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VTSVTTTQRSGRLRQLGVDSAYVLLGFPLATVSFTVIVAMLAAGIATAVLVIGLPILVGTLLVARVLADI ERLRLPAVLRRPRIRPAYRKAAPGAGVWNRLGAVMADAQSWLDVVHAVVRFPVSLVTFSVVVSWWAAALG GTSTAAWDWAVPRGPDNQSLAQLIGLGDSTVARIGFQTAAGLLCLVSLPWVVRGCALLDAGLARTLLCGV SEMRQTITVLAEQKSAATSAEAHALRRLERDIHDGPQQRLIRLAMDLGRARQHTQPGALQDIIDEAVVQT QETLDELRALSRGIAPPVLTDRGLPSALAALAIRCTVPVELNVDPGLGTSAGRPDPAVETTVYFAVAEAL TNVAKHSEATTCRVTVAAVPPTAQGSARISAEIIDDGRGGAHIAKGHGLAGLADRIRAGGGTLDVSSPAG GPSTIAVALPV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0458 | - | - | 100% (431) | two-component system sensor kinase |
| M. smegmatis MC2 155 | MSMEG_4968 | - | 4e-43 | 33.18% (422) | two-component system sensor kinase |
| M. smegmatis MC2 155 | MSMEG_2804 | - | 5e-33 | 39.29% (224) | two-component system sensor kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3156c | devS | 9e-11 | 26.15% (195) | two component sensor histidine kinase DEVS |
| M. gilvum PYR-GCK | Mflv_2281 | - | 3e-40 | 33.49% (436) | integral membrane sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv3132c | devS | 1e-10 | 26.15% (195) | two component sensor histidine kinase DEVS |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4499 | - | 2e-28 | 40.09% (222) | putative two-component system sensor kinase |
| M. marinum M | MMAR_3479 | - | 2e-09 | 24.15% (236) | two-component sensor histidine kinase |
| M. avium 104 | MAV_0874 | - | 2e-09 | 26.61% (218) | hypothetical protein MAV_0874 |
| M. thermoresistible (build 8) | TH_1533 | - | 1e-40 | 32.64% (435) | two-component system sensor kinase |
| M. ulcerans Agy99 | MUL_2422 | devS | 2e-09 | 25.64% (195) | two component sensor histidine kinase DevS |
| M. vanbaalenii PYR-1 | Mvan_0262 | - | 3e-46 | 33.57% (420) | putative signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2281|M.gilvum_PYR-GCK --------------------------------------------------
TH_1533|M.thermoresistible__bu --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
Rv3132c|M.tuberculosis_H37Rv -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
MUL_2422|M.ulcerans_Agy99 MTDEPHPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
MMAR_3479|M.marinum_M ----------------------------------------MHAQLDELLA
MSMEG_0458|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0262|M.vanbaalenii_PYR-1 ----------------------------------------------MVWP
MAB_4499|M.abscessus_ATCC_1997 -----------------------------------MQQAAQASSPRPILM
MAV_0874|M.avium_104 --------------------------------------------------
