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MGVVKQRADQLGRPDVAAETWQQCQLAHRPRLCWSQPARLAFWSGGGPVRAWLGRAGVRWATPSLAGVCR CEYGVPVGMTGDFELERVHKLHQLRSYRLVSVLRLGVLVFLIGAMLIGTPQHEWAQQITLVVVYVLAAAG ALLLAFSPRRVAASGAVTIRSWEPLAFTAVDIAVLTAFQLLSADGIYPLLMMTLLPILVGVDVSSRRAMV VLAFTIVGFTIAGVHDNVLLGDAGWPDSVFVFSLYAFLCATALVVVRTEERRVRSVAGLSALREALLAQT MTASEVLQRWISESIHDGPLQDVLVARQELVELQSVWPGDDRVERALAGLQSASERLRQATFELHPAVLE QVGLGAAVEQLATFTARRSGIEVSTDVDYPIRNEIDPIMFGVARELLSNVVHHARAKHVSVSLGITDGAC VLDVADDGVGITGGTAARRLGEGHIGLASHRARVDAAGGTFVFLDAPAGTHVCVELPLKSVPSPAPDRHP PAGATSREALAASPRRRRPLGH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4783 | - | - | 100% (513) | two-component sensor kinase |
| M. marinum M | MMAR_4781 | - | e-154 | 68.98% (403) | two-component sensor kinase |
| M. marinum M | MMAR_3479 | - | 4e-08 | 26.09% (161) | two-component sensor histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0868 | - | 1e-158 | 70.63% (412) | two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_0729 | - | 4e-36 | 31.30% (393) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0845 | - | 1e-157 | 70.39% (412) | two component sensor kinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0061 | - | 4e-33 | 33.43% (329) | two component sensor kinase |
| M. avium 104 | MAV_0874 | - | 1e-141 | 63.30% (406) | hypothetical protein MAV_0874 |
| M. smegmatis MC2 155 | MSMEG_0106 | - | 1e-36 | 32.15% (395) | sensory histidine kinase |
| M. thermoresistible (build 8) | TH_4203 | - | 4e-12 | 26.50% (234) | PUTATIVE sensor histidine kinase |
| M. ulcerans Agy99 | MUL_0350 | - | 1e-158 | 68.82% (417) | two component sensor kinase |
| M. vanbaalenii PYR-1 | Mvan_2071 | - | 2e-17 | 30.08% (246) | multi-sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0729|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0106|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0061|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 --------------------------------------------------
MAV_0874|M.avium_104 --------------------------------------------------
MMAR_4783|M.marinum_M --------------------------------------------------
Mvan_2071|M.vanbaalenii_PYR-1 MPTRFLERVVRSPARPLGLGIAVAAGFLAAEVLAVFALKKIAPENAFGAL
TH_4203|M.thermoresistible__bu --------------------------------------------------
Mflv_0729|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0106|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0061|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 -------------------------------------------------M
MAV_0874|M.avium_104 --------------------------------------------------
MMAR_4783|M.marinum_M ----------------------------------------------MMGV
