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VPSYGNLGRLGGRHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMVVGTSRSEWPQQ IVLIGVYAVAALWALLLAYSASRRFFALRRFRSMGRLEPFAFTAVDVLILTGFQLLSTDGIYPLLIMILL PVLVGLDVSTRRAAVVLACTLVGFAVAVLGDPVMLRAIGWPETIFRFALYAFLCATALMVVRIEERHTRS VAGLSALRAELLAQTMTASEVLQRRIAEAIHDGPLQDVLAARQELIELDAVTPGDERVGRALAGLQSASE RLRQATFELHPAVLEQVGLGPAVKQLAASTAQRSGIKISTDIDYPIRSGIDPIVFGVVRELLSNVVRHSG ATTASVRLGITDEKCVLDVADDGVGVTGDTMARRLGEGHIGLASHRARVDAAGGVLVFLATPRGTHVCVE LPLKR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0845 | - | - | 100% (425) | POSSIBLE TWO COMPONENT SENSOR KINASE |
| M. tuberculosis H37Rv | Rv2027c | - | 6e-11 | 28.57% (210) | histidine kinase response regulator |
| M. tuberculosis H37Rv | Rv3132c | devS | 7e-11 | 27.96% (186) | two component sensor histidine kinase DEVS |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0868 | - | 0.0 | 99.76% (425) | two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_0729 | - | 5e-41 | 31.62% (389) | integral membrane sensor signal transduction histidine kinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0061 | - | 9e-31 | 29.08% (392) | two component sensor kinase |
| M. marinum M | MMAR_4781 | - | 1e-166 | 76.43% (403) | two-component sensor kinase |
| M. avium 104 | MAV_0874 | - | 1e-161 | 72.10% (405) | hypothetical protein MAV_0874 |
| M. smegmatis MC2 155 | MSMEG_0106 | - | 6e-43 | 33.51% (388) | sensory histidine kinase |
| M. thermoresistible (build 8) | TH_4203 | - | 7e-14 | 31.31% (214) | PUTATIVE sensor histidine kinase |
| M. ulcerans Agy99 | MUL_0350 | - | 1e-169 | 74.76% (424) | two component sensor kinase |
| M. vanbaalenii PYR-1 | Mvan_2071 | - | 2e-18 | 30.08% (236) | multi-sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4781|M.marinum_M --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 --------------------------------------------------
MAV_0874|M.avium_104 --------------------------------------------------
Mflv_0729|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0106|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0061|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2071|M.vanbaalenii_PYR-1 MPTRFLERVVRSPARPLGLGIAVAAGFLAAEVLAVFALKKIAPENAFGAL
TH_4203|M.thermoresistible__bu --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4781|M.marinum_M --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 --------------------------------------------------
MAV_0874|M.avium_104 --------------------------------------------------
