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TDEPHPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVEGRDRLDGLVEAMLVVTSGLEL DATLRTIVHSATNLVDARYCALEVHDRDKRVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLE DISQHPASIGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQALAAAAGIAIANAR LYEQAKARQAWIGATRDIATELLSGTEPASVFRLVAEEALKLTSADAALVAIPVDEDVPASEVAQLLVIE TVGNAVAAAEGCTIAVAGTALAEVLLDSAPRQVDKIAVEDVDELGDMGPALVLPLRATDAVAGVVVLLHP SSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVVTERDRIARDLHDHVIQRLFAIGLALQGSVP RTREPKVQQRLSEVIDDLQGVIQEIRTTIFDLHGSSQGVTRLRQRIDAAVAAFGSSGLRTTVQFIGPLSV VDNVLADHAEAVVREAVSNAVRHAQATTLTVRVKVDDDLCIEVSDNGRGMPKTYTSSGLTNLRRRAQEAG GQFTIESPAAGGGTLLRWSAPLIQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2422 | devS | - | 100% (585) | two component sensor histidine kinase DevS |
| M. ulcerans Agy99 | MUL_0350 | - | 1e-07 | 25.89% (197) | two component sensor kinase |
| M. ulcerans Agy99 | MUL_2542 | - | 1e-05 | 24.59% (370) | sensor kinase from two component regulatory system |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3156c | devS | 0.0 | 78.48% (567) | two component sensor histidine kinase DEVS |
| M. gilvum PYR-GCK | Mflv_3844 | - | 0.0 | 64.18% (564) | GAF sensor signal transduction histidine kinase |
| M. tuberculosis H37Rv | Rv3132c | devS | 0.0 | 78.48% (567) | two component sensor histidine kinase DEVS |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3890c | - | 1e-146 | 51.67% (569) | histidine kinase response regulator |
| M. marinum M | MMAR_1517 | devS | 0.0 | 98.80% (585) | two-component sensor histidine kinase DevS |
| M. avium 104 | MAV_4108 | - | 1e-117 | 43.33% (547) | GAF family protein |
| M. smegmatis MC2 155 | MSMEG_5241 | - | 0.0 | 65.07% (564) | GAF family protein |
| M. thermoresistible (build 8) | TH_0388 | - | 3e-78 | 63.75% (240) | TWO COMPONENT SENSOR HISTIDINE KINASE DEVS |
| M. vanbaalenii PYR-1 | Mvan_1395 | - | 0.0 | 63.52% (562) | GAF sensor signal transduction histidine kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2422|M.ulcerans_Agy99 MTDEPHPQDAGPSLGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
MMAR_1517|M.marinum_M MTDEPHPQDAGPALGVPSGDGLRPLRLTLSQLRLRELLVEVQERVEQIVE
Mb3156c|M.bovis_AF2122/97 -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
