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MVWPAPPSRRWAPLSRLPSPPDQHGGVTVPTSPPTDPTTVTDMPPTRTGTDWPRLLLAPVAPAAWRAYLY VHLVSVLAIVDIAFLFAAGLASALMILTVIGIPLLALLVMSGRAWNRLYRALAQLVGAQIDAPPEFERPA GRLQVVTAALTDSVGWRSLGFLTLHAVLMTPIGFAVVVGVVASALLIVSPVVWLVTGEPFISLVEPVDSL AVYVVLSVAGVLALYLLGWVMIGISRVHVRVAAALLGPTGRERRVAQLENARAGVVDDAAARLQRVERDL HDGTQARLITVAMALARADEHLAEAGDTAQARMLVSDALANTKDTLAELRDLIRGIRPPALDLGLGPAIH TLAARNPIPVDVTVDLSVRPSIGVETMAYFCVAELLANVSKHSGAGAAAVRVAGDATELRIDVEDNGSGG VQVGNGSGLTGLAERLAMVDGRLEIDSPAGGPTVVTVVVPPGAGQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0262 | - | - | 100% (465) | putative signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_4385 | - | 3e-35 | 30.54% (406) | integral membrane sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_5907 | - | 8e-33 | 30.73% (384) | integral membrane sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0868 | - | 6e-14 | 28.15% (302) | two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_0967 | - | 1e-36 | 31.03% (406) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0845 | - | 2e-13 | 26.89% (331) | two component sensor kinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4499 | - | 1e-31 | 35.59% (222) | putative two-component system sensor kinase |
| M. marinum M | MMAR_4783 | - | 2e-09 | 25.38% (327) | two-component sensor kinase |
| M. avium 104 | MAV_4108 | - | 2e-11 | 32.35% (204) | GAF family protein |
| M. smegmatis MC2 155 | MSMEG_0458 | - | 3e-46 | 33.57% (420) | two-component system sensor kinase |
| M. thermoresistible (build 8) | TH_1533 | - | 5e-37 | 38.49% (265) | two-component system sensor kinase |
| M. ulcerans Agy99 | MUL_2422 | devS | 4e-09 | 27.55% (196) | two component sensor histidine kinase DevS |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4108|M.avium_104 MTGN---------------------------------------RFDELAA
MUL_2422|M.ulcerans_Agy99 MTDEPHPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4783|M.marinum_M --------------------------------------------------
Mflv_0967|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0458|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0262|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1533|M.thermoresistible__bu --------------------------------------------------