Mflv_0729|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0106|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0061|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2071|M.vanbaalenii_PYR-1 LLLGVLVVSAGWGFGLSIATSLASAAVYAYLHLEGRDSLAPALIIFLTLA
TH_4203|M.thermoresistible__bu --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4781|M.marinum_M --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 ---------------MMNSRQREADRRQFAPSCRRQDESAGQSLGQRRTE
MAV_0874|M.avium_104 --------------------------------------------------
Mflv_0729|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0106|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0061|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2071|M.vanbaalenii_PYR-1 LLTNALVGQARLRAAEAEQRRREADLSADLARVMLRAPALGPALEDAGRR
TH_4203|M.thermoresistible__bu --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv ---MPSYGNLGRLGG-RHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVL
Mb0868|M.bovis_AF2122/97 ---MPSYGNLGRLGG-RHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVL
MMAR_4781|M.marinum_M ------------------------MVTSDAELARVRRTHQLRAYRIGSVL
MUL_0350|M.ulcerans_Agy99 RSPNPSCANYGQLVGSCRLYGVPVVVTSDAELARVRRTHQLRAYRIGSVL
MAV_0874|M.avium_104 -----------------------MAVAGDAELERVRAVHQMRSYRIGSVL
Mflv_0729|M.gilvum_PYR-GCK ------------------------MTGPFRFPSAWREFLAAEPVRVSAVL
MSMEG_0106|M.smegmatis_MC2_155 -----------------------------MISGRIVEFFASQPVRVSAVL
MAB_0061|M.abscessus_ATCC_1997 ----------------------------MTRLDNMADYFAAEPMRVSAWL
Mvan_2071|M.vanbaalenii_PYR-1 FADVLGLPYATLTVGGGATGADEMAIDLVDGAEHTGTLLVPRDLPLASVR
TH_4203|M.thermoresistible__bu -------------------------VTSGPHPDPVRDLSEQLLTADRELV
Rv0845|M.tuberculosis_H37Rv RIG-----VVGLMVAAMVVGTSRSEWP-QQIVLIGVYAVAALWALL----
Mb0868|M.bovis_AF2122/97 RIG-----VVGLMVAAMVVGTSRSEWP-QQIVLIGVYAVAALWALL----
MMAR_4781|M.marinum_M RIG-----VVLFMVAAMLVGTPRREWG-AQTALICVYAFAALWALA----
MUL_0350|M.ulcerans_Agy99 RIG-----VVLFMVAAMLVGTPRREWG-AQTALICVYAFAALWALA----
MAV_0874|M.avium_104 RVG-----VVGLMVAAMIIGTARSEWP-QESVLILLYGIIALGAVA----
Mflv_0729|M.gilvum_PYR-GCK RLP-----LIGLIAVLVWIWEVNHWLPGLYAAILGSYAVVAVVWLL----
MSMEG_0106|M.smegmatis_MC2_155 RLP-----LIGLIFVLVMVWEVDHWLPGLYAVILGLYAAAAVLWLV----
MAB_0061|M.abscessus_ATCC_1997 RLP-----LIGLIVLLGSDPNIQMWHNGVYYGVLAAYTLSAVVWVG----
Mvan_2071|M.vanbaalenii_PYR-1 RIHRMVPSLQALLAAACDREDITAELEASRRELERFFAVASDLLFIGTYV
TH_4203|M.thermoresistible__bu LLR-------ELIQAASRGPGVEPLAAAAARMITAATASDVCFVHVLD--
: :: :
