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MVQAPAPSLGAAVASGPRYLLSSWPWRALVWTMFGGVLSAVLLIGAPLILLLGVSRSLRNAVWSPLLEIE CARLSLIDDAAAERVRRDLSTARVEQRLPALRQVGYVLFTALIAGPWGVVLVAFLAILTVVMVAAPWLVR PGEPINVALWLIDTPGEAWFAALLGLVVLVLTAYLVGAYAAAVGQLAVVSLADPQALQREVTRLEHSRTA LLTAVEQERRRIESDLHDRVQHRLMALALTLGLAENVHGDNDAGRLAADAHRQVDDIAAELRAVLLGIQP RALTEHGLIAAVTDLIGPYPLPVRVDFGATEVPRRLPSAIEQTAYLVLTEALTNVVKHASASTVTIAADR QDGMWWFMIRDDGCGGAVLQQHRGLATLAARVQAVNGTLTISSPAGGPTEVSMRCPI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5907 | - | - | 100% (408) | integral membrane sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_4385 | - | 4e-34 | 34.32% (338) | integral membrane sensor signal transduction histidine kinase |
| M. vanbaalenii PYR-1 | Mvan_0262 | - | 7e-33 | 30.73% (384) | putative signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0868 | - | 3e-10 | 29.28% (222) | two component sensor kinase |
| M. gilvum PYR-GCK | Mflv_0967 | - | 1e-180 | 75.74% (408) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv0845 | - | 3e-10 | 29.28% (222) | two component sensor kinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4499 | - | 9e-23 | 34.98% (223) | putative two-component system sensor kinase |
| M. marinum M | MMAR_3479 | - | 1e-12 | 28.22% (287) | two-component sensor histidine kinase |
| M. avium 104 | MAV_4108 | - | 7e-13 | 32.20% (205) | GAF family protein |
| M. smegmatis MC2 155 | MSMEG_4968 | - | 4e-35 | 37.12% (264) | two-component system sensor kinase |
| M. thermoresistible (build 8) | TH_1533 | - | 6e-38 | 40.15% (259) | two-component system sensor kinase |
| M. ulcerans Agy99 | MUL_2422 | devS | 5e-12 | 26.22% (370) | two component sensor histidine kinase DevS |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_5907|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0967|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4968|M.smegmatis_MC2_155 --------------------------------------------------
TH_1533|M.thermoresistible__bu --------------------------------------------------
MMAR_3479|M.marinum_M ----------------------------------------MHAQLDELLA
MAV_4108|M.avium_104 ---------------------------------------MTGNRFDELAA
MUL_2422|M.ulcerans_Agy99 MTDEPHPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
MAB_4499|M.abscessus_ATCC_1997 ----------------------------------------MQQAAQASSP
Mb0868|M.bovis_AF2122/97 --------------------------------------------------
Rv0845|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_5907|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0967|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4968|M.smegmatis_MC2_155 --------------------------------------------------
TH_1533|M.thermoresistible__bu ------------------------------------------------MV
MMAR_3479|M.marinum_M ARDQMEQLLRVIVEIGSDLDLDATLRRIVLAARELTSAPYGALAVRDPEG
MAV_4108|M.avium_104 ARDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVRDWHA
MUL_2422|M.ulcerans_Agy99 GRDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEVHDRDK
MAB_4499|M.abscessus_ATCC_1997 RPILMPDYISGWRTQLFGSTPPSARLGIVAAVVLLVAESMLTIFLRTIAP
Mb0868|M.bovis_AF2122/97 --------MPSYGNLGRLG--GRHEYGVLVAMTSSAELDRVRWAHQLR-S
Rv0845|M.tuberculosis_H37Rv --------MPSYGNLGRLG--GRHEYGVLVAMTSSAELDRVRWAHQLR-S
Mvan_5907|M.vanbaalenii_PYR-1 --------------------------MMVQAPAPSLGAAVASGPRYLLSS
Mflv_0967|M.gilvum_PYR-GCK --------------------------MMVQAPARTLVAAMISGPRYLVSM
MSMEG_4968|M.smegmatis_MC2_155 ---------------------------MVTGAAIATVWFWIPLAIMIIGV
TH_1533|M.thermoresistible__bu AVTAETAPAPAPTRTARLG--VVPTASMVTGAAIALVWFWIPLTILIVGI
MMAR_3479|M.marinum_M TLIRFIHAGMDDDVARRIG--HLPVGKGVLGVSLVETPALRLDDLTMHPA
MAV_4108|M.avium_104 NLISFVHEGMDAETVRRIG--HHPVGKGLLSLSLLDTPALRMDDLTAHPA
MUL_2422|M.ulcerans_Agy99 RVLQFVYEGIDEDTVARIG--HLPEGLGIIGLLIDEPKPLRLEDISQHPA
MAB_4499|M.abscessus_ATCC_1997 TEHLAAVYLIGILVISVIWRLRLALAMSIASAIVFDCIRNWPKANPLSTE
: .
