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MMVQAPARTLVAAMISGPRYLVSMWPWRALLWTVFGGVLGTVLIVGLPLILVMGVSRSARTAVWAPLLEI ECARLSLIDEAAAERARSDVNAARAQQRLPTLRQAGYMVLTAMFTGPWGVVLVGFSAILIGVMVAAPWLV RPGEPINVGLWLIDSSGEAWAAVTLGIALLVLAAYLVGAYAAAVAQITVAALVDPHALQREVARLEHSRT ALLDAVEQERRRIESDLHDRVQHRLVALALTLGIAENAHGDSAAGRLAADAHGQVDDIAAELRSVLLGIL PRALTEHGLVAAATDLIGRYPVAVEADFGATEIPARLPGPVEHTAYLVLNEALTNSAKHASAGHVTITAD RRDGLWWLVIRDDGRGGATIQPGRGLATLAARVEAVNGTLTVTSPAGGPTEVGMRCPV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0967 | - | - | 100% (408) | integral membrane sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_2281 | - | 1e-34 | 38.71% (248) | integral membrane sensor signal transduction histidine kinase |
| M. gilvum PYR-GCK | Mflv_5015 | - | 5e-17 | 30.04% (253) | GAF sensor signal transduction histidine kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3156c | devS | 1e-11 | 28.40% (243) | two component sensor histidine kinase DEVS |
| M. tuberculosis H37Rv | Rv3132c | devS | 1e-11 | 28.40% (243) | two component sensor histidine kinase DEVS |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4499 | - | 1e-20 | 34.53% (223) | putative two-component system sensor kinase |
| M. marinum M | MMAR_1517 | devS | 2e-12 | 28.52% (263) | two-component sensor histidine kinase DevS |
| M. avium 104 | MAV_4108 | - | 1e-11 | 30.69% (202) | GAF family protein |
| M. smegmatis MC2 155 | MSMEG_4968 | - | 2e-33 | 38.19% (254) | two-component system sensor kinase |
| M. thermoresistible (build 8) | TH_1533 | - | 8e-36 | 38.93% (262) | two-component system sensor kinase |
| M. ulcerans Agy99 | MUL_2422 | devS | 1e-12 | 28.52% (263) | two component sensor histidine kinase DevS |
| M. vanbaalenii PYR-1 | Mvan_5907 | - | 1e-180 | 75.74% (408) | integral membrane sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0967|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5907|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4968|M.smegmatis_MC2_155 --------------------------------------------------
TH_1533|M.thermoresistible__bu --------------------------------------------------
Mb3156c|M.bovis_AF2122/97 -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
Rv3132c|M.tuberculosis_H37Rv -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
MMAR_1517|M.marinum_M MTDEPHPQDAGPALGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
MUL_2422|M.ulcerans_Agy99 MTDEPHPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
MAV_4108|M.avium_104 ---------------------------------------MTGNRFDELAA
MAB_4499|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0967|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5907|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4968|M.smegmatis_MC2_155 --------------------------------------------------
TH_1533|M.thermoresistible__bu -------------------------------------------MVAVTAE
Mb3156c|M.bovis_AF2122/97 GRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQH
Rv3132c|M.tuberculosis_H37Rv GRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQH
MMAR_1517|M.marinum_M GRDRLDGLVEAMLVVTSGLELNATLRTIVHSATNLVDARYCALEVHDRDK
MUL_2422|M.ulcerans_Agy99 GRDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEVHDRDK
MAV_4108|M.avium_104 ARDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVRDWHA
MAB_4499|M.abscessus_ATCC_1997 ---------------MQQAAQASSPRPILMPDYISGWRTQLFGSTPPSAR
Mflv_0967|M.gilvum_PYR-GCK -------------------MMVQAPARTLVAAMISGPRYLVSMWPWRALL
Mvan_5907|M.vanbaalenii_PYR-1 -------------------MMVQAPAPSLGAAVASGPRYLLSSWPWRALV
MSMEG_4968|M.smegmatis_MC2_155 --------------------MVTGAAIATVWFWIPLAIMIIGVSSIPSVI
TH_1533|M.thermoresistible__bu TAPAPAPTRTARLGVVPTASMVTGAAIALVWFWIPLTILIVGISSIPSVI
Mb3156c|M.bovis_AF2122/97 RVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASI
Rv3132c|M.tuberculosis_H37Rv RVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASI
MMAR_1517|M.marinum_M RVLQFVYEGIDEDTVARIGHLPEGLGVIGLLIDEPKPLRLEDISQHPASI
MUL_2422|M.ulcerans_Agy99 RVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLEDISQHPASI
MAV_4108|M.avium_104 NLISFVHEGMDAETVRRIGHHPVGKGLLSLSLLDTPALRMDDLTAHPAAA
MAB_4499|M.abscessus_ATCC_1997 LGIVAAVVLLVAESMLTIFLRTIAPTEHLAAVYLIGILVISVIWRLRLAL
. :
Mflv_0967|M.gilvum_PYR-GCK WT-----VFGGVLGTVLIVGLPLILVMGVSRSARTAVWAPLLEIECARLS
Mvan_5907|M.vanbaalenii_PYR-1 WT-----MFGGVLSAVLLIGAPLILLLGVSRSLRNAVWSPLLEIECARLS
MSMEG_4968|M.smegmatis_MC2_155 GF-----LLAGVVFIYLMRG-----VEWVERARSEAVFALNISIPPRPRT
TH_1533|M.thermoresistible__bu GF-----LLAGVVFIYLIRG-----VEWVERIRSEAVFGMGIPIPPRRLS
Mb3156c|M.bovis_AF2122/97 GFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALA
Rv3132c|M.tuberculosis_H37Rv GFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALA
MMAR_1517|M.marinum_M GFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQALA
MUL_2422|M.ulcerans_Agy99 GFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQALA
MAV_4108|M.avium_104 GFPEHHPAMRAFLAVPITIRGAVFGNLYLTHVDEARVFSDADEMAARALA
MAB_4499|M.abscessus_ATCC_1997 AMS----IASAIVFDCIRNWPKANPLSTESHNLITHLSFLAVTLTASALA
.: : : :
Mflv_0967|M.gilvum_PYR-GCK LIDEAAAERARSDV-NAARAQQRLPTLRQAGYMVLTAMFTGPWGVVLVGF
Mvan_5907|M.vanbaalenii_PYR-1 LIDDAAAERVRRDL-STARVEQRLPALRQVGYVLFTALIAGPWGVVLVAF
MSMEG_4968|M.smegmatis_MC2_155 HHSGFQGWAHQLWL-DVSSTRFWKGVAHHYLRMIYDLLAAG------IAF
TH_1533|M.thermoresistible__bu PHTGFQRWAHQLWL-DISSARFWKAAAHHYLRMSYDMLAVG------VAF
Mb3156c|M.bovis_AF2122/97 AAAGIAVANARLYQ-QAKARQSWIEATRDIATELLSGTEPAT-VFRLVAA
Rv3132c|M.tuberculosis_H37Rv AAAGIAVANARLYQ-QAKARQSWIEATRDIATELLSGTEPAT-VFRLVAA
MMAR_1517|M.marinum_M AAAGIAIANARLYE-QAKARQAWIGATRDIATELLSGTEPAS-VFRLVAE
MUL_2422|M.ulcerans_Agy99 AAAGIAIANARLYE-QAKARQAWIGATRDIATELLSGTEPAS-VFRLVAE
MAV_4108|M.avium_104 FAAAVAIDNAQVFE-RERMSVKWIEASREITTALLSRTEPHRRPMQLIAE
MAB_4499|M.abscessus_ATCC_1997 ALARAGTIEAERRRREAAAIAQQQAALRRTATLVASNVSPVELYAKVVEE
. . : :
Mflv_0967|M.gilvum_PYR-GCK SAILIGVMVAAPWLVRPGEPIN--------VGLWLIDSSGEAWAAVTLGI
Mvan_5907|M.vanbaalenii_PYR-1 LAILTVVMVAAPWLVRPGEPIN--------VALWLIDTPGEAWFAALLGL
MSMEG_4968|M.smegmatis_MC2_155 ALLAFAFIGPAASMAIRDSDDD--------AGLVFLS-PPIAWLLAVIAV
TH_1533|M.thermoresistible__bu ALLAFAFLGPAGAIAVRNSDDN--------AGLTFLP-PALAVVLAVIAV
Mb3156c|M.bovis_AF2122/97 EALKLTAADAALVAVPVDEDMP-AADVGELLVIETVGSAVASTVGRTIPV
Rv3132c|M.tuberculosis_H37Rv EALKLTAADAALVAVPVDEDMP-AADVGELLVIETVGSAVASIVGRTIPV
MMAR_1517|M.marinum_M EALKLTSADAALVAVPVDEDVP-ASEVAQLLVIETVGNAVAAAEGCTIAV
MUL_2422|M.ulcerans_Agy99 EALKLTSADAALVAIPVDEDVP-ASEVAQLLVIETVGNAVAAAEGCTIAV
MAV_4108|M.avium_104 RACALTDAEQAIVLVPADPEQPGNPEVDTLVVSAAVGLPAADVLGQRVPV
MAB_4499|M.abscessus_ATCC_1997 AARCFASPTAVLVQLMPGDEGT----IVAGHGTEESRTPPAGKRFPLLDS
. . . :
Mflv_0967|M.gilvum_PYR-GCK ALLVLAAYLVG-------------------------------AYAAAVAQ
Mvan_5907|M.vanbaalenii_PYR-1 VVLVLTAYLVG-------------------------------AYAAAVGQ
MSMEG_4968|M.smegmatis_MC2_155 AAAAAILVFAP-------------------------------ALDAAIDR
TH_1533|M.thermoresistible__bu AAAAAILFFAP-------------------------------AVDARIDR
Mb3156c|M.bovis_AF2122/97 AGAVLREVFVNGIPRRVDRVDLEGLDELADAG--PALLLPLRARGTVAGV
Rv3132c|M.tuberculosis_H37Rv AGAVLREVFVNGIPRRVDRVDLEGLDELADAG--PALLLPLRARGTVAGV
MMAR_1517|M.marinum_M AGTALAEVLLDSAPRQVDKIAVEGVDELGDTG--PALVLPLRATDAVAGV
MUL_2422|M.ulcerans_Agy99 AGTALAEVLLDSAPRQVDKIAVEDVDELGDMG--PALVLPLRATDAVAGV
MAV_4108|M.avium_104 RGSTSGAVFKSGEPLITDEFRYP-IQAFTDAGRRPAIVMPLRARDEVVGV
MAB_4499|M.abscessus_ATCC_1997 NNVARELRLTP-------------------------AVCAPIVVDAKHWG
. : .
Mflv_0967|M.gilvum_PYR-GCK ITVAALVDPHALQREVARLEHS---------------------RTALLDA
Mvan_5907|M.vanbaalenii_PYR-1 LAVVSLADPQALQREVTRLEHS---------------------RTALLTA
MSMEG_4968|M.smegmatis_MC2_155 WLLS-PSPTAALQHRVNALADA---------------------REGAVSS
TH_1533|M.thermoresistible__bu WLLP-PSSTEALQHQVSALSDA---------------------RAGAVSS
Mb3156c|M.bovis_AF2122/97 VVVLSQGGPGAFTDEQLEMMAAFADQAALAWQ------LATSQRRMRELD
Rv3132c|M.tuberculosis_H37Rv VVVLSQGGPGAFTDEQLEMMAAFADQAALAWQ------LATSQRRMRELD
MMAR_1517|M.marinum_M VVLLHPSSPESVTEEQLEMMAAFADQAALALQ------LATSQRRMRELD
MUL_2422|M.ulcerans_Agy99 VVLLHPSSPESVTEEQLEMMAAFADQAALALQ------LATSQRRMRELD
MAV_4108|M.avium_104 IAIARGTEQPPFDESYLDLVRDFATHAAIALV------LAAAREDARQLA
MAB_4499|M.abscessus_ATCC_1997 TLIVGSHTPAQRDQDIRAGVRDFADLVATAIANAATREELAASRARIVSA
: .
Mflv_0967|M.gilvum_PYR-GCK VEQERRRIESDLHDRVQHRLVALALTLGIAENAHGDSA--AGRLAADAHG
Mvan_5907|M.vanbaalenii_PYR-1 VEQERRRIESDLHDRVQHRLMALALTLGLAENVHGDND--AGRLAADAHR
MSMEG_4968|M.smegmatis_MC2_155 AQTERHRIERDLHDSVQPRLVSLAMTIGLAQTKLDSDLPAAKELIAEAHD
TH_1533|M.thermoresistible__bu AQTERHRIERDLHDSVQPRLVSLAMTIGLAQTKLDTDLPAAKKLIAEAHE
Mb3156c|M.bovis_AF2122/97 VLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPE--VQQRLSDVVD
Rv3132c|M.tuberculosis_H37Rv VLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPE--VQQRLSDVVD
MMAR_1517|M.marinum_M VMTERDRIARDLHDHVIQRLFAIGLALQGSVPRTREPK--VQQRLSEVID
MUL_2422|M.ulcerans_Agy99 VVTERDRIARDLHDHVIQRLFAIGLALQGSVPRTREPK--VQQRLSEVID
MAV_4108|M.avium_104 VLAERERIAHDLHDHVIQRLFAAGMDLQGTLARARSPE--VADRLNRTLD
MAB_4499|M.abscessus_ATCC_1997 SDTARRRLERDLHDGAQQRLAYLRLKLGMVRAAVPATDAELTQELNNLDT
* *: **** . ** : :
Mflv_0967|M.gilvum_PYR-GCK QVDDIAAELRSVLLGILPRALTEHGLVAAATDLIGRYPVA--VEADFGAT
Mvan_5907|M.vanbaalenii_PYR-1 QVDDIAAELRAVLLGIQPRALTEHGLIAAVTDLIGPYPLP--VRVDFGAT
MSMEG_4968|M.smegmatis_MC2_155 EAKNALVELRNVVRGIAPTILADRGLDAALSSVAQRAQNS--GVPTTLDV
TH_1533|M.thermoresistible__bu DAKSALAELRDVVRGIAPTILTDRGLDAALSAVVQRAETS--GVPTTLNL
Mb3156c|M.bovis_AF2122/97 DLQDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADS-GLRTSVQFV
Rv3132c|M.tuberculosis_H37Rv DLQDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADS-GLRTSVQFV
MMAR_1517|M.marinum_M DLQGVIQEIRTTIFDLHGSSQGVTRLRQRIDAAVAAFGSS-GLRTTVQFI
MUL_2422|M.ulcerans_Agy99 DLQGVIQEIRTTIFDLHGSSQGVTRLRQRIDAAVAAFGSS-GLRTTVQFI
