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DVLMSLLRPQAVLSKVITGAGSWGVRKPRYGDPAFCLMLEGSCVLDADGLDSIALSQGDFLLLPETPEFT LSAGPEATPSFSALDHSPHTRHGDASAPVTMRMLGGYFRFDPANAALLVALLPPVIHVRGGDPDAPRLTR LVELIAEEADADGACRDAILQRLVEVLLIEAARVQSAPDLAGPHRGLITGLADPVLAPALRALHADIAHG WTVEGLARTASVSRAVFAQKFTRAMGLTPMQYLLEWRVAVAKDLMRSERLSIAQLAQRVGYQSATAFTTA FTRVAGAPPTEFARTLAPGGV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5242 | - | - | 100% (302) | helix-turn-helix domain-containing protein |
| M. gilvum PYR-GCK | Mflv_2899 | - | 9e-12 | 38.89% (90) | helix-turn-helix domain-containing protein |
| M. gilvum PYR-GCK | Mflv_1437 | - | 3e-10 | 31.63% (98) | AraC family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1430 | - | 4e-05 | 40.00% (50) | transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv1395 | - | 4e-05 | 40.00% (50) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0767c | - | 9e-25 | 31.82% (242) | AraC family transcriptional regulator |
| M. marinum M | MMAR_1063 | - | 1e-06 | 27.07% (133) | transcriptional regulatory protein |
| M. avium 104 | MAV_0221 | - | 5e-05 | 32.32% (99) | transcriptional regulator, AraC family protein |
| M. smegmatis MC2 155 | MSMEG_4655 | - | 1e-11 | 31.61% (193) | transcriptional regulator, AraC family protein |
| M. thermoresistible (build 8) | TH_3120 | - | 6e-12 | 35.92% (103) | PUTATIVE transcriptional regulator, AraC family with |
| M. ulcerans Agy99 | MUL_0821 | - | 9e-07 | 27.07% (133) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_1013 | - | 1e-131 | 79.05% (296) | helix-turn-helix domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1063|M.marinum_M --------------MAQAARLIQHRSGVP--------IYGYRTDPDIPRV
MUL_0821|M.ulcerans_Agy99 --------MDYLWRMAQAARLIQHRSGVP--------IYGYRTDPDIPRV
Mflv_5242|M.gilvum_PYR-GCK ----MDVLMSLLRPQAVLSKVITGAGSWG--------VRKPRYGDPAFCL
Mvan_1013|M.vanbaalenii_PYR-1 ----MEVLMSLLRPEAVLSKVITGGGRWS--------VRKPRYGDPAFCL
Mb1430|M.bovis_AF2122/97 -------MGHLPPPAEVRHPVYATRVLCE--------VANERGVPTADVL
Rv1395|M.tuberculosis_H37Rv -------MGHLPPPAEVRHPVYATRVLCE--------VANERGVPTADVL
MAB_0767c|M.abscessus_ATCC_199 MIHNPDYFADQPKSLSWPTGSPSIDAFSG--------ILSAIGLRGESAL
MSMEG_4655|M.smegmatis_MC2_155 -------MQTERELLTEICERIDRHARGD--------MHTRIDGLLLSKA
MAV_0221|M.avium_104 -------MYRPSPPLAEHIEYFGYWRGDE--------ALGVHTSRALPRG
TH_3120|M.thermoresistible__bu -VAALVLDGLAIFEFGVICEVFGVDRTDDGVPPVDFTVCGPRAGQPVRTS
MMAR_1063|M.marinum_M SVLRPGPEDLGDR------ARHIHDFPALWYVPAAGLVYIAAAGQVLEPT
MUL_0821|M.ulcerans_Agy99 SVRRPGPEDLGDR------ARHIHDFPALWYVPAAGLVYIAAAGQVLEPT
Mflv_5242|M.gilvum_PYR-GCK MLEGSCVLDADG-------LDSIALSQGDFLLLPETPEFTLSAGPEATPS
Mvan_1013|M.vanbaalenii_PYR-1 MLEGLCVLDADG-------LDPLELRQGDFLLLPQTPEFTLGAGGDVAPT
Mb1430|M.bovis_AF2122/97 AGTAIEPADLDDPDAVVGALDEITAVRRLLARLPDDAGIGIDVGSRFALT
Rv1395|M.tuberculosis_H37Rv AGTAIEPADLDDPDAVVGALDEITAVRRLLARLPDDAGIGIDVGSRFALT
MAB_0767c|M.abscessus_ATCC_199 RCSAELPFDVSVPAN--ERVLHIAETAGLRVYVDGNPVCVLAAG-DMVLM
MSMEG_4655|M.smegmatis_MC2_155 AGSSRPDYTVTEP-------LLVVMARGGKRIMVGDEVYEYRTGEMLIVT
MAV_0221|M.avium_104 AVTAIIDVGGRTDLG--------FYASDARTPLTVPPAFAAGAGATAYVV
TH_3120|M.thermoresistible__bu FGATLTPDSGLDGLAGADLVAIPAIRQDDYLPEALDAVRAAADAGAIILT
.
