For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TGNRFDELAAARDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVRDWHANLISFVHEGM DAETVRRIGHHPVGKGLLSLSLLDTPALRMDDLTAHPAAAGFPEHHPAMRAFLAVPITIRGAVFGNLYLT HVDEARVFSDADEMAARALAFAAAVAIDNAQVFERERMSVKWIEASREITTALLSRTEPHRRPMQLIAER ACALTDAEQAIVLVPADPEQPGNPEVDTLVVSAAVGLPAADVLGQRVPVRGSTSGAVFKSGEPLITDEFR YPIQAFTDAGRRPAIVMPLRARDEVVGVIAIARGTEQPPFDESYLDLVRDFATHAAIALVLAAAREDARQ LAVLAERERIAHDLHDHVIQRLFAAGMDLQGTLARARSPEVADRLNRTLDDLQTIIEEIRTTIFALRSPA AVAGDFRHRIQRVIAELTENRDLVTTVRMDGPMTAVGAELAEHAEAVTAEAVSNAVRHSGASRLTVQIGV ADMFTLDVIDNGRGIAAGNTRRSGLANMTRRAEQLGGSCEISSPPGGGTRVHWTAPLLDH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4108 | - | - | 100% (551) | GAF family protein |
| M. avium 104 | MAV_2108 | - | 1e-99 | 56.81% (345) | stage II sporulation protein E (SpoIIE) |
| M. avium 104 | MAV_2508 | - | 4e-49 | 45.91% (220) | PAS domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2052c | - | 1e-121 | 43.85% (545) | histidine kinase response regulator |
| M. gilvum PYR-GCK | Mflv_3844 | - | 1e-114 | 42.94% (545) | GAF sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv2027c | - | 1e-121 | 43.85% (545) | histidine kinase response regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3890c | - | 1e-105 | 41.23% (536) | histidine kinase response regulator |
| M. marinum M | MMAR_3479 | - | 0.0 | 71.61% (546) | two-component sensor histidine kinase |
| M. smegmatis MC2 155 | MSMEG_3941 | - | 1e-132 | 48.34% (542) | GAF family protein |
| M. thermoresistible (build 8) | TH_0388 | - | 9e-60 | 48.75% (240) | TWO COMPONENT SENSOR HISTIDINE KINASE DEVS |
| M. ulcerans Agy99 | MUL_2422 | devS | 1e-117 | 43.33% (547) | two component sensor histidine kinase DevS |
| M. vanbaalenii PYR-1 | Mvan_1413 | - | 1e-163 | 54.41% (544) | GAF sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2052c|M.bovis_AF2122/97 -----MTHPDRAN------VNPGSPPVRETLSQLRLRELLLEVQDRIEQI
Rv2027c|M.tuberculosis_H37Rv -----MTHPDRAN------VNPGSPPLRETLSQLRLRELLLEVQDRIEQI
Mflv_3844|M.gilvum_PYR-GCK MHDGAVADADDHR------ARDGARPVRTTLSQLRLRELLTEVQDRVEQI
MUL_2422|M.ulcerans_Agy99 --MTDEPHPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQI
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 -------MVEDVG--------AQPNRVTAELAHLQLRELLAEVQGRIEQI