MAB_4499|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4108|M.avium_104 ARDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVRDWHA
MUL_2422|M.ulcerans_Agy99 GRDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEVHDRDK
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4783|M.marinum_M -----------MMGVVKQRADQLGRPDVAAETWQQCQLAHRPRLCWSQPA
Mflv_0967|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0458|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0262|M.vanbaalenii_PYR-1 ---------------------------------MVWPAPPSRRWAPLSRL
TH_1533|M.thermoresistible__bu --------------------------------------------------
MAB_4499|M.abscessus_ATCC_1997 ----------------------MQQAAQASSPRPILMPDYISGWRTQLFG
MAV_4108|M.avium_104 NLISFVHEGMDAETVRRIGHHPVGKGLLSLSLLDTPALRMDDLTAHPAAA
MUL_2422|M.ulcerans_Agy99 RVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLEDISQHPASI
Mb0868|M.bovis_AF2122/97 --------MPSYGNLGRLGG-----------RHEYGVLVAMTSSAELDRV
Rv0845|M.tuberculosis_H37Rv --------MPSYGNLGRLGG-----------RHEYGVLVAMTSSAELDRV
MMAR_4783|M.marinum_M RLAFWSGGGPVRAWLGRAGVRWATPSLAGVCRCEYGVPVGMTGDFELERV
Mflv_0967|M.gilvum_PYR-GCK -----------------------------------MMVQAPARTLVAAMI
MSMEG_0458|M.smegmatis_MC2_155 --------MTSVTTTQRSGR-----------------LRQLGVDSAYVLL
Mvan_0262|M.vanbaalenii_PYR-1 PSPPDQHGGVTVPTSPPTDPTTVTDMPPTRTGTDWPRLLLAPVAPAAWRA
TH_1533|M.thermoresistible__bu ------MVAVTAETAPAPAP--------------TRTARLGVVPTASMVT
MAB_4499|M.abscessus_ATCC_1997 STPPSARLGIVAAVVLLVAESMLTIFLRTIAPTEHLAAVYLIGILVISVI
MAV_4108|M.avium_104 GFPEHHPAMRAFLAVPITIRGAVFGNLYLTHVDEARVFSDADEMAARALA
MUL_2422|M.ulcerans_Agy99 GFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQALA
Mb0868|M.bovis_AF2122/97 RWAHQLRSYRIASVLRIGVVGLMVAAMVVGTSRS---------------E
Rv0845|M.tuberculosis_H37Rv RWAHQLRSYRIASVLRIGVVGLMVAAMVVGTSRS---------------E
MMAR_4783|M.marinum_M HKLHQLRSYRLVSVLRLGVLVFLIGAMLIGTPQH---------------E
Mflv_0967|M.gilvum_PYR-GCK SGPRYLVSMWPWRALLWTVFGGVLGTVLIVGLPLILVMG---------VS
MSMEG_0458|M.smegmatis_MC2_155 GFPLATVSFTVIVAMLAAGIATAVLVIGLPILVG----------------
Mvan_0262|M.vanbaalenii_PYR-1 YLYVHLVSVLAIVDIAFLFAAGLASALMILTVIG----------------
TH_1533|M.thermoresistible__bu GAAIALVWFWIPLTILIVGISSIPSVIGFLLAGV----------------
MAB_4499|M.abscessus_ATCC_1997 WRLRLALAMSIASAIVFDCIRNWPKANPLSTESHN----------LITHL
: .
MAV_4108|M.avium_104 FAAAVAIDNAQVFERERMSVKWIEASREITTALLSRTEPHRRPMQLIAER