Mvan_2071|M.vanbaalenii_PYR-1 LLLGVLVVSAGWGFGLSIATSLASAAVYAYLHLEGRDSLAPALIIFLTLA
TH_4203|M.thermoresistible__bu --------------------------------------------------
Mflv_0729|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0106|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0061|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0868|M.bovis_AF2122/97 -------------------------------------------MPSYGNL
Rv0845|M.tuberculosis_H37Rv -------------------------------------------MPSYGNL
MUL_0350|M.ulcerans_Agy99 MNSRQREADRRQFAPSCRRQDESAGQS------LGQRRTERSPNPSCANY
MAV_0874|M.avium_104 --------------------------------------------------
MMAR_4783|M.marinum_M VKQRADQLGRPDVAAETWQQCQLAHRPRLCWSQPARLAFWSGGGPVRAWL
Mvan_2071|M.vanbaalenii_PYR-1 LLTNALVGQARLRAAEAEQRRREADLSADLARVMLRAPALGPALEDAGRR
TH_4203|M.thermoresistible__bu --------------------------------------------------
Mflv_0729|M.gilvum_PYR-GCK ------------------------MTGPFRFPSAWREFLAAEPVRVSAVL
MSMEG_0106|M.smegmatis_MC2_155 -----------------------------MISGRIVEFFASQPVRVSAVL
MAB_0061|M.abscessus_ATCC_1997 ----------------------------MTRLDNMADYFAAEPMRVSAWL
Mb0868|M.bovis_AF2122/97 G----------RLGG-RHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVL
Rv0845|M.tuberculosis_H37Rv G----------RLGG-RHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVL
MUL_0350|M.ulcerans_Agy99 G----------QLVGSCRLYGVPVVVTSDAELARVRRTHQLRAYRIGSVL
MAV_0874|M.avium_104 -----------------------MAVAGDAELERVRAVHQMRSYRIGSVL
MMAR_4783|M.marinum_M GRAGVRWATPSLAGVCRCEYGVPVGMTGDFELERVHKLHQLRSYRLVSVL
Mvan_2071|M.vanbaalenii_PYR-1 FADVLGLPYATLTVGGGATGADEMAIDLVDGAEHTGTLLVPRDLPLASVR
TH_4203|M.thermoresistible__bu -------------------------VTSGPHPDPVRDLSEQLLTADRELV
Mflv_0729|M.gilvum_PYR-GCK RLP-----LIGLIAVLVWIWEVNHWLPGLYAAILGSYAVVAVVWLLAVS-
MSMEG_0106|M.smegmatis_MC2_155 RLP-----LIGLIFVLVMVWEVDHWLPGLYAVILGLYAAAAVLWLVVVI-
MAB_0061|M.abscessus_ATCC_1997 RLP-----LIGLIVLLGSDPNIQMWHNGVYYGVLAAYTLSAVVWVGIAV-
Mb0868|M.bovis_AF2122/97 RIG-----VVGLMVAAMVVGTSRSEWP-QQIVLIGVYAVAALWALLLAYS
Rv0845|M.tuberculosis_H37Rv RIG-----VVGLMVAAMVVGTSRSEWP-QQIVLIGVYAVAALWALLLAYS
MUL_0350|M.ulcerans_Agy99 RIG-----VVLFMVAAMLVGTPRREWG-AQTALICVYAFAALWALALAFR
MAV_0874|M.avium_104 RVG-----VVGLMVAAMIIGTARSEWP-QESVLILLYGIIALGAVALAFA
MMAR_4783|M.marinum_M RLG-----VLVFLIGAMLIGTPQHEWA-QQITLVVVYVLAAAGALLLAFS
Mvan_2071|M.vanbaalenii_PYR-1 RIHRMVPSLQALLAAACDREDITAELEASRRELERFFAVASDLLFIGTYV
TH_4203|M.thermoresistible__bu LLR-------ELIQAASRGPGVEPLAAAAARMITAATASDVCFVHVLD--
: :: :
Mflv_0729|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0106|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0061|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0868|M.bovis_AF2122/97 ASRRFFALR-----------------------------------------