MAV_4108|M.avium_104 -----------------------------------------MTGNRFDEL
MMAR_3479|M.marinum_M ------------------------------------------MHAQLDEL
Mvan_1413|M.vanbaalenii_PYR-1 -----------------------MSNRQQRAFGRRHPADLRRIHEQLDEL
MSMEG_3941|M.smegmatis_MC2_155 ----------------------------------------MGQSHTDDSP
Mb2052c|M.bovis_AF2122/97 VEG-RDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRG
Rv2027c|M.tuberculosis_H37Rv VEG-RDRLDGLIDAILAITSGLKLDATLRAIVHTAAELVDARYGALGVRG
Mflv_3844|M.gilvum_PYR-GCK IRG-RDRLDGLVEAMLAVTSGLELDETLRTIVHTAIELVDAQYGALGVRG
MUL_2422|M.ulcerans_Agy99 VEG-RDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEVHD
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 VDGTRGRMDALLDAVMAVSSGLELDATLREIVCAASELVSARYGALGVVG
MAV_4108|M.avium_104 AAA-RDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVRD
MMAR_3479|M.marinum_M LAA-RDQMEQLLRVIVEIGSDLDLDATLRRIVLAARELTSAPYGALAVRD
Mvan_1413|M.vanbaalenii_PYR-1 AAD-RDQMGQLLQVAVEIGSDLELNATLQRIVRAARGMTAARYGAIGVWG
MSMEG_3941|M.smegmatis_MC2_155 EAV-EVRMAALLQDMASLDAGLEPESTLHGILDAIMRVSGACYGAAGLCA
Mb2052c|M.bovis_AF2122/97 YDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHP
Rv2027c|M.tuberculosis_H37Rv YDHRLVEFVYEGIDEETRHLIGSLPEGRGVLGALIEEPKPIRLDDISRHP
Mflv_3844|M.gilvum_PYR-GCK HDQELVEFIYEGIDEPMRERIGHLPEGRGVLGVLINDPKPIRLEDISRHA
MUL_2422|M.ulcerans_Agy99 RDKRVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLEDISQHP
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 SDEKLAEFVYEGIDEATRDLIGPLPTGHGVLGVVIDEAKPLRLRDIAAHP
MAV_4108|M.avium_104 WHANLISFVHEGMDAETVRRIGHHPVGKGLLSLSLLDTPALRMDDLTAHP
MMAR_3479|M.marinum_M PEGTLIRFIHAGMDDDVARRIGHLPVGKGVLGVSLVETPALRLDDLTMHP
Mvan_1413|M.vanbaalenii_PYR-1 TDDLLSDFVHDGMDEGTVQAVGHPPVGKGLLGFLRQGTDPVRLDNAAEHP
MSMEG_3941|M.smegmatis_MC2_155 PDGTPATFLQAG---ALAQAVPDSPD-RDMLGFLRNRTGPLRIDGLARSA
Mb2052c|M.bovis_AF2122/97 ASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQ
Rv2027c|M.tuberculosis_H37Rv ASVGFPLHHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSDDDEVLVQ
Mflv_3844|M.gilvum_PYR-GCK DSVGFPPNHPPMRTFLGVPVRIRDEVFGNLYLTEKSDGQPFSEDDEVLVQ
MUL_2422|M.ulcerans_Agy99 ASIGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQ
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 ASVGFPANHPPMRTFLGVPVQVRGEVFGRLYLTEKLDGQEFTEDDEVVVR
MAV_4108|M.avium_104 AAAGFPEHHPAMRAFLAVPITIRGAVFGNLYLTHVDEARVFSDADEMAAR
MMAR_3479|M.marinum_M AACGFPEHHPPMRAFLAVPITIRGTVFGSLYLTHVDPGRKFSESDEFAAR
Mvan_1413|M.vanbaalenii_PYR-1 SAVGFPQHHPAMRAFIGVPIVIRGEPFGSLYLADDRPDFAFAEADEMTVR
MSMEG_3941|M.smegmatis_MC2_155 AEVGLPELLPPMRAVLGVPLVSHGEVLGSLYVADSRAGFEFSDAHVGVVE
Mb2052c|M.bovis_AF2122/97 ALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADP-AMVFRLI
Rv2027c|M.tuberculosis_H37Rv ALAAAAGIAVDNARLFEESRTREAWIEATRDIGTQMLAGADP-AMVFRLI
Mflv_3844|M.gilvum_PYR-GCK ALAAAAGIAIDNARLYAQSQARQSWIEATRDIGTELLSGIDP-AGVFRRV
MUL_2422|M.ulcerans_Agy99 ALAAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEP-ASVFRLV
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 ALAGAAGIAIENARLYQHARRREQWQRATADITAELLGGVDP-GKALHLV
MAV_4108|M.avium_104 ALAFAAAVAIDNAQVFERERMSVKWIEASREITTALLSRTEPHRRPMQLI
MMAR_3479|M.marinum_M ALAFAAGVAIDNAQVFERERTAVKWMEASREITTALMSSTESRREPLQLI
Mvan_1413|M.vanbaalenii_PYR-1 ALASIAAVAIDNARLLDHARATVRWTDAGREITAAVLGGDDPYLRPLQLI
MSMEG_3941|M.smegmatis_MC2_155 VLATVAADVVHSVWHLAKVRTVARWVSASREITMALLGMSGGEDAPLRLI
Mb2052c|M.bovis_AF2122/97 AEEALTLMAGAATLVAVPLDDEAPAC-EVDDLVIVEVAGEISPAVKQMTV
Rv2027c|M.tuberculosis_H37Rv AEEALTLMAGAATLVAVPLDDEAPAC-EVDDLVIVEVAGEISPAVKQMTV
Mflv_3844|M.gilvum_PYR-GCK ADRAQKLSGAAATLVAVPDDPDLPVG-EVAELTVAASAGETIAAAHDP-I
MUL_2422|M.ulcerans_Agy99 AEEALKLTSADAALVAIPVDEDVPAS-EVAQLLVIETVGNAVAAAEGCTI
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 ASSAALLAEADFAFIALPAGDEE----DTAELVVAVCEGKGAEVLNDKLI
MAV_4108|M.avium_104 AERACALTDAEQAIVLVPADPEQPGNPEVDTLVVSAAVGLPAADVLGQRV
MMAR_3479|M.marinum_M AQRACTLTDAEQAIVLVPVESDLATD-EIDTLVVSAAVGLHAEEVVGQQV
Mvan_1413|M.vanbaalenii_PYR-1 VGRACELTGAEQGIVLVASDPEQPVD-EVDTLVVSTAAGRYADDVLGQRV
MSMEG_3941|M.smegmatis_MC2_155 VGRAAELTVASQAAILVPSEADRAPE-EVRSLTVAVAAGARADEVEGQQV
Mb2052c|M.bovis_AF2122/97 AVSGTSIGGVFHDRTPRRFDRLDLA--VDGPVEPGPALVLPLRAADTVAG
Rv2027c|M.tuberculosis_H37Rv AVSGTSIGGVFHDRTPRRFDRLDLA--VDGPVEPGPALVLPLRAADTVAG
Mflv_3844|M.gilvum_PYR-GCK PVAGTAIGDAFVHRTPGMTDRADIG--IGATV--GPALLLPLRAPDAVPG
MUL_2422|M.ulcerans_Agy99 AVAGTALAEVLLDSAPRQVDKIAVED-VDELGDMGPALVLPLRATDAVAG
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 PIDGSTSGSTFIDHEPRNVGRLAVNLAEGTDLAFGPALVLPLGGGESTAG