MAV_4108|M.avium_104 DLQTIIEEIRTTIFALRSPAAVAGDFRHRIQRVIAELTENRDLVTTVRMD
MAB_4499|M.abscessus_ATCC_1997 DLTAVTRELQEFSRGLHPAILSKG-LAPALRTLARRSLIP-----VRTEL
: *:: : :
Mflv_0967|M.gilvum_PYR-GCK EIPARLPGPVEHTAYLVLNEALTNSAKHASAG--HVTITADRRDGLWWLV
Mvan_5907|M.vanbaalenii_PYR-1 EVPRRLPSAIEQTAYLVLTEALTNVVKHASAS--TVTIAADRQDGMWWFM
MSMEG_4968|M.smegmatis_MC2_155 HLPHRLPDEVESVAYFVAAEALTNVIRHAQANQAVVTVRLDEPSATLHVS
TH_1533|M.thermoresistible__bu HLPRRLPEEVESVAYFVVAEALTNVVKHAQASQAVVTVRLNETDNTLQVS
Mb3156c|M.bovis_AF2122/97 GPLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDD---DLCIE
Rv3132c|M.tuberculosis_H37Rv GPLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDD---DLCIE
MMAR_1517|M.marinum_M GPLSVVDNVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDD---DLCIE
MUL_2422|M.ulcerans_Agy99 GPLSVVDNVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDD---DLCIE
MAV_4108|M.avium_104 GPMTAVGAELAEHAEAVTAEAVSNAVRHSGASRLTVQIGVAD---MFTLD
MAB_4499|M.abscessus_ATCC_1997 ELDQKYGESIEIAAYYVVAEALANTAKHSQAS--EVVIRAHEADDQIHIT
: * * **::* :*: * * : .
Mflv_0967|M.gilvum_PYR-GCK IRDDGRGGATIQ---PGRGLATLAARVEAVNGTLTVTSPAGG-PTEVGMR
Mvan_5907|M.vanbaalenii_PYR-1 IRDDGCGGAVLQ---QHRGLATLAARVQAVNGTLTISSPAGG-PTEVSMR
MSMEG_4968|M.smegmatis_MC2_155 VFDDGKGGARIESDANATGLRGLAERVRAAGGTFDVSSPATG-PTIVTAV
TH_1533|M.thermoresistible__bu VFDDGCGSAQISDRDNATGLRGLAERVRAAHGTFTVSSPPTG-PTIVTAV
Mb3156c|M.bovis_AF2122/97 VTDNGRG--LPDEFTG-SGLTNLRQRAEQAGGEFTLASVPGASGTVLRWS
Rv3132c|M.tuberculosis_H37Rv VTDNGRG--LPDEFTG-SGLTNLRQRAEQAGGEFTLASVPGASGTVLRWS
MMAR_1517|M.marinum_M VSDNGRG--MPKTYTS-SGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWS
MUL_2422|M.ulcerans_Agy99 VSDNGRG--MPKTYTS-SGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWS
MAV_4108|M.avium_104 VIDNGRG--IAAGNTRRSGLANMTRRAEQLGGSCEISSPPGG-GTRVHWT
MAB_4499|M.abscessus_ATCC_1997 ISDDGIGGAKPR---KGTGLIGLTDRVTALGGRLDVHSASGR-GTTMTAI
: *:* * ** : *. * : * . * :
Mflv_0967|M.gilvum_PYR-GCK CPV----
Mvan_5907|M.vanbaalenii_PYR-1 CPI----
MSMEG_4968|M.smegmatis_MC2_155 LPCGS--
TH_1533|M.thermoresistible__bu LPCGS--
Mb3156c|M.bovis_AF2122/97 APLSQ--
Rv3132c|M.tuberculosis_H37Rv APLSQ--
MMAR_1517|M.marinum_M APLIQ--
MUL_2422|M.ulcerans_Agy99 APLIQ--
MAV_4108|M.avium_104 APLLDH-
MAB_4499|M.abscessus_ATCC_1997 IPLHQSD
*