Rv0845|M.tuberculosis_H37Rv ASRRFFALR-----------------------------------------
MUL_0350|M.ulcerans_Agy99 RSRPMVSLD-----------------------------------------
MAV_0874|M.avium_104 PFRRWIGIG-----------------------------------------
MMAR_4783|M.marinum_M PRR--VAAS-----------------------------------------
Mvan_2071|M.vanbaalenii_PYR-1 DGVAQLTRVNPAFERALGYSAAELAARPLTEFIHPDDRDGTAAALDSVPQ
TH_4203|M.thermoresistible__bu --------------------------------------------------
Mflv_0729|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0106|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0061|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 --------------------------------------------------
MAV_0874|M.avium_104 --------------------------------------------------
MMAR_4783|M.marinum_M --------------------------------------------------
Mvan_2071|M.vanbaalenii_PYR-1 TDGATQFENRSLRRDGGVRWLEWNVVSDRGVLLGGARDVTERRREQDRLR
TH_4203|M.thermoresistible__bu --------------------------------------------------
Mflv_0729|M.gilvum_PYR-GCK --RGPVPRWADWASSAVDVLVIVSLCVVSGGATAALLPVFFLLPISVAFQ
MSMEG_0106|M.smegmatis_MC2_155 --RGPMPRWAEWASTAVDGLVLLALCAVSGGATAALLPVFFLLPISVAFQ
MAB_0061|M.abscessus_ATCC_1997 --RGQVADWVAPAATSADIAAVVMLCLASGAGNTELLPVFFLLPVSVAFQ
Mb0868|M.bovis_AF2122/97 -RFRSMGRLEPFAFTAVDVLILTGFQLLSTDGIYPLL-IMILLPVLVGLD
Rv0845|M.tuberculosis_H37Rv -RFRSMGRLEPFAFTAVDVLILTGFQLLSTDGIYPLL-IMILLPVLVGLD
MUL_0350|M.ulcerans_Agy99 -RFANIARYEPLAFTAVDVLALTGFQLLSTDGIYSLL-IMTLLPVLVALD
MAV_0874|M.avium_104 -RLAGVGRLEPFAFTVVDILALTIFQLLSTNGIYPLL-IMAMLPVLLGLD
MMAR_4783|M.marinum_M -GAVTIRSWEPLAFTAVDIAVLTAFQLLSADGIYPLL-MMTLLPILVGVD
Mvan_2071|M.vanbaalenii_PYR-1 MARTQQAALRRVATLVARGAPLSEVYDVAVTELAHSLGVNHVTLLAFEAD
TH_4203|M.thermoresistible__bu ---DTERSLTLAGATPPFDKEVGKIRLPLGQGISGWVASHREPVVITENK
. : . : : .
Mflv_0729|M.gilvum_PYR-GCK DRPALTAIIGSVTAVAYLTVWVFYS----------------RRDDEVGLP
MSMEG_0106|M.smegmatis_MC2_155 DRPLLTAMLGTATATGYLGAWIFYS----------------KRDDTVGLP
MAB_0061|M.abscessus_ATCC_1997 ERPAITAILGIITAVAYFGILVYYI----------------ADGNLERIP
Mb0868|M.bovis_AF2122/97 VSTRRAAVVLACTLVGFAVAVLGDP----------------VMLRAIGWP
Rv0845|M.tuberculosis_H37Rv VSTRRAAVVLACTLVGFAVAVLGDP----------------VMLRAIGWP
MUL_0350|M.ulcerans_Agy99 ISSRRAAVVLALTLVGFGLALAQDP----------------VVIRMNGWP
MAV_0874|M.avium_104 VSSRRAAVVLIFSMLGFAIAVLQDP----------------VMSSSVRLP
MMAR_4783|M.marinum_M VSSRRAMVVLAFTIVGFTIAGVHDN----------------VLLGDAGWP
Mvan_2071|M.vanbaalenii_PYR-1 DHAVVRAALKSAHQPGFAVGDRLSLDGGSISEQVHRTGLPARIDDYSEVP
TH_4203|M.thermoresistible__bu EADPRYLPFQSLRGRDFTSMVSVPMETD-----------PGGLVGVLNVH
. :
Mflv_0729|M.gilvum_PYR-GCK NMVYTQFGFLVWMAVATTALSFVLAHRAVRLRNLQEVR------------
MSMEG_0106|M.smegmatis_MC2_155 NVVYMQVGFLLWLAVATTALSLVLVRRSARVRALLDVR------------
MAB_0061|M.abscessus_ATCC_1997 GDEYVTWAALLWLTVFTTGMCFVLKRRSARVVQLVHIR------------
Mb0868|M.bovis_AF2122/97 ETIFR-FALYAFLCATALMVVRIEERHTRSVAGLSALR------------
Rv0845|M.tuberculosis_H37Rv ETIFR-FALYAFLCATALMVVRIEERHTRSVAGLSALR------------
MUL_0350|M.ulcerans_Agy99 EAIFR-FGLYAFLCATALMVVRSEERHARSVATLSVIR------------
MAV_0874|M.avium_104 EAGFR-FLLYGFLCCAAFLVVRIEERHTRSVAGLSALR------------
MMAR_4783|M.marinum_M DSVFV-FSLYAFLCATALVVVRTEERRVRSVAGLSALR------------
Mvan_2071|M.vanbaalenii_PYR-1 GRIATRLRELGIRSAAGSPLTVDGGTRGVLVVGSHAVQGVPDGTEAHIGD
TH_4203|M.thermoresistible__bu TVERREFTRRDVDLLLVIGRLIAGGLHQARLHRQLVARER---------A
: : :
Mflv_0729|M.gilvum_PYR-GCK -VQLVSEAMQ-----------------SDERHNREVAESLHDGPLQTLLA
MSMEG_0106|M.smegmatis_MC2_155 -RRLVQESAR-----------------ADELRDAELAEALHDGPLQTLLA
MAB_0061|M.abscessus_ATCC_1997 -EQLVLESMR-----------------ADERRNREVAERLHDGPLQNLLA
Mb0868|M.bovis_AF2122/97 -EELLAQTMT-----------------ASEVLQRRIAEAIHDGPLQDVLA
Rv0845|M.tuberculosis_H37Rv -AELLAQTMT-----------------ASEVLQRRIAEAIHDGPLQDVLA
MUL_0350|M.ulcerans_Agy99 -EELLAQTMT-----------------ASEVLQRRISESIHDGPLQDVLA
MAV_0874|M.avium_104 -EELLAQTMN-----------------ASDVSQRRISEFIHDGPLQDILA
MMAR_4783|M.marinum_M -EALLAQTMT-----------------ASEVLQRWISESIHDGPLQDVLV
Mvan_2071|M.vanbaalenii_PYR-1 FADLISTAIANAETRAELTASRARIVAAADEARRGFERDLHDGAQQRIVS
TH_4203|M.thermoresistible__bu HEIFVEQVIE-----------------AQELERRRLAADIHDGISQRLVT
:: : : . :*** * ::
Mflv_0729|M.gilvum_PYR-GCK ARLELDEARERNP-DPALD----AVYAALQETADGLRATVTELHPQVLAQ
MSMEG_0106|M.smegmatis_MC2_155 ARLELDELRERNP-DPALD----VVHAALQQTATGLRSTVTALHPQVLAQ
MAB_0061|M.abscessus_ATCC_1997 ARLRIEEVLERQS-DPVLT----AVHSSLRETAAELRGAVSSLHPQVLIE
Mb0868|M.bovis_AF2122/97 ARQELIELDAVTPGDERVG----RALAGLQSASERLRQATFELHPAVLEQ
Rv0845|M.tuberculosis_H37Rv ARQELIELDAVTPGDERVG----RALAGLQSASERLRQATFELHPAVLEQ
MUL_0350|M.ulcerans_Agy99 ARQELIELRAAAPHDQRVS----TALAGLQSASDLLRQATFELHPAVLEQ
MAV_0874|M.avium_104 VRQELVELDAAVPDDERIG----RALAGLQLASERLRQATFELHPAVLEQ
MMAR_4783|M.marinum_M ARQELVELQSVWPGDDRVE----RALAGLQSASERLRQATFELHPAVLEQ
Mvan_2071|M.vanbaalenii_PYR-1 LSLQLREAEAAVEGDEALRTQLSTVVNGLAGLHSDLQELSRGLHPAVLSR
TH_4203|M.thermoresistible__bu LSYRLDAAIRAVDDPATVTEQLSKARELADLTLEETRAAISGLRPPVLDD
.: : . : *:* **
Mflv_0729|M.gilvum_PYR-GCK LGLTAGIRELLRQL-QSRHLLEVDAELEEV-GEPQSQALLYRAARELLTN
MSMEG_0106|M.smegmatis_MC2_155 LGLAPAVRELLRQY-ENRGDLVIRANIADV-GQPEAQALLYRAARELLAN
MAB_0061|M.abscessus_ATCC_1997 LGLTAAIRELARQH-TARGIVDVSTAVEEV-GSPPAQPLVYRAAKELLTN