Rv3132c|M.tuberculosis_H37Rv -------MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVE
Mflv_3844|M.gilvum_PYR-GCK ----MHDGAVADADDHRARDGARPVRTTLSQLRLRELLTEVQDRVEQIIR
Mvan_1395|M.vanbaalenii_PYR-1 ---------------------MRPLRDTLSQLRLRELLNEVQDRVEQIVE
MSMEG_5241|M.smegmatis_MC2_155 ------MGGVNGHHPRRDDDQRTPLRDTLSQLRLRELLSEVQDRVEQIVE
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 -------------MVEDVGAQPNRVTAELAHLQLRELLAEVQGRIEQIVD
MAV_4108|M.avium_104 ---------------------------------------MTGNRFDELAA
MUL_2422|M.ulcerans_Agy99 G-RDRLDGLVEAMLVVTSGLELDATLRTIVHSATNLVDARYCALEVHDRD
MMAR_1517|M.marinum_M G-RDRLDGLVEAMLVVTSGLELNATLRTIVHSATNLVDARYCALEVHDRD
Mb3156c|M.bovis_AF2122/97 G-RDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQ
Rv3132c|M.tuberculosis_H37Rv G-RDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQ
Mflv_3844|M.gilvum_PYR-GCK G-RDRLDGLVEAMLAVTSGLELDETLRTIVHTAIELVDAQYGALGVRGHD
Mvan_1395|M.vanbaalenii_PYR-1 G-RDRLDGLLDAMLVVTSGLELDETLRTIVRTAIDLVDAQYGALGVRGHD
MSMEG_5241|M.smegmatis_MC2_155 G-RDRLDGLVEAMLVVTSGLELDVTLRTIVHTAIELVDARYGALGVRGED
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 GTRGRMDALLDAVMAVSSGLELDATLREIVCAASELVSARYGALGVVGSD
MAV_4108|M.avium_104 A-RDQTEKLLRVIAEIGAGLDLDATLHRIISAARELTSAPYGALAVRDWH
MUL_2422|M.ulcerans_Agy99 KRVLQFVYEGIDEDTVARIGHLPEGLGIIGLLIDEPKPLRLEDISQHPAS
MMAR_1517|M.marinum_M KRVLQFVYEGIDEDTVARIGHLPEGLGVIGLLIDEPKPLRLEDISQHPAS
Mb3156c|M.bovis_AF2122/97 HRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPAS
Rv3132c|M.tuberculosis_H37Rv HRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPAS
Mflv_3844|M.gilvum_PYR-GCK QELVEFIYEGIDEPMRERIGHLPEGRGVLGVLINDPKPIRLEDISRHADS
Mvan_1395|M.vanbaalenii_PYR-1 HELVEFIYQGIDEQSKELIGHLPEGRGVLGVLIDDPKPIRLDRISQHPAS
MSMEG_5241|M.smegmatis_MC2_155 HHLIEFIYEGITPEVREEIGPLPEGRGVLGVLIDDPKPIRLDDIRLHPAS
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 EKLAEFVYEGIDEATRDLIGPLPTGHGVLGVVIDEAKPLRLRDIAAHPAS
MAV_4108|M.avium_104 ANLISFVHEGMDAETVRRIGHHPVGKGLLSLSLLDTPALRMDDLTAHPAA
MUL_2422|M.ulcerans_Agy99 IGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQAL
MMAR_1517|M.marinum_M IGFPSHHPPMRTFLGVPVRVRDVSLGTLYLTDKTNGQPFSDDDELLVQAL
Mb3156c|M.bovis_AF2122/97 IGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQAL
Rv3132c|M.tuberculosis_H37Rv IGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQAL
Mflv_3844|M.gilvum_PYR-GCK VGFPPNHPPMRTFLGVPVRIRDEVFGNLYLTEKSDGQPFSEDDEVLVQAL
Mvan_1395|M.vanbaalenii_PYR-1 VGFPPNHPPMRTFLGVPVRIRDEVFGNLYLTEKADGQPFSEDDEVLVQAL
MSMEG_5241|M.smegmatis_MC2_155 VGFPPNHPPMRTFLGVPVRTRDKVFGNLYLTEKTNGQPFSEDDEVLVQAL
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 VGFPANHPPMRTFLGVPVQVRGEVFGRLYLTEKLDGQEFTEDDEVVVRAL
MAV_4108|M.avium_104 AGFPEHHPAMRAFLAVPITIRGAVFGNLYLTHVDEARVFSDADEMAARAL
MUL_2422|M.ulcerans_Agy99 AAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPAS-VFRLVAE
MMAR_1517|M.marinum_M AAAAGIAIANARLYEQAKARQAWIGATRDIATELLSGTEPAS-VFRLVAE
Mb3156c|M.bovis_AF2122/97 AAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPAT-VFRLVAA
Rv3132c|M.tuberculosis_H37Rv AAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPAT-VFRLVAA
Mflv_3844|M.gilvum_PYR-GCK AAAAGIAIDNARLYAQSQARQSWIEATRDIGTELLSGIDPAG-VFRRVAD
Mvan_1395|M.vanbaalenii_PYR-1 AAAAGIAIENARLYQQSKTRRSWIEATRDIGTEMLSGADPSK-VFRLVAD
MSMEG_5241|M.smegmatis_MC2_155 AAAAGIAVDNARLYEESQARQAWIAATRDIGTQLLSGTDPAT-VFRLVAA
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 AGAAGIAIENARLYQHARRREQWQRATADITAELLGGVDPGK-ALHLVAS
MAV_4108|M.avium_104 AFAAAVAIDNAQVFERERMSVKWIEASREITTALLSRTEPHRRPMQLIAE
MUL_2422|M.ulcerans_Agy99 EALKLTSADAALVAIPVDEDVPAS-EVAQLLVIETVGNAVAAAEGCTIAV
MMAR_1517|M.marinum_M EALKLTSADAALVAVPVDEDVPAS-EVAQLLVIETVGNAVAAAEGCTIAV
Mb3156c|M.bovis_AF2122/97 EALKLTAADAALVAVPVDEDMPAA-DVGELLVIETVGSAVASTVGRTIPV
Rv3132c|M.tuberculosis_H37Rv EALKLTAADAALVAVPVDEDMPAA-DVGELLVIETVGSAVASIVGRTIPV
Mflv_3844|M.gilvum_PYR-GCK RAQKLSGAAATLVAVPDDPDLPVG-EVAELTVAASAGETIA-AAHDPIPV
Mvan_1395|M.vanbaalenii_PYR-1 QSRLLSGAQSTLVAVRSDLDELDG-RVDELVVVATAGDGPG-VSLSAIPT
MSMEG_5241|M.smegmatis_MC2_155 EALTLTGADGTLVAVPADPDASA---AEELVIVEVAGAVPAEVEASAIPV
TH_0388|M.thermoresistible__bu --------------------------------------------------
MAB_3890c|M.abscessus_ATCC_199 SAALLAEADFAFIALPAGD---EE-DTAELVVAVCEGKGAEVLNDKLIPI
MAV_4108|M.avium_104 RACALTDAEQAIVLVPADPEQPGNPEVDTLVVSAAVGLPAADVLGQRVPV
MUL_2422|M.ulcerans_Agy99 AGTALAEVLLDSAPRQVDKIAVEDVD-ELGDMGPALVLPLRATDAVAGVV
MMAR_1517|M.marinum_M AGTALAEVLLDSAPRQVDKIAVEGVD-ELGDTGPALVLPLRATDAVAGVV
Mb3156c|M.bovis_AF2122/97 AGAVLREVFVNGIPRRVDRVDLEGLD-ELADAGPALLLPLRARGTVAGVV
Rv3132c|M.tuberculosis_H37Rv AGAVLREVFVNGIPRRVDRVDLEGLD-ELADAGPALLLPLRARGTVAGVV