Mb0868|M.bovis_AF2122/97 YRIASVLRIGVVGLMVAAMVVG--TSRSEWPQQIVLIGVYAVAALWALLL
Rv0845|M.tuberculosis_H37Rv YRIASVLRIGVVGLMVAAMVVG--TSRSEWPQQIVLIGVYAVAALWALLL
Mvan_5907|M.vanbaalenii_PYR-1 WPWRALVWTMFGGVLSAVLLIGAPLILLLGVSRSLRNAVWSPLLEIECAR
Mflv_0967|M.gilvum_PYR-GCK WPWRALLWTVFGGVLGTVLIVGLPLILVMGVSRSARTAVWAPLLEIECAR
MSMEG_4968|M.smegmatis_MC2_155 SSIPSVIGFLLAGVVFIYLMRG-----VEWVERARSEAVFALNISIPPRP
TH_1533|M.thermoresistible__bu SSIPSVIGFLLAGVVFIYLIRG-----VEWVERIRSEAVFGMGIPIPPRR
MMAR_3479|M.marinum_M ACGFPEHHPPMRAFLAVPITIRGTVFGSLYLTHVDPGRKFSESDEFAARA
MAV_4108|M.avium_104 AAGFPEHHPAMRAFLAVPITIRGAVFGNLYLTHVDEARVFSDADEMAARA
MUL_2422|M.ulcerans_Agy99 SIGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQA
MAB_4499|M.abscessus_ATCC_1997 SHNLITHLSFLAVTLTASALAALARAGTIEAERRRREAAAIAQQQAALRR
. :
Mb0868|M.bovis_AF2122/97 AYSASRRFFALRRFRSMGRLEPFAFTAVDVLILTGFQLLSTDG----IYP
Rv0845|M.tuberculosis_H37Rv AYSASRRFFALRRFRSMGRLEPFAFTAVDVLILTGFQLLSTDG----IYP
Mvan_5907|M.vanbaalenii_PYR-1 LSLIDDAAAERVRRDLSTARVEQRLPALRQVGYVLFTALIAGPWGVVLVA
Mflv_0967|M.gilvum_PYR-GCK LSLIDEAAAERARSDVNAARAQQRLPTLRQAGYMVLTAMFTGPWGVVLVG
MSMEG_4968|M.smegmatis_MC2_155 RTHHSGFQGWAHQLWLDVSSTRFWKGVAHHYLRMIYDLLAAG------IA
TH_1533|M.thermoresistible__bu LSPHTGFQRWAHQLWLDISSARFWKAAAHHYLRMSYDMLAVG------VA
MMAR_3479|M.marinum_M LAFAAGVAIDNAQVFERERTAVKWMEASREITTALMSSTESRREPLQLIA
MAV_4108|M.avium_104 LAFAAAVAIDNAQVFERERMSVKWIEASREITTALLSRTEPHRRPMQLIA
MUL_2422|M.ulcerans_Agy99 LAAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEP-ASVFRLVA
MAB_4499|M.abscessus_ATCC_1997 TATLVASNVSPVELYAKVVEEAARCFASPTAVLVQLMPGDEGTIVAGHGT
. .