MMAR_1063|M.marinum_M QFG---SLQGGVAMFFDPAALGGDGGSP-WPSWRTHPLLFPFLHGHSGGI
MUL_0821|M.ulcerans_Agy99 QFG---SLQAGVAMFFDPAALGGDGGSP-WPSWRTHPLLFPFLHGHSGGI
Mflv_5242|M.gilvum_PYR-GCK FSA---LDHSPHTRHGDASAPVTMRMLGGYFRFDPANAALLVALLPPVIH
Mvan_1013|M.vanbaalenii_PYR-1 FAG---LDHSRHTRHGGESEPVTMRMLGGYFRFDAANAPLLVALLPPLIL
Mb1430|M.bovis_AF2122/97 HFG---LFGFAVMSCGTLRELLTIAMR--YFALTTMHVDITLFETADDCL
Rv1395|M.tuberculosis_H37Rv HFG---LFGFAVMSCGTLRELLTIAMR--YFALTTMHVDITLFETADDCL
MAB_0767c|M.abscessus_ATCC_199 ARG---TAHRLSGAQPHGEPAGTLHWVSGRFTAERKAADPLLSVLPPAII
MSMEG_4655|M.smegmatis_MC2_155 ASL---PVTGHYLETDQPSLGMGLELRPAALAELALRAPARPALRTGSAG
MAV_0221|M.avium_104 RVA---PAHTVMTIHFRPAGALAFLGSP-LSDLEDALVGLEDLWGRDAAL
TH_3120|M.thermoresistible__bu VCSGAFLAGAAGLLDGRPCTTHWGLTEELARRYPTARVDRNVLYVDDGDL
MMAR_1063|M.marinum_M LRLEVPAARRSTWDG-------------------AIAAIEAELTARQQGY
MUL_0821|M.ulcerans_Agy99 LRLEVPAARRSTWDG-------------------AIAAIEAELTTRQQGY
Mflv_5242|M.gilvum_PYR-GCK VRGGDPDAPRLTR---------------------LVELIAEEADADGACR
Mvan_1013|M.vanbaalenii_PYR-1 VRADQPGAQRLHR---------------------LVELITGEADADGACR
Mb1430|M.bovis_AF2122/97 VELDASHLPADVRGFFIERDIAGIIATTTSFALPLAAKYADQVSAELAVD
Rv1395|M.tuberculosis_H37Rv VELDASHLPADVRGFFIERDIAGIIATTTSFALPLAAKYADQVSAELAVD
MAB_0767c|M.abscessus_ATCC_199 IQAARPGHEWLPLS---------------------LQLILAEILTPSPGS
MSMEG_4655|M.smegmatis_MC2_155 SAIAVGNADAEMLD----------------------AAARLLRLLDRPDD
MAV_0221|M.avium_104 LR-------------------------------------EQLIDAGSPPR
TH_3120|M.thermoresistible__bu ITSAGTAAG----------------------------IDACLHLVRRELG
MMAR_1063|M.marinum_M GQAVAAHLTLLLIELARLAR--DVVGDLR--------RSGEPLLAEVFEV
MUL_0821|M.ulcerans_Agy99 GQAVTAHLTLLLIELARLAR--DVVGDLR--------RSGEPLLAEVFEV
Mflv_5242|M.gilvum_PYR-GCK DAILQRLVEVLLIEAARVQSAPDLAGPHRGLITG----LADPVLAPALRA
Mvan_1013|M.vanbaalenii_PYR-1 DIILQRLVEVLLIEAMRVHTAADLGGAQRGLIAG----LADPVLAPALME
Mb1430|M.bovis_AF2122/97 AELLRPLLELVPVHDVAFGRAHNRVHFPRAMFDEPLPQADRHTLEMCIAQ
Rv1395|M.tuberculosis_H37Rv AELLRPLLELVPVHDVAFGRAHNRVHFPRAMFDEPLPQADRHTLEMCIAQ
MAB_0767c|M.abscessus_ATCC_199 WVMISRILDLLFIHAVREWSSSSHAEPGWLT------AAMDPRLAPVLTA
MSMEG_4655|M.smegmatis_MC2_155 APVLAPLVEQEILWRLLTGPHGDTVRQIALA------DSALTYINRAITW
MAV_0221|M.avium_104 RVALLQAFLVRRMRRNAVWP--------------------PARLAPVLRG