Mflv_2281|M.gilvum_PYR-GCK -----------MSAVTDTDTGADTAPVDVPDQSGAPSGRTRTLSVAASAS
TH_1533|M.thermoresistible__bu -----------MVAVT-----AETAPAPAPT-------RTARLGVVPTAS
Mb3156c|M.bovis_AF2122/97 GRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQH
Rv3132c|M.tuberculosis_H37Rv GRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQH
MUL_2422|M.ulcerans_Agy99 GRDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEVHDRDK
MMAR_3479|M.marinum_M ARDQMEQLLRVIVEIGSDLDLDATLRRIVLAARELTSAPYGALAVRDPEG
MSMEG_0458|M.smegmatis_MC2_155 -----------MTSVTTTQRSGRLRQLGVDSAYVLLGFPLATVSFTVIVA
Mvan_0262|M.vanbaalenii_PYR-1 APPSRRWAPLSRLPSPPDQHGGVTVPTSPPTDPTTVTDMPPTRTGTDWPR
MAB_4499|M.abscessus_ATCC_1997 PDYISGWRTQLFGSTPPSARLGIVAAVVLLVAESMLTIFLRTIAPTEHLA
MAV_0874|M.avium_104 --------------------MAVAGDAELERVRAVHQMRSYRIGSVLRVG
Mflv_2281|M.gilvum_PYR-GCK --------------------MLVGGAAASVWFWIPLAILVIGISSIPSVI
TH_1533|M.thermoresistible__bu --------------------MVTGAAIALVWFWIPLTILIVGISSIPSVI
Mb3156c|M.bovis_AF2122/97 RVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASI
Rv3132c|M.tuberculosis_H37Rv RVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASI
MUL_2422|M.ulcerans_Agy99 RVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLEDISQHPASI
MMAR_3479|M.marinum_M TLIRFIHAGMDDDVARRIGHLPVGKGVLGVSLVETPALRLDDLTMHPAAC
MSMEG_0458|M.smegmatis_MC2_155 -------------------MLAAGIATAVLVIGLPILVGTLLVARVLADI
Mvan_0262|M.vanbaalenii_PYR-1 ---------------LLLAPVAPAAWRAYLYVHLVSVLAIVDIAFLFAAG
MAB_4499|M.abscessus_ATCC_1997 AVYLIG----------ILVISVIWRLRLALAMSIASAIVFDCIRNWPKAN
MAV_0874|M.avium_104 ---------------------VVGLMVAAMIIGTARSEWPQESVLI----
: .
Mflv_2281|M.gilvum_PYR-GCK G-----------FLVAAVVFVYLMRGVDHVERVRNEAVFGMGIAVPPRR-
TH_1533|M.thermoresistible__bu G-----------FLLAGVVFIYLIRGVEWVERIRSEAVFGMGIPIPPRR-
Mb3156c|M.bovis_AF2122/97 GFPPYHP-PMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQA-
Rv3132c|M.tuberculosis_H37Rv GFPPYHP-PMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQA-
MUL_2422|M.ulcerans_Agy99 GFPSHHP-PMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQA-
MMAR_3479|M.marinum_M GFPEHHP-PMRAFLAVPITIRGTVFGSLYLTHVDPGRKFSESDEFAARA-
MSMEG_0458|M.smegmatis_MC2_155 ER-----------LRLPAVLRRPRIRPAYRKAAPGAGVWNRLGAVMADAQ
Mvan_0262|M.vanbaalenii_PYR-1 LAS---------ALMILTVIGIPLLALLVMSGRAWNRLYRALAQLVGAQI
MAB_4499|M.abscessus_ATCC_1997 PLSTESHNLITHLSFLAVTLTASALAALARAGTIEAERRRREAAAIAQQQ
MAV_0874|M.avium_104 ------------LLYGIIALGAVALAFAPFRRWIGIGRLAGVGRLEPFA-
.