MUL_2422|M.ulcerans_Agy99 AAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPAS-VFRLVAEE
Mb0868|M.bovis_AF2122/97 WPQQIVLIGVYAVAALWALLLAYSASRRFFALRRFRSMGRLEPFAFTAVD
Rv0845|M.tuberculosis_H37Rv WPQQIVLIGVYAVAALWALLLAYSASRRFFALRRFRSMGRLEPFAFTAVD
MMAR_4783|M.marinum_M WAQQITLVVVYVLAAAGALLLAFSPRR--VAASGAVTIRSWEPLAFTAVD
Mflv_0967|M.gilvum_PYR-GCK RSARTAVWAPLLEIECARLSLIDEAAAERARSDVNAARAQQRLPTLRQAG
MSMEG_0458|M.smegmatis_MC2_155 -----TLLVARVLADIERLRLPAVLRRPRIRPAYRKAAPGAGVWNRLGAV
Mvan_0262|M.vanbaalenii_PYR-1 -----IPLLALLVMSGRAWNRLYRALAQLVGAQIDAPPEFERPAGRLQVV
TH_1533|M.thermoresistible__bu --VFIYLIRGVEWVERIRSEAVFGMGIPIPPRRLSPHTGFQRWAHQLWLD
MAB_4499|M.abscessus_ATCC_1997 SFLAVTLTASALAALARAGTIEAERRRREAAAIAQQQAALRRTATLVASN
MAV_4108|M.avium_104 ACALTDAEQAIVLVPADPEQPGNPEVDTLVVSAAVGLPAADVLGQRVPVR
MUL_2422|M.ulcerans_Agy99 ALKLTSADAALVAIPVDEDVPAS-EVAQLLVIETVGNAVAAAEGCTIAVA
Mb0868|M.bovis_AF2122/97 VLILT----GFQLLSTDG---IYPLLIMILLPVLVGLDVSTRRAAVVLAC
Rv0845|M.tuberculosis_H37Rv VLILT----GFQLLSTDG---IYPLLIMILLPVLVGLDVSTRRAAVVLAC
MMAR_4783|M.marinum_M IAVLT----AFQLLSADG---IYPLLMMTLLPILVGVDVSSRRAMVVLAF
Mflv_0967|M.gilvum_PYR-GCK YMVLT-------AMFTGPWGVVLVGFSAILIGVMVAAPWLVRPGEPINVG
MSMEG_0458|M.smegmatis_MC2_155 MADAQSWLDVVHAVVRFPVSLVTFSVVVSWWAAALGGTSTAAWDWAVPRG
Mvan_0262|M.vanbaalenii_PYR-1 TAALTDSVGWRSLGFLTLHAVLMTPIGFAVVVGVVASALLIVSPVVWLVT
TH_1533|M.thermoresistible__bu ISSARFWKAAAHHYLRMSYDMLAVGVAFALLAFAFLGPAG---AIAVRNS
MAB_4499|M.abscessus_ATCC_1997 VSPVELYAKVVEEAARCFASPTAVLVQLMPGDEGTIVAGHGTEESRTPPA
.
MAV_4108|M.avium_104 GSTSGAVFKSGE---PLITDEFRYP-IQAFTDAGRRPAIVMPLRARDEVV
MUL_2422|M.ulcerans_Agy99 GTALAEVLLDSA---PRQVDKIAVEDVDELGDMG--PALVLPLRATDAVA
Mb0868|M.bovis_AF2122/97 TLVGFAVAVLGD---PVMLRAIGWP----------ETIFRFALYAFLCAT
Rv0845|M.tuberculosis_H37Rv TLVGFAVAVLGD---PVMLRAIGWP----------ETIFRFALYAFLCAT
MMAR_4783|M.marinum_M TIVGFTIAGVHD---NVLLGDAGWP----------DSVFVFSLYAFLCAT
Mflv_0967|M.gilvum_PYR-GCK ---LWLIDSSGE---AWAAVTLGIA------------LLVLAAYLVGAYA
MSMEG_0458|M.smegmatis_MC2_155 PDNQSLAQLIGLG--DSTVARIGFQTAAG------LLCLVSLPWVVRGCA
Mvan_0262|M.vanbaalenii_PYR-1 GEPFISLVEPVDS--LAVYVVLSVAG---------VLALYLLGWVMIGIS
TH_1533|M.thermoresistible__bu DDNAGLTFLPPAL--AVVLAVIAVA-------------AAAAILFFAPAV
MAB_4499|M.abscessus_ATCC_1997 GKRFPLLDSNNVARELRLTPAVCAPIVVDAKHWGTLIVGSHTPAQRDQDI