MAV_4108|M.avium_104 PVRGSTSGAVFKSGEPLITDEFRYPIQAFTDAGRRPAIVMPLRARDEVVG
MMAR_3479|M.marinum_M PVRGSTCGDVFRSGEPLISEAFSYPIEAFTDVAQRSAIVMPLSAHEKVAG
Mvan_1413|M.vanbaalenii_PYR-1 PVHGSTTGAVFQSGRPVITEAFGHSIPFFTDVGERPVVVVPLRSERQNLG
MSMEG_3941|M.smegmatis_MC2_155 PVSGSTSGRVFRTGESTMTDGFRYPITSFTDQGRRPAIVVPLRSATNNLG
Mb2052c|M.bovis_AF2122/97 VLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDR
Rv2027c|M.tuberculosis_H37Rv VLVALRSADEQPFSDKQLDMMAAFADQAALAWRLATAQRQMREVEILTDR
Mflv_3844|M.gilvum_PYR-GCK VLIVLRSVGAQPFRSDELDMLAAFADQAAQAWQLASTQHRLRELGILTDR
MUL_2422|M.ulcerans_Agy99 VVVLLHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVVTER
TH_0388|M.thermoresistible__bu VLVVCRAEEGRPFTDEQLEILVTFADQAALAWQLAATQRRMRELDVLSDR
MAB_3890c|M.abscessus_ATCC_199 VLILLRTVGAIAFDEEQLDMAASFAGQAALALEQAEVRLAKHELDVLADR
MAV_4108|M.avium_104 VIAIARGTEQPPFDESYLDLVRDFATHAAIALVLAAAREDARQLAVLAER
MMAR_3479|M.marinum_M VIAVARGADQPPFDARCLDLVSQFATHAAIALLLASGREDARQLTILAER
Mvan_1413|M.vanbaalenii_PYR-1 VLALARNASAPRFQAGDLDLVRDYAYHTAIAIVIARARGTANELAMFTDR
MSMEG_3941|M.smegmatis_MC2_155 VIAVARDADDPPFDVDEMAIMEDFAHHAAVALTLCRANEQARQLTVLSDR
*: : . : : :* ::* * . . .:: :.::*
Mb2052c|M.bovis_AF2122/97 DRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQ
Rv2027c|M.tuberculosis_H37Rv DRIARDLHDHVIQRLFAVGLTLQGAAPRARVPAVRESIYSSIDDLQEIIQ
Mflv_3844|M.gilvum_PYR-GCK DRIARDLHDHVIQRLFAVGLSLQGSIARARSEEVQQRLSANVDDLQSVIQ
MUL_2422|M.ulcerans_Agy99 DRIARDLHDHVIQRLFAIGLALQGSVPRTREPKVQQRLSEVIDDLQGVIQ
TH_0388|M.thermoresistible__bu DRIARDLHDHVIQRLFAVGLTLQGTIPRARSTEVQQRLSECIDDLQAVIG
MAB_3890c|M.abscessus_ATCC_199 DRIARDLHDHVIQRLFAVGLAMQSTHRRSVDPTVAARLADHIDQLHEVIQ
MAV_4108|M.avium_104 ERIAHDLHDHVIQRLFAAGMDLQGTLARARSPEVADRLNRTLDDLQTIIE
MMAR_3479|M.marinum_M ERIAHDLHDHVIQRLFASGMDLQGTLARARSPEVIDRLNRTVDDLQTIIE
Mvan_1413|M.vanbaalenii_PYR-1 ERIAHDLHDQVIQRVFAVGMDLQGVVARVRSPALNERLSNSVDELQAVIT
MSMEG_3941|M.smegmatis_MC2_155 ERIARDLHDHVIQRLFLAGMDLQGTIARTKSDLLKERLSRTVDDLQSIID
:***:****:****:* *: :*. * : : :*:*: :*
Mb2052c|M.bovis_AF2122/97 EIRSAIFDLHAGPSRATGLRHRLDKVIDQLA-IPALHTTVQYTGPLSVVD
Rv2027c|M.tuberculosis_H37Rv EIRSAIFDLHAGPSRATGLRHRLDKVIDQLA-IPALHTTVQYTGPLSVVD
Mflv_3844|M.gilvum_PYR-GCK EIRTAIFDLHGGSSAVTRLRQRLDAAVAAFP-ESGVRTSMQCAGPLSVVD