Mb0868|M.bovis_AF2122/97 VGLGPAVKQLAAST-AQRSGIKISTDIDYP-IRSGIDPIVFGVVRELLSN
Rv0845|M.tuberculosis_H37Rv VGLGPAVKQLAAST-AQRSGIKISTDIDYP-IRSGIDPIVFGVVRELLSN
MUL_0350|M.ulcerans_Agy99 VGLGAAVEQLASFH-AQRSGIRITDDVDYP-IRDEIDPIVFGVARELLSN
MAV_0874|M.avium_104 VGLGAAVQQLAEFT-AQRSGIEISTDIDYS-GRSAIDAVVFGVVRELLSN
MMAR_4783|M.marinum_M VGLGAAVEQLATFT-ARRSGIEVSTDVDYP-IRNEIDPIMFGVARELLSN
Mvan_2071|M.vanbaalenii_PYR-1 GGLKPAMRNLARRS-TVP--VELTVDIDRR-LPEPVEVAAYYVVAESLTN
TH_4203|M.thermoresistible__bu LGLSGGLASLAQSVGQLDIGVDIEVDLAETRLPDHIELALYRIAQECLQN
** .: .* : : : : : . * * *
Mflv_0729|M.gilvum_PYR-GCK IVKHADATTVRVRLARR----GDRVVLSVADDGAGFDPAILGTSLGQGH-
MSMEG_0106|M.smegmatis_MC2_155 VHKHARAATVTVRLFRQ----GERTVLTVVDDGVGFDPDIVAQSVAEGH-
MAB_0061|M.abscessus_ATCC_1997 AVKHGRAKNIRVELSSR----RCWLTLVVTDDGRGFDPRDLVLSVADGH-
Mb0868|M.bovis_AF2122/97 VVRHSGATTASVRLGIT----DEKCVLDVADDGVGVTGDTMARRLGEGH-
Rv0845|M.tuberculosis_H37Rv VVRHSGATTASVRLGIT----DEKCVLDVADDGVGVTGDTMARRLGEGH-
MUL_0350|M.ulcerans_Agy99 VVQHSRARNASVALGIS----DGVCVLDVADDGVGVSGETMARRLGQGH-
MAV_0874|M.avium_104 VVQHSRARTAAIMLGRT----DGTCVLHVVDDGVGFNQETVARRLGEGH-
MMAR_4783|M.marinum_M VVHHARAKHVSVSLGIT----DGACVLDVADDGVGITGGTAARRLGEGH-
Mvan_2071|M.vanbaalenii_PYR-1 VAKHAQADSVTVEIGLD----DAPDGGTLLR--LSVTDDGTGGASADGG-
TH_4203|M.thermoresistible__bu VVKHARARTARLTYAVDRGEHGEVARLEIVDDGVGFDTFEHPLGGDDMSG
:*. * : : .. :
Mflv_0729|M.gilvum_PYR-GCK IGLGSLIARFDAMGGSMRITSSDGQGTEVTATSPPEPA------------
MSMEG_0106|M.smegmatis_MC2_155 IGLASLQVRIEAMGGAMTISSEEGFGTQVTVIL-----------------
MAB_0061|M.abscessus_ATCC_1997 IGLASLTVPIEAAGGAVTITSAPGAGTRVSVTAPADMAA-----------
Mb0868|M.bovis_AF2122/97 IGLASHRARVDAAGGVLVFLATP-RGTHVCVELPLKR-------------
Rv0845|M.tuberculosis_H37Rv IGLASHRARVDAAGGVLVFLATP-RGTHVCVELPLKR-------------
MUL_0350|M.ulcerans_Agy99 IGLASHRARVDAAGGSLVFLNTP-TGTHVCVRIPLKG-------------
MAV_0874|M.avium_104 IGLASHRARVEAAGGELVFLDVP-VGTHVCVEVPLRN-------------
MMAR_4783|M.marinum_M IGLASHRARVDAAGGTFVFLDAP-AGTHVCVELPLKSVPSPAPDRHPPAG
Mvan_2071|M.vanbaalenii_PYR-1 SGLVGLRDRVEALSGQLTVTSRPGDGTSISATIPVD--------------
TH_4203|M.thermoresistible__bu YGLLSMAERAEIVGGRLNIRSRPGAGTAVIATIPLPPATR----------
** . : .* . . ** : .
Mflv_0729|M.gilvum_PYR-GCK -------------------
MSMEG_0106|M.smegmatis_MC2_155 -------------------
MAB_0061|M.abscessus_ATCC_1997 -------------------
Mb0868|M.bovis_AF2122/97 -------------------
Rv0845|M.tuberculosis_H37Rv -------------------
MUL_0350|M.ulcerans_Agy99 -------------------
MAV_0874|M.avium_104 -------------------
MMAR_4783|M.marinum_M ATSREALAASPRRRRPLGH
Mvan_2071|M.vanbaalenii_PYR-1 -------------------
TH_4203|M.thermoresistible__bu -------------------