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4781|M.marinum_M --------------------------------------------------
MUL_0350|M.ulcerans_Agy99 --------------------------------------------------
MAV_0874|M.avium_104 --------------------------------------------------
Mflv_0729|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0106|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0061|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2071|M.vanbaalenii_PYR-1 DGVAQLTRVNPAFERALGYSAAELAARPLTEFIHPDDRDGTAAALDSVPQ
TH_4203|M.thermoresistible__bu --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------LAYSASRRFFAL
Mb0868|M.bovis_AF2122/97 --------------------------------------LAYSASRRFFAL
MMAR_4781|M.marinum_M --------------------------------------LAFRRSRPMVSL
MUL_0350|M.ulcerans_Agy99 --------------------------------------LAFRRSRPMVSL
MAV_0874|M.avium_104 --------------------------------------LAFAPFRRWIGI
Mflv_0729|M.gilvum_PYR-GCK --------------------------------------AVSR--------
MSMEG_0106|M.smegmatis_MC2_155 --------------------------------------VVIR--------
MAB_0061|M.abscessus_ATCC_1997 --------------------------------------IAVR--------
Mvan_2071|M.vanbaalenii_PYR-1 TDGATQFENRSLRRDGGVRWLEWNVVSDRGVLLGGARDVTERRREQDRLR
TH_4203|M.thermoresistible__bu --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv RRFRSMGRLEPFAFTAVDVLILTGFQLLSTDGIYPLL-IMILLPVLVGLD
Mb0868|M.bovis_AF2122/97 RRFRSMGRLEPFAFTAVDVLILTGFQLLSTDGIYPLL-IMILLPVLVGLD
MMAR_4781|M.marinum_M DRFANIARYEPLAFTAVDVLALTGFQLLSTDGIYSLL-IMTLLPVLVALD
MUL_0350|M.ulcerans_Agy99 DRFANIARYEPLAFTAVDVLALTGFQLLSTDGIYSLL-IMTLLPVLVALD
MAV_0874|M.avium_104 GRLAGVGRLEPFAFTVVDILALTIFQLLSTNGIYPLL-IMAMLPVLLGLD
Mflv_0729|M.gilvum_PYR-GCK ---GPVPRWADWASSAVDVLVIVSLCVVSGGATAALLPVFFLLPISVAFQ
MSMEG_0106|M.smegmatis_MC2_155 ---GPMPRWAEWASTAVDGLVLLALCAVSGGATAALLPVFFLLPISVAFQ
MAB_0061|M.abscessus_ATCC_1997 ---GQVADWVAPAATSADIAAVVMLCLASGAGNTELLPVFFLLPVSVAFQ
Mvan_2071|M.vanbaalenii_PYR-1 MARTQQAALRRVATLVARGAPLSEVYDVAVTELAHSLGVNHVTLLAFEAD
TH_4203|M.thermoresistible__bu ---DTERSLTLAGATPPFDKEVGKIRLPLGQGISGWVASHREPVVITENK
. : . : : .
Rv0845|M.tuberculosis_H37Rv VSTRRAAVVLACTLVGFAVAVLGDP----------------VMLRAIGWP
Mb0868|M.bovis_AF2122/97 VSTRRAAVVLACTLVGFAVAVLGDP----------------VMLRAIGWP
MMAR_4781|M.marinum_M ISSRRAAVVLALTLVGFALALAQDP----------------VVIRMNGWP
MUL_0350|M.ulcerans_Agy99 ISSRRAAVVLALTLVGFGLALAQDP----------------VVIRMNGWP
MAV_0874|M.avium_104 VSSRRAAVVLIFSMLGFAIAVLQDP----------------VMSSSVRLP
Mflv_0729|M.gilvum_PYR-GCK DRPALTAIIGSVTAVAYLTVWVFYS----------------RRDDEVGLP