MUL_2422|M.ulcerans_Agy99 EIRTTIFDLHGSSQGVTRLRQRIDAAVAAFG-SSGLRTTVQFIGPLSVVD
TH_0388|M.thermoresistible__bu EIRTTIFDLHGGPATGSQIRQRIGEAANQFS-DAGVRTRVQFAGPLSVIS
MAB_3890c|M.abscessus_ATCC_199 EIRTAIFDLHTNDE---SLRATLRSTINELTAETGLRVSVRMSGPLDVVP
MAV_4108|M.avium_104 EIRTTIFALRSPAAVAGDFRHRIQRVIAELTENRDLVTTVRMDGPMTAVG
MMAR_3479|M.marinum_M EIRSTIFQLKSPSGRDGGFRQRIQQVVADLTEHRDVVTTIHMHGPMSAVQ
Mvan_1413|M.vanbaalenii_PYR-1 EIRSTIFNLQKPAEAHGAFAKRIRHAFQRLTEDREMAATLTVSGPMEVVA
MSMEG_3941|M.smegmatis_MC2_155 EIRTAIFDLQSPAASAMSFRQRIQAAVAAVTDNSPLATTVRISGPIVAVD
***::** *: : : . . : . : **: .:
Mb2052c|M.bovis_AF2122/97 TVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGIS-
Rv2027c|M.tuberculosis_H37Rv TVLANHAEAVLREAVSNAVRHANATSLAINVSVEDDVRVEVVDDGVGIS-
Mflv_3844|M.gilvum_PYR-GCK AGLADHAEAVVREAVSNAVRHAEASTVAVTVTVEDDLAITVTDDGRGIA-
MUL_2422|M.ulcerans_Agy99 NVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDDDLCIEVSDNGRGMP-
TH_0388|M.thermoresistible__bu AVLADHAEAVVREAVSNAVRHGGATDLSVDVSVDDDLTIEVTDNGRGFPE
MAB_3890c|M.abscessus_ATCC_199 ASTSGDAEAVVREAVSNVVRHARARELSVTVSVDDELVIEVVDDGIGIP-
MAV_4108|M.avium_104 AELAEHAEAVTAEAVSNAVRHSGASRLTVQIGVADMFTLDVIDNGRGIAA
MMAR_3479|M.marinum_M GELADHAEAVATEAISNAVRHSGAGRVTLDVSVGDMFSLEVVDDGCGISP
Mvan_1413|M.vanbaalenii_PYR-1 PSLVDDAEAVVLEGLSNAVRHSGAAAVAVEIAVGDDLVVEVCDDGQGIPA
MSMEG_3941|M.smegmatis_MC2_155 PALADDAEAVIVEAISNAVRHSGATSVTISIEVSDRLDIEVVDNGRGIPA
.**** *.:**.***. * ::: : * * . : * *:* *:.
Mb2052c|M.bovis_AF2122/97 GDITESGLRNLRQRADDAGGEFTVENMPTGG-TLLRWSAPLR--
Rv2027c|M.tuberculosis_H37Rv GDITESGLRNLRQRADDAGGEFTVENMPTGG-TLLRWSAPLR--
Mflv_3844|M.gilvum_PYR-GCK ADVTGSGLANLARRAQDVGGSFSVRRGAQVG-TTLTWRAPLP--
MUL_2422|M.ulcerans_Agy99 KTYTSSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPLIQ-
TH_0388|M.thermoresistible__bu GEVTESGLANLRHRARHAGGTLEVHNRPDGG-ARLHWSVPLT--
MAB_3890c|M.abscessus_ATCC_199 DVVARSGLSGLANRAAQSGGTFSVSAMDTGG-TRLVWSAPLP--
MAV_4108|M.avium_104 GNTRRSGLANMTRRAEQLGGSCEISSPPGGG-TRVHWTAPLLDH
MMAR_3479|M.marinum_M DVSRRSGLANMRSRAEKLGGTCGITTPTEGG-TRISWTVPFGDL
Mvan_1413|M.vanbaalenii_PYR-1 ESRRRSGLANLAARARAAGGELVIDTPPSGG-TRLIWSVPLART
MSMEG_3941|M.smegmatis_MC2_155 NTARCSGLANLKARAQQAGGSCQITSSAGSG-THVRWSAPLSGA
*** .: ** ** : * : : * .*: