGVDQEMVQRGKEIMRRAQEFAAHLPFSPMSPDLVARAVTR
MAV_0895|M.avium_104 TKLVSNS---------------ERIRGADYGMSATPEGAFGPLPTQDESV
* : * :
Mb3083c|M.bovis_AF2122/97 GVTRNRYLVYTSADIRALYAFKRYAWWPYTLVMRRVNVFFTRALRPGP--
Rv3057c|M.tuberculosis_H37Rv GVTRNRYLVYTSADIRALYAFKRYAWWPYTLVMRRVNVFFTRALRPGP--
MLBr_01740|M.leprae_Br4923 GVAKNRYLIYTSHDIRVLYGFKRLAWWPYGVVMKQVNVVFTRALRPSPAT
Mvan_3101|M.vanbaalenii_PYR-1 AVLRNEAIIVVPRWWKALWYLERLSPALSMRTAAAALKRTREVQSAVPPQ
Mflv_3370|M.gilvum_PYR-GCK GVLRNEAIIVVPRWWKALWYLERLSPALSMRTAAVALKRTREVQSAVPLQ
MSMEG_5235|M.smegmatis_MC2_155 AIERNKALLVKPRRAHASWLLARLAPGLMQRLSVRFVAAQRASQARTANH
TH_2445|M.thermoresistible__bu AVQRNKALLVKPRVAHAGWLFARLAPGLMQRASIRFVERQRAGQRAAQVG
MMAR_2600|M.marinum_M AVERNKAVAPVAAEAHVMYVLSRIMPPLAR-------------WVSAQMA
MUL_3160|M.ulcerans_Agy99 AVERNKAVAPVAAEAHVMYVLSRIMPPLAR-------------WVSAQMA
MAB_4022c|M.abscessus_ATCC_199 AVRYDLAVVPVRTEAWLGYVLGRVAPGINRRTTQAFSIERAERWGAWALG
MAV_0895|M.avium_104 SADDVARLTADAILANRLYILPHAAARESIRRRFERIDRTFDEQAAEGWT
. : : : :
Mb3083c|M.bovis_AF2122/97 -------------------------
Rv3057c|M.tuberculosis_H37Rv -------------------------
MLBr_01740|M.leprae_Br4923 MRCVEPIKVGVYSQPRSGEGGKSGN
Mvan_3101|M.vanbaalenii_PYR-1 -------------------------
Mflv_3370|M.gilvum_PYR-GCK -------------------------
MSMEG_5235|M.smegmatis_MC2_155 -------------------------
TH_2445|M.thermoresistible__bu R------------------------
MMAR_2600|M.marinum_M KAAK---------------------
MUL_3160|M.ulcerans_Agy99 KAAK---------------------
MAB_4022c|M.abscessus_ATCC_199 KLDDLNLLSRQGGVEEDRKPTAARR
MAV_0895|M.avium_104 H------------------------