Mb0868|M.bovis_AF2122/97 LLIMILLPVLVGLDVSTRRAAVVLA-------------------------
Rv0845|M.tuberculosis_H37Rv LLIMILLPVLVGLDVSTRRAAVVLA-------------------------
Mvan_5907|M.vanbaalenii_PYR-1 FLAILTVVMVAAPWLVRPGEPINVA-------------------------
Mflv_0967|M.gilvum_PYR-GCK FSAILIGVMVAAPWLVRPGEPINVG-------------------------
MSMEG_4968|M.smegmatis_MC2_155 FALLAFAFIGPAASMAIRDSDDDAG-------------------------
TH_1533|M.thermoresistible__bu FALLAFAFLGPAGAIAVRNSDDNAG-------------------------
MMAR_3479|M.marinum_M QRACTLTDAEQAIVLVPVESDLATD-EIDTLVVSAAVGLHAEEVVGQQVP
MAV_4108|M.avium_104 ERACALTDAEQAIVLVPADPEQPGNPEVDTLVVSAAVGLPAADVLGQRVP
MUL_2422|M.ulcerans_Agy99 EEALKLTSADAALVAIPVDEDVPAS-EVAQLLVIETVGNAVAAAEGCTIA
MAB_4499|M.abscessus_ATCC_1997 EESRTPPAGKRFPLLDSNNVARELR-------------------------
Mb0868|M.bovis_AF2122/97 ----------------------------CTLVGFAVAVLGDPVMLRAIGW
Rv0845|M.tuberculosis_H37Rv ----------------------------CTLVGFAVAVLGDPVMLRAIGW
Mvan_5907|M.vanbaalenii_PYR-1 ----------------------------LWLIDTPGEAWFAALLGLVVLV
Mflv_0967|M.gilvum_PYR-GCK ----------------------------LWLIDSSGEAWAAVTLGIALLV
MSMEG_4968|M.smegmatis_MC2_155 ----------------------------LVFLS-PPIAWLLAVIAVAAAA
TH_1533|M.thermoresistible__bu ----------------------------LTFLP-PALAVVLAVIAVAAAA
MMAR_3479|M.marinum_M VRGSTCGDVFRSGEPLISEAFSYP-IEAFTDVAQRSAIVMPLSAHEKVAG
MAV_4108|M.avium_104 VRGSTSGAVFKSGEPLITDEFRYP-IQAFTDAGRRPAIVMPLRARDEVVG
MUL_2422|M.ulcerans_Agy99 VAGTALAEVLLDSAPRQVDKIAVEDVDELGDMG--PALVLPLRATDAVAG
MAB_4499|M.abscessus_ATCC_1997 ----------------------------LTPAVCAPIVVDAKHWGTLIVG
Mb0868|M.bovis_AF2122/97 PETIFRFALYAFLCATALMVVRIEERHTRSVAGLSALR-EELLAQTMTAS
Rv0845|M.tuberculosis_H37Rv PETIFRFALYAFLCATALMVVRIEERHTRSVAGLSALR-AELLAQTMTAS
Mvan_5907|M.vanbaalenii_PYR-1 LTAYLVGAYAAAVGQLAVVSLADPQALQREVTRLEHSR-TALLTAVEQER
Mflv_0967|M.gilvum_PYR-GCK LAAYLVGAYAAAVAQITVAALVDPHALQREVARLEHSR-TALLDAVEQER
MSMEG_4968|M.smegmatis_MC2_155 AILVFAPALDAAIDRWLLS-PSPTAALQHRVNALADAR-EGAVSSAQTER
TH_1533|M.thermoresistible__bu AILFFAPAVDARIDRWLLP-PSSTEALQHQVSALSDAR-AGAVSSAQTER
MMAR_3479|M.marinum_M VIAVARGADQPPFDARCLDLVSQFATHAAIALLLASGREDARQLTILAER
MAV_4108|M.avium_104 VIAIARGTEQPPFDESYLDLVRDFATHAAIALVLAAAREDARQLAVLAER
MUL_2422|M.ulcerans_Agy99 VVVLLHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVVTER
MAB_4499|M.abscessus_ATCC_1997 SHTPAQRDQDIRAGVRDFADLVATAIANAATREELAASRARIVSASDTAR
. .