MAV_4108|M.avium_104 GVIAIARGTEQPPFDESYLDLVRDFATHAAIALVLAAAREDARQLAVLAE
MUL_2422|M.ulcerans_Agy99 GVVVLLHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVVTE
Mb0868|M.bovis_AF2122/97 ALMVVRIEERHTRSVAGLSALREELLAQTMTASEVLQR------------
Rv0845|M.tuberculosis_H37Rv ALMVVRIEERHTRSVAGLSALRAELLAQTMTASEVLQR------------
MMAR_4783|M.marinum_M ALVVVRTEERRVRSVAGLSALREALLAQTMTASEVLQR------------
Mflv_0967|M.gilvum_PYR-GCK AAVAQITVAALVDPHALQREVARLEHSRTALLDAVEQERR----------
MSMEG_0458|M.smegmatis_MC2_155 LLDAGLARTLLCGVSEMRQTITVLAEQKSAATSAEAHALR----------
Mvan_0262|M.vanbaalenii_PYR-1 RVHVRVAAALLG-PTGRERRVAQLENARAGVVDDAAARLQ----------
TH_1533|M.thermoresistible__bu DARIDRWLLPPSSTEALQHQVSALSDARAGAVSSAQTERH----------
MAB_4499|M.abscessus_ATCC_1997 RAGVRDFADLVATAIANAATREELAASRARIVSASDTARR----------
::
MAV_4108|M.avium_104 RERIAHDLHDHVIQRLFAAGMDLQGTLARARSP----EVADRLNRTLDDL
MUL_2422|M.ulcerans_Agy99 RDRIARDLHDHVIQRLFAIGLALQGSVPRTREP----KVQQRLSEVIDDL
Mb0868|M.bovis_AF2122/97 --RIAEAIHDGPLQDVLAARQELIELDAVTPG-------DERVGRALAGL
Rv0845|M.tuberculosis_H37Rv --RIAEAIHDGPLQDVLAARQELIELDAVTPG-------DERVGRALAGL
MMAR_4783|M.marinum_M --WISESIHDGPLQDVLVARQELVELQSVWPG-------DDRVERALAGL
Mflv_0967|M.gilvum_PYR-GCK --RIESDLHDRVQHRLVALALTLGIAENAHGDS----AAGRLAADAHGQV
MSMEG_0458|M.smegmatis_MC2_155 --RLERDIHDGPQQRLIRLAMDLGRARQHTQPG----ALQDIIDEAVVQT
Mvan_0262|M.vanbaalenii_PYR-1 --RVERDLHDGTQARLITVAMALARADEHLAEAGDTAQARMLVSDALANT
TH_1533|M.thermoresistible__bu --RIERDLHDSVQPRLVSLAMTIGLAQTKLDTDLP--AAKKLIAEAHEDA
MAB_4499|M.abscessus_ATCC_1997 --RLERDLHDGAQQRLAYLRLKLGMVRAAVPAT--DAELTQELNNLDTDL
: :** : :
MAV_4108|M.avium_104 QTIIEEIRTTIFALRSPAAVAGDFRHRIQRVIAELTENRDLVTTVRMDGP
MUL_2422|M.ulcerans_Agy99 QGVIQEIRTTIFDLHGSSQGVTRLRQRIDAAVAAFGSS-GLRTTVQFIGP
Mb0868|M.bovis_AF2122/97 QSASERLRQATFELHPAVLEQVGLGPAVKQLAASTAQRSGIKISTDIDYP
Rv0845|M.tuberculosis_H37Rv QSASERLRQATFELHPAVLEQVGLGPAVKQLAASTAQRSGIKISTDIDYP
MMAR_4783|M.marinum_M QSASERLRQATFELHPAVLEQVGLGAAVEQLATFTARRSGIEVSTDVDYP
Mflv_0967|M.gilvum_PYR-GCK DDIAAELRSVLLGILPRALTEHGLVAAATDLIGRYPVAVEADFGATEIPA
MSMEG_0458|M.smegmatis_MC2_155 QETLDELRALSRGIAPPVLTDRGLPSALAALAIRCTVPVELNVDPGLGTS
Mvan_0262|M.vanbaalenii_PYR-1 KDTLAELRDLIRGIRPPALDLG-LGPAIHTLAARNPIPVDVTVDLSVRPS
TH_1533|M.thermoresistible__bu KSALAELRDVVRGIAPTILTDRGLDAALSAVVQR-AETSGVPTTLNLHLP
MAB_4499|M.abscessus_ATCC_1997 TAVTRELQEFSRGLHP-AILSKGLAPALRTLARRSLIPVRTELELDQKYG
.:: : :
MAV_4108|M.avium_104 MTAVGAELAEHAEAVTAEAVSNAVRHSGASRLTVQIGVA------DMFT-
MUL_2422|M.ulcerans_Agy99 LSVVDNVLADHAEAVVREAVSNAVRHAQATTLTVRVKVD------DDLC-
Mb0868|M.bovis_AF2122/97 IR---SGIDPIVFGVVRELLSNVVRHSGATTASVRLGIT------DEKCV
Rv0845|M.tuberculosis_H37Rv IR---SGIDPIVFGVVRELLSNVVRHSGATTASVRLGIT------DEKCV
MMAR_4783|M.marinum_M IR---NEIDPIMFGVARELLSNVVHHARAKHVSVSLGIT------DGACV
Mflv_0967|M.gilvum_PYR-GCK RLP--GPVEHTAYLVLNEALTNSAKHASAGHVTITADRR------DGLWW
MSMEG_0458|M.smegmatis_MC2_155 AGRPDPAVETTVYFAVAEALTNVAKHSEATTCRVTVAAVPPTAQGSARIS
Mvan_0262|M.vanbaalenii_PYR-1 IG-----VETMAYFCVAELLANVSKHSGAGAAAVRVAGD------ATELR
TH_1533|M.thermoresistible__bu RRLP-EEVESVAYFVVAEALTNVVKHAQASQAVVTVRLN----ETDNTLQ
MAB_4499|M.abscessus_ATCC_1997 ES-----IEIAAYYVVAEALANTAKHSQASEVVIRAHEA------DDQIH
: * ::* :*: * :
MAV_4108|M.avium_104 LDVIDNGRGIAAGNTRR------SGLANMTRRAEQLGGSCEISSPP-GGG
MUL_2422|M.ulcerans_Agy99 IEVSDNGRGMPKTYTS-------SGLTNLRRRAQEAGGQFTIESPAAGGG
Mb0868|M.bovis_AF2122/97 LDVADDGVGVTGDTMARRLGEGHIGLASHRARVDAAGGVLVFLATPRGTH
Rv0845|M.tuberculosis_H37Rv LDVADDGVGVTGDTMARRLGEGHIGLASHRARVDAAGGVLVFLATPRGTH
MMAR_4783|M.marinum_M LDVADDGVGITGGTAARRLGEGHIGLASHRARVDAAGGTFVFLDAPAGTH
Mflv_0967|M.gilvum_PYR-GCK LVIRDDGRGGATIQPGR-------GLATLAARVEAVNGTLTV-TSPAGGP
MSMEG_0458|M.smegmatis_MC2_155 AEIIDDGRGGAHIAKGH-------GLAGLADRIRAGGGTLDV-SSPAGGP
Mvan_0262|M.vanbaalenii_PYR-1 IDVEDNGSGGVQVGNGS-------GLTGLAERLAMVDGRLEI-DSPAGGP
TH_1533|M.thermoresistible__bu VSVFDDGCGSAQISDRD----NATGLRGLAERVRAAHGTFTVSSPP-TGP
MAB_4499|M.abscessus_ATCC_1997 ITISDDGIGGAKPRKGT-------GLIGLTDRVTALGGRLDVHSASGRGT
: *:* * ** * * . ..
MAV_4108|M.avium_104 TRVHWTAPLLDH-----------------------------
MUL_2422|M.ulcerans_Agy99 TLLRWSAPLIQ------------------------------
Mb0868|M.bovis_AF2122/97 VCVELPLKR--------------------------------
Rv0845|M.tuberculosis_H37Rv VCVELPLKR--------------------------------
MMAR_4783|M.marinum_M VCVELPLKSVPSPAPDRHPPAGATSREALAASPRRRRPLGH
Mflv_0967|M.gilvum_PYR-GCK TEVGMRCPV--------------------------------
MSMEG_0458|M.smegmatis_MC2_155 STIAVALPV--------------------------------
Mvan_0262|M.vanbaalenii_PYR-1 TVVTVVVPPGAGQ----------------------------
TH_1533|M.thermoresistible__bu TIVTAVLPCGS------------------------------
MAB_4499|M.abscessus_ATCC_1997 TMTAIIPLHQSD-----------------------------