TH_3120|M.thermoresistible__bu SEVTNTIARHMVVPPQRDGGQRQFIDQPIPVR-------HSEGFAPHLDW
: : :
MMAR_1063|M.marinum_M IDRRHAEP---LSLRDVAAEVGMTPGHLTTIVRRRTGRTVQE--------
MUL_0821|M.ulcerans_Agy99 IDRRHAEP---LSLRDVAAEVGMTPGHLTTIVRRRTGRTVQE--------
Mflv_5242|M.gilvum_PYR-GCK LHADIAHG---WTVEGLARTASVSRAVFAQKFTRAMGLTPMQ--------
Mvan_1013|M.vanbaalenii_PYR-1 LHADVTHG---WTVEQLARVASVSRAVFAQRFTRTMGMPPMQ--------
Mb1430|M.bovis_AF2122/97 CDVLMQRNERRRGITALVRSKLFRDSGLFPTFTDVAGELDMHPRTLRRRL
Rv1395|M.tuberculosis_H37Rv CDVLMQRNERRRGITALVRSKLFRDSGLFPTFTDVAGELDMHPRTLRRRL
MAB_0767c|M.abscessus_ATCC_199 IHNNLEHP---WSIAELAQHARQSRSAFTQRFTELLGQPPAA--------
MSMEG_4655|M.smegmatis_MC2_155 MRDNYASP---VRIEDLARMAGMSTSVFHRHFRAVTAMSPLQ--------
MAV_0221|M.avium_104 ADLDPSMR-----VSKAQELSGLSRKRFAALFRCEVGLSPKA--------
TH_3120|M.thermoresistible__bu ILSNLDKT---HTVASLARRANMSPRTFARRFVEETGRTPMQ--------
: : . .
MMAR_1063|M.marinum_M ---------WIIERRMAQARELLVATDLAVGEVARRVGISDPGYFSRLFS
MUL_0821|M.ulcerans_Agy99 ---------WIIERRMAQARELLVATDLAVGEVARRVGISDPGYFSRLFS
Mflv_5242|M.gilvum_PYR-GCK ---------YLLEWRVAVAKDLMRSERLSIAQLAQRVGYQSATAFTTAFT
Mvan_1013|M.vanbaalenii_PYR-1 ---------YLLEWRVALAKELLRTERPAIAQLAQRVGYQSATAFTTAFT
Mb1430|M.bovis_AF2122/97 AEEGTSFRALLGEARSTVAVDLLRNVGLTVQQVSTRLGYTEVSTFSHAFK
Rv1395|M.tuberculosis_H37Rv AEEGTSFRALLGEARSTVAVDLLRNVGLTVQQVSTRLGYTEVSTFSHAFK
MAB_0767c|M.abscessus_ATCC_199 ---------YIGERRLDRAAHLLRSTTDPVRQIGRAVGYTSDAAFSRAFQ
MSMEG_4655|M.smegmatis_MC2_155 ---------FQKRIRLQQARSLLVSQPGDVAAVAHLVGYDSASQFTREYR
MAV_0221|M.avium_104 ---------YLRVLRLQAALRALDTP-ARGATIAADLGYFDQAHFVREFR
TH_3120|M.thermoresistible__bu ---------WVTDQRVLYARRLLEETDLDIHRIAARCGFGSTTLLRHHFR
* * : :. * . : :
MMAR_1063|M.marinum_M RAHGTSPRQWRALPPRH---------------
MUL_0821|M.ulcerans_Agy99 RAHGTSPRQWRALPPRH---------------
Mflv_5242|M.gilvum_PYR-GCK RVAGAPPTEFARTLAPGGV-------------
Mvan_1013|M.vanbaalenii_PYR-1 RVAGCSPTEFARTSGYVGDTG-----------
Mb1430|M.bovis_AF2122/97 RWYGVAPSEYSRRG------------------
Rv1395|M.tuberculosis_H37Rv RWYGVAPSEYSRRG------------------
MAB_0767c|M.abscessus_ATCC_199 RRFGEPPLRWRTHHRSG---------------
MSMEG_4655|M.smegmatis_MC2_155 RMFGAPPGQDAARLRAAHAPEPALLP------
MAV_0221|M.avium_104 AFTGATPTQYARRRSSMPGHVELAR-------
TH_3120|M.thermoresistible__bu RVIGVTPSDYRRRFACGSTTSGSTESGAEVTD
* .*