Mb0868|M.bovis_AF2122/97 EVLQRRIAEAIHDGPLQDVLAARQELIELDAVTP-GDERVGRALAGLQSA
Rv0845|M.tuberculosis_H37Rv EVLQRRIAEAIHDGPLQDVLAARQELIELDAVTP-GDERVGRALAGLQSA
Mvan_5907|M.vanbaalenii_PYR-1 RRIESDLHDRVQHRLMALALTLGLAENVHGDND--AGRLAADAHRQVDDI
Mflv_0967|M.gilvum_PYR-GCK RRIESDLHDRVQHRLVALALTLGIAENAHGDSA--AGRLAADAHGQVDDI
MSMEG_4968|M.smegmatis_MC2_155 HRIERDLHDSVQPRLVSLAMTIGLAQTKLDSDLPAAKELIAEAHDEAKNA
TH_1533|M.thermoresistible__bu HRIERDLHDSVQPRLVSLAMTIGLAQTKLDTDLPAAKKLIAEAHEDAKSA
MMAR_3479|M.marinum_M ERIAHDLHDHVIQRLFASGMDLQGTLARARSPE--VIDRLNRTVDDLQTI
MAV_4108|M.avium_104 ERIAHDLHDHVIQRLFAAGMDLQGTLARARSPE--VADRLNRTLDDLQTI
MUL_2422|M.ulcerans_Agy99 DRIARDLHDHVIQRLFAIGLALQGSVPRTREPK--VQQRLSEVIDDLQGV
MAB_4499|M.abscessus_ATCC_1997 RRLERDLHDGAQQRLAYLRLKLGMVRAAVPATDAELTQELNNLDTDLTAV
: : : :
Mb0868|M.bovis_AF2122/97 SERLRQATFELHPAVLEQVGLGPAVKQLAASTAQR-SGIKISTDID--YP
Rv0845|M.tuberculosis_H37Rv SERLRQATFELHPAVLEQVGLGPAVKQLAASTAQR-SGIKISTDID--YP
Mvan_5907|M.vanbaalenii_PYR-1 AAELRAVLLGIQPRALTEHGLIAAVTDLIGPYPLPVRVDFGATEVP--RR
Mflv_0967|M.gilvum_PYR-GCK AAELRSVLLGILPRALTEHGLVAAATDLIGRYPVAVEADFGATEIP--AR
MSMEG_4968|M.smegmatis_MC2_155 LVELRNVVRGIAPTILADRGLDAALSSVAQRAQNSGVPTTLDVHLP--HR
TH_1533|M.thermoresistible__bu LAELRDVVRGIAPTILTDRGLDAALSAVVQRAETSGVPTTLNLHLP--RR
MMAR_3479|M.marinum_M IEEIRSTIFQLKSPSGRDGGFRQRIQQVVADLTEHRDVVTTIHMHGPMSA
MAV_4108|M.avium_104 IEEIRTTIFALRSPAAVAGDFRHRIQRVIAELTENRDLVTTVRMDGPMTA
MUL_2422|M.ulcerans_Agy99 IQEIRTTIFDLHGSSQGVTRLRQRIDAAVAAFGSS-GLRTTVQFIGPLSV
MAB_4499|M.abscessus_ATCC_1997 TRELQEFSRGLHPAILS-KGLAPALRTLARRSLIP-----VRTELELDQK
.:: : :
Mb0868|M.bovis_AF2122/97 IRSGIDPIVFGVVRELLSNVVRHSGATTASVRLGITDEKCVLDVADDGVG
Rv0845|M.tuberculosis_H37Rv IRSGIDPIVFGVVRELLSNVVRHSGATTASVRLGITDEKCVLDVADDGVG
Mvan_5907|M.vanbaalenii_PYR-1 LPSAIEQTAYLVLTEALTNVVKHASAS--TVTIAADRQDGMWWFMIRDDG
Mflv_0967|M.gilvum_PYR-GCK LPGPVEHTAYLVLNEALTNSAKHASAG--HVTITADRRDGLWWLVIRDDG
MSMEG_4968|M.smegmatis_MC2_155 LPDEVESVAYFVAAEALTNVIRHAQANQAVVTVRLDEPSATLHVSVFDDG
TH_1533|M.thermoresistible__bu LPEEVESVAYFVVAEALTNVVKHAQASQAVVTVRLNETDNTLQVSVFDDG
MMAR_3479|M.marinum_M VQGELADHAEAVATEAISNAVRHSGAGRVTLDVSVGD---MFSLEVVDDG
MAV_4108|M.avium_104 VGAELAEHAEAVTAEAVSNAVRHSGASRLTVQIGVAD---MFTLDVIDNG
MUL_2422|M.ulcerans_Agy99 VDNVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDD---DLCIEVSDNG
MAB_4499|M.abscessus_ATCC_1997 YGESIEIAAYYVVAEALANTAKHSQAS--EVVIRAHEADDQIHITISDDG
: . * * ::* :*: * : : . . *
Mb0868|M.bovis_AF2122/97 VTGDTMARRLGEGHIGLASHRARVDAAGGVLVFLATPRG--THVCVELPL
Rv0845|M.tuberculosis_H37Rv VTGDTMARRLGEGHIGLASHRARVDAAGGVLVFLATPRG--THVCVELPL
Mvan_5907|M.vanbaalenii_PYR-1 CGGAVLQ-----QHRGLATLAARVQAVNGTLTISSPAGGP-TEVSMRCPI
Mflv_0967|M.gilvum_PYR-GCK RGGATIQ-----PGRGLATLAARVEAVNGTLTVTSPAGGP-TEVGMRCPV
MSMEG_4968|M.smegmatis_MC2_155 KGGARIESDA--NATGLRGLAERVRAAGGTFDVSSPATGP-TIVTAVLPC
TH_1533|M.thermoresistible__bu CGSAQISDRD--NATGLRGLAERVRAAHGTFTVSSPPTGP-TIVTAVLPC
MMAR_3479|M.marinum_M CGISPDVSRR----SGLANMRSRAEKLGGTCGITTPTEGG-TRISWTVPF
MAV_4108|M.avium_104 RGIAAGNTRR----SGLANMTRRAEQLGGSCEISSPPGGG-TRVHWTAPL
MUL_2422|M.ulcerans_Agy99 RGMPKTYTS-----SGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPL
MAB_4499|M.abscessus_ATCC_1997 IGGAKPRKG-----TGLIGLTDRVTALGGRLDVHSASGRG-TTMTAIIPL
** *. * . :.. * : *
Mb0868|M.bovis_AF2122/97 KR--
Rv0845|M.tuberculosis_H37Rv KR--
Mvan_5907|M.vanbaalenii_PYR-1 ----
Mflv_0967|M.gilvum_PYR-GCK ----
MSMEG_4968|M.smegmatis_MC2_155 GS--
TH_1533|M.thermoresistible__bu GS--
MMAR_3479|M.marinum_M GDL-
MAV_4108|M.avium_104 LDH-
MUL_2422|M.ulcerans_Agy99 IQ--
MAB_4499|M.abscessus_ATCC_1997 HQSD