MSMEG_0106|M.smegmatis_MC2_155 DRPLLTAMLGTATATGYLGAWIFYS----------------KRDDTVGLP
MAB_0061|M.abscessus_ATCC_1997 ERPAITAILGIITAVAYFGILVYYI----------------ADGNLERIP
Mvan_2071|M.vanbaalenii_PYR-1 DHAVVRAALKSAHQPGFAVGDRLSLDGGSISEQVHRTGLPARIDDYSEVP
TH_4203|M.thermoresistible__bu EADPRYLPFQSLRGRDFTSMVSVPMETD-----------PGGLVGVLNVH
. :
Rv0845|M.tuberculosis_H37Rv ETIFR-FALYAFLCATALMVVRIEERHTRSVAGLSALR------------
Mb0868|M.bovis_AF2122/97 ETIFR-FALYAFLCATALMVVRIEERHTRSVAGLSALR------------
MMAR_4781|M.marinum_M EAIFR-FGLYAFLCATALMVVRSEERHARSVATLSVIR------------
MUL_0350|M.ulcerans_Agy99 EAIFR-FGLYAFLCATALMVVRSEERHARSVATLSVIR------------
MAV_0874|M.avium_104 EAGFR-FLLYGFLCCAAFLVVRIEERHTRSVAGLSALR------------
Mflv_0729|M.gilvum_PYR-GCK NMVYTQFGFLVWMAVATTALSFVLAHRAVRLRNLQEVR------------
MSMEG_0106|M.smegmatis_MC2_155 NVVYMQVGFLLWLAVATTALSLVLVRRSARVRALLDVR------------
MAB_0061|M.abscessus_ATCC_1997 GDEYVTWAALLWLTVFTTGMCFVLKRRSARVVQLVHIR------------
Mvan_2071|M.vanbaalenii_PYR-1 GRIATRLRELGIRSAAGSPLTVDGGTRGVLVVGSHAVQGVPDGTEAHIGD
TH_4203|M.thermoresistible__bu TVERREFTRRDVDLLLVIGRLIAGGLHQARLHRQLVARER---------A
: : :
Rv0845|M.tuberculosis_H37Rv -AELLAQTMT-----------------ASEVLQRRIAEAIHDGPLQDVLA
Mb0868|M.bovis_AF2122/97 -EELLAQTMT-----------------ASEVLQRRIAEAIHDGPLQDVLA
MMAR_4781|M.marinum_M -EELLAQTMT-----------------ASEVLQRRISESIHDGPLQDVLA
MUL_0350|M.ulcerans_Agy99 -EELLAQTMT-----------------ASEVLQRRISESIHDGPLQDVLA
MAV_0874|M.avium_104 -EELLAQTMN-----------------ASDVSQRRISEFIHDGPLQDILA
Mflv_0729|M.gilvum_PYR-GCK -VQLVSEAMQ-----------------SDERHNREVAESLHDGPLQTLLA
MSMEG_0106|M.smegmatis_MC2_155 -RRLVQESAR-----------------ADELRDAELAEALHDGPLQTLLA
MAB_0061|M.abscessus_ATCC_1997 -EQLVLESMR-----------------ADERRNREVAERLHDGPLQNLLA
Mvan_2071|M.vanbaalenii_PYR-1 FADLISTAIANAETRAELTASRARIVAAADEARRGFERDLHDGAQQRIVS
TH_4203|M.thermoresistible__bu HEIFVEQVIE-----------------AQELERRRLAADIHDGISQRLVT
:: : : . :*** * :::
Rv0845|M.tuberculosis_H37Rv ARQELIELDAVTPGDERVG----RALAGLQSASERLRQATFELHPAVLEQ
Mb0868|M.bovis_AF2122/97 ARQELIELDAVTPGDERVG----RALAGLQSASERLRQATFELHPAVLEQ
MMAR_4781|M.marinum_M ARQELIELRAAAPHDQRVS----TALAGLQSASDLLRQATFELHPAVLEQ
MUL_0350|M.ulcerans_Agy99 ARQELIELRAAAPHDQRVS----TALAGLQSASDLLRQATFELHPAVLEQ
MAV_0874|M.avium_104 VRQELVELDAAVPDDERIG----RALAGLQLASERLRQATFELHPAVLEQ
Mflv_0729|M.gilvum_PYR-GCK ARLELDEARERNP-DPALD----AVYAALQETADGLRATVTELHPQVLAQ
MSMEG_0106|M.smegmatis_MC2_155 ARLELDELRERNP-DPALD----VVHAALQQTATGLRSTVTALHPQVLAQ
MAB_0061|M.abscessus_ATCC_1997 ARLRIEEVLERQS-DPVLT----AVHSSLRETAAELRGAVSSLHPQVLIE
Mvan_2071|M.vanbaalenii_PYR-1 LSLQLREAEAAVEGDEALRTQLSTVVNGLAGLHSDLQELSRGLHPAVLSR
TH_4203|M.thermoresistible__bu LSYRLDAAIRAVDDPATVTEQLSKARELADLTLEETRAAISGLRPPVLDD
.: : . : *:* **
Rv0845|M.tuberculosis_H37Rv VGLGPAVKQLAAST-AQRSGIKISTDIDYP-IRSGIDPIVFGVVRELLSN
Mb0868|M.bovis_AF2122/97 VGLGPAVKQLAAST-AQRSGIKISTDIDYP-IRSGIDPIVFGVVRELLSN
MMAR_4781|M.marinum_M VGLGAAVEQLASFH-AQRSGIRITDDVDYP-IRDEIDPIVFGVARELLSN
MUL_0350|M.ulcerans_Agy99 VGLGAAVEQLASFH-AQRSGIRITDDVDYP-IRDEIDPIVFGVARELLSN
MAV_0874|M.avium_104 VGLGAAVQQLAEFT-AQRSGIEISTDIDYS-GRSAIDAVVFGVVRELLSN
Mflv_0729|M.gilvum_PYR-GCK LGLTAGIRELLRQL-QSRHLLEVDAELEEV-GEPQSQALLYRAARELLTN
MSMEG_0106|M.smegmatis_MC2_155 LGLAPAVRELLRQY-ENRGDLVIRANIADV-GQPEAQALLYRAARELLAN
MAB_0061|M.abscessus_ATCC_1997 LGLTAAIRELARQH-TARGIVDVSTAVEEV-GSPPAQPLVYRAAKELLTN
Mvan_2071|M.vanbaalenii_PYR-1 GGLKPAMRNLARRS-TVP--VELTVDIDRR-LPEPVEVAAYYVVAESLTN
TH_4203|M.thermoresistible__bu LGLSGGLASLAQSVGQLDIGVDIEVDLAETRLPDHIELALYRIAQECLQN
** .: .* : : : : : . * * *
Rv0845|M.tuberculosis_H37Rv VVRHSGATTASVRLGIT----DEKCVLDVADDGVGVTGDTMARRLGEGH-
Mb0868|M.bovis_AF2122/97 VVRHSGATTASVRLGIT----DEKCVLDVADDGVGVTGDTMARRLGEGH-
MMAR_4781|M.marinum_M VVQHSRARNASVALGIS----DGVCVLDVADDGVGVSGETMARRLGQGH-
MUL_0350|M.ulcerans_Agy99 VVQHSRARNASVALGIS----DGVCVLDVADDGVGVSGETMARRLGQGH-
MAV_0874|M.avium_104 VVQHSRARTAAIMLGRT----DGTCVLHVVDDGVGFNQETVARRLGEGH-
Mflv_0729|M.gilvum_PYR-GCK IVKHADATTVRVRLARR----GDRVVLSVADDGAGFDPAILGTSLGQGH-
MSMEG_0106|M.smegmatis_MC2_155 VHKHARAATVTVRLFRQ----GERTVLTVVDDGVGFDPDIVAQSVAEGH-
MAB_0061|M.abscessus_ATCC_1997 AVKHGRAKNIRVELSSR----RCWLTLVVTDDGRGFDPRDLVLSVADGH-
Mvan_2071|M.vanbaalenii_PYR-1 VAKHAQADSVTVEIGLD----DAPDGGTLLR--LSVTDDGTGGASADGG-
TH_4203|M.thermoresistible__bu VVKHARARTARLTYAVDRGEHGEVARLEIVDDGVGFDTFEHPLGGDDMSG
:*. * . : : .. :
Rv0845|M.tuberculosis_H37Rv IGLASHRARVDAAGGVLVFLATP-RGTHVCVELPLKR---
Mb0868|M.bovis_AF2122/97 IGLASHRARVDAAGGVLVFLATP-RGTHVCVELPLKR---
MMAR_4781|M.marinum_M IGLASHRARVDAAGGSLVFLNTP-TGTHVCVRIPLKG---
MUL_0350|M.ulcerans_Agy99 IGLASHRARVDAAGGSLVFLNTP-TGTHVCVRIPLKG---
MAV_0874|M.avium_104 IGLASHRARVEAAGGELVFLDVP-VGTHVCVEVPLRN---
Mflv_0729|M.gilvum_PYR-GCK IGLGSLIARFDAMGGSMRITSSDGQGTEVTATSPPEPA--
MSMEG_0106|M.smegmatis_MC2_155 IGLASLQVRIEAMGGAMTISSEEGFGTQVTVIL-------
MAB_0061|M.abscessus_ATCC_1997 IGLASLTVPIEAAGGAVTITSAPGAGTRVSVTAPADMAA-
Mvan_2071|M.vanbaalenii_PYR-1 SGLVGLRDRVEALSGQLTVTSRPGDGTSISATIPVD----
TH_4203|M.thermoresistible__bu YGLLSMAERAEIVGGRLNIRSRPGAGTAVIATIPLPPATR
** . : .* : . ** : .