Mflv_2281|M.gilvum_PYR-GCK --LSHYTGFQRWAHQLWLDISSARFWKAVAHHYVRLTYD-----------
TH_1533|M.thermoresistible__bu --LSPHTGFQRWAHQLWLDISSARFWKAAAHHYLRMSYD-----------
Mb3156c|M.bovis_AF2122/97 --LAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEP-ATVFRL
Rv3132c|M.tuberculosis_H37Rv --LAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEP-ATVFRL
MUL_2422|M.ulcerans_Agy99 --LAAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEP-ASVFRL
MMAR_3479|M.marinum_M --LAFAAGVAIDNAQVFERERTAVKWMEASREITTALMSSTESRREPLQL
MSMEG_0458|M.smegmatis_MC2_155 SWLDVVHAVVRFPVSLVTFSVVVSWWAAALGGTSTAAWDWAVP-------
Mvan_0262|M.vanbaalenii_PYR-1 DAPPEFERPAGRLQVVTAALTDSVGWRSLGFLTLHAVLMTPIG-------
MAB_4499|M.abscessus_ATCC_1997 AALRRTATLVASNVSPVELYAKVVEEAARCFASPTAVLVQLMP-------
MAV_0874|M.avium_104 -----FTVVDILALTIFQLLSTNGIYPLLIMAMLPVLLGLDVS-------
Mflv_2281|M.gilvum_PYR-GCK ----------------------ALATALAAGLLAFAFLAPAAAVATGHSD
TH_1533|M.thermoresistible__bu ----------------------MLAVGVAFALLAFAFLGPAGAIAVRNSD
Mb3156c|M.bovis_AF2122/97 VAAEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASTVGRTI
Rv3132c|M.tuberculosis_H37Rv VAAEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASIVGRTI
MUL_2422|M.ulcerans_Agy99 VAEEALKLTSADAALVAIPVDEDVPASEVAQLLVIETVGNAVAAAEGCTI
MMAR_3479|M.marinum_M IAQRACTLTDAEQAIVLVPVESDLATDEIDTLVVSAAVGLHAEEVVGQQV
MSMEG_0458|M.smegmatis_MC2_155 ------------------------RGPDNQSLAQLIGLGDSTVARIGFQT
Mvan_0262|M.vanbaalenii_PYR-1 -----------------------FAVVVGVVASALLIVSPVVWLVTGEPF
MAB_4499|M.abscessus_ATCC_1997 ------------------GDEGTIVAGHGTEESRTPPAGKRFPLLDSNNV
MAV_0874|M.avium_104 -------------------------SRRAAVVLIFSMLGFAIAVLQDPVM
.
Mflv_2281|M.gilvum_PYR-GCK PEAGLSFLPTP---------------------------LAWLLAVVALAA
TH_1533|M.thermoresistible__bu DNAGLTFLPPA---------------------------LAVVLAVIAVAA
Mb3156c|M.bovis_AF2122/97 PVAGAVLREVFVNGIPRRVDRVDLEGLDELADAGP--ALLLPLRARGTVA
Rv3132c|M.tuberculosis_H37Rv PVAGAVLREVFVNGIPRRVDRVDLEGLDELADAGP--ALLLPLRARGTVA
MUL_2422|M.ulcerans_Agy99 AVAGTALAEVLLDSAPRQVDKIAVEDVDELGDMGP--ALVLPLRATDAVA
MMAR_3479|M.marinum_M PVRGSTCGDVFRSGEPLISEAFSYP-IEAFTDVAQRSAIVMPLSAHEKVA
MSMEG_0458|M.smegmatis_MC2_155 AAG-----------------------------------LLCLVSLPWVVR
Mvan_0262|M.vanbaalenii_PYR-1 ISLVEPVDSLA---------------------------VYVVLSVAGVLA
MAB_4499|M.abscessus_ATCC_1997 ARELRLTPAVCAP-----------------------IVVDAKHWGTLIVG
MAV_0874|M.avium_104 SSSVRLPEAG----------------------------FRFLLYGFLCCA
.
Mflv_2281|M.gilvum_PYR-GCK AVAVVVFGPALDARIDRWLLPPSETAALQHEVSALADAR-AGAVTSAQTE
TH_1533|M.thermoresistible__bu AAAILFFAPAVDARIDRWLLPPSSTEALQHQVSALSDAR-AGAVSSAQTE
Mb3156c|M.bovis_AF2122/97 GVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTD
Rv3132c|M.tuberculosis_H37Rv GVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTD
MUL_2422|M.ulcerans_Agy99 GVVVLLHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVVTE
MMAR_3479|M.marinum_M GVIAVARGADQPPFDARCLDLVSQFATHAAIALLLASGREDARQLTILAE
MSMEG_0458|M.smegmatis_MC2_155 GCALLDAGLAR--------TLLCGVSEMRQTITVLAEQKSAATSAEAHAL
Mvan_0262|M.vanbaalenii_PYR-1 LYLLGWVMIGISRVHVRVAAALLGPTGRERRVAQLENAR-AGVVDDAAAR
MAB_4499|M.abscessus_ATCC_1997 SHTPAQRDQDIRAGVRDFADLVATAIANAATREELAASR-ARIVSASDTA
MAV_0874|M.avium_104 AFLVVR--------------IEERHTRSVAGLSALREELLAQTMNASDVS
* .
Mflv_2281|M.gilvum_PYR-GCK RHRIERDLHDSVQPRLVSLAMTIGLAQTKLDSD--PPTARALIAEAHDEA
TH_1533|M.thermoresistible__bu RHRIERDLHDSVQPRLVSLAMTIGLAQTKLDTD--LPAAKKLIAEAHEDA
Mb3156c|M.bovis_AF2122/97 RDRIARDLHDHVIQRLFAIGLALQGAVPHERN----PEVQQRLSDVVDDL
Rv3132c|M.tuberculosis_H37Rv RDRIARDLHDHVIQRLFAIGLALQGAVPHERN----PEVQQRLSDVVDDL
MUL_2422|M.ulcerans_Agy99 RDRIARDLHDHVIQRLFAIGLALQGSVPRTRE----PKVQQRLSEVIDDL
MMAR_3479|M.marinum_M RERIAHDLHDHVIQRLFASGMDLQGTLARARS----PEVIDRLNRTVDDL
MSMEG_0458|M.smegmatis_MC2_155 R-RLERDIHDGPQQRLIRLAMDLGRARQHTQP----GALQDIIDEAVVQT
Mvan_0262|M.vanbaalenii_PYR-1 LQRVERDLHDGTQARLITVAMALARADEHLAEAGDTAQARMLVSDALANT
MAB_4499|M.abscessus_ATCC_1997 RRRLERDLHDGAQQRLAYLRLKLGMVRAAVPAT--DAELTQELNNLDTDL
MAV_0874|M.avium_104 QRRISEFIHDGPLQDILAVRQELVELDAAVPDD-------ERIGRALAGL
*: . :** : : :
Mflv_2281|M.gilvum_PYR-GCK KNALVELRNVVRGIAPTILADRGLDAALSSVVQRANNS-GVSTTLSVHLP
TH_1533|M.thermoresistible__bu KSALAELRDVVRGIAPTILTDRGLDAALSAVVQRAETS-GVPTTLNLHLP
Mb3156c|M.bovis_AF2122/97 QDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADS-GLRTSVQFVGP
Rv3132c|M.tuberculosis_H37Rv QDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADS-GLRTSVQFVGP
MUL_2422|M.ulcerans_Agy99 QGVIQEIRTTIFDLHGSSQGVTRLRQRIDAAVAAFGSS-GLRTTVQFIGP
MMAR_3479|M.marinum_M QTIIEEIRSTIFQLKSPSGRDGGFRQRIQQVVADLTEHRDVVTTIHMHGP
MSMEG_0458|M.smegmatis_MC2_155 QETLDELRALSRGIAPPVLTDRGLPSALAALAIRCTVPVELNVDPGLGTS
Mvan_0262|M.vanbaalenii_PYR-1 KDTLAELRDLIRGIRPP-ALDLGLGPAIHTLAARNPIPVDVTVDLSV---
MAB_4499|M.abscessus_ATCC_1997 TAVTRELQEFSRGLHPAILSKG-LAPALRTLARRSLIP--VRTELELDQ-
MAV_0874|M.avium_104 QLASERLRQATFELHPAVLEQVGLGAAVQQLAEFTAQRSGIEISTDIDYS
.:: : . : : . : .
Mflv_2281|M.gilvum_PYR-GCK R-RLPDEVEACAYFVVAEALTNVSRHSSASNAAVTVRLDEA----ANQLH
TH_1533|M.thermoresistible__bu R-RLPEEVESVAYFVVAEALTNVVKHAQASQAVVTVRLNET----DNTLQ
Mb3156c|M.bovis_AF2122/97 LSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDD-------DLC
Rv3132c|M.tuberculosis_H37Rv LSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDD-------DLC
MUL_2422|M.ulcerans_Agy99 LSVVDNVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDD-------DLC
MMAR_3479|M.marinum_M MSAVQGELADHAEAVATEAISNAVRHSGAGRVTLDVSVGD-------MFS
MSMEG_0458|M.smegmatis_MC2_155 AGRPDPAVETTVYFAVAEALTNVAKHSEATTCRVTVAAVPPTAQGSARIS
Mvan_0262|M.vanbaalenii_PYR-1 --RPSIGVETMAYFCVAELLANVSKHSGAGAAAVRVAGDAT------ELR
MAB_4499|M.abscessus_ATCC_1997 --KYGESIEIAAYYVVAEALANTAKHSQASEVVIRAHEADD------QIH
MAV_0874|M.avium_104 G---RSAIDAVVFGVVRELLSNVVQHSRARTAAIMLGRTDG------TCV
: . . * ::*. :*: * :
Mflv_2281|M.gilvum_PYR-GCK VSVFDDGRGGARVVDGDDT-VDATGLRGLDERVRAARGTFTVSSPPTG-P
TH_1533|M.thermoresistible__bu VSVFDDGCGSAQISDRD----NATGLRGLAERVRAAHGTFTVSSPPTG-P
Mb3156c|M.bovis_AF2122/97 IEVTDNGRGLPDEFTG-------SGLTNLRQRAEQAGGEFTLASVPGASG
Rv3132c|M.tuberculosis_H37Rv IEVTDNGRGLPDEFTG-------SGLTNLRQRAEQAGGEFTLASVPGASG
MUL_2422|M.ulcerans_Agy99 IEVSDNGRGMPKTYTS-------SGLTNLRRRAQEAGGQFTIESPAAGGG
MMAR_3479|M.marinum_M LEVVDDGCGISPDVSRR------SGLANMRSRAEKLGGTCGITTPTEG-G
MSMEG_0458|M.smegmatis_MC2_155 AEIIDDGRGGAHIAKG-------HGLAGLADRIRAGGGTLDVSSPAGG-P
Mvan_0262|M.vanbaalenii_PYR-1 IDVEDNGSGGVQVGNG-------SGLTGLAERLAMVDGRLEIDSPAGG-P
MAB_4499|M.abscessus_ATCC_1997 ITISDDGIGGAKPRKG-------TGLIGLTDRVTALGGRLDVHSASGR-G
MAV_0874|M.avium_104 LHVVDDGVGFNQETVARRLGEGHIGLASHRARVEAAGGELVFLDVPVG--
: *:* * ** . * * . .
Mflv_2281|M.gilvum_PYR-GCK TIVTAVLPCGS--
TH_1533|M.thermoresistible__bu TIVTAVLPCGS--
Mb3156c|M.bovis_AF2122/97 TVLRWSAPLSQ--
Rv3132c|M.tuberculosis_H37Rv TVLRWSAPLSQ--
MUL_2422|M.ulcerans_Agy99 TLLRWSAPLIQ--
MMAR_3479|M.marinum_M TRISWTVPFGDL-
MSMEG_0458|M.smegmatis_MC2_155 STIAVALPV----
Mvan_0262|M.vanbaalenii_PYR-1 TVVTVVVPPGAGQ
MAB_4499|M.abscessus_ATCC_1997 TTMTAIIPLHQSD
MAV_0874|M.avium_104 THVCVEVPLRN--
: : *