Mflv_3844|M.gilvum_PYR-GCK AGTAIGDAFVHRTPGMTDRADIG-I---GATVGPALLLPLRAPDAVPGVL
Mvan_1395|M.vanbaalenii_PYR-1 HGSAIGEVFSTKTPVRFDTLELEPR---HLAPGPALVLPLRATDTVAGVL
MSMEG_5241|M.smegmatis_MC2_155 QDNAIGQAFRDRAPRRLDVLDGP------GLGGPALVLPLRATDTVAGVL
TH_0388|M.thermoresistible__bu ------------------------------------------------VL
MAB_3890c|M.abscessus_ATCC_199 DGSTSGSTFIDHEPRNVGRLAVNLAEGTDLAFGPALVLPLGGGESTAGVL
MAV_4108|M.avium_104 RGSTSGAVFKSGEPLITDEFRYPIQAFTDAGRRPAIVMPLRARDEVVGVI
*:
MUL_2422|M.ulcerans_Agy99 VLLHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVVTERDR
MMAR_1517|M.marinum_M VLLHPSSPESVTEEQLEMMAAFADQAALALQLATSQRRMRELDVMTERDR
Mb3156c|M.bovis_AF2122/97 VVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDR
Rv3132c|M.tuberculosis_H37Rv VVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDR
Mflv_3844|M.gilvum_PYR-GCK IVLRSVGAQPFRSDELDMLAAFADQAAQAWQLASTQHRLRELGILTDRDR
Mvan_1395|M.vanbaalenii_PYR-1 VALRPEGAPPFNAEELDMMAAFVDQAALAWQLATTQRQLRELDVLTDRDR
MSMEG_5241|M.smegmatis_MC2_155 VAVQGSGARPFTAEQLEMMTGFADQAAVAWQLASSQRRMSELDILADRDR
TH_0388|M.thermoresistible__bu VVCRAEEGRPFTDEQLEILVTFADQAALAWQLAATQRRMRELDVLSDRDR
MAB_3890c|M.abscessus_ATCC_199 ILLRTVGAIAFDEEQLDMAASFAGQAALALEQAEVRLAKHELDVLADRDR
MAV_4108|M.avium_104 AIARGTEQPPFDESYLDLVRDFATHAAIALVLAAAREDARQLAVLAERER
.. . *:: *. :** * * : :* ::::*:*
MUL_2422|M.ulcerans_Agy99 IARDLHDHVIQRLFAIGLALQGSVPRTREPKVQQRLSEVIDDLQGVIQEI
MMAR_1517|M.marinum_M IARDLHDHVIQRLFAIGLALQGSVPRTREPKVQQRLSEVIDDLQGVIQEI
Mb3156c|M.bovis_AF2122/97 IARDLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEI
Rv3132c|M.tuberculosis_H37Rv IARDLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEI
Mflv_3844|M.gilvum_PYR-GCK IARDLHDHVIQRLFAVGLSLQGSIARARSEEVQQRLSANVDDLQSVIQEI
Mvan_1395|M.vanbaalenii_PYR-1 IARDLHDHVIQRLFAVGLALQGTIPRARAPEVRERLTDCVDDLQQVIQEI
MSMEG_5241|M.smegmatis_MC2_155 IARDLHDHVIQRLFAVGLSLQGTIPRARSAEVQQRIADCVDDLQAVISEI
TH_0388|M.thermoresistible__bu IARDLHDHVIQRLFAVGLTLQGTIPRARSTEVQQRLSECIDDLQAVIGEI
MAB_3890c|M.abscessus_ATCC_199 IARDLHDHVIQRLFAVGLAMQSTHRRSVDPTVAARLADHIDQLHEVIQEI
MAV_4108|M.avium_104 IAHDLHDHVIQRLFAAGMDLQGTLARARSPEVADRLNRTLDDLQTIIEEI
**:************ *: :*.: : * *: :*:*: :* **
MUL_2422|M.ulcerans_Agy99 RTTIFDLHGSSQGVTRLRQRIDAAVAAFG-SSGLRTTVQFIGPLSVVDNV
MMAR_1517|M.marinum_M RTTIFDLHGSSQGVTRLRQRIDAAVAAFG-SSGLRTTVQFIGPLSVVDNV
Mb3156c|M.bovis_AF2122/97 RTTIYDLHGASQGITRLRQRIDAAVAQFA-DSGLRTSVQFVGPLSVVDSA
Rv3132c|M.tuberculosis_H37Rv RTTIYDLHGASQGITRLRQRIDAAVAQFA-DSGLRTSVQFVGPLSVVDSA
Mflv_3844|M.gilvum_PYR-GCK RTAIFDLHGGSSAVTRLRQRLDAAVAAFP-ESGVRTSMQCAGPLSVVDAG
Mvan_1395|M.vanbaalenii_PYR-1 RTAIFDLHGGHGGSNRLRQRLDEAIAQFT-ASDVHTTVQFSGPLSVVDPA
MSMEG_5241|M.smegmatis_MC2_155 RTAIFDLHHTAPGGTRLRQRLDEAIAQFS-GAGLHTTSQFVGPLSVVDAE
TH_0388|M.thermoresistible__bu RTTIFDLHGGPATGSQIRQRIGEAANQFS-DAGVRTRVQFAGPLSVISAV
MAB_3890c|M.abscessus_ATCC_199 RTAIFDLHTNDES---LRATLRSTINELTAETGLRVSVRMSGPLDVVPAS
MAV_4108|M.avium_104 RTTIFALRSPAAVAGDFRHRIQRVIAELTENRDLVTTVRMDGPMTAVGAE
**:*: *: :* : . : .: . : **: .:
MUL_2422|M.ulcerans_Agy99 LADHAEAVVREAVSNAVRHAQATTLTVRVKVDDDLCIEVSDNGRGMP-KT
MMAR_1517|M.marinum_M LADHAEAVVREAVSNAVRHAQATTLTVRVKVDDDLCIEVSDNGRGMP-KT
Mb3156c|M.bovis_AF2122/97 LADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLP-DE
Rv3132c|M.tuberculosis_H37Rv LADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLP-DE
Mflv_3844|M.gilvum_PYR-GCK LADHAEAVVREAVSNAVRHAEASTVAVTVTVEDDLAITVTDDGRGIA-AD
Mvan_1395|M.vanbaalenii_PYR-1 LSDHAEAVVREAVSNAIRHSGATTLDVSVTAADELIIEVADDGCGMP-AD
MSMEG_5241|M.smegmatis_MC2_155 LADHAEAVLREAVSNVVRHSGANELTVRVKVEDDLSIEVTDDGEGIS-GP
TH_0388|M.thermoresistible__bu LADHAEAVVREAVSNAVRHGGATDLSVDVSVDDDLTIEVTDNGRGFPEGE
MAB_3890c|M.abscessus_ATCC_199 TSGDAEAVVREAVSNVVRHARARELSVTVSVDDELVIEVVDDGIGIP-DV
MAV_4108|M.avium_104 LAEHAEAVTAEAVSNAVRHSGASRLTVQIGVADMFTLDVIDNGRGIAAGN
: .**** *****.:**. * : * : . * : : * *:* *:.
MUL_2422|M.ulcerans_Agy99 YTSSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPLIQ-
MMAR_1517|M.marinum_M YTSSGLTNLRRRAQEAGGQFTIESPAAGGGTLLRWSAPLIQ-
Mb3156c|M.bovis_AF2122/97 FTGSGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ-
Rv3132c|M.tuberculosis_H37Rv FTGSGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ-
Mflv_3844|M.gilvum_PYR-GCK VTGSGLANLARRAQDVGGSFSVRRGAQV-GTTLTWRAPLP--
Mvan_1395|M.vanbaalenii_PYR-1 VTESGLTNLRQRAGDVGGTFTVESGDAG-GTRLRWCAPLR--
MSMEG_5241|M.smegmatis_MC2_155 VTESGLSNLRQRADQCGGELRIIDRPGG-GTILRWTAPLPD-
TH_0388|M.thermoresistible__bu VTESGLANLRHRARHAGGTLEVHNRPDG-GARLHWSVPLT--
MAB_3890c|M.abscessus_ATCC_199 VARSGLSGLANRAAQSGGTFSVSAMDTG-GTRLVWSAPLP--
MAV_4108|M.avium_104 TRRSGLANMTRRAEQLGGSCEISSPPGG-GTRVHWTAPLLDH
***:.: .** . ** : *: : * .**